Sharon C. A. Chen Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research Westmead Hospital Biography Publications Institution JoVE Articles Sharon C. A. Chen has not added a biography. If you are Sharon C. A. Chen and would like to personalize this page please email our Author Liaison for assistance. Publications Clinical Utility of Aspergillus Galactomannan and PCR in Bronchoalveolar Lavage Fluid for the Diagnosis of Invasive Pulmonary Aspergillosis in Patients with Haematological Malignancies Diagnostic Microbiology and Infectious Disease. Mar, 2014 | Pubmed ID: 24768294 Functional Disruption of Yeast Metacaspase, Mca1, Leads to Miltefosine Resistance and Inability to Mediate Miltefosine-induced Apoptotic Effects Fungal Genetics and Biology : FG & B. Jun, 2014 | Pubmed ID: 24731805 Candida Quercitrusa Candidemia: Investigation of Three Clustered Cases and Mycological Characteristics of This Novel Species Journal of Clinical Microbiology. Apr, 2014 | Pubmed ID: 24696025 Echinocandins in the Treatment of Candidaemia and Invasive Candidiasis: Clinical and Economic Perspectives International Journal of Antimicrobial Agents. Mar, 2014 | Pubmed ID: 24670423 Anti-granulocyte-macrophage Colony-stimulating Factor Autoantibodies Are a Risk Factor for Central Nervous System Infection by Cryptococcus Gattii in Otherwise Immunocompetent Patients MBio. 2014 | Pubmed ID: 24643864 A Loop-mediated Isothermal Amplification (LAMP) Assay for Strongyloides Stercoralis in Stool That Uses a Visual Detection Method with SYTO-82 Fluorescent Dye The American Journal of Tropical Medicine and Hygiene. Feb, 2014 | Pubmed ID: 24323513 Thermomyces Lanuginosus Infective Endocarditis: Case Report and a Review of Endocarditis Due to Uncommon Moulds Medical Mycology Case Reports. Sep, 2013 | Pubmed ID: 24432243 Functional Characterization of the Hexose Transporter Hxt13p: an Efflux Pump That Mediates Resistance to Miltefosine in Yeast Fungal Genetics and Biology : FG & B. Dec, 2013 | Pubmed ID: 24076076 Fungal Infections and Treatment in Cystic Fibrosis Current Opinion in Pulmonary Medicine. Nov, 2013 | Pubmed ID: 24060984 Rapid Identification of Gram-negative Organisms from Blood Culture Bottles Using a Modified Extraction Method and MALDI-TOF Mass Spectrometry Diagnostic Microbiology and Infectious Disease. Oct, 2013 | Pubmed ID: 23891220 In Vitro Activity of Miltefosine As a Single Agent and in Combination with Voriconazole or Posaconazole Against Uncommon Filamentous Fungal Pathogens The Journal of Antimicrobial Chemotherapy. Dec, 2013 | Pubmed ID: 23861311 Utility of Bronchoalveolar Lavage Fluid Galactomannan Alone or in Combination with PCR for the Diagnosis of Invasive Aspergillosis in Adult Hematology Patients: A Systematic Review and Meta-analysis Critical Reviews in Microbiology. Jun, 2013 | Pubmed ID: 23799871 Molecular Epidemiology Linking Multihospital Clusters of Opportunistic Pneumocystis Jirovecii Pneumonia Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Oct, 2013 | Pubmed ID: 23794722 Post-transplant Pneumocystis Jirovecii Pneumonia-a Re-emerged Public Health Problem? Kidney International. Jun, 2013 | Pubmed ID: 23739237 Antifungal Therapy and Management of Complications of Cryptococcosis Due to Cryptococcus Gattii Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. May, 2013 | Pubmed ID: 23697747 Galactomannan and PCR Versus Culture and Histology for Directing Use of Antifungal Treatment for Invasive Aspergillosis in High-risk Haematology Patients: a Randomised Controlled Trial The Lancet Infectious Diseases. Jun, 2013 | Pubmed ID: 23639612 Pharmacoeconomics of Empirical Antifungal Use in Febrile Neutropenic Hematological Malignancy and Hematopoietic Stem Cell Transplant Patients