Sridhar Mani Department of Genetics Albert Einstein College of Medicine Biography Publications Institution JoVE Articles Sridhar Mani has not added a biography. If you are Sridhar Mani and would like to personalize this page please email our Author Liaison for assistance. Publications Understanding and Modulating Mammalian-Microbial Communication for Improved Human Health Annual Review of Pharmacology and Toxicology. Oct, 2013 | Pubmed ID: 24160697 Clinical Outcome and Prognostic Markers for Patients with Gynecologic Malignancies in Phase 1 Clinical Trials: a Single Institution Experience from 1999 to 2010 Gynecologic Oncology. Oct, 2013 | Pubmed ID: 23877015 Molecular Insights into Microbial β-glucuronidase Inhibition to Abrogate CPT-11 Toxicity Molecular Pharmacology. Aug, 2013 | Pubmed ID: 23690068 Therapeutic Targeting of CPT-11 Induced Diarrhea: a Case for Prophylaxis Current Drug Targets. Jun, 2013 | Pubmed ID: 23597015 Chrysin Ameliorates Chemically Induced Colitis in the Mouse Through Modulation of a PXR/NF-κB Signaling Pathway The Journal of Pharmacology and Experimental Therapeutics. Jun, 2013 | Pubmed ID: 23536316 Novel Yeast-based Strategy Unveils Antagonist Binding Regions on the Nuclear Xenobiotic Receptor PXR The Journal of Biological Chemistry. May, 2013 | Pubmed ID: 23525103 Protective Effect of Naringenin Against Experimental Colitis Via Suppression of Toll-like Receptor 4/NF-κB Signalling The British Journal of Nutrition. Aug, 2013 | Pubmed ID: 23506745 Methodologies to Decipher the Cell Secretome Biochimica Et Biophysica Acta. Nov, 2013 | Pubmed ID: 23376189 PXR Antagonists and Implication in Drug Metabolism Drug Metabolism Reviews. Feb, 2013 | Pubmed ID: 23330542 Pregnane Xenobiotic Receptor in Cancer Pathogenesis and Therapeutic Response Cancer Letters. Jan, 2013 | Pubmed ID: 22939994 Alleviation of Gut Inflammation by Cdx2/Pxr Pathway in a Mouse Model of Chemical Colitis PloS One. 2012 | Pubmed ID: 22815676 Safety, Pharmacokinetics, and Activity of EZN-2208, a Novel Conjugate of Polyethylene Glycol and SN38, in Patients with Advanced Malignancies Cancer. Dec, 2012 | Pubmed ID: 22674635 Pharmacokinetics and Safety of Bortezomib in Patients with Advanced Malignancies and Varying Degrees of Liver Dysfunction: Phase I NCI Organ Dysfunction Working Group Study NCI-6432 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2012 | Pubmed ID: 22394984 Phase I Dose Escalation Study of KOS-1584, a Novel Epothilone, in Patients with Advanced Solid Tumors Cancer Chemotherapy and Pharmacology. Feb, 2012 | Pubmed ID: 21874318 Sixth International Congress on Shwachman-Diamond Syndrome: from Patients to Genes and Back Annals of the New York Academy of Sciences. Dec, 2011 | Pubmed ID: 22191554 Metformin Suppresses Pregnane X Receptor (PXR)-regulated Transactivation of CYP3A4 Gene Biochemical Pharmacology. Dec, 2011 | Pubmed ID: 21920351 Pregnane X Receptor Activation Induces FGF19-dependent Tumor Aggressiveness in Humans and Mice The Journal of Clinical Investigation. Aug, 2011 | Pubmed ID: 21747170 Dose-escalating and Pharmacological Study of Bortezomib in Adult Cancer Patients with Impaired Renal Function: a National Cancer Institute Organ Dysfunction Working Group Study Cancer Chemotherapy and Pharmacology. Dec, 2011 | Pubmed ID: 21479634 In Vivo and in Vitro Characterization of a First-in-class Novel Azole Analog That Targets Pregnane X Receptor Activation Molecular Pharmacology. Jul, 2011 | Pubmed ID: 21464197 Post-translational Modification of Pregnane X Receptor Pharmacological Research : the Official Journal of the Italian Pharmacological Society. Jul, 2011 | Pubmed ID: 21397695 Acetylation of Pregnane X Receptor Protein Determines Selective Function Independent of Ligand Activation Biochemical and Biophysical Research Communications. Mar, 2011 | Pubmed ID: 21329659 Potent Inhibition of Rhabdoid Tumor Cells by Combination of Flavopiridol and 4OH-tamoxifen BMC Cancer. 