Simon Melov Buck Institute for Research on Aging Biography Publications Institution JoVE Articles Simon Melov has not added a biography. If you are Simon Melov and would like to personalize this page please email our Author Liaison for assistance. Publications Massage Therapy Attenuates Inflammatory Signaling After Exercise-induced Muscle Damage Science Translational Medicine. Feb, 2012 | Pubmed ID: 22301554 Mitochondrial Oxidative Stress Caused by Sod2 Deficiency Promotes Cellular Senescence and Aging Phenotypes in the Skin Aging. Jan, 2012 | Pubmed ID: 22278880 Human Embryonic Stem Cells Express Elevated Levels of Multiple Pro-apoptotic BCL-2 Family Members PloS One. 2011 | Pubmed ID: 22174832 On the Programmed/non-programmed Nature of Ageing Within the Life History Current Biology : CB. Sep, 2011 | Pubmed ID: 21959160 Cellular Senescence: a Link Between Cancer and Age-related Degenerative Disease? Seminars in Cancer Biology. Dec, 2011 | Pubmed ID: 21925603 Life Span Extension Via EIF4G Inhibition is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. Elegans Cell Metabolism. Jul, 2011 | Pubmed ID: 21723504 Loss of Intestinal Nuclei and Intestinal Integrity in Aging C. elegans Aging Cell. Aug, 2011 | Pubmed ID: 21501374 Endurance Exercise Rescues Progeroid Aging and Induces Systemic Mitochondrial Rejuvenation in MtDNA Mutator Mice Proceedings of the National Academy of Sciences of the United States of America. Mar, 2011 | Pubmed ID: 21368114 The Garlic Constituent Diallyl Trisulfide Increases the Lifespan of C. Elegans Via Skn-1 Activation Experimental Gerontology. Jun, 2011 | Pubmed ID: 21296648 Impaired Spare Respiratory Capacity in Cortical Synaptosomes from Sod2 Null Mice Free Radical Biology & Medicine. Apr, 2011 | Pubmed ID: 21215798 Insulin-like Signaling Determines Survival During Stress Via Posttranscriptional Mechanisms in C. Elegans Cell Metabolism. Sep, 2010 | Pubmed ID: 20816092 Eccentric Exercise Activates Novel Transcriptional Regulation of Hypertrophic Signaling Pathways Not Affected by Hormone Changes PloS One. 2010 | Pubmed ID: 20502695 Limb Immobilization Induces a Coordinate Down-regulation of Mitochondrial and Other Metabolic Pathways in Men and Women PloS One. 2009 | Pubmed ID: 19654872 A Human Protein Interaction Network Shows Conservation of Aging Processes Between Human and Invertebrate Species PLoS Genetics. Mar, 2009 | Pubmed ID: 19293945 Increase in Mitochondrial Biogenesis, Oxidative Stress, and Glycolysis in Murine Lymphomas Free Radical Biology & Medicine. Feb, 2009 | Pubmed ID: 19038329 Age-related Behaviors Have Distinct Transcriptional Profiles in Caenorhabditis Elegans Aging Cell. Dec, 2008 | Pubmed ID: 18778409 Pharmacogenetic Analysis of Lithium-induced Delayed Aging in Caenorhabditis Elegans The Journal of Biological Chemistry. Jan, 2008 | Pubmed ID: 17959600 Global and Targeted Gene Expression and Protein Content in Skeletal Muscle of Young Men Following Short-term Creatine Monohydrate Supplementation Physiological Genomics. Jan, 2008 | Pubmed ID: 17957000 Gene Expression Changes Associated with Aging in C. Elegans WormBook : the Online Review of C. Elegans Biology. 2007 | Pubmed ID: 18050504 Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau PloS One. 2007 | Pubmed ID: 17579710 Resistance Exercise Reverses Aging in Human Skeletal Muscle PloS One. 2007 | Pubmed ID: 17520024 Dramatic Age-related Changes in Nuclear and Genome Copy Number in the Nematode Caenorhabditis Elegans Aging Cell. Apr, 2007 | Pubmed ID: 17286610 Nigrostriatal Dopaminergic Neurodegeneration in the Weaver Mouse is Mediated Via Neuroinflammation and Alleviated by Minocycline Administration The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2006 | Pubmed ID: 17093086 Pol II-expressed ShRNA Knocks Down Sod2 Gene Expression and Causes