Expert Review of Pharmacoeconomics & Outcomes Research. Apr, 2013 | Pubmed ID: 23570433 Economic Evaluation of Micafungin Vs. Liposomal Amphotericin B (LAmB) for the Treatment of Candidaemia and Invasive Candidiasis (IC) Mycoses. Sep, 2013 | Pubmed ID: 23496163 Generalized Subcutaneous Phaeohyphomycosis Caused by Phialophora Verrucosa: Report of a Case and Review of Literature Mycopathologia. Apr, 2013 | Pubmed ID: 23392822 Current Status of Matrix-assisted Laser Desorption Ionisation-time of Flight Mass Spectrometry in the Clinical Microbiology Laboratory Pathology. Jan, 2013 | Pubmed ID: 23255029 Practical Identification of Eight Medically Important Trichosporon Species by Reverse Line Blot Hybridization (RLB) Assay and Rolling Circle Amplification (RCA) Medical Mycology. Apr, 2013 | Pubmed ID: 23186014 Cryptococcosis, Lymphoproliferative Disorders and Modern Day Chemotherapy Regimens Leukemia & Lymphoma. Mar, 2013 | Pubmed ID: 23035788 Clinical Utility of the Cryptococcal Antigen Lateral Flow Assay in a Diagnostic Mycology Laboratory PloS One. 2012 | Pubmed ID: 23166705 In Vitro Susceptibilities of Yeast Species to Fluconazole and Voriconazole As Determined by the 2010 National China Hospital Invasive Fungal Surveillance Net (CHIF-NET) Study Journal of Clinical Microbiology. Dec, 2012 | Pubmed ID: 23035204 Multicenter Study of Posaconazole Therapeutic Drug Monitoring: Exposure-response Relationship and Factors Affecting Concentration Antimicrobial Agents and Chemotherapy. Nov, 2012 | Pubmed ID: 22890761 Multicenter Study of Voriconazole Pharmacokinetics and Therapeutic Drug Monitoring Antimicrobial Agents and Chemotherapy. Sep, 2012 | Pubmed ID: 22751544 Coccidioidal Septic Arthritis: Lessons Learned from a Clinical and Laboratory Perspective The Medical Journal of Australia. Jun, 2012 | Pubmed ID: 22708769 Clinical Manifestations of Cryptococcus Gattii Infection: Determinants of Neurological Sequelae and Death Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Sep, 2012 | Pubmed ID: 22670042 Hospital Costs, Length of Stay and Mortality Attributable to Invasive Scedosporiosis in Haematology Patients The Journal of Antimicrobial Chemotherapy. Sep, 2012 | Pubmed ID: 22643193 Sporotrichosis (Sporothrix Schenckii Infection) in the New South Wales Mid-north Coast, 2000-2010 The Medical Journal of Australia. May, 2012 | Pubmed ID: 22621152 Pneumonia and Lung Infections Due to Emerging and Unusual Fungal Pathogens Seminars in Respiratory and Critical Care Medicine. Dec, 2011 | Pubmed ID: 22167398 Seeking Clarity Within Cloudy Effluents: Differentiating Fungal from Bacterial Peritonitis in Peritoneal Dialysis Patients PloS One. 2011 | Pubmed ID: 22145033 Nosocomial Pneumocystis Jirovecii Pneumonia: Lessons from a Cluster in Kidney Transplant Recipients Transplantation. Dec, 2011 | Pubmed ID: 22129760 Matrix-assisted Laser Desorption Ionization-time of Flight Mass Spectrometry Identification of Yeasts is Contingent on Robust Reference Spectra PloS One. 2011 | Pubmed ID: 22022438 Pneumocystis Jirovecii Pneumonia in Non-HIV-infected Patients: New Risks and Diagnostic Tools Current Opinion in Infectious Diseases. Dec, 2011 | Pubmed ID: 21986616 Three-locus Identification, Genotyping, and Antifungal Susceptibilities of Medically Important Trichosporon Species from China Journal of Clinical Microbiology. Nov, 2011 | Pubmed ID: 21900517 Identification of Bacteria in Blood Culture Broths Using Matrix-assisted Laser Desorption-ionization Sepsityper™ and Time of Flight Mass Spectrometry PloS One. 2011 | Pubmed ID: 21858058 Direct Effects of Non-antifungal Agents Used in Cancer Chemotherapy and Organ Transplantation on the Development and Virulence of Candida and Aspergillus Species Virulence. Jul-Aug, 