Sridhar Mani

Publications

• Understanding and Modulating Mammalian-Microbial Communication for Improved Human Health
  Annual Review of Pharmacology and Toxicology. Oct, 2013  |   Pubmed ID: 24160697
• Clinical Outcome and Prognostic Markers for Patients with Gynecologic Malignancies in Phase 1 Clinical Trials: a Single Institution Experience from 1999 to 2010
  Gynecologic Oncology. Oct, 2013  |   Pubmed ID: 23877015
• Molecular Insights into Microbial β-glucuronidase Inhibition to Abrogate CPT-11 Toxicity
  Molecular Pharmacology. Aug, 2013  |   Pubmed ID: 23690068
• Therapeutic Targeting of CPT-11 Induced Diarrhea: a Case for Prophylaxis
  Current Drug Targets. Jun, 2013  |   Pubmed ID: 23597015
• Chrysin Ameliorates Chemically Induced Colitis in the Mouse Through Modulation of a PXR/NF-κB Signaling Pathway
  The Journal of Pharmacology and Experimental Therapeutics. Jun, 2013  |   Pubmed ID: 23536316
• Novel Yeast-based Strategy Unveils Antagonist Binding Regions on the Nuclear Xenobiotic Receptor PXR
  The Journal of Biological Chemistry. May, 2013  |   Pubmed ID: 23525103
• Protective Effect of Naringenin Against Experimental Colitis Via Suppression of Toll-like Receptor 4/NF-κB Signalling
  The British Journal of Nutrition. Aug, 2013  |   Pubmed ID: 23506745
• Methodologies to Decipher the Cell Secretome
  Biochimica Et Biophysica Acta. Nov, 2013  |   Pubmed ID: 23376189
• PXR Antagonists and Implication in Drug Metabolism
  Drug Metabolism Reviews. Feb, 2013  |   Pubmed ID: 23330542
• Pregnane Xenobiotic Receptor in Cancer Pathogenesis and Therapeutic Response
  Cancer Letters. Jan, 2013  |   Pubmed ID: 22939994
• Alleviation of Gut Inflammation by Cdx2/Pxr Pathway in a Mouse Model of Chemical Colitis
  PloS One. 2012  |   Pubmed ID: 22815676
• Safety, Pharmacokinetics, and Activity of EZN-2208, a Novel Conjugate of Polyethylene Glycol and SN38, in Patients with Advanced Malignancies
  Cancer. Dec, 2012  |   Pubmed ID: 22674635
• Pharmacokinetics and Safety of Bortezomib in Patients with Advanced Malignancies and Varying Degrees of Liver Dysfunction: Phase I NCI Organ Dysfunction Working Group Study NCI-6432
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2012  |   Pubmed ID: 22394984
• Phase I Dose Escalation Study of KOS-1584, a Novel Epothilone, in Patients with Advanced Solid Tumors
  Cancer Chemotherapy and Pharmacology. Feb, 2012  |   Pubmed ID: 21874318
• Sixth International Congress on Shwachman-Diamond Syndrome: from Patients to Genes and Back
  Annals of the New York Academy of Sciences. Dec, 2011  |   Pubmed ID: 22191554
• Metformin Suppresses Pregnane X Receptor (PXR)-regulated Transactivation of CYP3A4 Gene
  Biochemical Pharmacology. Dec, 2011  |   Pubmed ID: 21920351
• Pregnane X Receptor Activation Induces FGF19-dependent Tumor Aggressiveness in Humans and Mice
  The Journal of Clinical Investigation. Aug, 2011  |   Pubmed ID: 21747170
• Dose-escalating and Pharmacological Study of Bortezomib in Adult Cancer Patients with Impaired Renal Function: a National Cancer Institute Organ Dysfunction Working Group Study
  Cancer Chemotherapy and Pharmacology. Dec, 2011  |   Pubmed ID: 21479634
• In Vivo and in Vitro Characterization of a First-in-class Novel Azole Analog That Targets Pregnane X Receptor Activation
  Molecular Pharmacology. Jul, 2011  |   Pubmed ID: 21464197
• Post-translational Modification of Pregnane X Receptor
  Pharmacological Research : the Official Journal of the Italian Pharmacological Society. Jul, 2011  |   Pubmed ID: 21397695
• Acetylation of Pregnane X Receptor Protein Determines Selective Function Independent of Ligand Activation
  Biochemical and Biophysical Research Communications. Mar, 2011  |   Pubmed ID: 21329659
• Potent Inhibition of Rhabdoid Tumor Cells by Combination of Flavopiridol and 4OH-tamoxifen
  BMC Cancer. 2010  |   Pubmed ID: 21092078
• Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme
  Science (New York, N.Y.). Nov, 2010  |   Pubmed ID: 21051639