2010 | Pubmed ID: 21092078 Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme Science (New York, N.Y.). Nov, 2010 | Pubmed ID: 21051639 Induction of CYP3A4 by Vinblastine: Role of the Nuclear Receptor NR1I2 The Annals of Pharmacotherapy. Nov, 2010 | Pubmed ID: 20959500 Evaluation of Computational Docking to Identify Pregnane X Receptor Agonists in the ToxCast Database Environmental Health Perspectives. Oct, 2010 | Pubmed ID: 20558333 Orphan Nuclear Receptors As Targets for Drug Development Pharmaceutical Research. Aug, 2010 | Pubmed ID: 20372994 Phase II Study of Paclitaxel Plus the Protein Kinase C Inhibitor Bryostatin-1 in Advanced Pancreatic Carcinoma American Journal of Clinical Oncology. Apr, 2010 | Pubmed ID: 19738452 Intravenous Administration of Reolysin, a Live Replication Competent RNA Virus is Safe in Patients with Advanced Solid Tumors Investigational New Drugs. Oct, 2010 | Pubmed ID: 19572105 Design, Synthesis and Biological Evaluation of 2H-benzo[b][1,4] Oxazine Derivatives As Hypoxia Targeted Compounds for Cancer Therapeutics Bioorganic & Medicinal Chemistry Letters. Aug, 2009 | Pubmed ID: 19515559 A Phase I Study of Eribulin Mesylate (E7389), a Mechanistically Novel Inhibitor of Microtubule Dynamics, in Patients with Advanced Solid Malignancies Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2009 | Pubmed ID: 19509177 Elucidating the 'Jekyll and Hyde' Nature of PXR: the Case for Discovering Antagonists or Allosteric Antagonists Pharmaceutical Research. Aug, 2009 | Pubmed ID: 19415465 Alterations of Chemotherapeutic Pharmacokinetic Profiles by Drug-drug Interactions Expert Opinion on Drug Metabolism & Toxicology. Feb, 2009 | Pubmed ID: 19239394 The Efficacy and Safety of Ixabepilone Monotherapy in the Treatment of Breast and Gynecologic Malignancies Expert Opinion on Drug Safety. Jan, 2009 | Pubmed ID: 19236220 A Phase 1 Open-label, Accelerated Dose-escalation Study of the Hypoxia-activated Prodrug AQ4N in Patients with Advanced Malignancies Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2008 | Pubmed ID: 18981010 Novel Orphan Nuclear Receptors-coregulator Interactions Controlling Anti-cancer Drug Metabolism Current Drug Metabolism. Sep, 2008 | Pubmed ID: 18781912 Expanding the Roles for Pregnane X Receptor in Cancer: Proliferation and Drug Resistance in Ovarian Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2008 | Pubmed ID: 18765524 Synthesis of Novel Ketoconazole Derivatives As Inhibitors of the Human Pregnane X Receptor (PXR; NR1I2; Also Termed SXR, PAR) Bioorganic & Medicinal Chemistry Letters. Jul, 2008 | Pubmed ID: 18583127 Computational Discovery of Novel Low Micromolar Human Pregnane X Receptor Antagonists Molecular Pharmacology. Sep, 2008 | Pubmed ID: 18579710 The Effect of Ketoconazole on the Pharmacokinetics and Pharmacodynamics of Ixabepilone: a First in Class Epothilone B Analogue in Late-phase Clinical Development Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2008 | Pubmed ID: 18451235 Agranulocytosis Induced by Nonchemotherapy Drugs Annals of Internal Medicine. Feb, 2008 | Pubmed ID: 18283213 Phase I and Pharmacokinetic Study of Imatinib Mesylate in Patients with Advanced Malignancies and Varying Degrees of Renal Dysfunction: a Study by the National Cancer Institute Organ Dysfunction Working Group Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2008 | Pubmed ID: 18235116 Rhabdoid Tumor Growth is Inhibited by Flavopiridol Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2008 | Pubmed ID: 18223228 The Phytoestrogen Coumestrol is a Naturally Occurring Antagonist of the Human Pregnane X Receptor Molecular Endocrinology (Baltimore, Md.). Apr, 2008 | Pubmed ID: 18096694 Oxaliplatin Pharmacokinetics and Pharmacodynamics in Adult Cancer Patients with Impaired Renal Function Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2007 | Pubmed ID: 17699862 Human Pregnane X Receptor Antagonists and Agonists Define Molecular Requirements for Different Binding Sites Molecular Pharmacology. Sep, 2007 | Pubmed ID: 17576789 Dose-escalating and Pharmacologic Study of Oxaliplatin in Adult Cancer Patients with Impaired Hepatic Function: a National Cancer Institute Organ Dysfunction Working