2011 | Pubmed ID: 21701255 Defining Reference Sequences for Nocardia Species by Similarity and Clustering Analyses of 16S RRNA Gene Sequence Data PloS One. 2011 | Pubmed ID: 21687706 Cost-effectiveness Analysis of Anidulafungin Versus Fluconazole for the Treatment of Invasive Candidiasis The Journal of Antimicrobial Chemotherapy. Aug, 2011 | Pubmed ID: 21628305 Fatal Mycotic Aneurysms Due to Scedosporium and Pseudallescheria Infection Journal of Clinical Microbiology. May, 2011 | Pubmed ID: 21430108 Nocardia Infections of the Face and Neck Current Infectious Disease Reports. Apr, 2011 | Pubmed ID: 21365376 Development and Validation of a Multiplex PCR for Detection of Scedosporium Spp. in Respiratory Tract Specimens from Patients with Cystic Fibrosis Journal of Clinical Microbiology. Apr, 2011 | Pubmed ID: 21325557 Design Issues in a Randomized Controlled Trial of a Pre-emptive Versus Empiric Antifungal Strategy for Invasive Aspergillosis in Patients with High-risk Hematologic Malignancies Leukemia & Lymphoma. Feb, 2011 | Pubmed ID: 21281234 Echinocandin Antifungal Drugs in Fungal Infections: a Comparison Drugs. Jan, 2011 | Pubmed ID: 21175238 Recent Advances in Management of Cryptococcal Meningitis: Commentary F1000 Medicine Reports. 2010 | Pubmed ID: 21170376 Abundance of Pseudallescheria/Scedosporium Species in the Australian Urban Environment Suggests a Possible Source for Scedosporiosis Including the Colonization of Airways in Cystic Fibrosis Medical Mycology. Nov, 2010 | Pubmed ID: 21067333 Scedosporium Aurantiacum is As Virulent As S. Prolificans, and Shows Strain-specific Virulence Differences, in a Mouse Model Medical Mycology. Nov, 2010 | Pubmed ID: 21067330 Clinical Associations and Prevalence of Scedosporium Spp. in Australian Cystic Fibrosis Patients: Identification of Novel Risk Factors? Medical Mycology. Nov, 2010 | Pubmed ID: 21067328 New Molecular and Surrogate Biomarker-based Tests in the Diagnosis of Bacterial and Fungal Infection in Febrile Neutropenic Patients Current Opinion in Infectious Diseases. Dec, 2010 | Pubmed ID: 20827189 SecA1 Gene Sequence Polymorphisms for Species Identification of Nocardia Species and Recognition of Intraspecies Genetic Diversity Journal of Clinical Microbiology. Nov, 2010 | Pubmed ID: 20810768 Antifungal Therapy in Invasive Fungal Infections Current Opinion in Pharmacology. Oct, 2010 | Pubmed ID: 20598943 In Vitro Antifungal Activities of Bis(alkylpyridinium)alkane Compounds Against Pathogenic Yeasts and Molds Antimicrobial Agents and Chemotherapy. Aug, 2010 | Pubmed ID: 20530227 Candidaemia in Adult Cancer Patients: Risks for Fluconazole-resistant Isolates and Death The Journal of Antimicrobial Chemotherapy. May, 2010 | Pubmed ID: 20202987 Protein-losing Enteropathy and Hypogammaglobulinaemia As First Manifestations of Disseminated Histoplasmosis Coincident with Nocardia Infection Journal of Medical Microbiology. May, 2010 | Pubmed ID: 20133412 Comparison of Whole Blood, Serum, and Plasma for Early Detection of Candidemia by Multiplex-tandem PCR Journal of Clinical Microbiology. Mar, 2010 | Pubmed ID: 20042634 Identification of Pathogenic Nocardia Species by Reverse Line Blot Hybridization Targeting the 16S RRNA and 16S-23S RRNA Gene Spacer Regions Journal of Clinical Microbiology. Feb, 2010 | Pubmed ID: 19955277 Fungal-derived Immune Modulating Molecules Advances in Experimental Medicine and Biology. 2009 | Pubmed ID: 20054979 Diagnostic and Typing Methods for Investigating Legionella Infection New South Wales Public Health Bulletin. Sep-Oct, 2009 | Pubmed ID: 19917208 Molecular Epidemiology of Invasive Aspergillosis: Lessons Learned from an Outbreak Investigation in an Australian Hematology Unit Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America. Dec, 2009 | Pubmed ID: 19848605 Assignment of Reference 5'-end 16S RDNA Sequences and Species-Specific Sequence Polymorphisms Improves Species Identification of Nocardia The Open Microbiology Journal. 