• Induction of CYP3A4 by Vinblastine: Role of the Nuclear Receptor NR1I2
  The Annals of Pharmacotherapy. Nov, 2010  |   Pubmed ID: 20959500
• Evaluation of Computational Docking to Identify Pregnane X Receptor Agonists in the ToxCast Database
  Environmental Health Perspectives. Oct, 2010  |   Pubmed ID: 20558333
• Orphan Nuclear Receptors As Targets for Drug Development
  Pharmaceutical Research. Aug, 2010  |   Pubmed ID: 20372994
• Phase II Study of Paclitaxel Plus the Protein Kinase C Inhibitor Bryostatin-1 in Advanced Pancreatic Carcinoma
  American Journal of Clinical Oncology. Apr, 2010  |   Pubmed ID: 19738452
• Intravenous Administration of Reolysin, a Live Replication Competent RNA Virus is Safe in Patients with Advanced Solid Tumors
  Investigational New Drugs. Oct, 2010  |   Pubmed ID: 19572105
• Design, Synthesis and Biological Evaluation of 2H-benzo[b][1,4] Oxazine Derivatives As Hypoxia Targeted Compounds for Cancer Therapeutics
  Bioorganic & Medicinal Chemistry Letters. Aug, 2009  |   Pubmed ID: 19515559
• A Phase I Study of Eribulin Mesylate (E7389), a Mechanistically Novel Inhibitor of Microtubule Dynamics, in Patients with Advanced Solid Malignancies
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2009  |   Pubmed ID: 19509177
• Elucidating the 'Jekyll and Hyde' Nature of PXR: the Case for Discovering Antagonists or Allosteric Antagonists
  Pharmaceutical Research. Aug, 2009  |   Pubmed ID: 19415465
• Alterations of Chemotherapeutic Pharmacokinetic Profiles by Drug-drug Interactions
  Expert Opinion on Drug Metabolism & Toxicology. Feb, 2009  |   Pubmed ID: 19239394
• The Efficacy and Safety of Ixabepilone Monotherapy in the Treatment of Breast and Gynecologic Malignancies
  Expert Opinion on Drug Safety. Jan, 2009  |   Pubmed ID: 19236220
• A Phase 1 Open-label, Accelerated Dose-escalation Study of the Hypoxia-activated Prodrug AQ4N in Patients with Advanced Malignancies
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2008  |   Pubmed ID: 18981010
• Novel Orphan Nuclear Receptors-coregulator Interactions Controlling Anti-cancer Drug Metabolism
  Current Drug Metabolism. Sep, 2008  |   Pubmed ID: 18781912
• Expanding the Roles for Pregnane X Receptor in Cancer: Proliferation and Drug Resistance in Ovarian Cancer
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2008  |   Pubmed ID: 18765524
• Synthesis of Novel Ketoconazole Derivatives As Inhibitors of the Human Pregnane X Receptor (PXR; NR1I2; Also Termed SXR, PAR)
  Bioorganic & Medicinal Chemistry Letters. Jul, 2008  |   Pubmed ID: 18583127
• Computational Discovery of Novel Low Micromolar Human Pregnane X Receptor Antagonists
  Molecular Pharmacology. Sep, 2008  |   Pubmed ID: 18579710
• The Effect of Ketoconazole on the Pharmacokinetics and Pharmacodynamics of Ixabepilone: a First in Class Epothilone B Analogue in Late-phase Clinical Development
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2008  |   Pubmed ID: 18451235
• Agranulocytosis Induced by Nonchemotherapy Drugs
  Annals of Internal Medicine. Feb, 2008  |   Pubmed ID: 18283213
• Phase I and Pharmacokinetic Study of Imatinib Mesylate in Patients with Advanced Malignancies and Varying Degrees of Renal Dysfunction: a Study by the National Cancer Institute Organ Dysfunction Working Group
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2008  |   Pubmed ID: 18235116
• Rhabdoid Tumor Growth is Inhibited by Flavopiridol
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2008  |   Pubmed ID: 18223228
• The Phytoestrogen Coumestrol is a Naturally Occurring Antagonist of the Human Pregnane X Receptor
  Molecular Endocrinology (Baltimore, Md.). Apr, 2008  |   Pubmed ID: 18096694
• Oxaliplatin Pharmacokinetics and Pharmacodynamics in Adult Cancer Patients with Impaired Renal Function
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2007  |   Pubmed ID: 17699862
• Human Pregnane X Receptor Antagonists and Agonists Define Molecular Requirements for Different Binding Sites
