Stephen R. Holdsworth

Publications

• Deoxyribonuclease 1 Reduces Pathogenic Effects of Cigarette Smoke Exposure in the Lung
  Scientific Reports. Sep, 2017  |   Pubmed ID: 28935869
• ANCA-Associated Vasculitis: Pathogenesis, Models, and Preclinical Testing
  Seminars in Nephrology. Sep, 2017  |   Pubmed ID: 28863790
• Dominant Protection from HLA-linked Autoimmunity by Antigen-specific Regulatory T Cells
  Nature. 05, 2017  |   Pubmed ID: 28467828
• T Cell Receptor Assessment in Autoimmune Disease Requires Access to the Most Adjacent Immunologically Active Organ
  Journal of Autoimmunity. Jul, 2017  |   Pubmed ID: 28318808
• Interleukin-17RA Promotes Humoral Responses and Glomerular Injury in Experimental Rapidly Progressive Glomerulonephritis
  Nephron. 2017  |   Pubmed ID: 27941331
• Induced Regulatory T Cells Are Phenotypically Unstable and Do Not Protect Mice from Rapidly Progressive Glomerulonephritis
  Immunology. Jan, 2017  |   Pubmed ID: 27606831
• Activated Renal Dendritic Cells Cross Present Intrarenal Antigens After Ischemia-Reperfusion Injury
  Transplantation. May, 2017  |   Pubmed ID: 27495751
• CD8+ T Cells Effect Glomerular Injury in Experimental Anti-Myeloperoxidase GN
  Journal of the American Society of Nephrology : JASN. Jan, 2017  |   Pubmed ID: 27288012
• The NLRP3 Inflammasome in Kidney Disease and Autoimmunity
  Nephrology (Carlton, Vic.). Sep, 2016  |   Pubmed ID: 27011059
• Biologics for the Treatment of Autoimmune Renal Diseases
  Nature Reviews. Nephrology. Apr, 2016  |   Pubmed ID: 26949177
• Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase
  Journal of Immunology Research. 2016  |   Pubmed ID: 26904693
• Mast Cell Stabilization Ameliorates Autoimmune Anti-Myeloperoxidase Glomerulonephritis
  Journal of the American Society of Nephrology : JASN. May, 2016  |   Pubmed ID: 26374606
• Regulatory T Cells in Immune-mediated Renal Disease
  Nephrology (Carlton, Vic.). Feb, 2016  |   Pubmed ID: 26206106
• Endogenous Toll-Like Receptor 9 Regulates AKI by Promoting Regulatory T Cell Recruitment
  Journal of the American Society of Nephrology : JASN. Mar, 2016  |   Pubmed ID: 26116356
• Myeloperoxidase Peptide-Based Nasal Tolerance in Experimental ANCA-Associated GN
  Journal of the American Society of Nephrology : JASN. Feb, 2016  |   Pubmed ID: 26047792
• Targeting IL-17 and IL-23 in Immune Mediated Renal Disease
  Current Medicinal Chemistry. 2015  |   Pubmed ID: 26521930
• The Lung Immune Response to Bacteria in Chronic Obstructive Pulmonary Disease
  American Journal of Respiratory and Critical Care Medicine. Oct, 2015  |   Pubmed ID: 26426789
• Renal Participation of Myeloperoxidase in Antineutrophil Cytoplasmic Antibody (ANCA)-associated Glomerulonephritis
  Kidney International. Nov, 2015  |   Pubmed ID: 26176828
• Programmed Death 1 and Its Ligands Do Not Limit Experimental Foreign Antigen-induced Immune Complex Glomerulonephritis
  Nephrology (Carlton, Vic.). Dec, 2015  |   Pubmed ID: 26043977
• Cytokines: Names and Numbers You Should Care About
  Clinical Journal of the American Society of Nephrology : CJASN. Dec, 2015  |   Pubmed ID: 25941193
• FMS-like Tyrosine Kinase 3 Ligand Treatment Does Not Ameliorate Experimental Rapidly Progressive Glomerulonephritis
  PloS One. 2015  |   Pubmed ID: 25849330
• Nontypeable Haemophilus Influenzae Induces Sustained Lung Oxidative Stress and Protease Expression
  PloS One. 2015  |   Pubmed ID: 25793977
