Stefan Lehr Department of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center Heinrich Heine University Biography Publications Institution JoVE Articles Stefan Lehr has not added a biography. If you are Stefan Lehr and would like to personalize this page please email our Author Liaison for assistance. Publications Mechanisms of Insulin Resistance in Primary and Secondary Non-Alcoholic Fatty Liver Diabetes. May, 2017 | Pubmed ID: 28490610 Differential Patterns of Impaired Cardiorespiratory Fitness and Cardiac Autonomic Dysfunction in Recently Diagnosed Type 1 and Type 2 Diabetes Diabetes Care. Feb, 2017 | Pubmed ID: 27899499 Association Between Copy-number Variation on Metabolic Phenotypes and HDL-C Levels in Patients with Polycystic Ovary Syndrome Molecular Biology Reports. Feb, 2017 | Pubmed ID: 27878529 Lipidomics-Reshaping the Analysis and Perception of Type 2 Diabetes International Journal of Molecular Sciences. Nov, 2016 | Pubmed ID: 27827927 Mass Spectrometry in Life Science Research Archives of Physiology and Biochemistry. Dec, 2016 | Pubmed ID: 27808565 Oxygen and Differentiation Status Modulate the Effect of X-ray Irradiation on Physiology and Mitochondrial Proteome of Human Neuroblastoma Cells Archives of Physiology and Biochemistry. Dec, 2016 | Pubmed ID: 27615280 Impact of Fibroblast Growth Factor 21 on the Secretome of Human Perivascular Preadipocytes and Adipocytes: a Targeted Proteomics Approach Archives of Physiology and Biochemistry. Dec, 2016 | Pubmed ID: 27494767 Untargeted Mass Spectrometric Approach in Metabolic Healthy Offspring of Patients with Type 2 Diabetes Reveals Medium-chain Acylcarnitine As Potential Biomarker for Lipid Induced Glucose Intolerance (LGIT) Archives of Physiology and Biochemistry. Dec, 2016 | Pubmed ID: 27373781 Specific Metabolic Profiles and Their Relationship to Insulin Resistance in Recent-Onset Type 1 and Type 2 Diabetes The Journal of Clinical Endocrinology and Metabolism. May, 2016 | Pubmed ID: 26829444 Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2016 | Pubmed ID: 26586662 Increased Cathepsin D Protein Expression is a Biomarker for Osteosarcomas, Pulmonary Metastases and Other Bone Malignancies Oncotarget. Jun, 2015 | Pubmed ID: 26203049 Deep Serum Discoveries: SDF-1α and HSA Fragments in Myelodysplastic Syndromes American Journal of Hematology. Sep, 2015 | Pubmed ID: 26010554 Methods for Proteomics-based Analysis of the Human Muscle Secretome Using an in Vitro Exercise Model Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25820713 Investigating the Adipose Tissue Secretome: a Protocol to Generate High-quality Samples Appropriate for Comprehensive Proteomic Profiling Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25820712 Peroxisomes Compensate Hepatic Lipid Overflow in Mice with Fatty Liver Biochimica Et Biophysica Acta. Jul, 2015 | Pubmed ID: 25790917 Deficiency in Lymphotoxin β Receptor Protects from Atherosclerosis in ApoE-deficient Mice Circulation Research. Apr, 2015 | Pubmed ID: 25740843 Isolation and Quality Control of Functional Mitochondria Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25630999 Preparation of "functional" Mitochondria: a Challenging Business Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25630998 Phosphorylation of Sterol Regulatory Element-binding Protein (SREBP)-1c by P38 Kinases, ERK and JNK Influences Lipid Metabolism and the Secretome of Human Liver Cell Line HepG2 Archives of Physiology and Biochemistry. Dec, 2014 | Pubmed ID: 25353341 Proteomics in Practice Archives of Physiology and Biochemistry. Dec, 2014 | Pubmed ID: 25353340 Identification of Novel Adipokines Differential Regulated in C57BL/Ks and C57BL/6 Archives of Physiology and Biochemistry. Dec, 2014 | Pubmed ID: 25319219 Interleukin-6-dependent Phenotypic Modulation of Cardiac Fibroblasts After Acute Myocardial Infarction Basic Research in Cardiology. 