  Molecular Pharmacology. Sep, 2007  |   Pubmed ID: 17576789
• Dose-escalating and Pharmacologic Study of Oxaliplatin in Adult Cancer Patients with Impaired Hepatic Function: a National Cancer Institute Organ Dysfunction Working Group Study
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2007  |   Pubmed ID: 17575231
• Activated Pregnenolone X-receptor is a Target for Ketoconazole and Its Analogs
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2007  |   Pubmed ID: 17438109
• Phase I Study of Inhaled Doxorubicin for Patients with Metastatic Tumors to the Lungs
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2007  |   Pubmed ID: 17317836
• Pharmacokinetic and Safety Study of Weekly Irinotecan and Oral Capecitabine in Patients with Advanced Solid Cancers
  Investigational New Drugs. Jun, 2007  |   Pubmed ID: 17195945
• Phase II Trial of Nolatrexed Dihydrochloride [Thymitaq, AG 337] in Patients with Advanced Hepatocellular Carcinoma
  Investigational New Drugs. Feb, 2007  |   Pubmed ID: 16957834
• Autoantibody Cancer Biomarker: Extracellular Protein Kinase A
  Cancer Research. Sep, 2006  |   Pubmed ID: 16982736
• Phase II Study of Mitomycin-C, Adriamycin, Cisplatin (MAP) and Bleomycin-CCNU in Patients with Advanced Cancer of the Anal Canal: An Eastern Cooperative Oncology Group Study E7282
  Investigational New Drugs. Sep, 2006  |   Pubmed ID: 16763788
• A Phase I Safety and Dose Escalation Trial of Docetaxel Combined with GEM231, a Second Generation Antisense Oligonucleotide Targeting Protein Kinase A R1alpha in Patients with Advanced Solid Cancers
  Investigational New Drugs. Mar, 2006  |   Pubmed ID: 16683205
• Disposition of 9-nitrocamptothecin and Its 9-aminocamptothecin Metabolite in Relation to ABC Transporter Genotypes
  Investigational New Drugs. Sep, 2006  |   Pubmed ID: 16505951
• Clinical and Pharmacokinetic Study Evaluating the Effect of Food on the Disposition of 9-nitrocamptothecin and Its 9-aminocamptothecin Metabolite in Patients with Solid Tumors
  Cancer Chemotherapy and Pharmacology. May, 2006  |   Pubmed ID: 16205924
• Phase I and Pharmacokinetic Study of the Novel Redox-active Agent, Motexafin Gadolinium, with Concurrent Radiation Therapy in Patients with Locally Advanced Pancreatic or Biliary Cancers
  Cancer Chemotherapy and Pharmacology. Apr, 2006  |   Pubmed ID: 16133531
• Activation of the Steroid and Xenobiotic Receptor (human Pregnane X Receptor) by Nontaxane Microtubule-stabilizing Agents
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2005  |   Pubmed ID: 16144941
• Phase II Trials of Dolastatin-10 in Advanced Pancreaticobiliary Cancers
  Investigational New Drugs. Oct, 2005  |   Pubmed ID: 16133801
• A Study of Cytotoxic Synergy of UCN-01 and Flavopiridol in Syngeneic Pair of Cell Lines
  Investigational New Drugs. Aug, 2005  |   Pubmed ID: 16012789
• Modulation of Irinotecan with Cyclosporine: a Phase II Trial in Advanced Colorectal Cancer
  Cancer Chemotherapy and Pharmacology. Oct, 2005  |   Pubmed ID: 15895230
• A Phase II Trial of Fixed Dose Rate Gemcitabine in Patients with Advanced Biliary Tree Carcinoma
  American Journal of Clinical Oncology. Dec, 2004  |   Pubmed ID: 15577433
• A Phase I Trial of Pharmacologic Modulation of Irinotecan with Cyclosporine and Phenobarbital
  Clinical Pharmacology and Therapeutics. Nov, 2004  |   Pubmed ID: 15536463
• Phase I Clinical Trial of CEP-2563 Dihydrochloride, a Receptor Tyrosine Kinase Inhibitor, in Patients with Refractory Solid Tumors
  Investigational New Drugs. Nov, 2004  |   Pubmed ID: 15292715
• UCN-01 Alters Phosphorylation of Akt and GSK3beta and Induces Apoptosis in Six Independent Human Neuroblastoma Cell Lines
  Journal of Neurochemistry. Aug, 2004  |   Pubmed ID: 15255949
• The Clinical Development of New Mitotic Inhibitors That Stabilize the Microtubule
  Anti-cancer Drugs. Jul, 2004  |   Pubmed ID: 15205596
