Simon Melov Buck Institute for Research on Aging Biography Publications Institution JoVE Articles Simon Melov has not added a biography. If you are Simon Melov and would like to personalize this page please email our Author Liaison for assistance. Publications Massage Therapy Attenuates Inflammatory Signaling After Exercise-induced Muscle Damage Science Translational Medicine. Feb, 2012 | Pubmed ID: 22301554 Mitochondrial Oxidative Stress Caused by Sod2 Deficiency Promotes Cellular Senescence and Aging Phenotypes in the Skin Aging. Jan, 2012 | Pubmed ID: 22278880 Human Embryonic Stem Cells Express Elevated Levels of Multiple Pro-apoptotic BCL-2 Family Members PloS One. 2011 | Pubmed ID: 22174832 On the Programmed/non-programmed Nature of Ageing Within the Life History Current Biology : CB. Sep, 2011 | Pubmed ID: 21959160 Cellular Senescence: a Link Between Cancer and Age-related Degenerative Disease? Seminars in Cancer Biology. Dec, 2011 | Pubmed ID: 21925603 Life Span Extension Via EIF4G Inhibition is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. Elegans Cell Metabolism. Jul, 2011 | Pubmed ID: 21723504 Loss of Intestinal Nuclei and Intestinal Integrity in Aging C. elegans Aging Cell. Aug, 2011 | Pubmed ID: 21501374 Endurance Exercise Rescues Progeroid Aging and Induces Systemic Mitochondrial Rejuvenation in MtDNA Mutator Mice Proceedings of the National Academy of Sciences of the United States of America. Mar, 2011 | Pubmed ID: 21368114 The Garlic Constituent Diallyl Trisulfide Increases the Lifespan of C. Elegans Via Skn-1 Activation Experimental Gerontology. Jun, 2011 | Pubmed ID: 21296648 Impaired Spare Respiratory Capacity in Cortical Synaptosomes from Sod2 Null Mice Free Radical Biology & Medicine. Apr, 2011 | Pubmed ID: 21215798 Insulin-like Signaling Determines Survival During Stress Via Posttranscriptional Mechanisms in C. Elegans Cell Metabolism. Sep, 2010 | Pubmed ID: 20816092 Eccentric Exercise Activates Novel Transcriptional Regulation of Hypertrophic Signaling Pathways Not Affected by Hormone Changes PloS One. 2010 | Pubmed ID: 20502695 Limb Immobilization Induces a Coordinate Down-regulation of Mitochondrial and Other Metabolic Pathways in Men and Women PloS One. 2009 | Pubmed ID: 19654872 A Human Protein Interaction Network Shows Conservation of Aging Processes Between Human and Invertebrate Species PLoS Genetics. Mar, 2009 | Pubmed ID: 19293945 Increase in Mitochondrial Biogenesis, Oxidative Stress, and Glycolysis in Murine Lymphomas Free Radical Biology & Medicine. Feb, 2009 | Pubmed ID: 19038329 Age-related Behaviors Have Distinct Transcriptional Profiles in Caenorhabditis Elegans Aging Cell. Dec, 2008 | Pubmed ID: 18778409 Pharmacogenetic Analysis of Lithium-induced Delayed Aging in Caenorhabditis Elegans The Journal of Biological Chemistry. Jan, 2008 | Pubmed ID: 17959600 Global and Targeted Gene Expression and Protein Content in Skeletal Muscle of Young Men Following Short-term Creatine Monohydrate Supplementation Physiological Genomics. Jan, 2008 | Pubmed ID: 17957000 Gene Expression Changes Associated with Aging in C. Elegans WormBook : the Online Review of C. Elegans Biology. 2007 | Pubmed ID: 18050504 Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau PloS One. 2007 | Pubmed ID: 17579710 Resistance Exercise Reverses Aging in Human Skeletal Muscle PloS One. 2007 | Pubmed ID: 17520024 Dramatic Age-related Changes in Nuclear and Genome Copy Number in the Nematode Caenorhabditis Elegans Aging Cell. Apr, 2007 | Pubmed ID: 17286610 Nigrostriatal Dopaminergic Neurodegeneration in the Weaver Mouse is Mediated Via Neuroinflammation and Alleviated by Minocycline Administration The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2006 | Pubmed ID: 17093086 Pol II-expressed ShRNA Knocks Down Sod2 Gene Expression and Causes