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Other Publications (52)
- American Journal of Physiology. Heart and Circulatory Physiology
- American Journal of Physiology. Heart and Circulatory Physiology
- The Journal of Physiology
- Circulation Research
- The Journal of Physiology
- Cardiovascular Research
- FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
- Journal of Applied Physiology (Bethesda, Md. : 1985)
- Journal of Applied Physiology (Bethesda, Md. : 1985)
- Microcirculation (New York, N.Y. : 1994)
- Microcirculation (New York, N.Y. : 1994)
- The Journal of Physiology
- Microcirculation (New York, N.Y. : 1994)
- The Journal of Physiology
- Microcirculation (New York, N.Y. : 1994)
- Microcirculation (New York, N.Y. : 1994)
- Microcirculation (New York, N.Y. : 1994)
- The Journal of Physiology
- Microcirculation (New York, N.Y. : 1994)
- Proceedings of the National Academy of Sciences of the United States of America
- Journal of Applied Physiology (Bethesda, Md. : 1985)
- American Journal of Physiology. Heart and Circulatory Physiology
- Journal of Applied Physiology (Bethesda, Md. : 1985)
- Proceedings of the National Academy of Sciences of the United States of America
- American Journal of Physiology. Heart and Circulatory Physiology
- The Journal of Physiology
- Circulation Research
- Journal of Applied Physiology (Bethesda, Md. : 1985)
- Microcirculation (New York, N.Y. : 1994)
- Developmental Biology
- Journal of Neuroscience Methods
- Science Translational Medicine
- Circulation Research
- Microcirculation (New York, N.Y. : 1994)
- The Journal of Physiology
- The Journal of Physiology
- The Journal of Physiology
- Journal of Applied Physiology (Bethesda, Md. : 1985)
- Microcirculation (New York, N.Y. : 1994)
- American Journal of Physiology. Heart and Circulatory Physiology
- American Journal of Physiology. Heart and Circulatory Physiology
- British Journal of Pharmacology
- Basic & Clinical Pharmacology & Toxicology
- Microcirculation (New York, N.Y. : 1994)
- The Journal of Physiology
- Circulation Research
- Microcirculation (New York, N.Y. : 1994)
- The Journal of Physiology
- The Journal of Physiology
- Microcirculation (New York, N.Y. : 1994)
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Arteriosclerosis, Thrombosis, and Vascular Biology
Articles by Steven S. Segal in JoVE
Other articles by Steven S. Segal on PubMed
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Perivascular Innervation: a Multiplicity of Roles in Vasomotor Control and Myoendothelial Signaling
Microcirculation (New York, N.Y. : 1994).
Apr, 2013 |
Pubmed ID: 23289720 The control of vascular resistance and tissue perfusion reflect coordinated changes in the diameter of feed arteries and the arteriolar networks they supply. Against a background of myogenic tone and metabolic demand, vasoactive signals originating from perivascular sympathetic and sensory nerves are integrated with endothelium-derived signals to produce vasodilation or vasoconstriction. PVNs release adrenergic, cholinergic, peptidergic, purinergic, and nitrergic neurotransmitters that lead to SMC contraction or relaxation via their actions on SMCs, ECs, or other PVNs. ECs release autacoids that can have opposing actions on SMCs. Respective cell layers are connected directly to each other through GJs at discrete sites via MEJs projecting through holes in the IEL. Whereas studies of intercellular communication in the vascular wall have centered on endothelium-derived signals that govern SMC relaxation, attention has increasingly focused on signaling from SMCs to ECs. Thus, via MEJs, neurotransmission from PVNs can evoke distinct responses from ECs subsequent to acting on SMCs. To integrate this emerging area of investigation in light of vasomotor control, the present review synthesizes current understanding of signaling events that originate within SMCs in response to perivascular neurotransmission in light of EC feedback. Although often ignored in studies of the resistance vasculature, PVNs are integral to blood flow control and can provide a physiological stimulus for myoendothelial communication. Greater understanding of these underlying signaling events and how they may be affected by aging and disease will provide new approaches for selective therapeutic interventions.
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