• Suppression of Autoimmunity and Renal Disease in Pristane-Induced Lupus by Myeloperoxidase
  Arthritis & Rheumatology (Hoboken, N.J.). Jul, 2015  |   Pubmed ID: 25777776
• Mouse Models of Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis
  Current Pharmaceutical Design. 2015  |   Pubmed ID: 25777754
• T Cell Mediated Autoimmune Glomerular Disease in Mice
  Current Protocols in Immunology. Nov, 2014  |   Pubmed ID: 25367126
• Glomerulonephritis Induced by Heterologous Anti-GBM Globulin As a Planted Foreign Antigen
  Current Protocols in Immunology. Aug, 2014  |   Pubmed ID: 25081909
• FcγRIIB Regulates T-cell Autoreactivity, ANCA Production, and Neutrophil Activation to Suppress Anti-myeloperoxidase Glomerulonephritis
  Kidney International. Dec, 2014  |   Pubmed ID: 24869670
• Endogenous Myeloperoxidase is a Mediator of Joint Inflammation and Damage in Experimental Arthritis
  Arthritis & Rheumatology (Hoboken, N.J.). Apr, 2014  |   Pubmed ID: 24757143
• Innate IL-17A-producing Leukocytes Promote Acute Kidney Injury Via Inflammasome and Toll-like Receptor Activation
  The American Journal of Pathology. May, 2014  |   Pubmed ID: 24631024
• Histopathologic and Clinical Predictors of Kidney Outcomes in ANCA-associated Vasculitis
  American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. Feb, 2014  |   Pubmed ID: 24183110
• MicroRNA-155 a New Therapeutic Target in Crescentic GN
  Journal of the American Society of Nephrology : JASN. Dec, 2013  |   Pubmed ID: 24158984
• Myeloperoxidase (MPO)-specific CD4+ T Cells Contribute to MPO-anti-neutrophil Cytoplasmic Antibody (ANCA) Associated Glomerulonephritis
  Cellular Immunology. Mar, 2013  |   Pubmed ID: 23665205
• Neutrophil Myeloperoxidase Regulates T-cell-driven Tissue Inflammation in Mice by Inhibiting Dendritic Cell Function
  Blood. May, 2013  |   Pubmed ID: 23509155
• Reply: To PMID 23142009
  The Journal of Allergy and Clinical Immunology. Apr, 2013  |   Pubmed ID: 23453686
• The HLA-DRB1*15:01-restricted Goodpasture's T Cell Epitope Induces GN
  Journal of the American Society of Nephrology : JASN. Feb, 2013  |   Pubmed ID: 23411782
• Thymic Deletion and Regulatory T Cells Prevent Antimyeloperoxidase GN
  Journal of the American Society of Nephrology : JASN. Mar, 2013  |   Pubmed ID: 23393320
• Chest Pain and Exacerbations of Bronchiectasis
  International Journal of General Medicine. 2012  |   Pubmed ID: 23271921
• 对不可流感嗜血杆菌与慢性阻塞性肺疾病患者的肺 T 细胞反应。
  The Journal of Allergy and Clinical Immunology. Nov, 2012  |   Pubmed ID: 23142009
• Mast Cells Contribute to Peripheral Tolerance and Attenuate Autoimmune Vasculitis
  Journal of the American Society of Nephrology : JASN. Dec, 2012  |   Pubmed ID: 23138486
• The Immunodominant Myeloperoxidase T-cell Epitope Induces Local Cell-mediated Injury in Antimyeloperoxidase Glomerulonephritis
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2012  |   Pubmed ID: 22955884
• Mast Cell Activation and Degranulation Promotes Renal Fibrosis in Experimental Unilateral Ureteric Obstruction
  Kidney International. Sep, 2012  |   Pubmed ID: 22673890
• Endogenous Tim-1 (Kim-1) Promotes T-cell Responses and Cell-mediated Injury in Experimental Crescentic Glomerulonephritis
  Kidney International. May, 2012  |   Pubmed ID: 22205357
• Renal Dendritic Cells Adopt a Pro-inflammatory Phenotype in Obstructive Uropathy to Activate T Cells but Do Not Directly Contribute to Fibrosis
  The American Journal of Pathology. Jan, 2012  |   Pubmed ID: 22079432
