Stephan M. Jakob Department of Intensive Care Medicine, Inselspital, Bern University Hospital University of Bern Biography Publications Institution JoVE Articles Stephan M. Jakob has not added a biography. If you are Stephan M. Jakob and would like to personalize this page please email our Author Liaison for assistance. Publications Early Changes of Muscle Membrane Properties in Porcine Faecal Peritonitis Critical Care (London, England). 2014 | Pubmed ID: 25145497 Interference of Angiotensin II and Enalapril with Hepatic Blood Flow Regulation American Journal of Physiology. Gastrointestinal and Liver Physiology. Sep, 2014 | Pubmed ID: 25059826 Angiotensin II in Septic Shock: Effects on Tissue Perfusion, Organ Function, and Mitochondrial Respiration in a Porcine Model of Fecal Peritonitis Critical Care Medicine. Aug, 2014 | Pubmed ID: 24797374 Sedation Level and Prevalence of Delirium: Response to Brummel and Ely Intensive Care Medicine. Jan, 2014 | Pubmed ID: 24061632 Different Contribution of Splanchnic Organs to Hyperlactatemia in Fecal Peritonitis and Cardiac Tamponade BioMed Research International. 2013 | Pubmed ID: 24228242 No Evidence for a Local Renin-angiotensin System in Liver Mitochondria Scientific Reports. 2013 | Pubmed ID: 23959064 Effect of Sedation Level on the Prevalence of Delirium when Assessed with CAM-ICU and ICDSC Intensive Care Medicine. Dec, 2013 | Pubmed ID: 23921976 Mitochondrial Function in Sepsis European Journal of Clinical Investigation. May, 2013 | Pubmed ID: 23496374 Haemodynamic Variables and Functional Outcome in Hypothermic Patients Following Out-of-hospital Cardiac Arrest Resuscitation. Jun, 2013 | Pubmed ID: 23092896 Randomized, Double-blind Trial of the Effect of Fluid Composition on Electrolyte, Acid-base, and Fluid Homeostasis in Patients Early After Subarachnoid Hemorrhage Neurocritical Care. Feb, 2013 | Pubmed ID: 22872427 Effect of Remifentanil on Mitochondrial Oxygen Consumption of Cultured Human Hepatocytes PloS One. 2012 | Pubmed ID: 23028840 Effect of Treatment Delay on Disease Severity and Need for Resuscitation in Porcine Fecal Peritonitis Critical Care Medicine. Oct, 2012 | Pubmed ID: 22890256 The Role of Androgens on Hypoxia-inducible Factor (HIF)-1α-induced Angiogenesis and on the Survival of Ischemically Challenged Skin Flaps in a Rat Model Microsurgery. Sep, 2012 | Pubmed ID: 22707412 A New Rabbit Model for the Study of Early Brain Injury After Subarachnoid Hemorrhage Journal of Neuroscience Methods. Jul, 2012 | Pubmed ID: 22595025 Effects of Cardiac Preload Reduction and Dobutamine on Hepatosplanchnic Blood Flow Regulation in Porcine Endotoxemia American Journal of Physiology. Gastrointestinal and Liver Physiology. Jul, 2012 | Pubmed ID: 22556139 Dexmedetomidine Vs Midazolam or Propofol for Sedation During Prolonged Mechanical Ventilation: Two Randomized Controlled Trials JAMA. Mar, 2012 | Pubmed ID: 22436955 Cancer Therapy Modulates VEGF Signaling and Viability in Adult Rat Cardiac Microvascular Endothelial Cells and Cardiomyocytes Journal of Molecular and Cellular Cardiology. May, 2012 | Pubmed ID: 22326847 Gastrointestinal Function in Intensive Care Patients: Terminology, Definitions and Management. Recommendations of the ESICM Working Group on Abdominal Problems Intensive Care Medicine. Mar, 2012 | Pubmed ID: 22310869 Postoperative Splanchnic Blood Flow Redistribution in Response to Fluid Challenges in the Presence and