Group Study Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2007 | Pubmed ID: 17575231 Activated Pregnenolone X-receptor is a Target for Ketoconazole and Its Analogs Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2007 | Pubmed ID: 17438109 Phase I Study of Inhaled Doxorubicin for Patients with Metastatic Tumors to the Lungs Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2007 | Pubmed ID: 17317836 Pharmacokinetic and Safety Study of Weekly Irinotecan and Oral Capecitabine in Patients with Advanced Solid Cancers Investigational New Drugs. Jun, 2007 | Pubmed ID: 17195945 Phase II Trial of Nolatrexed Dihydrochloride [Thymitaq, AG 337] in Patients with Advanced Hepatocellular Carcinoma Investigational New Drugs. Feb, 2007 | Pubmed ID: 16957834 Autoantibody Cancer Biomarker: Extracellular Protein Kinase A Cancer Research. Sep, 2006 | Pubmed ID: 16982736 Phase II Study of Mitomycin-C, Adriamycin, Cisplatin (MAP) and Bleomycin-CCNU in Patients with Advanced Cancer of the Anal Canal: An Eastern Cooperative Oncology Group Study E7282 Investigational New Drugs. Sep, 2006 | Pubmed ID: 16763788 A Phase I Safety and Dose Escalation Trial of Docetaxel Combined with GEM231, a Second Generation Antisense Oligonucleotide Targeting Protein Kinase A R1alpha in Patients with Advanced Solid Cancers Investigational New Drugs. Mar, 2006 | Pubmed ID: 16683205 Disposition of 9-nitrocamptothecin and Its 9-aminocamptothecin Metabolite in Relation to ABC Transporter Genotypes Investigational New Drugs. Sep, 2006 | Pubmed ID: 16505951 Clinical and Pharmacokinetic Study Evaluating the Effect of Food on the Disposition of 9-nitrocamptothecin and Its 9-aminocamptothecin Metabolite in Patients with Solid Tumors Cancer Chemotherapy and Pharmacology. May, 2006 | Pubmed ID: 16205924 Phase I and Pharmacokinetic Study of the Novel Redox-active Agent, Motexafin Gadolinium, with Concurrent Radiation Therapy in Patients with Locally Advanced Pancreatic or Biliary Cancers Cancer Chemotherapy and Pharmacology. Apr, 2006 | Pubmed ID: 16133531 Activation of the Steroid and Xenobiotic Receptor (human Pregnane X Receptor) by Nontaxane Microtubule-stabilizing Agents Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2005 | Pubmed ID: 16144941 Phase II Trials of Dolastatin-10 in Advanced Pancreaticobiliary Cancers Investigational New Drugs. Oct, 2005 | Pubmed ID: 16133801 A Study of Cytotoxic Synergy of UCN-01 and Flavopiridol in Syngeneic Pair of Cell Lines Investigational New Drugs. Aug, 2005 | Pubmed ID: 16012789 Modulation of Irinotecan with Cyclosporine: a Phase II Trial in Advanced Colorectal Cancer Cancer Chemotherapy and Pharmacology. Oct, 2005 | Pubmed ID: 15895230 A Phase II Trial of Fixed Dose Rate Gemcitabine in Patients with Advanced Biliary Tree Carcinoma American Journal of Clinical Oncology. Dec, 2004 | Pubmed ID: 15577433 A Phase I Trial of Pharmacologic Modulation of Irinotecan with Cyclosporine and Phenobarbital Clinical Pharmacology and Therapeutics. Nov, 2004 | Pubmed ID: 15536463 Phase I Clinical Trial of CEP-2563 Dihydrochloride, a Receptor Tyrosine Kinase Inhibitor, in Patients with Refractory Solid Tumors Investigational New Drugs. Nov, 2004 | Pubmed ID: 15292715 UCN-01 Alters Phosphorylation of Akt and GSK3beta and Induces Apoptosis in Six Independent Human Neuroblastoma Cell Lines Journal of Neurochemistry. Aug, 2004 | Pubmed ID: 15255949 The Clinical Development of New Mitotic Inhibitors That Stabilize the Microtubule Anti-cancer Drugs. Jul, 2004 | Pubmed ID: 15205596 9-Aminocamptothecin (9-AC) Given As a 120-hour Continuous Infusion in Patients with Advanced Adenocarcinomas of the Stomach and Gastroesophageal Junction: A Phase II Trial of the University of Chicago Phase II Consortium Investigational New Drugs. Aug, 2004 | Pubmed ID: 15122080 Phase I Clinical and Pharmacokinetic Study of BMS-247550, a Novel Derivative of Epothilone B, in Solid Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2004 | Pubmed ID: 14977827 TNFerade Biologic, an Adenovector with a Radiation-inducible Promoter, Carrying the Human