• Mast Cells Mediate Acute Kidney Injury Through the Production of TNF
  Journal of the American Society of Nephrology : JASN. Dec, 2011  |   Pubmed ID: 22021718
• Tim-1 Promotes Cisplatin Nephrotoxicity
  American Journal of Physiology. Renal Physiology. Nov, 2011  |   Pubmed ID: 21835770
• Interleukin-17A Promotes Early but Attenuates Established Disease in Crescentic Glomerulonephritis in Mice
  The American Journal of Pathology. Sep, 2011  |   Pubmed ID: 21741931
• The Emergence of TH17 Cells As Effectors of Renal Injury
  Journal of the American Society of Nephrology : JASN. Feb, 2011  |   Pubmed ID: 21289213
• The IL-27 Receptor Has Biphasic Effects in Crescentic Glomerulonephritis Mediated Through Th1 Responses
  The American Journal of Pathology. Feb, 2011  |   Pubmed ID: 21281790
• Endogenous Foxp3(+) T-regulatory Cells Suppress Anti-glomerular Basement Membrane Nephritis
  Kidney International. May, 2011  |   Pubmed ID: 21248715
• Toll-like Receptor 2 Induces Th17 Myeloperoxidase Autoimmunity While Toll-like Receptor 9 Drives Th1 Autoimmunity in Murine Vasculitis
  Arthritis and Rheumatism. Apr, 2011  |   Pubmed ID: 21190299
• The Th17-defining Transcription Factor RORγt Promotes Glomerulonephritis
  Journal of the American Society of Nephrology : JASN. Mar, 2011  |   Pubmed ID: 21183590
• Lung Diffusing Capacity in Adult Bronchiectasis: a Longitudinal Study
  Respiratory Care. Dec, 2010  |   Pubmed ID: 21122177
• Toll-like Receptor 9 Enhances Nephritogenic Immunity and Glomerular Leukocyte Recruitment, Exacerbating Experimental Crescentic Glomerulonephritis
  The American Journal of Pathology. Nov, 2010  |   Pubmed ID: 20847283
• Intrinsic Renal Cell and Leukocyte-derived TLR4 Aggravate Experimental Anti-MPO Glomerulonephritis
  Kidney International. Dec, 2010  |   Pubmed ID: 20844472
• Review: T Helper 17 Cells: Their Role in Glomerulonephritis
  Nephrology (Carlton, Vic.). Aug, 2010  |   Pubmed ID: 20649870
• Th17 Cells Promote Autoimmune Anti-myeloperoxidase Glomerulonephritis
  Journal of the American Society of Nephrology : JASN. Jun, 2010  |   Pubmed ID: 20299361
• Th1 and Th17 Cells Induce Proliferative Glomerulonephritis
  Journal of the American Society of Nephrology : JASN. Dec, 2009  |   Pubmed ID: 19820122
• Atorvastatin Enhances Humoral Immune Responses but Does Not Alter Renal Injury in Experimental Crescentic Glomerulonephritis
  Nephrology (Carlton, Vic.). Oct, 2009  |   Pubmed ID: 19796023
• Endogenous CD100 Promotes Glomerular Injury and Macrophage Recruitment in Experimental Crescentic Glomerulonephritis
  Immunology. Sep, 2009  |   Pubmed ID: 19689741
• IL-1RI Deficiency Ameliorates Early Experimental Renal Interstitial Fibrosis
  Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Oct, 2009  |   Pubmed ID: 19465557
• Phenotypes of Adult Bronchiectasis: Onset of Productive Cough in Childhood and Adulthood
  COPD. Apr, 2009  |   Pubmed ID: 19378226
• IL-23, Not IL-12, Directs Autoimmunity to the Goodpasture Antigen
  Journal of the American Society of Nephrology : JASN. May, 2009  |   Pubmed ID: 19357249
• Role of Mast Cells in Progressive Renal Diseases
  Journal of the American Society of Nephrology : JASN. Dec, 2008  |   Pubmed ID: 18776124
• Advances in the Pathogenesis of Goodpasture's Disease: from Epitopes to Autoantibodies to Effector T Cells
  Journal of Autoimmunity. Nov, 2008  |   Pubmed ID: 18502098
