Other Publications (1)
Articles by Seema Nandi in JoVE
Characterizing Cell Migration Within Three-dimensional In Vitro Wound Environments Seema Nandi1,2, Ashley C. Brown1,2 1Joint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina - Chapel Hill, 2Comparative Medicine Institute, North Carolina State University The goal of this protocol is to evaluate the effect of pro- and anti-migratory factors on cell migration within a three-dimensional fibrin matrix.
Other articles by Seema Nandi on PubMed
Platelet-mimetic Strategies for Modulating the Wound Environment and Inflammatory Responses Experimental Biology and Medicine (Maywood, N.J.). May, 2016 | Pubmed ID: 27190260 Platelets closely interface with the immune system to fight pathogens, target wound sites, and regulate tissue repair. Natural platelet levels within the body can be depleted for a variety of reasons, including excessive bleeding following traumatic injury, or diseases such as cancer and bacterial or viral infections. Platelet transfusions are commonly used to improve platelet count and hemostatic function in these cases, but transfusions can be complicated by the contamination risks and short storage life of donated platelets. Lyophilized platelets that can be freeze-dried and stored for longer periods of time and synthetic platelet-mimetic technologies that can enhance or replace the functions of natural platelets, while minimizing adverse immune responses have been explored as alternatives to transfusion. Synthetic platelets typically comprise nanoparticles surface-decorated with peptides or ligands to recreate specific biological characteristics of platelets, including targeting of wound and disease sites and facilitating platelet aggregation. Recent efforts in synthetic platelet design have additionally focused on matching platelet shape and mechanics to recreate the marginalization and clot contraction capabilities of natural platelets. The ability to specifically tune the properties of synthetic platelet-mimetic materials has shown utility in a variety of applications including hemostasis, drug delivery, and targeted delivery of cancer therapeutics.