Shelton Earp

Publications

• Bimodal Age Distribution at Diagnosis in Breast Cancer Persists Across Molecular and Genomic Classifications
  Breast Cancer Research and Treatment. Sep, 2019  |   Pubmed ID: 31535320
• Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology
  Journal of the American Chemical Society. Oct, 2019  |   Pubmed ID: 31497954
• TAM Family Receptor Kinase Inhibition Reverses MDSC-Mediated Suppression and Augments Anti-PD-1 Therapy in Melanoma
  Cancer Immunology Research. Oct, 2019  |   Pubmed ID: 31451482
• Kinome Profiling of Non-Hodgkin Lymphoma Identifies Tyro3 As a Therapeutic Target in Primary Effusion Lymphoma
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2019  |   Pubmed ID: 31346082
• Beyond Growth Signaling: Apoptotic Sensor MERTK Activates AKT by a Novel Mechanism
  Molecular & Cellular Oncology. 2019  |   Pubmed ID: 31211243
• MERTK Mediated Novel Site Akt Phosphorylation Alleviates SAV1 Suppression
  Nature Communications. 04, 2019  |   Pubmed ID: 30944303
• SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)
  Journal of Medicinal Chemistry. Mar, 2019  |   Pubmed ID: 30768268
• Inhibition of MERTK Promotes Suppression of Tumor Growth in BRAF Mutant and BRAF Wild-Type Melanoma
  Molecular Cancer Therapeutics. 02, 2019  |   Pubmed ID: 30482852
• The Prognostic Significance of Low-Frequency Somatic Mutations in Metastatic Cutaneous Melanoma
  Frontiers in Oncology. 2018  |   Pubmed ID: 30662871
• ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer
  Molecular Cell. 10, 2018  |   Pubmed ID: 30270106
• MERTK Promotes Resistance to Irreversible EGFR Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancers Expressing Wild-type Family Members
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 12, 2018  |   Pubmed ID: 30194074
• MERTK Mediates Intrinsic and Adaptive Resistance to AXL-targeting Agents
  Molecular Cancer Therapeutics. 11, 2018  |   Pubmed ID: 30093568
• Identification of Clonal Hematopoiesis Mutations in Solid Tumor Patients Undergoing Unpaired Next-Generation Sequencing Assays
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 12, 2018  |   Pubmed ID: 29866652
• Factor XIIIA-expressing Inflammatory Monocytes Promote Lung Squamous Cancer Through Fibrin Cross-linking
  Nature Communications. 05, 2018  |   Pubmed ID: 29777108
• Tumor-secreted Pros1 Inhibits Macrophage M1 Polarization to Reduce Antitumor Immune Response
  The Journal of Clinical Investigation. 06, 2018  |   Pubmed ID: 29708510
• Enhancing Next-Generation Sequencing-Guided Cancer Care Through Cognitive Computing
  The Oncologist. 02, 2018  |   Pubmed ID: 29158372
• The Small-molecule MERTK Inhibitor UNC2025 Decreases Platelet Activation and Prevents Thrombosis
  Journal of Thrombosis and Haemostasis : JTH. 02, 2018  |   Pubmed ID: 29045015
• Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study
  Journal of the National Cancer Institute. 02, 2018  |   Pubmed ID: 28859290
• Discovery of Macrocyclic Pyrimidines As MerTK-Specific Inhibitors
  ChemMedChem. 02, 2017  |   Pubmed ID: 28032464
• Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors
  ACS Medicinal Chemistry Letters. Dec, 2016  |   Pubmed ID: 27994735
• MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme
  PloS One. 2016  |   Pubmed ID: 27783662
• The MERTK/FLT3 Inhibitor MRX-2843 Overcomes Resistance-conferring FLT3 Mutations in Acute Myeloid Leukemia
  JCI Insight. Mar, 2016  |   Pubmed ID: 27158668
• Germline Analysis from Tumor-Germline Sequencing Dyads to Identify Clinically Actionable Secondary Findings
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2016  |   Pubmed ID: 27083775
• Small Molecule Inhibition of MERTK Is Efficacious in Non-Small Cell Lung Cancer Models Independent of Driver Oncogene Status
  Molecular Cancer Therapeutics. Sep, 2015  |   Pubmed ID: 26162689
• Combined Targeted DNA Sequencing in Non-Small Cell Lung Cancer (NSCLC) Using UNCseq and NGScopy, and RNA Sequencing Using UNCqeR for the Detection of Genetic Aberrations in NSCLC
  PloS One. 2015  |   Pubmed ID: 26076459
• Mutation of Androgen Receptor N-terminal Phosphorylation Site Tyr-267 Leads to Inhibition of Nuclear Translocation and DNA Binding
  PloS One. 2015  |   Pubmed ID: 25950519
• Mer590, a Novel Monoclonal Antibody Targeting MER Receptor Tyrosine Kinase, Decreases Colony Formation and Increases Chemosensitivity in Non-small Cell Lung Cancer
  Oncotarget. Nov, 2014  |   Pubmed ID: 25372020
• UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor
  Journal of Medicinal Chemistry. Aug, 2014  |   Pubmed ID: 25068800
• Discovery of Mer Specific Tyrosine Kinase Inhibitors for the Treatment and Prevention of Thrombosis
