Silvia Muro Fischell Department of Bioengineering University of Maryland Biography Publications Institution JoVE Articles Silvia Muro has not added a biography. If you are Silvia Muro and would like to personalize this page please email our Author Liaison for assistance. Publications Investigating Polymer Thiolation in Gene Delivery Journal of Biomaterials Science. Polymer Edition. 2013 | Pubmed ID: 23647248 In Vivo Performance of Polymer Nanocarriers Dually-targeted to Epitopes of the Same or Different Receptors Biomaterials. Apr, 2013 | Pubmed ID: 23398883 Comparative Binding, Endocytosis, and Biodistribution of Antibodies and Antibody-coated Carriers for Targeted Delivery of Lysosomal Enzymes to ICAM-1 Versus Transferrin Receptor Journal of Inherited Metabolic Disease. May, 2013 | Pubmed ID: 22968581 Acute and Chronic Shear Stress Differently Regulate Endothelial Internalization of Nanocarriers Targeted to Platelet-endothelial Cell Adhesion Molecule-1 ACS Nano. Oct, 2012 | Pubmed ID: 22957767 Biodistribution and Endocytosis of ICAM-1-targeting Antibodies Versus Nanocarriers in the Gastrointestinal Tract in Mice International Journal of Nanomedicine. 2012 | Pubmed ID: 22915850 Challenges in Design and Characterization of Ligand-targeted Drug Delivery Systems Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2012 | Pubmed ID: 22709588 Transport of Nanocarriers Across Gastrointestinal Epithelial Cells by a New Transcellular Route Induced by Targeting ICAM-1 Journal of Controlled Release : Official Journal of the Controlled Release Society. Oct, 2012 | Pubmed ID: 22698938 Endothelial Targeting of Polymeric Nanoparticles Stably Labeled with the PET Imaging Radioisotope Iodine-124 Biomaterials. Jul, 2012 | Pubmed ID: 22560201 Effect of Thiol Pendant Conjugates on Plasmid DNA Binding, Release, and Stability of Polymeric Delivery Vectors Biomacromolecules. May, 2012 | Pubmed ID: 22515194 Intercellular Adhesion Molecule 1 Engagement Modulates Sphingomyelinase and Ceramide, Supporting Uptake of Drug Carriers by the Vascular Endothelium Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2012 | Pubmed ID: 22328778 A Fibrinogen-derived Peptide Provides Intercellular Adhesion Molecule-1-specific Targeting and Intraendothelial Transport of Polymer Nanocarriers in Human Cell Cultures and Mice The Journal of Pharmacology and Experimental Therapeutics. Mar, 2012 | Pubmed ID: 22160267 Effect of Flow on Endothelial Endocytosis of Nanocarriers Targeted to ICAM-1 Journal of Controlled Release : Official Journal of the Controlled Release Society. Feb, 2012 | Pubmed ID: 21951807 Enhanced Delivery of α-glucosidase for Pompe Disease by ICAM-1-targeted Nanocarriers: Comparative Performance of a Strategy for Three Distinct Lysosomal Storage Disorders Nanomedicine : Nanotechnology, Biology, and Medicine. Jul, 2012 | Pubmed ID: 21906578 Effect of Glycocalyx on Drug Delivery Carriers Targeted to Endothelial Cells International Journal of Transport Phenomena. Jan, 2011 | Pubmed ID: 22679359 Endothelial Targeting of Antibody-decorated Polymeric Filomicelles ACS Nano. Sep, 2011 | Pubmed ID: 21838300 Enhanced Endothelial Delivery and Biochemical Effects of α-galactosidase by ICAM-1-targeted Nanocarriers for Fabry Disease Journal of Controlled Release : Official Journal of the Controlled Release Society. Feb, 2011 | Pubmed ID: 21047542 Optimizing Endothelial Targeting by Modulating the Antibody Density and Particle Concentration of Anti-ICAM Coated Carriers Journal of Controlled Release : Official Journal of the Controlled Release Society. Feb, 2011 | Pubmed ID: 21047540 New Biotechnological and Nanomedicine Strategies for Treatment of Lysosomal Storage Disorders Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. Mar-Apr, 2010 | Pubmed ID: 20112244 Flow Dynamics, Binding and Detachment of Spherical Carriers Targeted to ICAM-1 on Endothelial Cells Biorheology. 