Steven A. Carr Broad Institute of MIT and Harvard Biography Publications Institution JoVE Articles Steven A. Carr has not added a biography. If you are Steven A. Carr and would like to personalize this page please email our Author Liaison for assistance. Publications STK33 Kinase Inhibitor BRD-8899 Has No Effect on KRAS-dependent Cancer Cell Viability Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012 | Pubmed ID: 22323609 Identifying Cellular Targets of Small-molecule Probes and Drugs with Biochemical Enrichment and SILAC Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22065222 ITRAQ Labeling is Superior to MTRAQ for Quantitative Global Proteomics and Phosphoproteomics Molecular & Cellular Proteomics : MCP. Dec, 2011 | Pubmed ID: 22210691 Inter-laboratory Evaluation of Automated, Multiplexed Peptide Immunoaffinity Enrichment Coupled to Multiple Reaction Monitoring Mass Spectrometry for Quantifying Proteins in Plasma Molecular & Cellular Proteomics : MCP. Dec, 2011 | Pubmed ID: 22199228 The Matrisome: in Silico Definition and in Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices Molecular & Cellular Proteomics : MCP. Dec, 2011 | Pubmed ID: 22159717 Systematic Discovery of TLR Signaling Components Delineates Viral-sensing Circuits Cell. Nov, 2011 | Pubmed ID: 22078882 Cdk5 is Required for Memory Function and Hippocampal Plasticity Via the CAMP Signaling Pathway PloS One. 2011 | Pubmed ID: 21984943 Mutations in MTFMT Underlie a Human Disorder of Formylation Causing Impaired Mitochondrial Translation Cell Metabolism. Sep, 2011 | Pubmed ID: 21907147 Status and Prospects for Discovery and Verification of New Biomarkers of Cardiovascular Disease by Proteomics Circulation Research. Aug, 2011 | Pubmed ID: 21817166 AAK1 Identified As an Inhibitor of Neuregulin-1/ErbB4-dependent Neurotrophic Factor Signaling Using Integrative Chemical Genomics and Proteomics Chemistry & Biology. Jul, 2011 | Pubmed ID: 21802010 Selective Killing of Cancer Cells by a Small Molecule Targeting the Stress Response to ROS Nature. Jul, 2011 | Pubmed ID: 21753854 Exoplasmic Cysteine Cys384 of the HDL Receptor SR-BI is Critical for Its Sensitivity to a Small-molecule Inhibitor and Normal Lipid Transport Activity Proceedings of the National Academy of Sciences of the United States of America. Jul, 2011 | Pubmed ID: 21746906 A Pipeline That Integrates the Discovery and Verification of Plasma Protein Biomarkers Reveals Candidate Markers for Cardiovascular Disease Nature Biotechnology. Jul, 2011 | Pubmed ID: 21685905 Lipid Profiling Identifies a Triacylglycerol Signature of Insulin Resistance and Improves Diabetes Prediction in Humans The Journal of Clinical Investigation. Apr, 2011 | Pubmed ID: 21403394 Evaluation of Large Scale Quantitative Proteomic Assay Development Using Peptide Affinity-based Mass Spectrometry Molecular & Cellular Proteomics : MCP. Apr, 2011 | Pubmed ID: 21245105 Overview of Peptide and Protein Analysis by Mass Spectrometry Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [et Al.]. Nov, 2010 | Pubmed ID: 21104985 Effect of Collision Energy Optimization on the Measurement of Peptides by Selected Reaction Monitoring (SRM) Mass Spectrometry Analytical Chemistry. Dec, 2010 | Pubmed ID: 21090646 DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-cycle Checkpoint Network Controlled by MK2-mediated RNA Stabilization Molecular Cell. Oct, 2010 | Pubmed ID: 20932473 Chemical Genetic Strategy Identifies Histone Deacetylase 1 (HDAC1) and HDAC2 As Therapeutic Targets in Sickle Cell Disease Proceedings of the National Academy of Sciences of the United States of America. Jul, 2010 | Pubmed ID: 20616024 Metabolic Signatures of Exercise in Human Plasma Science Translational Medicine. May, 2010 | Pubmed ID: 20505214 Rictor Phosphorylation on the Thr-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2 Molecular Cancer Research : MCR. Jun, 2010 | Pubmed ID: 20501647 Optimizing Performance of Glycopeptide Capture for Plasma Proteomics Journal of Proteome Research. Apr, 2010 | Pubmed ID: 20235580 A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G(2)/M DNA Damage Checkpoint PLoS Biology. Jan, 2010 | Pubmed ID: 20126263 Integration of Proteomic-based Tools for Improved Biomarkers of Myocardial Injury Clinical Chemistry. Feb, 2010 | Pubmed ID: 20022985 Automated Detection of Inaccurate and Imprecise Transitions in Peptide Quantification by Multiple Reaction Monitoring Mass Spectrometry Clinical Chemistry. Feb, 2010 | Pubmed ID: 20022980 Analytical Validation of Protein-based Multiplex Assays: a Workshop Report by the NCI-FDA Interagency Oncology Task Force on Molecular Diagnostics Clinical Chemistry. Feb, 2010 | Pubmed ID: 20007859 Protein-based Multiplex Assays: Mock Presubmissions to the US Food and Drug Administration Clinical Chemistry. Feb, 2010 | Pubmed ID: 20007858 Repeatability and Reproducibility in Proteomic Identifications by Liquid Chromatography-tandem Mass Spectrometry Journal of Proteome Research. Feb, 2010 | Pubmed ID: 19921851 Introduction: Advances in Protein Analysis for the Clinical Laboratory Clinical Chemistry. Feb, 2010 | Pubmed ID: 19910505 Interlaboratory Study Characterizing a Yeast Performance Standard for Benchmarking LC-MS Platform Performance Molecular & Cellular Proteomics : MCP. Feb, 2010 | Pubmed ID: 19858499 Performance Metrics for Liquid Chromatography-tandem Mass Spectrometry Systems in Proteomics Analyses Molecular & Cellular Proteomics : MCP. Feb, 2010 | Pubmed ID: 19837981 ZBED6, a Novel Transcription Factor Derived from a Domesticated DNA Transposon Regulates IGF2 Expression and Muscle Growth PLoS Biology. Dec, 2009 | Pubmed ID: 20016685 Empirical Bayes Analysis of Quantitative Proteomics Experiments PloS One. 2009 | Pubmed ID: 19829701 Proteomic and Genetic Approaches Identify Syk As an AML Target Cancer Cell. Oct, 2009 | Pubmed ID: 19800574 Quantification of Cardiovascular Biomarkers in Patient Plasma by Targeted Mass Spectrometry and Stable Isotope Dilution Molecular & Cellular Proteomics : MCP. Oct, 2009 | Pubmed ID: 19596694 Multi-site Assessment of the Precision and Reproducibility of Multiple Reaction Monitoring-based Measurements of Proteins in Plasma Nature Biotechnology. Jul, 2009 | Pubmed ID: 19561596 Plk1 Self-organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells PLoS Biology. May, 2009 | Pubmed ID: 19468302 Developing Multiplexed Assays for Troponin I and Interleukin-33 in Plasma by Peptide Immunoaffinity Enrichment and Targeted Mass Spectrometry Clinical Chemistry. Jun, 2009 | Pubmed ID: 19372185 Directed Sample Interrogation Utilizing an Accurate Mass Exclusion-based Data-dependent Acquisition Strategy (AMEx) Journal of Proteome Research. Jun, 2009 | Pubmed ID: 19344186 Identifying the Proteins to Which Small-molecule Probes and Drugs Bind in Cells Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19255428 Prediction of High-responding Peptides for Targeted Protein Assays by Mass Spectrometry Nature Biotechnology. Feb, 2009 | Pubmed ID: 19169245 A Human Proteome Detection and Quantitation Project Molecular & Cellular Proteomics : MCP. May, 2009 | Pubmed ID: 19131327 Bead-based Profiling of Tyrosine Kinase Phosphorylation Identifies SRC As a Potential Target for Glioblastoma Therapy Nature Biotechnology. Jan, 2009 | Pubmed ID: 19098899 Protein Quantitation Through Targeted Mass Spectrometry: the Way out of Biomarker Purgatory? Clinical Chemistry. Nov, 2008 | Pubmed ID: 18957555 Metabolite Profiling of Blood from Individuals Undergoing Planned Myocardial Infarction Reveals Early Markers of Myocardial Injury The Journal of Clinical Investigation. Oct, 2008 | Pubmed ID: 18769631 Metabolic Profiling of the Human Response to a Glucose Challenge Reveals Distinct Axes of Insulin Sensitivity Molecular Systems Biology. 