Stephen L. Archer Department of Medicine Queen's University Biography Publications Institution JoVE Articles Stephen L. Archer has not added a biography. If you are Stephen L. Archer and would like to personalize this page please email our Author Liaison for assistance. Publications Survival in Pulmonary Hypertension Due to Chronic Lung Disease: Influence of Low Diffusion Capacity of the Lungs for Carbon Monoxide The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Sep, 2018 | Pubmed ID: 30391191 Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities International Journal of Molecular Sciences. Sep, 2018 | Pubmed ID: 30213070 A Step Closer to Understanding How Riociguat Results in Remodelling of the Right Ventricle in Chronic Thromboembolic Pulmonary Hypertension The Canadian Journal of Cardiology. Sep, 2018 | Pubmed ID: 30170664 Increased Drp1-Mediated Mitochondrial Fission Promotes Proliferation and Collagen Production by Right Ventricular Fibroblasts in Experimental Pulmonary Arterial Hypertension Frontiers in Physiology. 2018 | Pubmed ID: 30042687 A Pro-con Debate: Current Controversies in PAH Pathogenesis at the American Thoracic Society International Conference in 2017 American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2018 | Pubmed ID: 29877097 Standards and Methodological Rigor in Pulmonary Arterial Hypertension Preclinical and Translational Research Circulation Research. Mar, 2018 | Pubmed ID: 29599278 Pulmonary Arterial Hypertension: Pathogenesis and Clinical Management BMJ (Clinical Research Ed.). 03, 2018 | Pubmed ID: 29540357 Increasing Incidence and Prevalence of World Health Organization Groups 1 to 4 Pulmonary Hypertension: A Population-Based Cohort Study in Ontario, Canada Circulation. Cardiovascular Quality and Outcomes. Feb, 2018 | Pubmed ID: 29444925 Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications Circulation. Jul, 2018 | Pubmed ID: 29431643 Disproportionate Right Ventricular Dysfunction and Poor Survival in Group 3 Pulmonary Hypertension American Journal of Respiratory and Critical Care Medicine. Jun, 2018 | Pubmed ID: 29360393 Models and Molecular Mechanisms of World Health Organization Group 2 to 4 Pulmonary Hypertension Hypertension (Dallas, Tex. : 1979). 01, 2018 | Pubmed ID: 29158355 Interleukin-6 is Independently Associated with Right Ventricular Function in Pulmonary Arterial Hypertension The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Mar, 2018 | Pubmed ID: 28893516 Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension Circulation. Dec, 2017 | Pubmed ID: 29255124 Resistance over Compliance Describes Right Ventricular Afterload Better Than Resistance-compliance Time: a Friendly Amendment Pulmonary Circulation. Mar, 2017 | Pubmed ID: 28680587 Colchicine Depolymerizes Microtubules, Increases Junctophilin-2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension Journal of the American Heart Association. May, 2017 | Pubmed ID: 28566298 Abnormal Angiogenesis in Blood Outgrowth Endothelial Cells Derived from Von Willebrand Disease Patients Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis. Mar, 2017 | Pubmed ID: 28362648 Ischemia-induced Drp1 and Fis1-mediated Mitochondrial Fission and Right Ventricular Dysfunction in Pulmonary Hypertension Journal of Molecular Medicine (Berlin, Germany). Apr, 2017 | Pubmed ID: 28265681 MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype American Journal of Respiratory and Critical Care Medicine. Feb, 2017 | Pubmed ID: 27648837 Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine Chest. Jan, 2017 | Pubmed ID: 27645688 Pulmonary Pulse Wave Transit Time is Associated with Right Ventricular-pulmonary Artery Coupling in Pulmonary Arterial Hypertension Pulmonary Circulation. Dec, 2016 | Pubmed ID: 28090301 Executive Summary of the American Heart Association and American Thoracic Society Joint Guidelines for Pediatric Pulmonary Hypertension American Journal of Respiratory and Critical Care Medicine. Oct, 2016 | Pubmed ID: 27689707 The Role of Drp1 Adaptor Proteins MiD49 and MiD51 in Mitochondrial Fission: Implications for Human Disease Clinical Science (London, England : 1979). 11, 2016 | Pubmed ID: 27660309 Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications Advances in Experimental Medicine and Biology. 2016 | Pubmed ID: 27343087 Pulmonary Hypertension Begets Pulmonary Hypertension: Mutually Reinforcing Roles for Haemodynamics, Inflammation, and Cancer-like Phenotypes Cardiovascular Research. 07, 2016 | Pubmed ID: 27216865 Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension American Journal of Respiratory and Critical Care Medicine. 