• T-bet Deficiency Attenuates Renal Injury in Experimental Crescentic Glomerulonephritis
  Journal of the American Society of Nephrology : JASN. Mar, 2008  |   Pubmed ID: 18235099
• Distinct in Vivo Roles of CD80 and CD86 in the Effector T-cell Responses Inducing Antigen-induced Arthritis
  Immunology. Aug, 2008  |   Pubmed ID: 18217945
• Intrarenal Antigens Activate CD4+ Cells Via Co-stimulatory Signals from Dendritic Cells
  Journal of the American Society of Nephrology : JASN. Mar, 2008  |   Pubmed ID: 18184859
• Leukocytes in Glomerular Injury
  Seminars in Immunopathology. Nov, 2007  |   Pubmed ID: 17938927
• Cytokines in Glomerulonephritis
  Seminars in Nephrology. May, 2007  |   Pubmed ID: 17533006
• Microbiologic Follow-up Study in Adult Bronchiectasis
  Respiratory Medicine. Aug, 2007  |   Pubmed ID: 17467966
• Endogenous Myeloperoxidase Promotes Neutrophil-mediated Renal Injury, but Attenuates T Cell Immunity Inducing Crescentic Glomerulonephritis
  Journal of the American Society of Nephrology : JASN. Mar, 2007  |   Pubmed ID: 17267745
• CD100 Enhances Dendritic Cell and CD4+ Cell Activation Leading to Pathogenetic Humoral Responses and Immune Complex Glomerulonephritis
  Journal of Immunology (Baltimore, Md. : 1950). Sep, 2006  |   Pubmed ID: 16920982
• Anti-neutrophil Cytoplasmic Antibodies and Effector CD4+ Cells Play Nonredundant Roles in Anti-myeloperoxidase Crescentic Glomerulonephritis
  Journal of the American Society of Nephrology : JASN. Jul, 2006  |   Pubmed ID: 16769746
• Characterisation of the Onset and Presenting Clinical Features of Adult Bronchiectasis
  Respiratory Medicine. Dec, 2006  |   Pubmed ID: 16650970
• T Cells in Crescentic Glomerulonephritis
  Journal of the American Society of Nephrology : JASN. May, 2006  |   Pubmed ID: 16624930
• Inducible Co-stimulatory Molecule Ligand is Protective During the Induction and Effector Phases of Crescentic Glomerulonephritis
  Journal of the American Society of Nephrology : JASN. Apr, 2006  |   Pubmed ID: 16540559
• The Isolation and Purification of Biologically Active Recombinant and Native Autoantigens for the Study of Autoimmune Disease
  Journal of Immunological Methods. Jan, 2006  |   Pubmed ID: 16388818
• A Pathogenetic Role for Mast Cells in Experimental Crescentic Glomerulonephritis
  Journal of the American Society of Nephrology : JASN. Jan, 2006  |   Pubmed ID: 16319187
• Outcome in Adult Bronchiectasis
  COPD. Mar, 2005  |   Pubmed ID: 17136958
• Granulocyte Macrophage Colony-stimulating Factor Expression by Both Renal Parenchymal and Immune Cells Mediates Murine Crescentic Glomerulonephritis
  Journal of the American Society of Nephrology : JASN. Sep, 2005  |   Pubmed ID: 16033860
• Leukocyte Phenotype and Function Predicts Infection Risk in Renal Transplant Recipients
  Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Oct, 2005  |   Pubmed ID: 16030032
• CD80 and CD86 Costimulatory Molecules Regulate Crescentic Glomerulonephritis by Different Mechanisms
  Kidney International. Aug, 2005  |   Pubmed ID: 16014035
• Glomerular Expression of CD80 and CD86 is Required for Leukocyte Accumulation and Injury in Crescentic Glomerulonephritis
  Journal of the American Society of Nephrology : JASN. Jul, 2005  |   Pubmed ID: 15944341
• IL-12p40 and IL-18 in Crescentic Glomerulonephritis: IL-12p40 is the Key Th1-defining Cytokine Chain, Whereas IL-18 Promotes Local Inflammation and Leukocyte Recruitment
  Journal of the American Society of Nephrology : JASN. Jul, 2005  |   Pubmed ID: 15888563
