Scott K. Durum Cytokines and Immunity Section, Cancer Innovation Laboratory, National Cancer Institute National Institutes of Health Biography Publications Institution JoVE Articles Scott K. Durum has not added a biography. If you are Scott K. Durum and would like to personalize this page please email our Author Liaison for assistance. Publications IL-27 Induces an IFN-like Signature in Murine Macrophages Which in Turn Modulate Colonic Epithelium Frontiers in Immunology. 2023 | Pubmed ID: 37153622 A Focused Review of Ras Guanine Nucleotide-Releasing Protein 1 in Immune Cells and Cancer International Journal of Molecular Sciences. Jan, 2023 | Pubmed ID: 36675167 IL-7: Comprehensive Review Cytokine. Dec, 2022 | Pubmed ID: 36201890 Joost J. Oppenheim (1934-2022) Nature Immunology. Aug, 2022 | Pubmed ID: 35835963 Trained ILC3 Responses Promote Intestinal Defense Science (New York, N.Y.). Feb, 2022 | Pubmed ID: 35201883 Mutations That Collaborate with IL-7Ra Signaling Pathways to Drive ALL Advances in Biological Regulation. May, 2021 | Pubmed ID: 33578108 NRARP Displays Either Pro- or Anti-tumoral Roles in T-cell Acute Lymphoblastic Leukemia Depending on Notch and Wnt Signaling Oncogene. Jan, 2020 | Pubmed ID: 31586130 New Anti-IL-7Rα Monoclonal Antibodies Show Efficacy Against T Cell Acute Lymphoblastic Leukemia in Pre-clinical Models Leukemia. Jan, 2020 | Pubmed ID: 31439943 IL-22 and Its Receptors Are Increased in Human and Experimental COPD and Contribute to Pathogenesis The European Respiratory Journal. Jul, 2019 | Pubmed ID: 31196943 Clonal Vγ6Vδ4 T Cells Promote IL-17-mediated Immunity Against Skin Infection Proceedings of the National Academy of Sciences of the United States of America. May, 2019 | Pubmed ID: 31088972 Can We Target Endogenous Anti-inflammatory Responses As a Therapeutic Strategy for Inflammatory Bowel Disease? Inflammatory Bowel Diseases. Sep, 2018 | Pubmed ID: 30020451 Cytokine Tuning of Intestinal Epithelial Function Frontiers in Immunology. 2018 | Pubmed ID: 29922293 Inhibiting Janus Kinase 1 and BCL-2 to Treat T Cell Acute Lymphoblastic Leukemia with IL7-Rα Mutations Oncotarget. Apr, 2018 | Pubmed ID: 29854301 The Artificial Sweetener Splenda Promotes Gut Proteobacteria, Dysbiosis, and Myeloperoxidase Reactivity in Crohn's Disease-Like Ileitis Inflammatory Bowel Diseases. Apr, 2018 | Pubmed ID: 29554272 Mutant IL-7Rα and Mutant NRas Are Sufficient to Induce Murine T Cell Acute Lymphoblastic Leukemia Leukemia. Aug, 2018 | Pubmed ID: 29535426 The Promise of Janus Kinase Inhibitors in the Treatment of Hematological Malignancies Cytokine. Oct, 2017 | Pubmed ID: 28277287 Th22 Cells Form a Distinct Th Lineage from Th17 Cells In Vitro with Unique Transcriptional Properties and Tbet-Dependent Th1 Plasticity Journal of Immunology (Baltimore, Md. : 1950). Jan, 2017 | Pubmed ID: 28100680 Therapeutic Targeting of IL-7Rα Signaling Pathways in ALL Treatment Blood. Jul, 2016 | Pubmed ID: 27268088 Interleukin-27 As a Novel Therapy for Inflammatory Bowel Disease: A Critical Review of the Literature Inflammatory Bowel Diseases. Sep, 2016 | Pubmed ID: 27243591 Development and Preclinical Application of an Immunocompetent Transplant Model of Basal Breast Cancer with Lung, Liver and Brain Metastases PloS One. 2016 | Pubmed ID: 27171183 IL-22-Expressing Murine Lymphocytes Display Plasticity and Pathogenicity in Reporter Mice Frontiers in Immunology. 