Stuart H. Orkin

Publications

• Characterizing Heterogeneity in Leukemic Cells Using Single-cell Gene Expression Analysis
  Genome Biology. 2014  |   Pubmed ID: 25517911
• Complementary Genomic Approaches Highlight the PI3K/mTOR Pathway As a Common Vulnerability in Osteosarcoma
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2014  |   Pubmed ID: 25512523
• Mouse Regulatory DNA Landscapes Reveal Global Principles of Cis-regulatory Evolution
  Science (New York, N.Y.). Nov, 2014  |   Pubmed ID: 25411453
• A Comparative Encyclopedia of DNA Elements in the Mouse Genome
  Nature. Nov, 2014  |   Pubmed ID: 25409824
• Inflammatory Signaling Regulates Embryonic Hematopoietic Stem and Progenitor Cell Production
  Genes & Development. Dec, 2014  |   Pubmed ID: 25395663
• Myeloproliferative Neoplasms Can Be Initiated from a Single Hematopoietic Stem Cell Expressing JAK2-V617F
  The Journal of Experimental Medicine. Oct, 2014  |   Pubmed ID: 25288396
• TMEM14C is Required for Erythroid Mitochondrial Heme Metabolism
  The Journal of Clinical Investigation. Oct, 2014  |   Pubmed ID: 25157825
• Characterization of Genomic Deletion Efficiency Mediated by Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/Cas9 Nuclease System in Mammalian Cells
  The Journal of Biological Chemistry. Aug, 2014  |   Pubmed ID: 24907273
• Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors
  Cell. Apr, 2014  |   Pubmed ID: 24766805
• Distinct, Strict Requirements for Gfi-1b in Adult Bone Marrow Red Cell and Platelet Generation
  The Journal of Experimental Medicine. May, 2014  |   Pubmed ID: 24711581
• Corepressor Rcor1 is Essential for Murine Erythropoiesis
  Blood. May, 2014  |   Pubmed ID: 24652990
• Analysis of Chromatin-state Plasticity Identifies Cell-type-specific Regulators of H3K27me3 Patterns
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2014  |   Pubmed ID: 24395799
• Distinct and Combinatorial Functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in Mouse Embryonic Stem Cell Identity
  Molecular Cell. Jan, 2014  |   Pubmed ID: 24361252
• Polycomb Repressive Complex 2 Regulates Normal Hematopoietic Stem Cell Function in a Developmental-stage-specific Manner
  Cell Stem Cell. Jan, 2014  |   Pubmed ID: 24239285
• Calpain 2 Activation of P-TEFb Drives Megakaryocyte Morphogenesis and is Disrupted by Leukemogenic GATA1 Mutation
  Developmental Cell. Dec, 2013  |   Pubmed ID: 24369834
• An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level
  Science (New York, N.Y.). Oct, 2013  |   Pubmed ID: 24115442
• Mapping Cellular Hierarchy by Single-cell Analysis of the Cell Surface Repertoire
  Cell Stem Cell. Oct, 2013  |   Pubmed ID: 24035353
• Targeted Disruption of the EZH2-EED Complex Inhibits EZH2-dependent Cancer
  Nature Chemical Biology. Oct, 2013  |   Pubmed ID: 23974116
• Delineating the Mixed Lineage Leukemia Gene Expression Network in Hematopoietic Stem Cells
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013  |   Pubmed ID: 23824294
• Histone Demethylase Lsd1 Represses Hematopoietic Stem and Progenitor Cell Signatures During Blood Cell Maturation
  ELife. 2013  |   Pubmed ID: 23795291
• Corepressor-dependent Silencing of Fetal Hemoglobin Expression by BCL11A
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013  |   Pubmed ID: 23576758
• ETV1 Directs Androgen Metabolism and Confers Aggressive Prostate Cancer in Targeted Mice and Patients
  Genes & Development. Mar, 2013  |   Pubmed ID: 23512661
• Genome-wide Association Studies of Hematologic Phenotypes: a Window into Human Hematopoiesis
  Current Opinion in Genetics & Development. Jun, 2013  |   Pubmed ID: 23477921