2009 | Pubmed ID: 19639036 Not Just Little Adults: Candidemia Epidemiology, Molecular Characterization, and Antifungal Susceptibility in Neonatal and Pediatric Patients Pediatrics. May, 2009 | Pubmed ID: 19403503 Genotyping of Scedosporium Species: a Review of Molecular Approaches Medical Mycology. Jun, 2009 | Pubmed ID: 19085455 Practical Method for Detection and Identification of Candida, Aspergillus, and Scedosporium Spp. by Use of Rolling-circle Amplification Journal of Clinical Microbiology. Jul, 2008 | Pubmed ID: 18495860 Molecular Typing of Australian Scedosporium Isolates Showing Genetic Variability and Numerous S. Aurantiacum Emerging Infectious Diseases. Feb, 2008 | Pubmed ID: 18258122 Treatment of Scedosporiosis with Voriconazole: Clinical Experience with 107 Patients Antimicrobial Agents and Chemotherapy. May, 2008 | Pubmed ID: 18212110 Antifungal Agents The Medical Journal of Australia. Oct, 2007 | Pubmed ID: 17908006 In Vitro Activities of Miltefosine and Two Novel Antifungal Biscationic Salts Against a Panel of 77 Dermatophytes Antimicrobial Agents and Chemotherapy. Jun, 2007 | Pubmed ID: 17371821 Cryptococcal Phospholipase B Antigen is Not Detected in Serum of Patients Infected with Cryptococcus Neoformans Using a Sandwich Enzyme-linked Immunosorbent Assay FEMS Yeast Research. May, 2007 | Pubmed ID: 17266733 Successful Treatment of a Localised CDC Group EF-4a Infection in a Cat Journal of Feline Medicine and Surgery. Feb, 2007 | Pubmed ID: 16934513 Community-acquired Methicillin-resistant Staphylococcus Aureus: Time for Action Pathology. Jun, 2006 | Pubmed ID: 16753738 Disseminated Mycobacterium Avium Infection in Young Cats: Overrepresentation of Abyssinian Cats Journal of Feline Medicine and Surgery. Feb, 2006 | Pubmed ID: 16226469 Cryptococcal Phospholipases: a Novel Lysophospholipase Discovered in the Pathogenic Fungus Cryptococcus Gattii The Biochemical Journal. Dec, 2004 | Pubmed ID: 15320865 A Review of Nucleic Acid-based Diagnostic Tests for Systemic Mycoses with an Emphasis on Polymerase Chain Reaction-based Assays Medical Mycology. Aug, 2002 | Pubmed ID: 12230214 Strain-dependent Effects of Environmental Signals on the Production of Extracellular Phospholipase by Cryptococcus Neoformans FEMS Microbiology Letters. Apr, 2002 | Pubmed ID: 12007802 Cryptococcosis in Australasia and the Treatment of Cryptococcal and Other Fungal Infections with Liposomal Amphotericin B The Journal of Antimicrobial Chemotherapy. Feb, 2002 | Pubmed ID: 11801583 Rápida identificação de bactérias gram-negativas de Sangue Cultura Caldo Usando MALDI-TOF Espectrometria de Massa Timothy J. Gray1, Lee Thomas1, Tom Olma1, David H. Mitchell1, Jon R. Iredell1,2,3, Sharon C. A. Chen1,3 1Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, 2Centre for Research Excellence in Critical Infection, Westmead Millennium Institute, Westmead Hospital, 3Sydney Emerging Infectious Diseases Institute, University of Sydney, Westmead Hospital JoVE 51663 Immunology and Infection
Rápida identificação de bactérias gram-negativas de Sangue Cultura Caldo Usando MALDI-TOF Espectrometria de Massa Timothy J. Gray1, Lee Thomas1, Tom Olma1, David H. Mitchell1, Jon R. Iredell1,2,3, Sharon C. A. Chen1,3 1Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, 2Centre for Research Excellence in Critical Infection, Westmead Millennium Institute, Westmead Hospital, 3Sydney Emerging Infectious Diseases Institute, University of Sydney, Westmead Hospital JoVE 51663 Immunology and Infection