Absence of Endotoxemia in a Porcine Model Shock (Augusta, Ga.). Jan, 2012 | Pubmed ID: 21993445 Traumatic Subarachnoid Hemorrhage, Basal Ganglia Hematoma and Ischemic Stroke Caused by a Torn Lenticulostriate Artery Acta Neurochirurgica. Jan, 2012 | Pubmed ID: 21976234 Effects of Catecholamines on Hepatic and Skeletal Muscle Mitochondrial Respiration After Prolonged Exposure to Faecal Peritonitis in Pigs Innate Immunity. Apr, 2012 | Pubmed ID: 21525237 CO(2)-Dependent Vasomotor Reactivity of Cerebral Arteries in Patients with Severe Traumatic Brain Injury: Time Course and Effect of Augmentation of Cardiac Output with Dobutamine Journal of Neurotrauma. Jun, 2012 | Pubmed ID: 21501044 Dimethyloxalylglycine Stabilizes HIF-1α in Cultured Human Endothelial Cells and Increases Random-pattern Skin Flap Survival in Vivo Plastic and Reconstructive Surgery. Aug, 2011 | Pubmed ID: 21788833 Early Non-invasive Cardiac Output Monitoring in Hemodynamically Unstable Intensive Care Patients: a Multi-center Randomized Controlled Trial Critical Care (London, England). 2011 | Pubmed ID: 21676229 Continua Por Vía Intratecal Trinitrato Glicerilo Previene El Vasoespasmo Cerebral Retardada En El Modelo De Conejo De Una Sola Hemorragia Subaracnoidea En Vivo Acta Neurochirurgica. Aug, 2011 | Pubmed ID: 21671141 Comparison of Porcine and Human Coagulation by Thrombelastometry Thrombosis Research. Nov, 2011 | Pubmed ID: 21492909 Comparison of Non-calibrated Pulse-contour Analysis with Continuous Thermodilution for Cardiac Output Assessment in Patients with Induced Hypothermia After Cardiac Arrest Resuscitation. Apr, 2011 | Pubmed ID: 21292380 Current Approach to the Haemodynamic Management of Septic Shock Patients in European Intensive Care Units: a Cross-sectional, Self-reported Questionnaire-based Survey European Journal of Anaesthesiology. Apr, 2011 | Pubmed ID: 21088597 Review Article: Improving Outcome After Major Surgery: Pathophysiological Considerations Anesthesia and Analgesia. May, 2011 | Pubmed ID: 20736438 Toll-like Receptor-3-induced Mitochondrial Dysfunction in Cultured Human Hepatocytes Mitochondrion. Jan, 2011 | Pubmed ID: 20691286 Does Hypercapnic Acidosis Preserve Mucosal Oxygenation During Hemorrhage? Shock (Augusta, Ga.). Dec, 2010 | Pubmed ID: 21079493 Brain Herniation in a Patient with Apparently Normal Intracranial Pressure: a Case Report Journal of Medical Case Reports. 2010 | Pubmed ID: 20807427 Extra-intracraneal Derivación Arterial Imitando Ruptura Del Aneurisma: Intracraneal, Presión Controlada Subaracnoidea Hemorragia Conejo Modelo Journal of Neuroscience Methods. Aug, 2010 | Pubmed ID: 20624427 Increasing Abdominal Pressure with and Without PEEP: Effects on Intra-peritoneal, Intra-organ and Intra-vascular Pressures BMC Gastroenterology. 2010 | Pubmed ID: 20598159 Pulse Pressure Variation and Volume Responsiveness During Acutely Increased Pulmonary Artery Pressure: an Experimental Study Critical Care (London, England). 2010 | Pubmed ID: 20576099 Pulse-pressure Variation and Hemodynamic Response in Patients with Elevated Pulmonary Artery Pressure: a Clinical Study Critical Care (London, England). 2010 | Pubmed ID: 20540730 Effects of TLR Agonists on the Hypoxia-regulated Transcription Factor HIF-1alpha and Dendritic Cell Maturation Under Normoxic Conditions PloS One. 2010 | Pubmed ID: 20539755 500 Ml of Blood Loss Does Not Decrease Non-invasive Tissue Oxygen Saturation (StO2) As Measured by Near Infrared Spectroscopy - A Hypothesis Generating Pilot Study in Healthy Adult Women Journal of Trauma Management & Outcomes. 