Stephan E. Lehnart Heart Research Center Goettingen Biography Publications Institution JoVE Articles Stephan E. Lehnart has not added a biography. If you are Stephan E. Lehnart and would like to personalize this page please email our Author Liaison for assistance. Publications Toward Panoramic in Situ Mapping of Action Potential Propagation in Transgenic Hearts to Investigate Initiation and Therapeutic Control of Arrhythmias Frontiers in Physiology. 2014 | Pubmed ID: 25249982 Transgenic Mice for Real-time Visualization of CGMP in Intact Adult Cardiomyocytes Circulation Research. Apr, 2014 | Pubmed ID: 24599804 Tuning the Electrical Properties of the Heart by Differential Trafficking of KATP Ion Channel Complexes Journal of Cell Science. May, 2014 | Pubmed ID: 24569881 Imaging T-tubules: Dynamic Membrane Structures for Deep Functions Cardiovascular Research. May, 2013 | Pubmed ID: 23504549 Superresolution Microscopy in Heart - Cardiac Nanoscopy Journal of Molecular and Cellular Cardiology. May, 2013 | Pubmed ID: 23219451 Understanding the Physiology of Heart Failure Through Cellular and in Vivo Models-towards Targeting of Complex Mechanisms Experimental Physiology. Mar, 2013 | Pubmed ID: 23064508 Stimulated Emission Depletion Live-cell Super-resolution Imaging Shows Proliferative Remodeling of T-tubule Membrane Structures After Myocardial Infarction Circulation Research. Aug, 2012 | Pubmed ID: 22723297 Ablation of Junctin or Triadin is Associated with Increased Cardiac Injury Following Ischaemia/reperfusion Cardiovascular Research. May, 2012 | Pubmed ID: 22411973 Rationale, Objectives, and Design of the EUTrigTreat Clinical Study: a Prospective Observational Study for Arrhythmia Risk Stratification and Assessment of Interrelationships Among Repolarization Markers and Genotype Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. Mar, 2012 | Pubmed ID: 22117037 SAP97 and Dystrophin Macromolecular Complexes Determine Two Pools of Cardiac Sodium Channels Nav1.5 in Cardiomyocytes Circulation Research. Feb, 2011 | Pubmed ID: 21164104 Phosphorylation of the Ryanodine Receptor Mediates the Cardiac Fight or Flight Response in Mice The Journal of Clinical Investigation. Dec, 2010 | Pubmed ID: 21099118 Differential Cardiac Remodeling in Preload Versus Afterload Circulation. Sep, 2010 | Pubmed ID: 20733099 An Antidote for Calcium Leak: Targeting Molecular Arrhythmia Mechanisms Journal of Molecular and Cellular Cardiology. Feb, 2010 | Pubmed ID: 19931542 K201 Improves Aspects of the Contractile Performance of Human Failing Myocardium Via Reduction in Ca2+ Leak from the Sarcoplasmic Reticulum Basic Research in Cardiology. Mar, 2010 | Pubmed ID: 19718543 Abnormalities of Calcium Metabolism and Myocardial Contractility Depression in the Failing Heart Heart Failure Reviews. Dec, 2009 | Pubmed ID: 19434491 Inhibition of Extracellular Signal-regulated Kinase Signaling to Prevent Cardiomyopathy Caused by Mutation in the Gene Encoding A-type Lamins Human Molecular Genetics. Jan, 2009 | Pubmed ID: 18927124 Arrhythmogenic Right Ventricular Cardiomyopathy in Boxer Dogs is Associated with Calstabin2 Deficiency Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology. Jun, 2008 | Pubmed ID: 18515204 Leaky Ca2+ Release Channel/ryanodine Receptor 2 Causes Seizures and Sudden Cardiac Death in Mice The Journal of Clinical Investigation. Jun, 2008 | Pubmed ID: 18483626 Remodeling of Ryanodine Receptor Complex Causes "leaky" Channels: a Molecular Mechanism for Decreased Exercise Capacity Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18268335 不整脈の継承: 診断、フェノタイピング、分子メカニズム、およびイオン チャネルの機能に影響を与える遺伝子の突然変異のプライマリの心筋症の治療アプローチに関する国立心臓、肺、血液研究所およびまれな病気オフィス ワーク ショップ コンセンサス レポート。 