2014 | Pubmed ID: 25236954 Profiling of Low Molecular Weight Proteins in Plasma from Locally Irradiated Individuals Journal of Radiation Research. Jul, 2014 | Pubmed ID: 24570173 The Secretome of the Working Human Skeletal Muscle--a Promising Opportunity to Combat the Metabolic Disaster? Proteomics. Clinical Applications. Feb, 2014 | Pubmed ID: 24376246 Secretome Profiling of Primary Human Skeletal Muscle Cells Biochimica Et Biophysica Acta. May, 2014 | Pubmed ID: 23994228 Cytokine Response of Primary Human Myotubes in an in Vitro Exercise Model American Journal of Physiology. Cell Physiology. Oct, 2013 | Pubmed ID: 23926130 A Mutation in the C-fos Gene Associated with Congenital Generalized Lipodystrophy Orphanet Journal of Rare Diseases. Aug, 2013 | Pubmed ID: 23919306 2-dimensional Gel Electrophoresis Reloaded Archives of Physiology and Biochemistry. Jul, 2013 | Pubmed ID: 23837539 The Impact of Pre-analytical Conditions on the Serum Proteome: Heat-stabilization Versus Nitrogen Storage Archives of Physiology and Biochemistry. Jul, 2013 | Pubmed ID: 23826811 So Close and Yet So Far: Mitochondria and Peroxisomes Are One but with Specific Talents Archives of Physiology and Biochemistry. Jul, 2013 | Pubmed ID: 23705958 2D-ToGo Workflow: Increasing Feasibility and Reproducibility of 2-dimensional Gel Electrophoresis Archives of Physiology and Biochemistry. Jul, 2013 | Pubmed ID: 23679042 Platelet Proteome Analysis Reveals Integrin-dependent Aggregation Defects in Patients with Myelodysplastic Syndromes Molecular & Cellular Proteomics : MCP. May, 2013 | Pubmed ID: 23382103 Multiplex Immunoassays: an Invaluable Tool for Biomarker Discovery and Validation Archives of Physiology and Biochemistry. Oct, 2012 | Pubmed ID: 22747464 Genetic Variants in Central Metabolic Genes Influence Some but Not All Relations of Inflammatory Markers in a Collective with Polycystic Ovary Syndrome Archives of Physiology and Biochemistry. Jun, 2012 | Pubmed ID: 22738153 Sex Steroid-induced Changes in Circulating Monocyte Chemoattractant Protein-1 Levels May Contribute to Metabolic Dysfunction in Obese Men The Journal of Clinical Endocrinology and Metabolism. Jul, 2012 | Pubmed ID: 22523336 Chemerin As Biomarker for Insulin Sensitivity in Males Without Typical Characteristics of Metabolic Syndrome Archives of Physiology and Biochemistry. Jul, 2012 | Pubmed ID: 22335466 Combination of Highly Efficient Hexapeptide Ligand Library-based Sample Preparation with 2D DIGE for the Analysis of the Hidden Human Serum/plasma Proteome Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22311760 Multifluorescence 2D Gel Imaging and Image Analysis Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22311751 Adipokines: a Treasure Trove for the Discovery of Biomarkers for Metabolic Disorders Proteomics. Clinical Applications. Jan, 2012 | Pubmed ID: 22213627 Qualitative Characteristics of HDL in Young Patients of an Acute Myocardial Infarction Atherosclerosis. Jan, 2012 | Pubmed ID: 22056215 Identification and Validation of Novel Adipokines Released from Primary Human Adipocytes Molecular & Cellular Proteomics : MCP. Jan, 2012 | Pubmed ID: 21947364 The Non-steroidal Anti-inflammatory Drugs Sulindac Sulfide and Diclofenac Induce Apoptosis and Differentiation in Human Acute Myeloid Leukemia Cells Through an AP-1 Dependent Pathway Apoptosis : an International Journal on Programmed Cell Death. Sep, 2011 | Pubmed ID: 21739277 Dipeptidyl Peptidase 