Stephen L. Archer

Publications

• Differentiating COVID-19 Pneumonia from Acute Respiratory Distress Syndrome (ARDS) and High Altitude Pulmonary Edema (HAPE): Therapeutic Implications
  Circulation. May, 2020  |   Pubmed ID: 32369390
• Supra-coronary Aortic Banding Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension in Rats by Increasing Systolic Right Coronary Artery Perfusion
  Acta Physiologica (Oxford, England). Apr, 2020  |   Pubmed ID: 32339403
• Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis
  Circulation Research. Jun, 2020  |   Pubmed ID: 32216531
• Novel Mutations and Decreased Expression of the Epigenetic Regulator TET2 in Pulmonary Arterial Hypertension
  Circulation. Mar, 2020  |   Pubmed ID: 32192357
• Mitochondria in the Pulmonary Vasculature in Health and Disease: Oxygen-Sensing, Metabolism, and Dynamics
  Comprehensive Physiology. Mar, 2020  |   Pubmed ID: 32163206
• Hypochloremia Is a Noninvasive Predictor of Mortality in Pulmonary Arterial Hypertension
  Journal of the American Heart Association. Mar, 2020  |   Pubmed ID: 32079477
• An Epigenetic Increase in Mitochondrial Fission by MiD49 and MiD51 Regulates the Cell Cycle in Cancer: Diagnostic and Therapeutic Implications
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2020  |   Pubmed ID: 32068312
• Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes
  Critical Care Medicine. Feb, 2020  |   Pubmed ID: 31939812
• Identification of Novel Dynamin-related Protein 1 (Drp1) GTPase Inhibitors: Therapeutic Potential of Drpitor1 and Drpitor1a in Cancer and Cardiac Ischemia-reperfusion Injury
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2020  |   Pubmed ID: 31914641
• Clinical Value of Non-coding RNAs in Cardiovascular, Pulmonary, and Muscle Diseases
  American Journal of Physiology. Cell Physiology. 01, 2020  |   Pubmed ID: 31483703
• Response by Dunham-Snary and Archer to Letter Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction"
  Circulation Research. Sep, 2019  |   Pubmed ID: 31557123
• Metabolic Syndrome Exacerbates Pulmonary Hypertension Due to Left Heart Disease
  Circulation Research. 08, 2019  |   Pubmed ID: 31154939
• Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction
  Circulation Research. 06, 2019  |   Pubmed ID: 30922174
• Pathophysiology, Incidence, Management, and Consequences of Cardiac Arrhythmia in Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension
  Pulmonary Circulation. Jan-Mar, 2019  |   Pubmed ID: 30747032
• Clinical Determinants and Prognostic Implications of Right Ventricular Dysfunction in Pulmonary Hypertension Caused by Chronic Lung Disease
  Journal of the American Heart Association. 01, 2019  |   Pubmed ID: 30646788
• Repurposing Medications for Treatment of Pulmonary Arterial Hypertension: What's Old Is New Again
  Journal of the American Heart Association. 01, 2019  |   Pubmed ID: 30590974
• Genetic Determinants of Risk in Pulmonary Arterial Hypertension: International Genome-wide Association Studies and Meta-analysis
  The Lancet. Respiratory Medicine. 03, 2019  |   Pubmed ID: 30527956
• Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities
  Frontiers in Cardiovascular Medicine. 2018  |   Pubmed ID: 30740395
• Survival in Pulmonary Hypertension Due to Chronic Lung Disease: Influence of Low Diffusion Capacity of the Lungs for Carbon Monoxide
  The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Sep, 2018  |   Pubmed ID: 30391191
• Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities
  International Journal of Molecular Sciences. Sep, 2018  |   Pubmed ID: 30213070
• A Step Closer to Understanding How Riociguat Results in Remodelling of the Right Ventricle in Chronic Thromboembolic Pulmonary Hypertension
  The Canadian Journal of Cardiology. Sep, 2018  |   Pubmed ID: 30170664