Circulation. Nov, 2007 | Pubmed ID: 17998470 Modulation of the Ryanodine Receptor and Intracellular Calcium Annual Review of Biochemistry. 2007 | Pubmed ID: 17506640 Novel Targets for Treating Heart and Muscle Disease: Stabilizing Ryanodine Receptors and Preventing Intracellular Calcium Leak Current Opinion in Pharmacology. Apr, 2007 | Pubmed ID: 17306622 Phosphodiesterase 4D and Heart Failure: a Cautionary Tale Expert Opinion on Therapeutic Targets. Oct, 2006 | Pubmed ID: 16981825 心臓リアノジン受容体の安定化は、細胞内カルシウムリークと不整脈を防止 Proceedings of the National Academy of Sciences of the United States of America. May, 2006 | Pubmed ID: 16672364 リアノジン受容体/カルシウム放出チャネルのPKAリン酸化:心不全の進行の重要なメディエータ Proceedings of the National Academy of Sciences of the United States of America. Jan, 2006 | Pubmed ID: 16407108 リアノジン受容体複合体のホスホジエステラーゼ4D欠乏は心不全や不整脈を促進する Cell. Oct, 2005 | Pubmed ID: 16213210 リアノジン受容体をターゲットとした抗不整脈薬療法 Annals of the New York Academy of Sciences. Jun, 2005 | Pubmed ID: 16093511 心不全の新しい治療ターゲット:欠陥のあるリアノジン受容体ドメイン間相互作用はCa2 +のリークが細胞内に貢献するかもしれない Circulation. Jun, 2005 | Pubmed ID: 15983258 リアノジン受容体に結合するCalstabinを強化する心不全における心筋および骨格筋機能を改善する Proceedings of the National Academy of Sciences of the United States of America. Jul, 2005 | Pubmed ID: 15972811 心房細動中に欠陥のある心臓リアノジン受容体規制 Circulation. Apr, 2005 | Pubmed ID: 15851612 細胞内カルシウム放出と心臓病 Annual Review of Physiology. 2005 | Pubmed ID: 15709953 Calstabin欠乏症、リアノジン受容体と、心臓突然死 Biochemical and Biophysical Research Communications. Oct, 2004 | Pubmed ID: 15336974 心疾患における心臓リアノジン受容体の機能と規制 Annals of the New York Academy of Sciences. May, 2004 | Pubmed ID: 15201156 カルシウムリリースチャネル(リアノジン受容体)リークに関連付けられた家族性多形性心室頻拍の突然の死 Circulation. Jun, 2004 | Pubmed ID: 15197150 タンパク質Calstabin2を安定化させる受容体リアノジンスルー不整脈からの保護 Science (New York, N.Y.). Apr, 2004 | Pubmed ID: 15073377 のCa2 + /カルモジュリン依存性プロテインキナーゼIIのリン酸化は、心臓リアノジン受容体を調節する Circulation Research. Apr, 2004 | Pubmed ID: 15016728 Immunophilins and Coupled Gating of Ryanodine Receptors Current Topics in Medicinal Chemistry. 2003 | Pubmed ID: 12871170 FKBP12.6欠乏と不良カルシウム放出チャネル(リアノジン受容体)運動誘発性の心臓突然死にリンクされた関数 Cell. Jun, 2003 | Pubmed ID: 12837242 PKA Phosphorylation Activates the Calcium Release Channel (ryanodine Receptor) in Skeletal Muscle: Defective Regulation in Heart Failure The Journal of Cell Biology. Mar, 2003 | Pubmed ID: 12629052 Coronary Perfusion Cocktails for in Vivo Gene Transfer Methods in Molecular Biology (Clifton, N.J.). 2003 | Pubmed ID: 12597011 細胞内の β 遮断: Galpha(i2) の過剰発現踏み込むそのまま心筋 β-アドレナリンの応答。 Cardiovascular Research. Aug, 2002 | Pubmed ID: 12123769 Potentiation of Beta-adrenergic Inotropic Response by Pyruvate in Failing Human Myocardium Cardiovascular Research. Jan, 2002 | Pubmed ID: 11744019 心房と心室から心筋細胞における管状膜ネットワークの解析 Eva Wagner*1,2,3, Sören Brandenburg*1,2, Tobias Kohl1,2, Stephan E. Lehnart1,2,3,4 1Heart Research Center Goettingen, 2Clinic of Cardiology & Pulmonology, University Medical Center Goettingen, 3German Center for Cardiovascular Research (DZHK) partner site Goettingen, 4BioMET, Center for Biomedical Engineering & Technology, University of Maryland School of Medicine JoVE 51823 Bioengineering
心房と心室から心筋細胞における管状膜ネットワークの解析 Eva Wagner*1,2,3, Sören Brandenburg*1,2, Tobias Kohl1,2, Stephan E. Lehnart1,2,3,4 1Heart Research Center Goettingen, 2Clinic of Cardiology & Pulmonology, University Medical Center Goettingen, 3German Center for Cardiovascular Research (DZHK) partner site Goettingen, 4BioMET, Center for Biomedical Engineering & Technology, University of Maryland School of Medicine JoVE 51823 Bioengineering