• Sustained PU.1 Levels Balance Cell-cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells
  Molecular Cell. Mar, 2013  |   Pubmed ID: 23395001
• The Switch from Fetal to Adult Hemoglobin
  Cold Spring Harbor Perspectives in Medicine. Jan, 2013  |   Pubmed ID: 23209159
• TiF1-gamma Plays an Essential Role in Murine Hematopoiesis and Regulates Transcriptional Elongation of Erythroid Genes
  Developmental Biology. Jan, 2013  |   Pubmed ID: 23159334
• Altered Hematopoiesis in Trisomy 21 As Revealed Through in Vitro Differentiation of Isogenic Human Pluripotent Cells
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012  |   Pubmed ID: 23045682
• Combinatorial Assembly of Developmental Stage-specific Enhancers Controls Gene Expression Programs During Human Erythropoiesis
  Developmental Cell. Oct, 2012  |   Pubmed ID: 23041383
• Cyclin D3 Coordinates the Cell Cycle During Differentiation to Regulate Erythrocyte Size and Number
  Genes & Development. Sep, 2012  |   Pubmed ID: 22929040
• Reawakening Fetal Hemoglobin: Prospects for New Therapies for the β-globin Disorders
  Blood. Oct, 2012  |   Pubmed ID: 22904296
• Scl Represses Cardiomyogenesis in Prospective Hemogenic Endothelium and Endocardium
  Cell. Aug, 2012  |   Pubmed ID: 22863011
• The CACCC-binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and is Required for Proper Erythroid Maturation in Vivo
  Molecular and Cellular Biology. Aug, 2012  |   Pubmed ID: 22711990
• Exome Sequencing Identifies GATA1 Mutations Resulting in Diamond-Blackfan Anemia
  The Journal of Clinical Investigation. Jul, 2012  |   Pubmed ID: 22706301
• MAnorm: a Robust Model for Quantitative Comparison of ChIP-Seq Data Sets
  Genome Biology. 2012  |   Pubmed ID: 22424423
• Polycomb Repressive Complex 2 is Required for MLL-AF9 Leukemia
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2012  |   Pubmed ID: 22396593
• MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension: Results of a Network Bioinformatics Approach
  Circulation. Mar, 2012  |   Pubmed ID: 22371328
• Haploinsufficiency of Dnmt1 Impairs Leukemia Stem Cell Function Through Derepression of Bivalent Chromatin Domains
  Genes & Development. Feb, 2012  |   Pubmed ID: 22345515
• MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways
  Science Translational Medicine. Feb, 2012  |   Pubmed ID: 22344686
• A Human Stem Cell Model of Early Alzheimer's Disease Pathology in Down Syndrome
  Science Translational Medicine. Mar, 2012  |   Pubmed ID: 22344463
• PRC2 Directly Methylates GATA4 and Represses Its Transcriptional Activity
  Genes & Development. Jan, 2012  |   Pubmed ID: 22215809
• Dnmt3a Silences Hematopoietic Stem Cell Self-renewal
  Nature Genetics. Jan, 2012  |   Pubmed ID: 22200773
• Polycomb Repressiven Komplexe 2 Regelt Die Normalen Entwicklung Des Herzens Maus
  Circulation Research. Feb, 2012  |   Pubmed ID: 22158708
• Embryonic Stem Cell-specific Signatures in Cancer: Insights into Genomic Regulatory Networks and Implications for Medicine
  Genome Medicine. 2011  |   Pubmed ID: 22126538
• Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing
  Science (New York, N.Y.). Nov, 2011  |   Pubmed ID: 21998251
• Zfp281 Functions As a Transcriptional Repressor for Pluripotency of Mouse Embryonic Stem Cells
  Stem Cells (Dayton, Ohio). Nov, 2011  |   Pubmed ID: 21915945
• A Functional Element Necessary for Fetal Hemoglobin Silencing
  The New England Journal of Medicine. Sep, 2011  |   Pubmed ID: 21879898
• MicroRNA-21 Limits in Vivo Immune Response-mediated Activation of the IL-12/IFN-gamma Pathway, Th1 Polarization, and the Severity of Delayed-type Hypersensitivity
