Shaun R. Coughlin

Publications

• Gαi/o-coupled Receptor Signaling Restricts Pancreatic β-cell Expansion
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2015  |   Pubmed ID: 25695968
• Redundancy and Interaction of Thrombin- and Collagen-mediated Platelet Activation in Tail Bleeding and Carotid Thrombosis in Mice
  Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2014  |   Pubmed ID: 25278288
• Podoplanin Maintains High Endothelial Venule Integrity by Interacting with Platelet CLEC-2
  Nature. Oct, 2013  |   Pubmed ID: 23995678
• IL-7 Production in Murine Lymphatic Endothelial Cells and Induction in the Setting of Peripheral Lymphopenia
  International Immunology. Aug, 2013  |   Pubmed ID: 23657000
• PAR1 Contributes to Influenza A Virus Pathogenicity in Mice
  The Journal of Clinical Investigation. Jan, 2013  |   Pubmed ID: 23202729
• High-resolution Crystal Structure of Human Protease-activated Receptor 1
  Nature. Dec, 2012  |   Pubmed ID: 23222541
• TMEM16F Forms a Ca2+-activated Cation Channel Required for Lipid Scrambling in Platelets During Blood Coagulation
  Cell. Sep, 2012  |   Pubmed ID: 23021219
• Wnt/β-catenin Signaling is Differentially Regulated by Gα Proteins and Contributes to Fibrous Dysplasia
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011  |   Pubmed ID: 22106277
• Carcinoma Mucins Trigger Reciprocal Activation of Platelets and Neutrophils in a Murine Model of Trousseau Syndrome
  Blood. Oct, 2011  |   Pubmed ID: 21860019
• The Sphingosine 1-phosphate Receptor S1P₂ Maintains the Homeostasis of Germinal Center B Cells and Promotes Niche Confinement
  Nature Immunology. Jul, 2011  |   Pubmed ID: 21642988
• PAR2 Absence Completely Rescues Inflammation and Ichthyosis Caused by Altered CAP1/Prss8 Expression in Mouse Skin
  Nature Communications. Jan, 2011  |   Pubmed ID: 21245842
• Roles E Interacciones Entre Receptores Activados Proteasa Y P2ry12 En Hemostasia Y Trombosis
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2010  |   Pubmed ID: 20930120
• Identifying Patients at High Risk of a Cardiovascular Event in the Near Future: Current Status and Future Directions: Report of a National Heart, Lung, and Blood Institute Working Group
  Circulation. Mar, 2010  |   Pubmed ID: 20351302
• Local Protease Signaling Contributes to Neural Tube Closure in the Mouse Embryo
  Developmental Cell. Jan, 2010  |   Pubmed ID: 20152175
• Lymphatic Endothelial Cell Sphingosine Kinase Activity is Required for Lymphocyte Egress and Lymphatic Patterning
  The Journal of Experimental Medicine. Jan, 2010  |   Pubmed ID: 20026661
• Sphingosine-1-phosphate in the Plasma Compartment Regulates Basal and Inflammation-induced Vascular Leak in Mice
  The Journal of Clinical Investigation. Jul, 2009  |   Pubmed ID: 19603543
• Identification of a Transient Subpial Neurogenic Zone in the Developing Dentate Gyrus and Its Regulation by Cxcl12 and Reelin Signaling
  Development (Cambridge, England). Jan, 2009  |   Pubmed ID: 19103804
• Anatomical Profiling of G Protein-coupled Receptor Expression
  Cell. Oct, 2008  |   Pubmed ID: 18984166
• Maternal Par4 and Platelets Contribute to Defective Placenta Formation in Mouse Embryos Lacking Thrombomodulin
  Blood. Aug, 2008  |   Pubmed ID: 18490515
• Un Papel Crítico Para Isomerasa Del Disulfuro De Proteína Extracelular Durante La Formación Del Trombo En Ratones
  The Journal of Clinical Investigation. Mar, 2008  |   Pubmed ID: 18292814
• Probing Cell Type-specific Functions of Gi in Vivo Identifies GPCR Regulators of Insulin Secretion
  The Journal of Clinical Investigation. Dec, 2007  |   Pubmed ID: 17992256
• Receptor Activado Proteasa 2, Dipeptidil Peptidasa I Y Proteasas Median La Enteritis De Toxina De Clostridium Difficile
  Gastroenterology. Jun, 2007  |   Pubmed ID: 17570216
• Fetal Gene Defects Precipitate Platelet-mediated Pregnancy Failure in Factor V Leiden Mothers
  The Journal of Experimental Medicine. May, 2007  |   Pubmed ID: 17438064
• Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-phosphate
  Science (New York, N.Y.). Apr, 2007  |   Pubmed ID: 17363629
• Par4 is Required for Platelet Thrombus Propagation but Not Fibrin Generation in a Mouse Model of Thrombosis
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2007  |   Pubmed ID: 17190826
• Roles of Protease-activated Receptors in a Mouse Model of Endotoxemia
  Blood. May, 2006  |   Pubmed ID: 16434493
• Protease-activated Receptor-2 Activation Induces Acute Lung Inflammation by Neuropeptide-dependent Mechanisms
  Journal of Immunology (Baltimore, Md. : 1950). Aug, 2005  |   Pubmed ID: 16081834
• Essential Role for Galpha13 in Endothelial Cells During Embryonic Development
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2005  |   Pubmed ID: 15919816
• PAR1 Cleavage and Signaling in Response to Activated Protein C and Thrombin
  The Journal of Biological Chemistry. Apr, 2005  |   Pubmed ID: 15665002
• Platelets, Protease-activated Receptors, and Fibrinogen in Hematogenous Metastasis
  Blood. Jul, 2004  |   Pubmed ID: 15031212
• Regulated Shedding of PAR1 N-terminal Exodomain from Endothelial Cells
  The Journal of Biological Chemistry. Apr, 2004  |   Pubmed ID: 14982936
• Combined Deficiency of Protease-activated Receptor-4 and Fibrinogen Recapitulates the Hemostatic Defect but Not the Embryonic Lethality of Prothrombin Deficiency
  Blood. Jan, 2004  |   Pubmed ID: 14504091
• Protease-activated Receptors 1 and 4 Mediate Thrombin Signaling in Endothelial Cells
  Blood. Nov, 2003  |   Pubmed ID: 12869501
• The Rho Guanine Nucleotide Exchange Factor Lsc Homo-oligomerizes and is Negatively Regulated Through Domains in Its Carboxyl Terminus That Are Absent in Novel Splenic Isoforms
  The Journal of Biological Chemistry. Aug, 2003  |   Pubmed ID: 12773540
• PARticipation in Inflammation
  The Journal of Clinical Investigation. Jan, 2003  |   Pubmed ID: 12511583
• Descripción General De La Alianza Para La Señalización Celular
  Nature. Dec, 2002  |   Pubmed ID: 12478301
• Protection Against Thrombosis in Mice Lacking PAR3
  Blood. Nov, 2002  |   Pubmed ID: 12384423
• Genetic Evidence That Protease-activated Receptors Mediate Factor Xa Signaling in Endothelial Cells
  The Journal of Biological Chemistry. May, 2002  |   Pubmed ID: 11850418