• 9-Aminocamptothecin (9-AC) Given As a 120-hour Continuous Infusion in Patients with Advanced Adenocarcinomas of the Stomach and Gastroesophageal Junction: A Phase II Trial of the University of Chicago Phase II Consortium
  Investigational New Drugs. Aug, 2004  |   Pubmed ID: 15122080
• Phase I Clinical and Pharmacokinetic Study of BMS-247550, a Novel Derivative of Epothilone B, in Solid Tumors
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2004  |   Pubmed ID: 14977827
• TNFerade Biologic, an Adenovector with a Radiation-inducible Promoter, Carrying the Human Tumor Necrosis Factor Alpha Gene: a Phase I Study in Patients with Solid Tumors
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2004  |   Pubmed ID: 14726502
• Administration of Oxaliplatin to Patients with Renal Dysfunction: a Preliminary Report of the National Cancer Institute Organ Dysfunction Working Group
  Seminars in Oncology. Aug, 2003  |   Pubmed ID: 14523791
• Pharmacology of Oxaliplatin in Solid Tumor Patients with Hepatic Dysfunction: a Preliminary Report of the National Cancer Institute Organ Dysfunction Working Group
  Seminars in Oncology. Aug, 2003  |   Pubmed ID: 14523790
• A Safety Study of a Mixed-backbone Oligonucleotide (GEM231) Targeting the Type I Regulatory Subunit Alpha of Protein Kinase A Using a Continuous Infusion Schedule in Patients with Refractory Solid Tumors
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2003  |   Pubmed ID: 14519628
• Dose-escalating and Pharmacological Study of Oxaliplatin in Adult Cancer Patients with Impaired Renal Function: a National Cancer Institute Organ Dysfunction Working Group Study
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jul, 2003  |   Pubmed ID: 12860942
• Erlotinib (Tarceva): a Promising Drug Targeting Epidermal Growth Factor Receptor Tyrosine Kinase
  Expert Review of Anticancer Therapy. Jun, 2003  |   Pubmed ID: 12820772
• Current Approaches to Novel Therapeutics in Pancreatic Cancer
  Investigational New Drugs. Feb, 2003  |   Pubmed ID: 12795537
• A Phase II Study of Rebeccamycin Analog NSC 655649 in Patients with Metastatic Colorectal Cancer
  Investigational New Drugs. Feb, 2003  |   Pubmed ID: 12795535
• The BCL2-family of Protein Ligands As Cancer Drugs: the Next Generation of Therapeutics
  Current Medicinal Chemistry. Anti-cancer Agents. May, 2003  |   Pubmed ID: 12769779
• A Pilot Study of Edrecolomab (Panorex, 17-1A Antibody) and Capecitabine in Patients with Advanced or Metastatic Adenocarcinoma
  Cancer Investigation. Apr, 2003  |   Pubmed ID: 12743982
• Phase 1 Dose Escalation Study of Docetaxel with Filgrastim Support in Patients with Advanced Solid Tumors
  Medical Oncology (Northwood, London, England). 2003  |   Pubmed ID: 12665678
• Flavopiridol and Trastuzumab Synergistically Inhibit Proliferation of Breast Cancer Cells: Association with Selective Cooperative Inhibition of Cyclin D1-dependent Kinase and Akt Signaling Pathways
  Molecular Cancer Therapeutics. Jul, 2002  |   Pubmed ID: 12479366
• Phase I Clinical Trial of Irinotecan with Oral Capecitabine in Patients with Gastrointestinal and Other Solid Malignancies
  American Journal of Clinical Oncology. Oct, 2002  |   Pubmed ID: 12393999
• Validation of the Pharmacodynamics of BMS-247550, an Analogue of Epothilone B, During a Phase I Clinical Study
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2002  |   Pubmed ID: 12114401
• Estimation of the Effect of Food on the Disposition of Oral 5-fluorouracil in Combination with Eniluracil
  Cancer Chemotherapy and Pharmacology. May, 2002  |   Pubmed ID: 11976834
• Phase I Clinical and Pharmacokinetic Study of Protein Kinase C-alpha Antisense Oligonucleotide ISIS 3521 Administered in Combination with 5-fluorouracil and Leucovorin in Patients with Advanced Cancer
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2002  |   Pubmed ID: 11948111
• Oxaliplatin: a Review of Evolving Concepts
  Cancer Investigation. 2002  |   Pubmed ID: 11901545
• Tyrosine Kinase Inhibitors: a Clinical Perspective
  Current Oncology Reports. Jan, 2002  |   Pubmed ID: 11734109