  Journal of Immunology (Baltimore, Md. : 1950). Sep, 2011  |   Pubmed ID: 21849676
• Verlust Des Retinoblastom Verbindliches Protein 2 (RBP2) Unterdrückt Histon Demethylase Tumorentstehung in Mäusen Fehlt Rb1 Oder Men1
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2011  |   Pubmed ID: 21788502
• Chromatin Connections to Pluripotency and Cellular Reprogramming
  Cell. Jun, 2011  |   Pubmed ID: 21663790
• Genome Medicine: Stem Cells, Genomics and Translational Research
  Genome Medicine. 2011  |   Pubmed ID: 21658298
• The Erythroid/myeloid Lineage Fate Paradigm Takes a New Player
  The EMBO Journal. Mar, 2011  |   Pubmed ID: 21407249
• Context-dependent Function of "GATA Switch" Sites in Vivo
  Blood. May, 2011  |   Pubmed ID: 21398579
• Tet1 Und Tet2 Regeln 5-Hydroxymethylcytosine Produktion Und Zell-Linie-Spezifikation in Mäuseder Embryonalen Stammzellen
  Cell Stem Cell. Feb, 2011  |   Pubmed ID: 21295276
• MicroRNA-15a Und-16-1 Des Gesetzes über MYB, Fetales Hämoglobin Ausdruck Im Menschlichen Trisomie 13 Zu Erhöhen
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011  |   Pubmed ID: 21205891
• Update on Fetal Hemoglobin Gene Regulation in Hemoglobinopathies
  Current Opinion in Pediatrics. Feb, 2011  |   Pubmed ID: 21157349
• Therapeutic Levels of Fetal Hemoglobin in Erythroid Progeny of β-thalassemic CD34+ Cells After Lentiviral Vector-mediated Gene Transfer
  Blood. Mar, 2011  |   Pubmed ID: 21156846
• Networking Erythropoiesis
  The Journal of Experimental Medicine. Nov, 2010  |   Pubmed ID: 21098097
• Fine-mapping at Three Loci Known to Affect Fetal Hemoglobin Levels Explains Additional Genetic Variation
  Nature Genetics. Dec, 2010  |   Pubmed ID: 21057501
• Modifier Genes in Mendelian Disorders: the Example of Hemoglobin Disorders
  Annals of the New York Academy of Sciences. Dec, 2010  |   Pubmed ID: 21039591
• Epigenetic Antagonism Between Polycomb and SWI/SNF Complexes During Oncogenic Transformation
  Cancer Cell. Oct, 2010  |   Pubmed ID: 20951942
• A Myc Network Accounts for Similarities Between Embryonic Stem and Cancer Cell Transcription Programs
  Cell. Oct, 2010  |   Pubmed ID: 20946988
• A Single Cis Element Maintains Repression of the Key Developmental Regulator Gata2
  PLoS Genetics. Sep, 2010  |   Pubmed ID: 20838598
• Differential Roles of Sall4 Isoforms in Embryonic Stem Cell Pluripotency
  Molecular and Cellular Biology. Nov, 2010  |   Pubmed ID: 20837710
• Training Program in Cancer and Blood Diseases: Pediatric Hematology/Oncology Fellowship Program, Children's Hospital Boston/Dana-Farber Cancer Institute
  American Journal of Hematology. Oct, 2010  |   Pubmed ID: 20730793
• Transcriptional Silencing of Fetal Hemoglobin by BCL11A
  Annals of the New York Academy of Sciences. Aug, 2010  |   Pubmed ID: 20712774
• Developmental Stage-specific Interplay of GATA1 and IGF Signaling in Fetal Megakaryopoiesis and Leukemogenesis
  Genes & Development. Aug, 2010  |   Pubmed ID: 20679399
• Medicine. Sickle Cell Disease at 100 Years
  Science (New York, N.Y.). Jul, 2010  |   Pubmed ID: 20647458
• TIF1gamma Steuerelemente Erythroid Zellen Schicksal Durch Die Regulierung Der Transkription Dehnung
  Cell. Jul, 2010  |   Pubmed ID: 20603019
• Sumoylation Regulates Interaction of FOG1 with C-terminal-binding Protein (CTBP)
  The Journal of Biological Chemistry. Sep, 2010  |   Pubmed ID: 20587419
• Transcriptional Silencing of {gamma}-globin by BCL11A Involves Long-range Interactions and Cooperation with SOX6
  Genes & Development. Apr, 2010  |   Pubmed ID: 20395365
• DNA Methylation in Adult Stem Cells: New Insights into Self-renewal