2010 | Pubmed ID: 20465822 Physiologic Response to Changing Positive End-expiratory Pressure During Neurally Adjusted Ventilatory Assist in Sedated, Critically Ill Adults Chest. Sep, 2010 | Pubmed ID: 20435654 Splanchnic Vasoregulation After Major Abdominal Surgery in Pigs World Journal of Surgery. Sep, 2010 | Pubmed ID: 20383500 Effects of Lung Recruitment Maneuvers on Splanchnic Organ Perfusion During Endotoxin-induced Pulmonary Arterial Hypertension Shock (Augusta, Ga.). Nov, 2010 | Pubmed ID: 20357696 The Effects of Mechanical Ventilation on Hepato-splanchnic Perfusion Current Opinion in Critical Care. Apr, 2010 | Pubmed ID: 20134320 Perioperative Metabolic Changes in Patients Undergoing Cardiac Surgery Nutrition (Burbank, Los Angeles County, Calif.). Apr, 2010 | Pubmed ID: 20053534 Usefulness of a Clinical Diagnosis of ICU-acquired Paresis to Predict Outcome in Patients with SIRS and Acute Respiratory Failure Intensive Care Medicine. Jan, 2010 | Pubmed ID: 19760204 Effect of Fluid Resuscitation on Mortality and Organ Function in Experimental Sepsis Models Critical Care (London, England). 2009 | Pubmed ID: 19930656 Hemodynamic Variables and Mortality in Cardiogenic Shock: a Retrospective Cohort Study Critical Care (London, England). 2009 | Pubmed ID: 19799772 Hypoxia Inducible Factor-1 Alpha Induction by Tumour Necrosis Factor-alpha, but Not by Toll-like Receptor Agonists, Modulates Cellular Respiration in Cultured Human Hepatocytes Liver International : Official Journal of the International Association for the Study of the Liver. Nov, 2009 | Pubmed ID: 19744167 Auditory Event-related Potentials, Bispectral Index, and Entropy for the Discrimination of Different Levels of Sedation in Intensive Care Unit Patients Anesthesia and Analgesia. Sep, 2009 | Pubmed ID: 19690250 Treatment of Acute Renal Failure in the Intensive Care Unit: Lower Costs by Intermittent Dialysis Than Continuous Venovenous Hemodiafiltration Artificial Organs. Aug, 2009 | Pubmed ID: 19624581 Effects of Endotoxin and Catecholamines on Hepatic Mitochondrial Respiration Inflammation. Oct, 2009 | Pubmed ID: 19603262 Perioperatoria Adrenocortical Respuesta a Dosis Bajas (1 Microg) ACTH Y Relación Con Las Complicaciones Postoperatorias En Pacientes Sometidos a Cirugía Abdominal Electiva Surgery. Jul, 2009 | Pubmed ID: 19541014 Septic Shock Resuscitation: What Goals and How to Achieve Them? Critical Care (London, England). 2009 | Pubmed ID: 19519939 Evaluación Del Estado De Recuperación Física Y Mental Después De La Resección Hepática Electiva European Journal of Anaesthesiology. Jul, 2009 | Pubmed ID: 19509504 Physical and Occupational Therapy During Sedation Stops Lancet. May, 2009 | Pubmed ID: 19446327 Elevado Nivel De Endotelina-1 En El Líquido Cefalorraquídeo Y La Falta De óxido Nítrico En El Plasma Arterial Basilar Asociado Con Vasoespasmo Cerebral Después De Una Hemorragia Subaracnoidea En Conejos Acta Neurochirurgica. Jul, 2009 | Pubmed ID: 19415172 Norepinephrine-induced Hypertension Dilates Vasospastic Basilar Artery After Subarachnoid Haemorrhage in Rabbits Acta Neurochirurgica. May, 2009 | Pubmed ID: 19343267 Thromboelastometry for the Assessment of Coagulation Abnormalities in Early and Established Adult Sepsis: a Prospective Cohort Study Critical Care (London, England). 