Sebastien Bonnet Department of Medicine, Pulmonary Hypertension Research Group (CRIUCPQ) Laval University Biography Publications Institution JoVE Articles Sebastien Bonnet has not added a biography. If you are Sebastien Bonnet and would like to personalize this page please email our Author Liaison for assistance. Publications NOGGIN: a New Therapeutic Target for PH? Focus on "Noggin Inhibits Hypoxia-Induced Proliferation by Targeting Store-operated Calcium Entry and TRPC Channels" American Journal of Physiology. Cell Physiology. Apr, 2015 | Pubmed ID: 25832472 Adaptation and Remodelling of the Pulmonary Circulation in Pulmonary Hypertension The Canadian Journal of Cardiology. Apr, 2015 | Pubmed ID: 25630876 Skeletal Muscle Proteomic Signature and Metabolic Impairment in Pulmonary Hypertension Journal of Molecular Medicine (Berlin, Germany). May, 2015 | Pubmed ID: 25548805 A MiR-208-Mef2 Axis Drives the Decompensation of Right Ventricular Function in Pulmonary Hypertension Circulation Research. Jan, 2015 | Pubmed ID: 25287062 Sirtuin 3 Deficiency is Associated with Inhibited Mitochondrial Function and Pulmonary Arterial Hypertension in Rodents and Humans Cell Metabolism. Nov, 2014 | Pubmed ID: 25284742 Alternatives to the Six-minute Walk Test in Pulmonary Arterial Hypertension PloS One. 2014 | Pubmed ID: 25111294 Vascular Remodeling Process in Pulmonary Arterial Hypertension, with Focus on MiR-204 and MiR-126 (2013 Grover Conference Series) Pulmonary Circulation. Jun, 2014 | Pubmed ID: 25006436 Impaired Angiogenesis and Peripheral Muscle Microcirculation Loss Contribute to Exercise Intolerance in Pulmonary Arterial Hypertension American Journal of Respiratory and Critical Care Medicine. Aug, 2014 | Pubmed ID: 24977625 Apolipoprotein A-I Mimetic Peptide 4F Rescues Pulmonary Hypertension by Inducing MicroRNA-193-3p Circulation. Aug, 2014 | Pubmed ID: 24963038 MiRNAs in PAH: Biomarker, Therapeutic Target or Both? Drug Discovery Today. Aug, 2014 | Pubmed ID: 24881781 Effect of Pulmonary Arterial Hypertension-specific Therapies on Health-related Quality of Life: a Systematic Review Chest. Sep, 2014 | Pubmed ID: 24626791 Role for DNA Damage Signaling in Pulmonary Arterial Hypertension Circulation. Feb, 2014 | Pubmed ID: 24270264 Targeting Cell Motility in Pulmonary Arterial Hypertension The European Respiratory Journal. Feb, 2014 | Pubmed ID: 23845719 Anti-inflammatory and Immunosuppressive Agents in PAH Handbook of Experimental Pharmacology. 2013 | Pubmed ID: 24092351 Signal Transduction in the Development of Pulmonary Arterial Hypertension Pulmonary Circulation. Apr, 2013 | Pubmed ID: 24015329 Therapeutic Potential of MicroRNA Modulation in Pulmonary Arterial Hypertension Current Vascular Pharmacology. May, 2013 | Pubmed ID: 23713859 Pim-1: A New Biomarker in Pulmonary Arterial Hypertension Pulmonary Circulation. Jan, 2013 | Pubmed ID: 23662177 Uncoupling Protein 2 Deficiency Mimics the Effects of Hypoxia and Endoplasmic Reticulum Stress on Mitochondria and Triggers Pseudohypoxic Pulmonary Vascular Remodeling and Pulmonary Hypertension Circulation Research. Jul, 2013 | Pubmed ID: 23652801 Critical Role for the Advanced Glycation End-products Receptor in Pulmonary Arterial Hypertension Etiology Journal of the American Heart Association. Feb, 2013 | Pubmed ID: 23525442 The Emergence of New Therapeutic Targets in Pulmonary Arterial Hypertension: from Now to the Near Future Expert Review of Respiratory Medicine. Feb, 2013 | Pubmed ID: 23362814 Repeatability and Responsiveness of Exercise Tests in Pulmonary Arterial Hypertension The European Respiratory Journal. Aug, 2013 | Pubmed ID: 23100508 STAT3 Signaling in Pulmonary Arterial Hypertension JAK-STAT. Oct, 2012 | Pubmed ID: 24058777 Ozone and Its Potential Control Strategy for Chon Buri City, Thailand Journal of the Air & Waste Management Association (1995). Dec, 2012 | Pubmed ID: 23362760 Framework for Life Cycle Sustainability Assessment of Municipal Solid Waste Management Systems with an Application to a