  Epigenetics : Official Journal of the DNA Methylation Society. Apr, 2010  |   Pubmed ID: 20364115
• Advances in the Understanding of Haemoglobin Switching
  British Journal of Haematology. Apr, 2010  |   Pubmed ID: 20201948
• MiR-125b-2 is a Potential OncomiR on Human Chromosome 21 in Megakaryoblastic Leukemia
  Genes & Development. Mar, 2010  |   Pubmed ID: 20194440
• Musings on Genome Medicine: Hepatitis C
  Genome Medicine. 2010  |   Pubmed ID: 20193049
• Perturbed Hematopoiesis in the Tc1 Mouse Model of Down Syndrome
  Blood. Apr, 2010  |   Pubmed ID: 20154221
• Systematic Tracking of Cell Fate Changes
  Nature Biotechnology. Feb, 2010  |   Pubmed ID: 20139953
• Jumonji Modulates Polycomb Activity and Self-renewal Versus Differentiation of Stem Cells
  Cell. Dec, 2009  |   Pubmed ID: 20064376
• Musings on Genome Medicine: Enzyme-replacement Therapy of the Lysosomal Storage Diseases
  Genome Medicine. 2009  |   Pubmed ID: 20017892
• Insights into GATA-1-mediated Gene Activation Versus Repression Via Genome-wide Chromatin Occupancy Analysis
  Molecular Cell. Nov, 2009  |   Pubmed ID: 19941827
• Musings on Genome Medicine: Crohn's Disease
  Genome Medicine. 2009  |   Pubmed ID: 19891793
• Musings on Genome Medicine: the Slow but Inexorable Process of Medical Care Reform in the United States
  Genome Medicine. 2009  |   Pubmed ID: 19822025
• DNA Methyltransferase 1 is Essential for and Uniquely Regulates Hematopoietic Stem and Progenitor Cells
  Cell Stem Cell. Oct, 2009  |   Pubmed ID: 19796624
• Musings on Genome Medicine: the Obama Effect Redux
  Genome Medicine. 2009  |   Pubmed ID: 19769781
• Developmental and Species-divergent Globin Switching Are Driven by BCL11A
  Nature. Aug, 2009  |   Pubmed ID: 19657335
• Translational Isoforms of FOG1 Regulate GATA1-interacting Complexes
  The Journal of Biological Chemistry. Oct, 2009  |   Pubmed ID: 19654328
• GATA-2 Reinforces Megakaryocyte Development in the Absence of GATA-1
  Molecular and Cellular Biology. Sep, 2009  |   Pubmed ID: 19620289
• TEL-AML1 Corrupts Hematopoietic Stem Cells to Persist in the Bone Marrow and Initiate Leukemia
  Cell Stem Cell. Jul, 2009  |   Pubmed ID: 19570513
• Musings on Genome Medicine: Cholesterol and Coronary Artery Disease
  Genome Medicine. 2009  |   Pubmed ID: 19519958
• Musings on Genome Medicine: Cancer Genetics and the Promise of Effective Treatment
  Genome Medicine. 2009  |   Pubmed ID: 19439059
• Musings on Genome Medicine: Gene Therapy
  Genome Medicine. 2009  |   Pubmed ID: 19435468
• Musings on Genome Medicine: Genome Wide Association Studies
  Genome Medicine. 2009  |   Pubmed ID: 19348690
• Musings on Genome Medicine: the Obama Effect
  Genome Medicine. 2009  |   Pubmed ID: 19341501
• Musings on Genome Medicine: Abuse of Genetic Tests
  Genome Medicine. 2009  |   Pubmed ID: 19341489
• A Genome-wide RNAi Screen Identifies a New Transcriptional Module Required for Self-renewal
  Genes & Development. Apr, 2009  |   Pubmed ID: 19339689
• Use of in Vivo Biotinylation to Study Protein-protein and Protein-DNA Interactions in Mouse Embryonic Stem Cells
  Nature Protocols. 2009  |   Pubmed ID: 19325547
• Tandem Affinity Purification of Protein Complexes in Mouse Embryonic Stem Cells Using in Vivo Biotinylation
  Current Protocols in Stem Cell Biology. Mar, 2009  |   Pubmed ID: 19306258
• Mef2C Ist Eine Übertragungslinie Eingeschränkten Ziel Scl/Tal1 Und Reguliert Megakaryopoiesis Und B-Zell-Homöostase
  Blood. Apr, 2009  |   Pubmed ID: 19211936
• Glimpses of the Epigenetic Landscape
  Cell Stem Cell. Jan, 2009  |   Pubmed ID: 19128786