Phenotypes of the Gene Knockout in Mice PLoS Genetics. Jan, 2006 | Pubmed ID: 16450009 Mitochondrial Reactive Oxygen Species in Mice Lacking Superoxide Dismutase 2: Attenuation Via Antioxidant Treatment The Journal of Biological Chemistry. Feb, 2006 | Pubmed ID: 16326710 Science Fact and the SENS Agenda. What Can We Reasonably Expect from Ageing Research? EMBO Reports. Nov, 2005 | Pubmed ID: 16264422 Biomarker Discovery and Analysis Platform: Application to Alzheimer's Disease BioTechniques. Oct, 2005 | Pubmed ID: 16235574 Alzheimer Disease Beta-amyloid Activity Mimics Cholesterol Oxidase The Journal of Clinical Investigation. Sep, 2005 | Pubmed ID: 16127459 Hyperplasia, Reduced E-cadherin Expression, and Developmental Arrest in Mammary Glands Oxidatively Stressed by Loss of Mitochondrial Superoxide Dismutase Breast (Edinburgh, Scotland). Aug, 2005 | Pubmed ID: 16085231 Pharmacogenomic Profiling of an Oxidative Stress-mediated Spongiform Encephalopathy Free Radical Biology & Medicine. Jul, 2005 | Pubmed ID: 15964507 Mice Transgenic for Alzheimer Disease Beta-amyloid Develop Lens Cataracts That Are Rescued by Antioxidant Treatment Free Radical Biology & Medicine. Jan, 2005 | Pubmed ID: 15607908 Gene Expression Profiling in Mitochondrial Disease: Assessment of Microarray Accuracy by High-throughput Q-PCR Mitochondrion. Sep, 2004 | Pubmed ID: 16120406 Microarrays As a Tool to Investigate the Biology of Aging: a Retrospective and a Look to the Future Science of Aging Knowledge Environment : SAGE KE. Oct, 2004 | Pubmed ID: 15498758 Proteomic Analysis of Mitochondrial Proteins International Review of Neurobiology. 2004 | Pubmed ID: 15482810 Modeling Mitochondrial Function in Aging Neurons Trends in Neurosciences. Oct, 2004 | Pubmed ID: 15374671 Microscale Fractionation Facilitates Detection of Differentially Expressed Proteins in Alzheimer's Disease Brain Samples Electrophoresis. Aug, 2004 | Pubmed ID: 15300776 Microarray Analysis of Gene Expression with Age in Individual Nematodes Aging Cell. Jun, 2004 | Pubmed ID: 15153179 Endogenous Mitochondrial Oxidative Stress: Neurodegeneration, Proteomic Analysis, Specific Respiratory Chain Defects, and Efficacious Antioxidant Therapy in Superoxide Dismutase 2 Null Mice Journal of Neurochemistry. Feb, 2004 | Pubmed ID: 14720215 Oxygen Sensitivity Severely Limits the Replicative Lifespan of Murine Fibroblasts Nature Cell Biology. Aug, 2003 | Pubmed ID: 12855956 Microarray Workshop on Aging Mechanisms of Ageing and Development. Jan, 2003 | Pubmed ID: 12618016 Spotlight on Nematode Mitochondria in RNAi Mega-screen Science of Aging Knowledge Environment : SAGE KE. Nov, 2002 | Pubmed ID: 14603016 Oxidative Stress and Aging: Beyond Correlation Aging Cell. Dec, 2002 | Pubmed ID: 12882341 Animal Models of Oxidative Stress, Aging, and Therapeutic Antioxidant Interventions The International Journal of Biochemistry & Cell Biology. Nov, 2002 | Pubmed ID: 12200034 Therapeutics Against Mitochondrial Oxidative Stress in Animal Models of Aging Annals of the New York Academy of Sciences. Apr, 2002 | Pubmed ID: 11976207 Applied Proteomics: Mitochondrial Proteins and Effect on Function Circulation Research. Mar, 2002 | Pubmed ID: 11884366 '...and C is for Clioquinol' - the AbetaCs of Alzheimer's Disease Trends in Neurosciences. Mar, 2002 | Pubmed ID: 11852134 Yetişkin Fare kardiyomiyositlerde Tek Hücre transkripsiyonel Profilleme James M. Flynn1, Luis F. Santana2, Simon Melov1 1Buck Institute for Research on Aging, 2Department of Physiology & Biophysics, University of Washington JoVE 3302 Biology
Yetişkin Fare kardiyomiyositlerde Tek Hücre transkripsiyonel Profilleme James M. Flynn1, Luis F. Santana2, Simon Melov1 1Buck Institute for Research on Aging, 2Department of Physiology & Biophysics, University of Washington JoVE 3302 Biology