Case Study in Thailand Waste Management & Research : the Journal of the International Solid Wastes and Public Cleansing Association, ISWA. Jul, 2012 | Pubmed ID: 22605020 Plumbagin Reverses Proliferation and Resistance to Apoptosis in Experimental PAH The European Respiratory Journal. Sep, 2012 | Pubmed ID: 22496325 Today's and Tomorrow's Imaging and Circulating Biomarkers for Pulmonary Arterial Hypertension Cellular and Molecular Life Sciences : CMLS. Sep, 2012 | Pubmed ID: 22446747 Krüppel-like Factor 5 Contributes to Pulmonary Artery Smooth Muscle Proliferation and Resistance to Apoptosis in Human Pulmonary Arterial Hypertension Respiratory Research. 2011 | Pubmed ID: 21951574 Dehydroepiandrosterone Inhibits the Src/STAT3 Constitutive Activation in Pulmonary Arterial Hypertension American Journal of Physiology. Heart and Circulatory Physiology. Nov, 2011 | Pubmed ID: 21890685 Pyruvate Dehydrogenase Inhibition by the Inflammatory Cytokine TNFα Contributes to the Pathogenesis of Pulmonary Arterial Hypertension Journal of Molecular Medicine (Berlin, Germany). Aug, 2011 | Pubmed ID: 21809123 From Oncoproteins/tumor Suppressors to MicroRNAs, the Newest Therapeutic Targets for Pulmonary Arterial Hypertension Journal of Molecular Medicine (Berlin, Germany). Nov, 2011 | Pubmed ID: 21761156 The Role of Nogo and the Mitochondria-endoplasmic Reticulum Unit in Pulmonary Hypertension Science Translational Medicine. Jun, 2011 | Pubmed ID: 21697531 RAGE-dependent Activation of the Oncoprotein Pim1 Plays a Critical Role in Systemic Vascular Remodeling Processes Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2011 | Pubmed ID: 21680901 Signal Transducers and Activators of Transcription-3/pim1 Axis Plays a Critical Role in the Pathogenesis of Human Pulmonary Arterial Hypertension Circulation. Mar, 2011 | Pubmed ID: 21382889 Role for MiR-204 in Human Pulmonary Arterial Hypertension The Journal of Experimental Medicine. Mar, 2011 | Pubmed ID: 21321078 Tumor Necrosis Factor Inhibitors As Novel Therapeutic Tools for Vascular Remodeling Diseases American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2010 | Pubmed ID: 20709868 Fatty Acid Oxidation and Malonyl-CoA Decarboxylase in the Vascular Remodeling of Pulmonary Hypertension Science Translational Medicine. Aug, 2010 | Pubmed ID: 20702857 HIF-1 Inhibition Decreases Systemic Vascular Remodelling Diseases by Promoting Apoptosis Through a Hexokinase 2-dependent Mechanism Cardiovascular Research. Oct, 2010 | Pubmed ID: 20498255 Dehydroepiandrosterone: A New Treatment for Vascular Remodeling Diseases Including Pulmonary Arterial Hypertension Pharmacology & Therapeutics. May, 2010 | Pubmed ID: 20206649 Dehydroepiandrosterone Reverses Systemic Vascular Remodeling Through the Inhibition of the Akt/GSK3-{beta}/NFAT Axis Circulation. Sep, 2009 | Pubmed ID: 19752325 Airway Delivery of Mesenchymal Stem Cells Prevents Arrested Alveolar Growth in Neonatal Lung Injury in Rats American Journal of Respiratory and Critical Care Medicine. Dec, 2009 | Pubmed ID: 19713449 Air Pollutant Emissions from Rice Straw Open Field Burning in India, Thailand and the Philippines Environmental Pollution (Barking, Essex : 1987). May, 2009 | Pubmed ID: 19201513 CD36 Expression Contributes to Age-induced Cardiomyopathy in Mice Circulation. Nov, 2007 | Pubmed ID: 17967771 Statin Therapy, Alone or with Rapamycin, Does Not Reverse Monocrotaline Pulmonary Arterial Hypertension: the Rapamcyin-atorvastatin-simvastatin Study American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2007 | Pubmed ID: 17675370 The Nuclear Factor of Activated T Cells in Pulmonary Arterial Hypertension Can Be Therapeutically Targeted Proceedings of the National Academy of Sciences of the United States of America. Jul, 2007 | Pubmed ID: 17596340 Potassium Channel Diversity in the Pulmonary Arteries and Pulmonary Veins: Implications for Regulation of the Pulmonary Vasculature in Health and During Pulmonary Hypertension Pharmacology & Therapeutics. Jul, 2007 | Pubmed ID: 