2009 | Pubmed ID: 19331653 Different Patterns of Siglec-9-mediated Neutrophil Death Responses in Septic Shock Shock (Augusta, Ga.). Oct, 2009 | Pubmed ID: 19295491 Assessment of Splanchnic Blood Flow Using Magnetic Resonance Imaging European Journal of Gastroenterology & Hepatology. Jun, 2009 | Pubmed ID: 19293721 Intra- and Inter-individual Variation of BIS-index and Entropy During Controlled Sedation with Midazolam/remifentanil and Dexmedetomidine/remifentanil in Healthy Volunteers: an Interventional Study Critical Care (London, England). 2009 | Pubmed ID: 19228415 Arterial Blood Pressure During Early Sepsis and Outcome Intensive Care Medicine. Jul, 2009 | Pubmed ID: 19189077 Shedding Light on Microcirculation? Intensive Care Medicine. Mar, 2009 | Pubmed ID: 19125231 Increased Splanchnic Oxygen Extraction Because of Routine Nursing Procedures Critical Care Medicine. Feb, 2009 | Pubmed ID: 19114883 Inverse Thermodilution with Conventional Pulmonary Artery Catheters for the Assessment of Cerebral, Hepatic, Renal, and Femoral Blood Flow Shock (Augusta, Ga.). Aug, 2009 | Pubmed ID: 19033887 Dexmedetomidine Versus Propofol/midazolam for Long-term Sedation During Mechanical Ventilation Intensive Care Medicine. Feb, 2009 | Pubmed ID: 18795253 Entropy and Bispectral Index for Assessment of Sedation, Analgesia and the Effects of Unpleasant Stimuli in Critically Ill Patients: an Observational Study Critical Care (London, England). 2008 | Pubmed ID: 18796156 Norepinephrine to Increase Blood Pressure in Endotoxaemic Pigs is Associated with Improved Hepatic Mitochondrial Respiration Critical Care (London, England). 2008 | Pubmed ID: 18625036 Thermodilution and Esophageal Doppler Ultrasound in the Assessment of Blood Flow Changes Induced by Endotoxin and Dobutamine The Journal of Trauma. Jul, 2008 | Pubmed ID: 18580513 Orthogonal Polarization Spectroscopy to Detect Mesenteric Hypoperfusion Intensive Care Medicine. Oct, 2008 | Pubmed ID: 18516589 Development and Simultaneous Application of Multiple Care Protocols in Critical Care: a Multicenter Feasibility Study Intensive Care Medicine. Aug, 2008 | Pubmed ID: 18385977 The Immediate and Sustained Effects of Volume Challenge on Regional Blood Flows in Pigs Anesthesia and Analgesia. Feb, 2008 | Pubmed ID: 18227321 La Prevención Del Vasoespasmo Cerebral Retardado En Infusión Continua Por Vía Intratecal De Glyceroltrinitrate Y Nimodipina En El Modelo De Conejo En Vivo Intensive Care Medicine. May, 2008 | Pubmed ID: 18214428 Tonometry Revisited: Perfusion-related, Metabolic, and Respiratory Components of Gastric Mucosal Acidosis in Acute Cardiorespiratory Failure Shock (Augusta, Ga.). May, 2008 | Pubmed ID: 18004228 Vasopressin in Septic Shock: Effects on Pancreatic, Renal, and Hepatic Blood Flow Critical Care (London, England). 2007 | Pubmed ID: 18078508 Sedation and Weaning from Mechanical Ventilation: Effects of Process Optimization Outside a Clinical Trial Journal of Critical Care. Sep, 2007 | Pubmed ID: 17869972 Intraperitoneal Microdialysis: Critique of an Editorial Critical Care Medicine. Jul, 2007 | Pubmed ID: 17581382 Effects of Vasopressin on Microcirculatory Blood Flow in the Gastrointestinal Tract in Anesthetized Pigs in Septic Shock Anesthesiology. Jun, 2007 | Pubmed ID: 17525591 Incidence of Low Central Venous Oxygen Saturation During Unplanned Admissions in a Multidisciplinary Intensive Care Unit: an Observational Study Critical Care (London, England). 