4 is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome Diabetes. Jul, 2011 | Pubmed ID: 21593202 Biomarker Discovery Using SELDI-TOF Protein Chip Technology Archives of Physiology and Biochemistry. Oct-Dec, 2010 | Pubmed ID: 20839924 Targeting Phosphoprotein Profiling by Combination of Hydroxyapatite-based Phosphoprotein Enrichment and SELDI-TOF MS Archives of Physiology and Biochemistry. Oct-Dec, 2010 | Pubmed ID: 20726833 ProteoMiner™ and SELDI-TOF-MS: a Robust and Highly Reproducible Combination for Biomarker Discovery from Whole Blood Serum Archives of Physiology and Biochemistry. Oct-Dec, 2010 | Pubmed ID: 20662595 Integrative Proteomics for the Future US HUPO Fifth Annual Conference from Genes to Function 22-25 February 2009, San Diego, CA, USA Proteomics. Clinical Applications. Jul, 2009 | Pubmed ID: 21136984 Mass Spectrometry-based Proteomics and Its Potential Use in Haematological Research Archives of Physiology and Biochemistry. Dec, 2009 | Pubmed ID: 19916740 Validation of Self-made Fluorescent Cyanine Dyes for 2D Gel-based Multi-fluorescence Protein Analysis Archives of Physiology and Biochemistry. Dec, 2009 | Pubmed ID: 19911952 Proteomics in Health and Disease Archives of Physiology and Biochemistry. Dec, 2009 | Pubmed ID: 19891519 Enhancing Mass Spectrometry Based Serum Profiling by a Combination of Free Flow Electrophoresis and ClinProt Archives of Physiology and Biochemistry. Dec, 2009 | Pubmed ID: 19888797 Combinatorial Hexapeptide Ligand Libraries (ProteoMiner): an Innovative Fractionation Tool for Differential Quantitative Clinical Proteomics Archives of Physiology and Biochemistry. Jul, 2009 | Pubmed ID: 19604127 A Critical Comparison Between Two Classical and a Kit-based Method for Mitochondria Isolation Proteomics. Jun, 2009 | Pubmed ID: 19415664 Glucuronic Acid Can Extend O-linked Core 1 Glycans, but It Contributes Only Weakly to the Negative Surface Charge of Drosophila Melanogaster Schneider-2 Cells FEBS Letters. May, 2008 | Pubmed ID: 18417079 Effect of Sterol Regulatory Element Binding Protein-1a on the Mitochondrial Protein Pattern in Human Liver Cells Detected by 2D-DIGE Biochemistry. Apr, 2005 | Pubmed ID: 15794649 Identification of Major ERK-related Phosphorylation Sites in Gab1 Biochemistry. Sep, 2004 | Pubmed ID: 15379552 Insulin-activated Erk-mitogen-activated Protein Kinases Phosphorylate Sterol Regulatory Element-binding Protein-2 at Serine Residues 432 and 455 in Vivo The Journal of Biological Chemistry. May, 2004 | Pubmed ID: 14988395 Reliability of EMG Time-frequency Measures of Fatigue During Repetitive Lifting Medicine and Science in Sports and Exercise. Aug, 2002 | Pubmed ID: 12165687 Primary Skin Fibroblasts As Human Model System for Proteome Analysis Proteomics. Mar, 2002 | Pubmed ID: 11921444 מודל הלב הפוכה עבור אוסף transstate Interstitial מן הלב עכברוש מבודד Kezhe Tan*1,2, Zhaoping Ding*1,2, Bodo Steckel2, Sonja Hartwig3, Stefan Lehr3, Xiaoming Deng1, Jürgen Schrader2 1Department of Anesthesiology, Changhai Hospital, Second Military Medical University, 2Department of Molecular Cardiology, Heinrich Heine University, 3Department of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Heinrich Heine University JoVE 55849 Medicine
מודל הלב הפוכה עבור אוסף transstate Interstitial מן הלב עכברוש מבודד Kezhe Tan*1,2, Zhaoping Ding*1,2, Bodo Steckel2, Sonja Hartwig3, Stefan Lehr3, Xiaoming Deng1, Jürgen Schrader2 1Department of Anesthesiology, Changhai Hospital, Second Military Medical University, 2Department of Molecular Cardiology, Heinrich Heine University, 3Department of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Heinrich Heine University JoVE 55849 Medicine