• ADAR1 is Essential for the Maintenance of Hematopoiesis and Suppression of Interferon Signaling
  Nature Immunology. Jan, 2009  |   Pubmed ID: 19060901
• Ausdruck Der Menschlichen Fetalen Hämoglobin Wird Durch Die Entwicklungs Phase-spezifische Hemmer BCL11A Geregelt
  Science (New York, N.Y.). Dec, 2008  |   Pubmed ID: 19056937
• EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency
  Molecular Cell. Nov, 2008  |   Pubmed ID: 19026780
• Polycomb Group Proteins Ezh2 and Rnf2 Direct Genomic Contraction and Imprinted Repression in Early Mouse Embryos
  Developmental Cell. Nov, 2008  |   Pubmed ID: 18848501
• Rb and Hematopoiesis: Stem Cells to Anemia
  Cell Division. 2008  |   Pubmed ID: 18775080
• GATA4 Mediates Gene Repression in the Mature Mouse Small Intestine Through Interactions with Friend of GATA (FOG) Cofactors
  Developmental Biology. Oct, 2008  |   Pubmed ID: 18692040
• DNA Polymorphisms at the BCL11A, HBS1L-MYB, and Beta-globin Loci Associate with Fetal Hemoglobin Levels and Pain Crises in Sickle Cell Disease
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2008  |   Pubmed ID: 18667698
• Conditional Mouse Osteosarcoma, Dependent on P53 Loss and Potentiated by Loss of Rb, Mimics the Human Disease
  Genes & Development. Jun, 2008  |   Pubmed ID: 18559481
• Requirement of Nanog Dimerization for Stem Cell Self-renewal and Pluripotency
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2008  |   Pubmed ID: 18436640
• Targeted Disruption of the Basic Krüppel-like Factor Gene (Klf3) Reveals a Role in Adipogenesis
  Molecular and Cellular Biology. Jun, 2008  |   Pubmed ID: 18391014
• Die Entstehung Von Hämatopoetischen Stammzellen Wird in Der Plazenta Gefäßsystem in Ermangelung Der Zirkulation Initiiert
  Cell Stem Cell. Mar, 2008  |   Pubmed ID: 18371450
• An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells
  Cell. Mar, 2008  |   Pubmed ID: 18358816
• PRC1 and Suv39h Specify Parental Asymmetry at Constitutive Heterochromatin in Early Mouse Embryos
  Nature Genetics. Apr, 2008  |   Pubmed ID: 18311137
• Antagonism of FOG-1 and GATA Factors in Fate Choice for the Mast Cell Lineage
  The Journal of Experimental Medicine. Mar, 2008  |   Pubmed ID: 18299398
• SnapShot: Blutbildung
  Cell. Feb, 2008  |   Pubmed ID: 18295585
• Blutbildung: Ein Sich Entwickelndes Paradigma Für Die Stammzellbiologie
  Cell. Feb, 2008  |   Pubmed ID: 18295580
• Oct4 Dependence of Chromatin Structure Within the Extended Nanog Locus in ES Cells
  Genes & Development. Mar, 2008  |   Pubmed ID: 18283123
• Rb Intrinsically Promotes Erythropoiesis by Coupling Cell Cycle Exit with Mitochondrial Biogenesis
  Genes & Development. Feb, 2008  |   Pubmed ID: 18258751
• Genome-wide Association Study Shows BCL11A Associated with Persistent Fetal Hemoglobin and Amelioration of the Phenotype of Beta-thalassemia
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008  |   Pubmed ID: 18245381
• A Protein Roadmap to Pluripotency and Faithful Reprogramming
  Cells, Tissues, Organs. 2008  |   Pubmed ID: 18196921
• Stem Cells Down Under-ISSCR 2007
  Cell Stem Cell. Sep, 2007  |   Pubmed ID: 18399027
• Site-directed, Virus-free, and Inducible RNAi in Embryonic Stem Cells
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2007  |   Pubmed ID: 18093939
• ETV6-NTRK3 Fusion Oncogene Initiates Breast Cancer from Committed Mammary Progenitors Via Activation of AP1 Complex
  Cancer Cell. Dec, 2007  |   Pubmed ID: 18068631
• Immunology: Changed Destiny
  Nature. Sep, 2007  |   Pubmed ID: 17898754
• Epigenetic Regulation of Hematopoietic Differentiation by Gfi-1 and Gfi-1b is Mediated by the Cofactors CoREST and LSD1
