Articles by Sivan Yuran in JoVE
短いペプチドの自己組織化によって順序付け生体分子構造の形成 Sivan Yuran1, Meital Reches1 1Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem 本論文では、自己組織化の自発的プロセスによる高度に秩序ペプチドベースの構造の形成を説明しています。この方法は、市販のペプチドおよび共通実験装置を利用しています。この技術は、ペプチドの多種多様に適用することができる、新たなペプチドベースアセンブリの発見につながることができる。
Other articles by Sivan Yuran on PubMed
Coassembly of Aromatic Dipeptides into Biomolecular Necklaces ACS Nano. Nov, 2012 | Pubmed ID: 23061818 This paper describes the formation of complex peptide-based structures by the coassembly of two simple peptides, the diphenylalanine peptide and its tert-butyl dicarbonate (Boc) protected analogue. Each of these peptides can self-assemble into a distinct architecture: the diphenylalanine peptide into tubular structures and its analogue into spheres. Integrated together, these peptides coassemble into a construction of beaded strings, where spherical assemblies are connected by elongated elements. Electron and scanning force microscopy demonstrated the morphology of these structures, which we termed "biomolecular necklaces". Additional experiments indicated the reversibility of the coassembly process and the stability of the structures. Furthermore, we suggest a possible mechanism of formation for the biomolecular necklaces. Our suggestion is based on the necklace model for polyelectrolyte chains, which proposes that a necklace structure appears as a result of counterion condensation on the backbone of a polyelectrolyte. Overall, the approach of coassembly, demonstrated using aromatic peptides, can be adapted to any peptides and may lead to the development and discovery of new self-assembled architectures formed by peptides and other biomolecules.