2015 | Pubmed ID: 26834739 Transcriptional Programs Define Molecular Characteristics of Innate Lymphoid Cell Classes and Subsets Nature Immunology. Mar, 2015 | Pubmed ID: 25621825 Adaptive Immunity to Murine Skin Commensals Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 25002505 IL-7 and TSLP Receptors: Twisted Sisters Blood. Jul, 2014 | Pubmed ID: 24993875 Chronic Exposure to Type-I IFN Under Lymphopenic Conditions Alters CD4 T Cell Homeostasis PLoS Pathogens. Mar, 2014 | Pubmed ID: 24603698 Targeting Interleukins for the Treatment of Inflammatory Bowel Disease-what Lies Beyond Anti-TNF Therapy? Inflammatory Bowel Diseases. Feb, 2014 | Pubmed ID: 24356385 Stemness of T Cells and the Hematopoietic Stem Cells: Fate, Memory, Niche, Cytokines Cytokine & Growth Factor Reviews. Dec, 2013 | Pubmed ID: 24231048 Oral Delivery of IL27 Recombinant Bacteria Attenuates Immune Colitis in Mice Gastroenterology. Oct, 2013 | Pubmed ID: 24120477 Regulation of in Vitro Human T Cell Development Through Interleukin-7 Deprivation and Anti-CD3 Stimulation BMC Immunology. Aug, 2012 | Pubmed ID: 22897934 The Major Isoforms of Bim Contribute to Distinct Biological Activities That Govern the Processes of Autophagy and Apoptosis in Interleukin-7 Dependent Lymphocytes Biochimica Et Biophysica Acta. Oct, 2012 | Pubmed ID: 22728771 The Human IL-7 Receptor Gene: Deletions, Polymorphisms and Mutations Seminars in Immunology. Jun, 2012 | Pubmed ID: 22425228 Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature Immunity. Dec, 2011 | Pubmed ID: 22177921 Detection of Nuclear and Membrane Antigens by Liquid-based Cytology Following Long-term Storage of D1 Cells, Karpas Cells, and Peripheral Blood Mononuclear Cells Annals of Clinical and Laboratory Science. 2011 | Pubmed ID: 22166505 Oncogenic IL7R Gain-of-function Mutations in Childhood T-cell Acute Lymphoblastic Leukemia Nature Genetics. Sep, 2011 | Pubmed ID: 21892159 Cdc25A-driven Proliferation Regulates CD62L Levels and Lymphocyte Movement in Response to Interleukin-7 Experimental Hematology. Dec, 2010 | Pubmed ID: 20831893 Interleukin-7 Regulates Bim Proapoptotic Activity in Peripheral T-cell Survival Molecular and Cellular Biology. Feb, 2010 | Pubmed ID: 19933849 Synergy of IL-23 and Th17 Cytokines: New Light on Inflammatory Bowel Disease Neurochemical Research. Jun, 2010 | Pubmed ID: 19915978 Visualization and Identification of IL-7 Producing Cells in Reporter Mice PloS One. Nov, 2009 | Pubmed ID: 19907640 Live from the Liver: Hepatocyte IL-7 Immunity. Mar, 2009 | Pubmed ID: 19303385 Development of Regulatory T Cells Requires IL-7Ralpha Stimulation by IL-7 or TSLP Blood. Oct, 2008 | Pubmed ID: 18664628 The Influence of IL-2 Family Cytokines on Activation and Function of Naturally Occurring Regulatory T Cells Journal of Leukocyte Biology. Oct, 2008 | Pubmed ID: 18653463 Interleukin-7 Receptor Expression: Intelligent Design Nature Reviews. Immunology. Feb, 2007 | Pubmed ID: 17259970 IL-7 Induces Myelopoiesis and Erythropoiesis Journal of Immunology (Baltimore, Md. : 1950). Feb, 2007 | Pubmed ID: 17237404 Role of the Intracellular Domain of IL-7 Receptor in T Cell Development Journal of Immunology (Baltimore, Md. : 1950). Jan, 2007 | Pubmed ID: 17182559 Inflammatory Processes Triggered by TCR Engagement or by Local Cytokine Expression: Differences in Profiles of Gene Expression and Infiltrating Cell Populations Journal of Leukocyte Biology. Sep, 2006 | Pubmed ID: 16793919 IL-7 Promotes T Cell Proliferation Through Destabilization of P27Kip1 The Journal of Experimental Medicine. Mar, 2006 | Pubmed ID: 16492801 Stat5a/b Are Essential for Normal Lymphoid Development and Differentiation Proceedings of the National Academy of Sciences of the United States of America. Jan, 2006 | Pubmed ID: 16418296 The Adaptive Immune Response in Neonatal