Phenotypes of the Gene Knockout in Mice PLoS Genetics. Jan, 2006 | Pubmed ID: 16450009 Mitochondrial Reactive Oxygen Species in Mice Lacking Superoxide Dismutase 2: Attenuation Via Antioxidant Treatment The Journal of Biological Chemistry. Feb, 2006 | Pubmed ID: 16326710 Science Fact and the SENS Agenda. What Can We Reasonably Expect from Ageing Research? EMBO Reports. Nov, 2005 | Pubmed ID: 16264422 Biomarker Discovery and Analysis Platform: Application to Alzheimer's Disease BioTechniques. Oct, 2005 | Pubmed ID: 16235574 Alzheimer Disease Beta-amyloid Activity Mimics Cholesterol Oxidase The Journal of Clinical Investigation. Sep, 2005 | Pubmed ID: 16127459 Hyperplasia, Reduced E-cadherin Expression, and Developmental Arrest in Mammary Glands Oxidatively Stressed by Loss of Mitochondrial Superoxide Dismutase Breast (Edinburgh, Scotland). Aug, 2005 | Pubmed ID: 16085231 Pharmacogenomic Profiling of an Oxidative Stress-mediated Spongiform Encephalopathy Free Radical Biology & Medicine. Jul, 2005 | Pubmed ID: 15964507 Mice Transgenic for Alzheimer Disease Beta-amyloid Develop Lens Cataracts That Are Rescued by Antioxidant Treatment Free Radical Biology & Medicine. Jan, 2005 | Pubmed ID: 15607908 Gene Expression Profiling in Mitochondrial Disease: Assessment of Microarray Accuracy by High-throughput Q-PCR Mitochondrion. Sep, 2004 | Pubmed ID: 16120406 Microarrays As a Tool to Investigate the Biology of Aging: a Retrospective and a Look to the Future Science of Aging Knowledge Environment : SAGE KE. Oct, 2004 | Pubmed ID: 15498758 Proteomic Analysis of Mitochondrial Proteins International Review of Neurobiology. 2004 | Pubmed ID: 15482810 Modeling Mitochondrial Function in Aging Neurons Trends in Neurosciences. Oct, 2004 | Pubmed ID: 15374671 Microscale Fractionation Facilitates Detection of Differentially Expressed Proteins in Alzheimer's Disease Brain Samples Electrophoresis. Aug, 2004 | Pubmed ID: 15300776 Microarray Analysis of Gene Expression with Age in Individual Nematodes Aging Cell. Jun, 2004 | Pubmed ID: 15153179 Endogenous Mitochondrial Oxidative Stress: Neurodegeneration, Proteomic Analysis, Specific Respiratory Chain Defects, and Efficacious Antioxidant Therapy in Superoxide Dismutase 2 Null Mice Journal of Neurochemistry. Feb, 2004 | Pubmed ID: 14720215 Oxygen Sensitivity Severely Limits the Replicative Lifespan of Murine Fibroblasts Nature Cell Biology. Aug, 2003 | Pubmed ID: 12855956 Microarray Workshop on Aging Mechanisms of Ageing and Development. Jan, 2003 | Pubmed ID: 12618016 Spotlight on Nematode Mitochondria in RNAi Mega-screen Science of Aging Knowledge Environment : SAGE KE. Nov, 2002 | Pubmed ID: 14603016 Oxidative Stress and Aging: Beyond Correlation Aging Cell. Dec, 2002 | Pubmed ID: 12882341 Animal Models of Oxidative Stress, Aging, and Therapeutic Antioxidant Interventions The International Journal of Biochemistry & Cell Biology. Nov, 2002 | Pubmed ID: 12200034 Therapeutics Against Mitochondrial Oxidative Stress in Animal Models of Aging Annals of the New York Academy of Sciences. Apr, 2002 | Pubmed ID: 11976207 Applied Proteomics: Mitochondrial Proteins and Effect on Function Circulation Research. Mar, 2002 | Pubmed ID: 11884366 '...and C is for Clioquinol' - the AbetaCs of Alzheimer's Disease Trends in Neurosciences. Mar, 2002 | Pubmed ID: 11852134 Profiling única célula transcricional dos cardiomiócitos de rato adulto James M. Flynn1, Luis F. Santana2, Simon Melov1 1Buck Institute for Research on Aging, 2Department of Physiology & Biophysics, University of Washington JoVE 3302 Biology
Profiling única célula transcricional dos cardiomiócitos de rato adulto James M. Flynn1, Luis F. Santana2, Simon Melov1 1Buck Institute for Research on Aging, 2Department of Physiology & Biophysics, University of Washington JoVE 3302 Biology