Tumor Necrosis Factor Alpha Gene: a Phase I Study in Patients with Solid Tumors Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2004 | Pubmed ID: 14726502 Administration of Oxaliplatin to Patients with Renal Dysfunction: a Preliminary Report of the National Cancer Institute Organ Dysfunction Working Group Seminars in Oncology. Aug, 2003 | Pubmed ID: 14523791 Pharmacology of Oxaliplatin in Solid Tumor Patients with Hepatic Dysfunction: a Preliminary Report of the National Cancer Institute Organ Dysfunction Working Group Seminars in Oncology. Aug, 2003 | Pubmed ID: 14523790 A Safety Study of a Mixed-backbone Oligonucleotide (GEM231) Targeting the Type I Regulatory Subunit Alpha of Protein Kinase A Using a Continuous Infusion Schedule in Patients with Refractory Solid Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2003 | Pubmed ID: 14519628 Dose-escalating and Pharmacological Study of Oxaliplatin in Adult Cancer Patients with Impaired Renal Function: a National Cancer Institute Organ Dysfunction Working Group Study Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jul, 2003 | Pubmed ID: 12860942 Erlotinib (Tarceva): a Promising Drug Targeting Epidermal Growth Factor Receptor Tyrosine Kinase Expert Review of Anticancer Therapy. Jun, 2003 | Pubmed ID: 12820772 Current Approaches to Novel Therapeutics in Pancreatic Cancer Investigational New Drugs. Feb, 2003 | Pubmed ID: 12795537 A Phase II Study of Rebeccamycin Analog NSC 655649 in Patients with Metastatic Colorectal Cancer Investigational New Drugs. Feb, 2003 | Pubmed ID: 12795535 The BCL2-family of Protein Ligands As Cancer Drugs: the Next Generation of Therapeutics Current Medicinal Chemistry. Anti-cancer Agents. May, 2003 | Pubmed ID: 12769779 A Pilot Study of Edrecolomab (Panorex, 17-1A Antibody) and Capecitabine in Patients with Advanced or Metastatic Adenocarcinoma Cancer Investigation. Apr, 2003 | Pubmed ID: 12743982 Phase 1 Dose Escalation Study of Docetaxel with Filgrastim Support in Patients with Advanced Solid Tumors Medical Oncology (Northwood, London, England). 2003 | Pubmed ID: 12665678 Flavopiridol and Trastuzumab Synergistically Inhibit Proliferation of Breast Cancer Cells: Association with Selective Cooperative Inhibition of Cyclin D1-dependent Kinase and Akt Signaling Pathways Molecular Cancer Therapeutics. Jul, 2002 | Pubmed ID: 12479366 Phase I Clinical Trial of Irinotecan with Oral Capecitabine in Patients with Gastrointestinal and Other Solid Malignancies American Journal of Clinical Oncology. Oct, 2002 | Pubmed ID: 12393999 Validation of the Pharmacodynamics of BMS-247550, an Analogue of Epothilone B, During a Phase I Clinical Study Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2002 | Pubmed ID: 12114401 Estimation of the Effect of Food on the Disposition of Oral 5-fluorouracil in Combination with Eniluracil Cancer Chemotherapy and Pharmacology. May, 2002 | Pubmed ID: 11976834 Phase I Clinical and Pharmacokinetic Study of Protein Kinase C-alpha Antisense Oligonucleotide ISIS 3521 Administered in Combination with 5-fluorouracil and Leucovorin in Patients with Advanced Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2002 | Pubmed ID: 11948111 Oxaliplatin: a Review of Evolving Concepts Cancer Investigation. 2002 | Pubmed ID: 11901545 Tyrosine Kinase Inhibitors: a Clinical Perspective Current Oncology Reports. Jan, 2002 | Pubmed ID: 11734109 स्तनधारी परमाणु रिसेप्टर अवशेष की पहचान के लिए खमीर दो संकर प्रणाली है कि रिवर्स ligands और / या गरम के साथ बातचीत Hao Li*1, Wei Dou*2, Emil Padikkala1, Sridhar Mani1 1Department of Genetics, Albert Einstein College of Medicine, 2Shanghai Key Laboratory of Complex Prescription and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine Biology
स्तनधारी परमाणु रिसेप्टर अवशेष की पहचान के लिए खमीर दो संकर प्रणाली है कि रिवर्स ligands और / या गरम के साथ बातचीत Hao Li*1, Wei Dou*2, Emil Padikkala1, Sridhar Mani1 1Department of Genetics, Albert Einstein College of Medicine, 2Shanghai Key Laboratory of Complex Prescription and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine Biology