Cerebral White Matter Damage Annals of Neurology. Dec, 2005 | Pubmed ID: 16250014 Cell Biology of IL-7, a Key Lymphotrophin Cytokine & Growth Factor Reviews. Aug-Oct, 2005 | Pubmed ID: 15996891 Cytokine-driven Cell Cycling is Mediated Through Cdc25A The Journal of Cell Biology. Jun, 2005 | Pubmed ID: 15928203 Distinct Regions of the Interleukin-7 Receptor Regulate Different Bcl2 Family Members Molecular and Cellular Biology. Jul, 2004 | Pubmed ID: 15226449 Interleukin-7 Inactivates the Pro-apoptotic Protein Bad Promoting T Cell Survival The Journal of Biological Chemistry. Jul, 2004 | Pubmed ID: 15123689 IL-7 Induces Tyrosine Phosphorylation of Clathrin Heavy Chain Cellular Signalling. Feb, 2004 | Pubmed ID: 14636898 Bcl11: Sibling Rivalry in Lymphoid Development Nature Immunology. Jun, 2003 | Pubmed ID: 12774073 Death and Baxes: Mechanisms of Lymphotrophic Cytokines Immunological Reviews. Jun, 2003 | Pubmed ID: 12752670 Interleukin-7 Induces MUC1 Cancer Biology & Therapy. Mar-Apr, 2003 | Pubmed ID: 12750562 Characterization of an Interleukin-7-dependent Thymic Cell Line Derived from a P53(-/-) Mouse Journal of Immunological Methods. Mar, 2003 | Pubmed ID: 12609543 Bax Deficiency Partially Corrects Interleukin-7 Receptor Alpha Deficiency Immunity. Nov, 2002 | Pubmed ID: 12433363 Lymphocide: Cytokines and the Control of Lymphoid Homeostasis Nature Reviews. Immunology. Nov, 2002 | Pubmed ID: 12415306 The Role of Cytokines in Lymphocyte Homeostasis BioTechniques. Oct, 2002 | Pubmed ID: 12395926 Activation-induced Cell Death of Aggressive Histology Lymphomas by CD40 Stimulation: Induction of Bax Blood. Jul, 2002 | Pubmed ID: 12070030 IL-7 Withdrawal Induces a Stress Pathway Activating P38 and Jun N-terminal Kinases Cellular Signalling. Sep, 2002 | Pubmed ID: 12034357 Co-culture et transduction de thymocytes murins sur des cellules stromales exprimant 4-Delta-like pour étudier les oncogènes dans la leucémie à cellules T Gisele O. L. Rodrigues1, WenQing Li1, Sarah D. Cramer1,2,3, Hila Y. Winer1, Tu Chun Hsu1,2,3, Timothy Gower4, Julie A. Hixon1, Scott K. Durum1 1Cytokines and Immunity Section, Cancer Innovation Laboratory, National Cancer Institute, National Institutes of Health, 2Comparative Biomedical Scientist Training Program, NIH, 3Department of Pathobiology and Diagnostic Investigation, Veterinary Diagnostic Laboratory, Michigan State University, 4NCI-Frederick Laboratory Animal Sciences Program JoVE 64271 Cancer Research Visualisation de l'IL-22 exprimant Lymphocytes en utilisant des souris Reporter Wei Shen1, Wenqing Li1, Julie A. Hixon1, Caroline Andrews1, Scott K. Durum1 1Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health Immunology and Infection
Co-culture et transduction de thymocytes murins sur des cellules stromales exprimant 4-Delta-like pour étudier les oncogènes dans la leucémie à cellules T Gisele O. L. Rodrigues1, WenQing Li1, Sarah D. Cramer1,2,3, Hila Y. Winer1, Tu Chun Hsu1,2,3, Timothy Gower4, Julie A. Hixon1, Scott K. Durum1 1Cytokines and Immunity Section, Cancer Innovation Laboratory, National Cancer Institute, National Institutes of Health, 2Comparative Biomedical Scientist Training Program, NIH, 3Department of Pathobiology and Diagnostic Investigation, Veterinary Diagnostic Laboratory, Michigan State University, 4NCI-Frederick Laboratory Animal Sciences Program JoVE 64271 Cancer Research
Visualisation de l'IL-22 exprimant Lymphocytes en utilisant des souris Reporter Wei Shen1, Wenqing Li1, Julie A. Hixon1, Caroline Andrews1, Scott K. Durum1 1Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health Immunology and Infection