  Journal of Medicinal Chemistry. Dec, 2013  |   Pubmed ID: 24219778
• Pseudo-cyclization Through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines As New Mer Kinase Inhibitors
  Journal of Medicinal Chemistry. Dec, 2013  |   Pubmed ID: 24195762
• UNC569, a Novel Small Molecule Mer Inhibitor with Efficacy Against Acute Lymphoblastic Leukemia in Vitro and in Vivo
  Molecular Cancer Therapeutics. Aug, 2013  |   Pubmed ID: 23997116
• Molecular Pathways: MERTK Signaling in Cancer
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2013  |   Pubmed ID: 23833304
• UNC1062, a New and Potent Mer Inhibitor
  European Journal of Medicinal Chemistry. Jul, 2013  |   Pubmed ID: 23693152
• MERTK Receptor Tyrosine Kinase is a Therapeutic Target in Melanoma
  The Journal of Clinical Investigation. May, 2013  |   Pubmed ID: 23585477
• Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia
  ACS Medicinal Chemistry Letters. Feb, 2012  |   Pubmed ID: 22662287
• Increased Hematopoietic Cells in the Mertk-/- Mouse Peritoneal Cavity: a Result of Augmented Migration
  Journal of Immunology (Baltimore, Md. : 1950). Jun, 2010  |   Pubmed ID: 20483720
• Dasatinib Inhibits Site-specific Tyrosine Phosphorylation of Androgen Receptor by Ack1 and Src Kinases
  Oncogene. Jun, 2010  |   Pubmed ID: 20383201
• A Novel Role for C-Src and STAT3 in Apoptotic Cell-mediated MerTK-dependent Immunoregulation of Dendritic Cells
  Blood. Oct, 2009  |   Pubmed ID: 19667404
• TAM Receptors Are Dispensable in the Phagocytosis and Killing of Bacteria
  Cellular Immunology. 2009  |   Pubmed ID: 19625016
• ErbB4 Splice Variants Cyt1 and Cyt2 Differ by 16 Amino Acids and Exert Opposing Effects on the Mammary Epithelium in Vivo
  Molecular and Cellular Biology. Sep, 2009  |   Pubmed ID: 19596786
• The E3 Ubiquitin Ligase WWP1 Selectively Targets HER4 and Its Proteolytically Derived Signaling Isoforms for Degradation
  Molecular and Cellular Biology. Feb, 2009  |   Pubmed ID: 19047365
• Research for North Carolina: The University Cancer Research Fund
  North Carolina Medical Journal. Jul-Aug, 2008  |   Pubmed ID: 18828322
• Capacitative Calcium Entry Contributes to the Differential Transactivation of the Epidermal Growth Factor Receptor in Response to Thiazolidinediones
  Molecular Pharmacology. Nov, 2007  |   Pubmed ID: 17686966
• The HER4 Cytoplasmic Domain, but Not Its C Terminus, Inhibits Mammary Cell Proliferation
  Molecular Endocrinology (Baltimore, Md.). Aug, 2007  |   Pubmed ID: 17505063
• Activated Cdc42-associated Kinase Ack1 Promotes Prostate Cancer Progression Via Androgen Receptor Tyrosine Phosphorylation
  Proceedings of the National Academy of Sciences of the United States of America. May, 2007  |   Pubmed ID: 17494760
• Apoptotic Cells Induce Mer Tyrosine Kinase-dependent Blockade of NF-kappaB Activation in Dendritic Cells
  Blood. Jan, 2007  |   Pubmed ID: 17008547
• The Intracellular Domain of ErbB4 Induces Differentiation of Mammary Epithelial Cells
  Molecular Biology of the Cell. Sep, 2006  |   Pubmed ID: 16837552
• Activated Tyrosine Kinase Ack1 Promotes Prostate Tumorigenesis: Role of Ack1 in Polyubiquitination of Tumor Suppressor Wwox
  Cancer Research. Nov, 2005  |   Pubmed ID: 16288044
• Role of Gas6 Receptors in Platelet Signaling During Thrombus Stabilization and Implications for Antithrombotic Therapy
  The Journal of Clinical Investigation. Feb, 2005  |   Pubmed ID: 15650770
• The C-mer Gene is Induced by Epstein-Barr Virus Immediate-early Protein BRLF1
  Journal of Virology. Nov, 2004  |   Pubmed ID: 15479819
• Dendritic Cells Can Be Rapidly Expanded Ex Vivo and Safely Administered in Patients with Metastatic Breast Cancer
  Cancer Immunology, Immunotherapy : CII. Sep, 2004  |   Pubmed ID: 15185007
• Dependence of Peroxisome Proliferator-activated Receptor Ligand-induced Mitogen-activated Protein Kinase Signaling on Epidermal Growth Factor Receptor Transactivation
  The Journal of Biological Chemistry. Nov, 2003  |   Pubmed ID: 12966092
• The EGF Receptor Family--multiple Roles in Proliferation, Differentiation, and Neoplasia with an Emphasis on HER4
  Transactions of the American Clinical and Climatological Association. 2003  |   Pubmed ID: 12813928
• Human Epidermal Receptor-2 Expression in Prostate Cancer
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2003  |   Pubmed ID: 12631612
• Transactivation of the EGF Receptor: is the PDGF Receptor an Unexpected Accomplice?
  Molecular Interventions. Jul, 2002  |   Pubmed ID: 14993390
• Inactivation of the Antiapoptotic Phosphatidylinositol 3-kinase-Akt Pathway by the Combined Treatment of Taxol and Mitogen-activated Protein Kinase Kinase Inhibition
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2002  |   Pubmed ID: 12114408