08, 2016 | Pubmed ID: 26926454 A Mitochondrial Redox Oxygen Sensor in the Pulmonary Vasculature and Ductus Arteriosus Pflugers Archiv : European Journal of Physiology. Jan, 2016 | Pubmed ID: 26395471 Gone Fission: an Asymptomatic STAT2 Mutation Elongates Mitochondria and Causes Human Disease Following Viral Infection Brain : a Journal of Neurology. Oct, 2015 | Pubmed ID: 26408653 Emerging Concepts in the Molecular Basis of Pulmonary Arterial Hypertension: Part I: Metabolic Plasticity and Mitochondrial Dynamics in the Pulmonary Circulation and Right Ventricle in Pulmonary Arterial Hypertension Circulation. May, 2015 | Pubmed ID: 25964279 Right Ventricular Adaptation and Failure in Pulmonary Arterial Hypertension The Canadian Journal of Cardiology. Apr, 2015 | Pubmed ID: 25840092 Mitochondrial Dynamics in Pulmonary Arterial Hypertension Journal of Molecular Medicine (Berlin, Germany). Mar, 2015 | Pubmed ID: 25672499 Soluble Guanylate Cyclase: a New Therapeutic Target for Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension Clinical Pharmacology and Therapeutics. Jan, 2015 | Pubmed ID: 25670386 Mitochondrial Dynamics in Cardiovascular Disease: Fission and Fusion Foretell Form and Function Journal of Molecular Medicine (Berlin, Germany). Mar, 2015 | Pubmed ID: 25669447 Inhibition of the Mitochondrial Fission Protein Dynamin-related Protein 1 Improves Survival in a Murine Cardiac Arrest Model Critical Care Medicine. Feb, 2015 | Pubmed ID: 25599491 Peripheral Blood Signature of Vasodilator-responsive Pulmonary Arterial Hypertension Circulation. Jan, 2015 | Pubmed ID: 25361553 The Right Ventricle in Pulmonary Arterial Hypertension: Disorders of Metabolism, Angiogenesis and Adrenergic Signaling in Right Ventricular Failure Circulation Research. Jun, 2014 | Pubmed ID: 24951766 Activation of the EGFR/p38/JNK Pathway by Mitochondrial-derived Hydrogen Peroxide Contributes to Oxygen-induced Contraction of Ductus Arteriosus Journal of Molecular Medicine (Berlin, Germany). Sep, 2014 | Pubmed ID: 24906456 SIRT3 Deacetylates and Activates OPA1 to Regulate Mitochondrial Dynamics During Stress Molecular and Cellular Biology. Mar, 2014 | Pubmed ID: 24344202 Dynamin-related Protein 1 (Drp1)-mediated Diastolic Dysfunction in Myocardial Ischemia-reperfusion Injury: Therapeutic Benefits of Drp1 Inhibition to Reduce Mitochondrial Fission FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2014 | Pubmed ID: 24076965 Relevant Issues in the Pathology and Pathobiology of Pulmonary Hypertension Journal of the American College of Cardiology. Dec, 2013 | Pubmed ID: 24355640 Atrioventricular Heart Block and Syncope Coincident with Diagnosis of Systemic Lupus Erythematosus The Canadian Journal of Cardiology. Oct, 2013 | Pubmed ID: 23916739 Cardiac Glutaminolysis: a Maladaptive Cancer Metabolism Pathway in the Right Ventricle in Pulmonary Hypertension Journal of Molecular Medicine (Berlin, Germany). Oct, 2013 | Pubmed ID: 23794090 Metabolism and Bioenergetics in the Right Ventricle and Pulmonary Vasculature in Pulmonary Hypertension Pulmonary Circulation. Jan, 2013 | Pubmed ID: 23662191 The Role of Redox Signaling in Epigenetics and Cardiovascular Disease Antioxidants & Redox Signaling. May, 2013 | Pubmed ID: 23480168 PGC1α-mediated Mitofusin-2 Deficiency in Female Rats and Humans with Pulmonary Arterial Hypertension American Journal of Respiratory and Critical Care Medicine. Apr, 2013 | Pubmed ID: 23449689 Role of Dynamin-related Protein 1 (Drp1)-mediated Mitochondrial Fission in Oxygen Sensing and Constriction of the Ductus Arteriosus Circulation Research. Mar, 2013 | Pubmed ID: 23334860 Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat Ping Yu Xiong*1,2, Shunsuke Baba*3,4, Naritomo Nishioka3,5, Yoshitaka Fujimoto3, Stephen L. Archer1, Susumu Minamisawa1,4 1Department of Medicine, Queen's University, 2Department of Biomedical and Molecular Sciences, Queen's University, 3Department of Cell Physiology, The Jikei University School of Medicine, 4Department of Pediatrics, The Jikei University School of Medicine, 5Department of Cardiovascular Surgery, The Jikei University School of Medicine JoVE 58787 Medicine
Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat Ping Yu Xiong*1,2, Shunsuke Baba*3,4, Naritomo Nishioka3,5, Yoshitaka Fujimoto3, Stephen L. Archer1, Susumu Minamisawa1,4 1Department of Medicine, Queen's University, 2Department of Biomedical and Molecular Sciences, Queen's University, 3Department of Cell Physiology, The Jikei University School of Medicine, 4Department of Pediatrics, The Jikei University School of Medicine, 5Department of Cardiovascular Surgery, The Jikei University School of Medicine JoVE 58787 Medicine