2008 | Pubmed ID: 18682704 A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology Cell. Jul, 2008 | Pubmed ID: 18614015 Accurate Inclusion Mass Screening: a Bridge from Unbiased Discovery to Targeted Assay Development for Biomarker Verification Molecular & Cellular Proteomics : MCP. Oct, 2008 | Pubmed ID: 18534968 Quantitative, Multiplexed Assays for Low Abundance Proteins in Plasma by Targeted Mass Spectrometry and Stable Isotope Dilution Molecular & Cellular Proteomics : MCP. Dec, 2007 | Pubmed ID: 17939991 Proteomic Screen Defines the Polo-box Domain Interactome and Identifies Rock2 As a Plk1 Substrate The EMBO Journal. May, 2007 | Pubmed ID: 17446864 PRAS40 is an Insulin-regulated Inhibitor of the MTORC1 Protein Kinase Molecular Cell. Mar, 2007 | Pubmed ID: 17386266 The Connectivity Map: Using Gene-expression Signatures to Connect Small Molecules, Genes, and Disease Science (New York, N.Y.). Sep, 2006 | Pubmed ID: 17008526 MSin1 is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct MTORC2s Current Biology : CB. Sep, 2006 | Pubmed ID: 16919458 Protein Biomarker Discovery and Validation: the Long and Uncertain Path to Clinical Utility Nature Biotechnology. Aug, 2006 | Pubmed ID: 16900146 PEPPeR, a Platform for Experimental Proteomic Pattern Recognition Molecular & Cellular Proteomics : MCP. Oct, 2006 | Pubmed ID: 16857664 Systematic Identification of Human Mitochondrial Disease Genes Through Integrative Genomics Nature Genetics. May, 2006 | Pubmed ID: 16582907 Mapping Posttranslational Modifications of Proteins by MS-based Selective Detection: Application to Phosphoproteomics Methods in Enzymology. 2005 | Pubmed ID: 16413312 Place of Pattern in Proteomic Biomarker Discovery Journal of Proteome Research. Jul-Aug, 2005 | Pubmed ID: 16083265 Phosphorylation by Cyclin B-Cdk Underlies Release of Mitotic Exit Activator Cdc14 from the Nucleolus Science (New York, N.Y.). Jul, 2004 | Pubmed ID: 15273393 Selective Detection of Glycopeptides on Ion Trap Mass Spectrometers Analytical Chemistry. Jun, 2004 | Pubmed ID: 15167790 TULA: an SH3- and UBA-containing Protein That Binds to C-Cbl and Ubiquitin Oncogene. Jun, 2004 | Pubmed ID: 15107835 N-Terminal Peptide Labeling Strategy for Incorporation of Isotopic Tags: a Method for the Determination of Site-specific Absolute Phosphorylation Stoichiometry Rapid Communications in Mass Spectrometry : RCM. 2002 | Pubmed ID: 12478578 Improved Sensitivity for Phosphopeptide Mapping Using Capillary Column HPLC and Microionspray Mass Spectrometry: Comparative Phosphorylation Site Mapping from Gel-derived Proteins Analytical Chemistry. Jul, 2002 | Pubmed ID: 12141686 Mass Spectrometry-based Methods for Phosphorylation Site Mapping of Hyperphosphorylated Proteins Applied to Net1, a Regulator of Exit from Mitosis in Yeast Molecular & Cellular Proteomics : MCP. Mar, 2002 | Pubmed ID: 12096118 الكمي من البروتينات عن طريق التخصيب الببتيد Immunoaffinity اقترن الطيف الكتلي Lei Zhao*1, Jeffrey R. Whiteaker*1, Matthew E. Pope2, Eric Kuhn3, Angela Jackson4, N. Leigh Anderson5, Terry W. Pearson2, Steven A. Carr3, Amanda G. Paulovich1 1Clinical Research Division, Fred Hutchinson Cancer Research Center - FHCRC, 2Department of Biochemistry and Microbiology, University of Victoria, 3Broad Institute of MIT and Harvard, 4Genome BC Proteomics Centre, University of Victoria, 5Plasma Proteome Institute JoVE 2812 Biology
الكمي من البروتينات عن طريق التخصيب الببتيد Immunoaffinity اقترن الطيف الكتلي Lei Zhao*1, Jeffrey R. Whiteaker*1, Matthew E. Pope2, Eric Kuhn3, Angela Jackson4, N. Leigh Anderson5, Terry W. Pearson2, Steven A. Carr3, Amanda G. Paulovich1 1Clinical Research Division, Fred Hutchinson Cancer Research Center - FHCRC, 2Department of Biochemistry and Microbiology, University of Victoria, 3Broad Institute of MIT and Harvard, 4Genome BC Proteomics Centre, University of Victoria, 5Plasma Proteome Institute JoVE 2812 Biology