2009 | Pubmed ID: 19721193 Oxygen Microscopy by Two-photon-excited Phosphorescence Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. Aug, 2008 | Pubmed ID: 18663708 Differential Intra-endothelial Delivery of Polymer Nanocarriers Targeted to Distinct PECAM-1 Epitopes Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2008 | Pubmed ID: 18606202 Control of Endothelial Targeting and Intracellular Delivery of Therapeutic Enzymes by Modulating the Size and Shape of ICAM-1-targeted Carriers Molecular Therapy : the Journal of the American Society of Gene Therapy. Aug, 2008 | Pubmed ID: 18560419 Delivery of Acid Sphingomyelinase in Normal and Niemann-pick Disease Mice Using Intercellular Adhesion Molecule-1-targeted Polymer Nanocarriers The Journal of Pharmacology and Experimental Therapeutics. May, 2008 | Pubmed ID: 18287213 RhoA Activation and Actin Reorganization Involved in Endothelial CAM-mediated Endocytosis of Anti-PECAM Carriers: Critical Role for Tyrosine 686 in the Cytoplasmic Tail of PECAM-1 Blood. Mar, 2008 | Pubmed ID: 18182571 In Vivo Imaging of 64Cu-labeled Polymer Nanoparticles Targeted to the Lung Endothelium Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jan, 2008 | Pubmed ID: 18077519 Advanced Drug Delivery Systems That Target the Vascular Endothelium Molecular Interventions. Apr, 2006 | Pubmed ID: 16565472 Endothelial Targeting of High-affinity Multivalent Polymer Nanocarriers Directed to Intercellular Adhesion Molecule 1 The Journal of Pharmacology and Experimental Therapeutics. Jun, 2006 | Pubmed ID: 16505161 Control of Intracellular Trafficking of ICAM-1-targeted Nanocarriers by Endothelial Na+/H+ Exchanger Proteins American Journal of Physiology. Lung Cellular and Molecular Physiology. May, 2006 | Pubmed ID: 16299052 Lysosomal Enzyme Delivery by ICAM-1-targeted Nanocarriers Bypassing Glycosylation- and Clathrin-dependent Endocytosis Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2006 | Pubmed ID: 16153895 ICAM-1 Recycling in Endothelial Cells: a Novel Pathway for Sustained Intracellular Delivery and Prolonged Effects of Drugs Blood. Jan, 2005 | Pubmed ID: 15367437 Endothelial Endocytic Pathways: Gates for Vascular Drug Delivery Current Vascular Pharmacology. Jul, 2004 | Pubmed ID: 15320826 Characterization of Endothelial Internalization and Targeting of Antibody-enzyme Conjugates in Cell Cultures and in Laboratory Animals Methods in Molecular Biology (Clifton, N.J.). 2004 | Pubmed ID: 15197300 Slow Intracellular Trafficking of Catalase Nanoparticles Targeted to ICAM-1 Protects Endothelial Cells from Oxidative Stress American Journal of Physiology. Cell Physiology. Nov, 2003 | Pubmed ID: 12878488 Immunotargeting of Catalase to the Pulmonary Endothelium Alleviates Oxidative Stress and Reduces Acute Lung Transplantation Injury Nature Biotechnology. Apr, 2003 | Pubmed ID: 12652312 A Novel Endocytic Pathway Induced by Clustering Endothelial ICAM-1 or PECAM-1 Journal of Cell Science. Apr, 2003 | Pubmed ID: 12640043 ICAM-directed Vascular Immunotargeting of Antithrombotic Agents to the Endothelial Luminal Surface Blood. May, 2003 | Pubmed ID: 12531816 Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers Rasa Ghaffarian1, Silvia Muro1,2 1Fischell Department of Bioengineering, University of Maryland, 2Institute for Bioscience and Biotechnology Research, University of Maryland JoVE 50638 Bioengineering
Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers Rasa Ghaffarian1, Silvia Muro1,2 1Fischell Department of Bioengineering, University of Maryland, 2Institute for Bioscience and Biotechnology Research, University of Maryland JoVE 50638 Bioengineering