17583356 A Mitochondria-K+ Channel Axis is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth Cancer Cell. Jan, 2007 | Pubmed ID: 17222789 Absence of Malonyl Coenzyme A Decarboxylase in Mice Increases Cardiac Glucose Oxidation and Protects the Heart from Ischemic Injury Circulation. Oct, 2006 | Pubmed ID: 17030679 An Abnormal Mitochondrial-hypoxia Inducible Factor-1alpha-Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats: Similarities to Human Pulmonary Arterial Hypertension Circulation. Jun, 2006 | Pubmed ID: 16735674 A Central Role for Oxygen-sensitive K+ Channels and Mitochondria in the Specialized Oxygen-sensing System Novartis Foundation Symposium. 2006 | Pubmed ID: 16686435 Analogues of N-hydroxycinnamoylphenalkylamides As Inhibitors of Human Melanocyte-tyrosinase Bioorganic & Medicinal Chemistry Letters. Apr, 2006 | Pubmed ID: 16442796 Discovery of Benzylidenebenzofuran-3(2H)-one (aurones) As Inhibitors of Tyrosinase Derived from Human Melanocytes Journal of Medicinal Chemistry. Jan, 2006 | Pubmed ID: 16392817 Sildenafil Improves Alveolar Growth and Pulmonary Hypertension in Hyperoxia-induced Lung Injury American Journal of Respiratory and Critical Care Medicine. Sep, 2005 | Pubmed ID: 15947285 Gene Therapy Targeting Survivin Selectively Induces Pulmonary Vascular Apoptosis and Reverses Pulmonary Arterial Hypertension The Journal of Clinical Investigation. Jun, 2005 | Pubmed ID: 15931388 Dichloroacetate Prevents and Reverses Pulmonary Hypertension by Inducing Pulmonary Artery Smooth Muscle Cell Apoptosis Circulation Research. Oct, 2004 | Pubmed ID: 15375007 Chronic Hypoxia Induces Nonreversible Right Ventricle Dysfunction and Dysplasia in Rats American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2004 | Pubmed ID: 15317673 Preferential Expression and Function of Voltage-gated, O2-sensitive K+ Channels in Resistance Pulmonary Arteries Explains Regional Heterogeneity in Hypoxic Pulmonary Vasoconstriction: Ionic Diversity in Smooth Muscle Cells Circulation Research. Aug, 2004 | Pubmed ID: 15217912 Sildenafil Alters Calcium Signaling and Vascular Tone in Pulmonary Arteries from Chronically Hypoxic Rats American Journal of Physiology. Lung Cellular and Molecular Physiology. Sep, 2004 | Pubmed ID: 15155272 Role of Ca(2+)-sensitive K(+) Channels in the Remission Phase of Pulmonary Hypertension in Chronic Obstructive Pulmonary Diseases Cardiovascular Research. Nov, 2003 | Pubmed ID: 14613862 Dehydroepiandrosterone (DHEA) Prevents and Reverses Chronic Hypoxic Pulmonary Hypertension Proceedings of the National Academy of Sciences of the United States of America. Aug, 2003 | Pubmed ID: 12878719 Upregulation of L-type Ca2+ Channels in Mesenteric and Skeletal Arteries of SHR Hypertension. Aug, 2002 | Pubmed ID: 12154116 Reversal of Chronic Hypoxia-induced Alterations in Pulmonary Artery Smooth Muscle Electromechanical Coupling Upon Air Breathing Cardiovascular Research. Mar, 2002 | Pubmed ID: 11922912 Artan Pulmoner Arter Pulsatif Akış Piglets içinde Hipoksik Pulmoner Hipertansiyon Artırır Audrey Courboulin1, Chantal Kang2, Olivier Baillard3,4,5, Sebastien Bonnet1, Pierre Bonnet6 1Department of Medicine, Pulmonary Hypertension Research Group (CRIUCPQ), Laval University, 2Institut National de la Recherche Agronomique, 3Université Diderot Paris, Sorbonne Paris Cité, 4Hôpital Lariboisière, Physiologie clinique Explorations Fonctionnelles, 5INSERM U 965, 6Service de Cardiologie, Centre Hospitalier Universitaire Tours Medicine
Artan Pulmoner Arter Pulsatif Akış Piglets içinde Hipoksik Pulmoner Hipertansiyon Artırır Audrey Courboulin1, Chantal Kang2, Olivier Baillard3,4,5, Sebastien Bonnet1, Pierre Bonnet6 1Department of Medicine, Pulmonary Hypertension Research Group (CRIUCPQ), Laval University, 2Institut National de la Recherche Agronomique, 3Université Diderot Paris, Sorbonne Paris Cité, 4Hôpital Lariboisière, Physiologie clinique Explorations Fonctionnelles, 5INSERM U 965, 6Service de Cardiologie, Centre Hospitalier Universitaire Tours Medicine