2007 | Pubmed ID: 17212816 Arterio-venous Gradients of Free Energy Change for Assessment of Systemic and Splanchnic Perfusion in Cardiac Surgery Patients Perfusion. Nov, 2006 | Pubmed ID: 17312859 Effect of Endotoxin, Dobutamine and Dopamine on Muscle Mitochondrial Respiration in Vitro Journal of Endotoxin Research. 2006 | Pubmed ID: 17254390 The Effects of Dexmedetomidine/remifentanil and Midazolam/remifentanil on Auditory-evoked Potentials and Electroencephalogram at Light-to-moderate Sedation Levels in Healthy Subjects Anesthesia and Analgesia. Nov, 2006 | Pubmed ID: 17056949 Membrane Microdialysis: Evaluation of a New Method to Assess Splanchnic Tissue Metabolism Critical Care Medicine. Oct, 2006 | Pubmed ID: 16915109 Effects of Prolonged Endotoxemia on Liver, Skeletal Muscle and Kidney Mitochondrial Function Critical Care (London, England). 2006 | Pubmed ID: 16895596 Decreasing Gut Wall Glucose As an Early Marker of Impaired Intestinal Perfusion Critical Care Medicine. Sep, 2006 | Pubmed ID: 16878039 Effects of Low Abdominal Blood Flow and Dobutamine on Blood Flow Distribution and on the Hepatic Arterial Buffer Response in Anaesthetized Pigs Shock (Augusta, Ga.). Apr, 2006 | Pubmed ID: 16670644 Reversible Encephalopathy Complicating Post-streptococcal Glomerulonephritis The Pediatric Infectious Disease Journal. Jan, 2006 | Pubmed ID: 16395114 Does Fluid Loading Influence Measurements of Intestinal Permeability? Critical Care (London, England). Jun, 2005 | Pubmed ID: 15987395 Preconditioning with Monophosphoryl Lipid A Improves Survival of Critically Ischemic Tissue Anesthesia and Analgesia. Jun, 2005 | Pubmed ID: 15920214 Comparison of Continuous and Intermittent Renal Replacement Therapy for Acute Renal Failure Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Aug, 2005 | Pubmed ID: 15886217 Severe Acute Pancreatitis: Case-oriented Discussion of Interdisciplinary Management Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]. 2005 | Pubmed ID: 15849485 Siglec-9 Transduces Apoptotic and Nonapoptotic Death Signals into Neutrophils Depending on the Proinflammatory Cytokine Environment Blood. Aug, 2005 | Pubmed ID: 15827126 Hepatosplanchnic Blood Flow Control and Oxygen Extraction Are Modified by the Underlying Mechanism of Impaired Perfusion Critical Care Medicine. Mar, 2005 | Pubmed ID: 15753759 Estimation of Central Venous Pressure by Ultrasound Resuscitation. Feb, 2005 | Pubmed ID: 15680529 Blood Pressure and Vessel Recanalization in the First Hours After Ischemic Stroke Stroke; a Journal of Cerebral Circulation. Feb, 2005 | Pubmed ID: 15637309 Blindness in the Intensive Care Unit Anesthesia and Analgesia. Jan, 2005 | Pubmed ID: 15616076 Midlatency Auditory-evoked Potentials in the Assessment of Sedation in Cardiac Surgery Patients Journal of Cardiothoracic and Vascular Anesthesia. Oct, 2004 | Pubmed ID: 15578465 N100 Auditory Potential and Electroencephalogram Discriminate Propofol-induced Sedation Levels Journal of Clinical Monitoring and Computing. Jun, 2004 | Pubmed ID: 15562982 Measuring Depth of Sedation with Auditory Evoked Potentials During Controlled Infusion of Propofol and Remifentanil in Healthy Volunteers Anesthesia and Analgesia. Dec, 2004 | Pubmed ID: 15562062 Changes in Splanchnic Circulation During an Alveolar Recruitment Maneuver in Healthy Porcine Lungs Anesthesia and Analgesia. May, 2004 | Pubmed ID: 15105226 Diagnosis