• Experimental Autoimmune Goodpasture's Disease: a Pathogenetic Role for Both Effector Cells and Antibody in Injury
  Kidney International. Feb, 2005  |   Pubmed ID: 15673304
• Endogenous IL-13 Limits Humoral Responses and Injury in Experimental Glomerulonephritis but Does Not Regulate Th1 Cell-mediated Crescentic Glomerulonephritis
  Journal of the American Society of Nephrology : JASN. Sep, 2004  |   Pubmed ID: 15339986
• Fibrin Independent Proinflammatory Effects of Tissue Factor in Experimental Crescentic Glomerulonephritis
  Kidney International. Aug, 2004  |   Pubmed ID: 15253718
• Experimental Autoimmune Anti-glomerular Basement Membrane Glomerulonephritis: a Protective Role for IFN-gamma
  Journal of the American Society of Nephrology : JASN. Jul, 2004  |   Pubmed ID: 15213264
• An IL-12-independent Role for CD40-CD154 in Mediating Effector Responses: Studies in Cell-mediated Glomerulonephritis and Dermal Delayed-type Hypersensitivity
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2004  |   Pubmed ID: 15210767
• Ex Vivo Lymphocyte Proliferative Function is Severely Inhibited in Renal Transplant Patients on Mycophenolate Mofetil Treatment
  Transplant Immunology. Jun-Jul, 2004  |   Pubmed ID: 15203129
• Leukocyte-derived Interleukin-1beta Interacts with Renal Interleukin-1 Receptor I to Promote Renal Tumor Necrosis Factor and Glomerular Injury in Murine Crescentic Glomerulonephritis
  The American Journal of Pathology. Jun, 2004  |   Pubmed ID: 15161633
• Contributions of IL-1beta and IL-1alpha to Crescentic Glomerulonephritis in Mice
  Journal of the American Society of Nephrology : JASN. Apr, 2004  |   Pubmed ID: 15034093
• The Role of Flow Cytometric ANCA Detection in Screening for Acute Pauci-immune Crescentic Glomerulonephritis
  Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Feb, 2004  |   Pubmed ID: 14736960
• Intrinsic Renal Cell Expression of CD40 Directs Th1 Effectors Inducing Experimental Crescentic Glomerulonephritis
  Journal of the American Society of Nephrology : JASN. Nov, 2003  |   Pubmed ID: 14569091
• Intrinsic Renal Cells Are the Major Source of Tumor Necrosis Factor Contributing to Renal Injury in Murine Crescentic Glomerulonephritis
  Journal of the American Society of Nephrology : JASN. Jul, 2003  |   Pubmed ID: 12819238
• T Cells in Glomerulonephritis
  Springer Seminars in Immunopathology. May, 2003  |   Pubmed ID: 12778334
• Plasminogen Activator Inhibitor-1 is a Significant Determinant of Renal Injury in Experimental Crescentic Glomerulonephritis
  Journal of the American Society of Nephrology : JASN. Jun, 2003  |   Pubmed ID: 12761249
• Laboratory Assessment of Immune Function in Renal Transplant Patients
  Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. May, 2003  |   Pubmed ID: 12686675
• Adaptive Immunity to Nontypeable Haemophilus Influenzae
  American Journal of Respiratory and Critical Care Medicine. Feb, 2003  |   Pubmed ID: 12433671
• IFN-gamma Production by Intrinsic Renal Cells and Bone Marrow-derived Cells is Required for Full Expression of Crescentic Glomerulonephritis in Mice
  Journal of Immunology (Baltimore, Md. : 1950). Apr, 2002  |   Pubmed ID: 11937574
• The Requirement for Granulocyte-macrophage Colony-stimulating Factor and Granulocyte Colony-stimulating Factor in Leukocyte-mediated Immune Glomerular Injury
  Journal of the American Society of Nephrology : JASN. Feb, 2002  |   Pubmed ID: 11805162