• Increased Drp1-Mediated Mitochondrial Fission Promotes Proliferation and Collagen Production by Right Ventricular Fibroblasts in Experimental Pulmonary Arterial Hypertension
  Frontiers in Physiology. 2018  |   Pubmed ID: 30042687
• A Pro-con Debate: Current Controversies in PAH Pathogenesis at the American Thoracic Society International Conference in 2017
  American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2018  |   Pubmed ID: 29877097
• Standards and Methodological Rigor in Pulmonary Arterial Hypertension Preclinical and Translational Research
  Circulation Research. Mar, 2018  |   Pubmed ID: 29599278
• Pulmonary Arterial Hypertension: Pathogenesis and Clinical Management
  BMJ (Clinical Research Ed.). 03, 2018  |   Pubmed ID: 29540357
• Increasing Incidence and Prevalence of World Health Organization Groups 1 to 4 Pulmonary Hypertension: A Population-Based Cohort Study in Ontario, Canada
  Circulation. Cardiovascular Quality and Outcomes. Feb, 2018  |   Pubmed ID: 29444925
• Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications
  Circulation. Jul, 2018  |   Pubmed ID: 29431643
• Disproportionate Right Ventricular Dysfunction and Poor Survival in Group 3 Pulmonary Hypertension
  American Journal of Respiratory and Critical Care Medicine. Jun, 2018  |   Pubmed ID: 29360393
• Models and Molecular Mechanisms of World Health Organization Group 2 to 4 Pulmonary Hypertension
  Hypertension (Dallas, Tex. : 1979). 01, 2018  |   Pubmed ID: 29158355
• Interleukin-6 is Independently Associated with Right Ventricular Function in Pulmonary Arterial Hypertension
  The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Mar, 2018  |   Pubmed ID: 28893516
• Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension
  Circulation. Dec, 2017  |   Pubmed ID: 29255124
• Resistance over Compliance Describes Right Ventricular Afterload Better Than Resistance-compliance Time: a Friendly Amendment
  Pulmonary Circulation. Mar, 2017  |   Pubmed ID: 28680587
• Colchicine Depolymerizes Microtubules, Increases Junctophilin-2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension
  Journal of the American Heart Association. May, 2017  |   Pubmed ID: 28566298
• Abnormal Angiogenesis in Blood Outgrowth Endothelial Cells Derived from Von Willebrand Disease Patients
  Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis. Mar, 2017  |   Pubmed ID: 28362648
• Ischemia-induced Drp1 and Fis1-mediated Mitochondrial Fission and Right Ventricular Dysfunction in Pulmonary Hypertension
  Journal of Molecular Medicine (Berlin, Germany). Apr, 2017  |   Pubmed ID: 28265681
• MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype
  American Journal of Respiratory and Critical Care Medicine. Feb, 2017  |   Pubmed ID: 27648837
• Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine
  Chest. Jan, 2017  |   Pubmed ID: 27645688
• Pulmonary Pulse Wave Transit Time is Associated with Right Ventricular-pulmonary Artery Coupling in Pulmonary Arterial Hypertension
  Pulmonary Circulation. Dec, 2016  |   Pubmed ID: 28090301
• Executive Summary of the American Heart Association and American Thoracic Society Joint Guidelines for Pediatric Pulmonary Hypertension
  American Journal of Respiratory and Critical Care Medicine. Oct, 2016  |   Pubmed ID: 27689707
• The Role of Drp1 Adaptor Proteins MiD49 and MiD51 in Mitochondrial Fission: Implications for Human Disease
  Clinical Science (London, England : 1979). 11, 2016  |   Pubmed ID: 27660309
• Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications
  Advances in Experimental Medicine and Biology. 2016  |   Pubmed ID: 27343087
• Pulmonary Hypertension Begets Pulmonary Hypertension: Mutually Reinforcing Roles for Haemodynamics, Inflammation, and Cancer-like Phenotypes
  Cardiovascular Research. 07, 2016  |   Pubmed ID: 27216865
• Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension
  American Journal of Respiratory and Critical Care Medicine. 08, 2016  |   Pubmed ID: 26926454
• A Mitochondrial Redox Oxygen Sensor in the Pulmonary Vasculature and Ductus Arteriosus
  Pflugers Archiv : European Journal of Physiology. Jan, 2016  |   Pubmed ID: 26395471
• Gone Fission: an Asymptomatic STAT2 Mutation Elongates Mitochondria and Causes Human Disease Following Viral Infection
  Brain : a Journal of Neurology. Oct, 2015  |   Pubmed ID: 26408653
• Emerging Concepts in the Molecular Basis of Pulmonary Arterial Hypertension: Part I: Metabolic Plasticity and Mitochondrial Dynamics in the Pulmonary Circulation and Right Ventricle in Pulmonary Arterial Hypertension
  Circulation. May, 2015  |   Pubmed ID: 25964279
• Right Ventricular Adaptation and Failure in Pulmonary Arterial Hypertension
  The Canadian Journal of Cardiology. Apr, 2015  |   Pubmed ID: 25840092
• Mitochondrial Dynamics in Pulmonary Arterial Hypertension
  Journal of Molecular Medicine (Berlin, Germany). Mar, 2015  |   Pubmed ID: 25672499
• Soluble Guanylate Cyclase: a New Therapeutic Target for Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension
  Clinical Pharmacology and Therapeutics. Jan, 2015  |   Pubmed ID: 25670386
• Mitochondrial Dynamics in Cardiovascular Disease: Fission and Fusion Foretell Form and Function
  Journal of Molecular Medicine (Berlin, Germany). Mar, 2015  |   Pubmed ID: 25669447
• Inhibition of the Mitochondrial Fission Protein Dynamin-related Protein 1 Improves Survival in a Murine Cardiac Arrest Model
  Critical Care Medicine. Feb, 2015  |   Pubmed ID: 25599491
• Peripheral Blood Signature of Vasodilator-responsive Pulmonary Arterial Hypertension
  Circulation. Jan, 2015  |   Pubmed ID: 25361553
• The Right Ventricle in Pulmonary Arterial Hypertension: Disorders of Metabolism, Angiogenesis and Adrenergic Signaling in Right Ventricular Failure
  Circulation Research. Jun, 2014  |   Pubmed ID: 24951766
• Activation of the EGFR/p38/JNK Pathway by Mitochondrial-derived Hydrogen Peroxide Contributes to Oxygen-induced Contraction of Ductus Arteriosus
  Journal of Molecular Medicine (Berlin, Germany). Sep, 2014  |   Pubmed ID: 24906456
• SIRT3 Deacetylates and Activates OPA1 to Regulate Mitochondrial Dynamics During Stress
  Molecular and Cellular Biology. Mar, 2014  |   Pubmed ID: 24344202
• Dynamin-related Protein 1 (Drp1)-mediated Diastolic Dysfunction in Myocardial Ischemia-reperfusion Injury: Therapeutic Benefits of Drp1 Inhibition to Reduce Mitochondrial Fission
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2014  |   Pubmed ID: 24076965
• Relevant Issues in the Pathology and Pathobiology of Pulmonary Hypertension
  Journal of the American College of Cardiology. Dec, 2013  |   Pubmed ID: 24355640
• Atrioventricular Heart Block and Syncope Coincident with Diagnosis of Systemic Lupus Erythematosus
  The Canadian Journal of Cardiology. Oct, 2013  |   Pubmed ID: 23916739
• Cardiac Glutaminolysis: a Maladaptive Cancer Metabolism Pathway in the Right Ventricle in Pulmonary Hypertension
  Journal of Molecular Medicine (Berlin, Germany). Oct, 2013  |   Pubmed ID: 23794090
• Metabolism and Bioenergetics in the Right Ventricle and Pulmonary Vasculature in Pulmonary Hypertension
  Pulmonary Circulation. Jan, 2013  |   Pubmed ID: 23662191
• The Role of Redox Signaling in Epigenetics and Cardiovascular Disease
  Antioxidants & Redox Signaling. May, 2013  |   Pubmed ID: 23480168
• PGC1α-mediated Mitofusin-2 Deficiency in Female Rats and Humans with Pulmonary Arterial Hypertension
  American Journal of Respiratory and Critical Care Medicine. Apr, 2013  |   Pubmed ID: 23449689
• Role of Dynamin-related Protein 1 (Drp1)-mediated Mitochondrial Fission in Oxygen Sensing and Constriction of the Ductus Arteriosus
  Circulation Research. Mar, 2013  |   Pubmed ID: 23334860