and Management of Electrolyte Emergencies Best Practice & Research. Clinical Endocrinology & Metabolism. Dec, 2003 | Pubmed ID: 14687593 Changes in Regional Blood Flow and PCO(2) Gradients During Isolated Abdominal Aortic Blood Flow Reduction Intensive Care Medicine. Dec, 2003 | Pubmed ID: 13680116 Apparent Heterogeneity of Regional Blood Flow and Metabolic Changes Within Splanchnic Tissues During Experimental Endotoxin Shock Anesthesia and Analgesia. Aug, 2003 | Pubmed ID: 12873953 Change in Stroke Volume in Response to Fluid Challenge: Assessment Using Esophageal Doppler Intensive Care Medicine. Oct, 2003 | Pubmed ID: 12684746 Splanchnic Blood Flow in Low-flow States Anesthesia and Analgesia. Apr, 2003 | Pubmed ID: 12651672 Clinical Review: Splanchnic Ischaemia Critical Care (London, England). Aug, 2002 | Pubmed ID: 12225604 Acute Normovolemic Hemodilution Improves Oxygenation in Ischemic Flap Tissue Anesthesiology. Jun, 2002 | Pubmed ID: 12170063 Splanchnic Vasoregulation During Mesenteric Ischemia and Reperfusion in Pigs Shock (Augusta, Ga.). Aug, 2002 | Pubmed ID: 12166777 Effects of Dopamine on Systemic and Regional Blood Flow and Metabolism in Septic and Cardiac Surgery Patients Shock (Augusta, Ga.). Jul, 2002 | Pubmed ID: 12095139 Effect of Dopamine-induced Changes in Splanchnic Blood Flow on MEGX Production from Lidocaine in Septic and Cardiac Surgery Patients Shock (Augusta, Ga.). Jul, 2002 | Pubmed ID: 12095126 ARDS. Monitoring Tissue Perfusion Critical Care Clinics. Jan, 2002 | Pubmed ID: 11910727 -Alta resolución respirometría para evaluar la función mitocondrial en células intactas y permeabilizadas Siamak Djafarzadeh1, Stephan M. Jakob1 1Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern JoVE 54985 Biology El Conejo Modelo Blood-shunt para el Estudio de la aguda y secuelas tardías de Hemorragia subaracnoidea: Aspectos Técnicos Lukas Andereggen3,4,5, Volker Neuschmelting1,6, Michael von Gunten7, Hans Rudolf Widmer5, Jukka Takala1, Stephan M. Jakob1, Javier Fandino1,2, Serge Marbacher1,2 1Department of Intensive Care Medicine, University and Bern University Hospital (Inselspital), 2Department of Neurosurgery, Kantonsspital Aarau, 3Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, 4Harvard Medical School, Boston Children's Hospital, 5Department of Neurosurgery, University and Bern University Hospital (Inselspital), 6Department of Neurosurgery, University Hospital Cologne, 7Institute of Pathology, Länggasse Bern Medicine
-Alta resolución respirometría para evaluar la función mitocondrial en células intactas y permeabilizadas Siamak Djafarzadeh1, Stephan M. Jakob1 1Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern JoVE 54985 Biology
El Conejo Modelo Blood-shunt para el Estudio de la aguda y secuelas tardías de Hemorragia subaracnoidea: Aspectos Técnicos Lukas Andereggen3,4,5, Volker Neuschmelting1,6, Michael von Gunten7, Hans Rudolf Widmer5, Jukka Takala1, Stephan M. Jakob1, Javier Fandino1,2, Serge Marbacher1,2 1Department of Intensive Care Medicine, University and Bern University Hospital (Inselspital), 2Department of Neurosurgery, Kantonsspital Aarau, 3Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, 4Harvard Medical School, Boston Children's Hospital, 5Department of Neurosurgery, University and Bern University Hospital (Inselspital), 6Department of Neurosurgery, University Hospital Cologne, 7Institute of Pathology, Länggasse Bern Medicine