  Molecular Cell. Aug, 2007  |   Pubmed ID: 17707228
• Prostaglandin E2 Regelt Vertebrate Hämatopoetische Stammzellen-Homöostase
  Nature. Jun, 2007  |   Pubmed ID: 17581586
• Rb Regulates Interactions Between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment
  Cell. Jun, 2007  |   Pubmed ID: 17574022
• Gata4 is Necessary for Normal Pulmonary Lobar Development
  American Journal of Respiratory Cell and Molecular Biology. Apr, 2007  |   Pubmed ID: 17142311
• The Hypomorphic Gata1low Mutation Alters the Proliferation/differentiation Potential of the Common Megakaryocytic-erythroid Progenitor
  Blood. Feb, 2007  |   Pubmed ID: 17038527
• Developmental Origin of a Bipotential Myocardial and Smooth Muscle Cell Precursor in the Mammalian Heart
  Cell. Dec, 2006  |   Pubmed ID: 17123591
• A Protein Interaction Network for Pluripotency of Embryonic Stem Cells
  Nature. Nov, 2006  |   Pubmed ID: 17093407
• Die Reise Der Hematopoietic Stammzellen Zu Entwickeln
  Development (Cambridge, England). Oct, 2006  |   Pubmed ID: 16968814
• Unraveling the Transcriptional Network Controlling ES Cell Pluripotency
  Genome Biology. 2006  |   Pubmed ID: 16942632
• Rb is Dispensable for Self-renewal and Multilineage Differentiation of Adult Hematopoietic Stem Cells
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2006  |   Pubmed ID: 16754850
• Notch Signaling Requires GATA-2 to Inhibit Myelopoiesis from Embryonic Stem Cells and Primary Hemopoietic Progenitors
  Journal of Immunology (Baltimore, Md. : 1950). May, 2006  |   Pubmed ID: 16621992
• Characterization of a Megakaryocyte-specific Enhancer of the Key Hemopoietic Transcription Factor GATA1
  The Journal of Biological Chemistry. May, 2006  |   Pubmed ID: 16551635
• Identification of Distinct Molecular Phenotypes in Acute Megakaryoblastic Leukemia by Gene Expression Profiling
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006  |   Pubmed ID: 16492768
• Reactions to the Hwang Scandal
  Science (New York, N.Y.). Feb, 2006  |   Pubmed ID: 16459360
• Phosphorylation of Gata1 at Serine Residues 72, 142, and 310 is Not Essential for Hematopoiesis in Vivo
  Blood. May, 2006  |   Pubmed ID: 16391009
• Zinc-finger Transcription Factor Gfi-1: Versatile Regulator of Lymphocytes, Neutrophils and Hematopoietic Stem Cells
  Current Opinion in Hematology. Jan, 2006  |   Pubmed ID: 16319680
• Specification of Astrocytes by BHLH Protein SCL in a Restricted Region of the Neural Tube
  Nature. Nov, 2005  |   Pubmed ID: 16292311
• Chipping Away at the Embryonic Stem Cell Network
  Cell. Sep, 2005  |   Pubmed ID: 16179251
• Plazenta Als Standort Für Hämatopoetische Stammzelle Entwicklung
  Experimental Hematology. Sep, 2005  |   Pubmed ID: 16140153
• Phosphatidylinositol 3-kinase/Akt Induced by Erythropoietin Renders the Erythroid Differentiation Factor GATA-1 Competent for TIMP-1 Gene Transactivation
  Molecular and Cellular Biology. Sep, 2005  |   Pubmed ID: 16107690
• The Transcription Factor GATA2 Regulates Differentiation of Brown Adipocytes
  EMBO Reports. Sep, 2005  |   Pubmed ID: 16082385
• Stem Cells: the Road Not Taken
  Nature. Jun, 2005  |   Pubmed ID: 15931202
• Developmental Stage-selective Effect of Somatically Mutated Leukemogenic Transcription Factor GATA1
  Nature Genetics. Jun, 2005  |   Pubmed ID: 15895080
• Frühe Asymmetrie Der Gen-Transkription in Embryonalen Menschlichen Linken Und Rechten Hirnrinde
  Science (New York, N.Y.). Jun, 2005  |   Pubmed ID: 15894532
• Haploinsuffizienz Von GATA-2, Stört Erwachsenen Hämatopoetischen Stamm-Zell-Homöostase
  Blood. Jul, 2005  |   Pubmed ID: 15811962
• Die Plazenta Ist Eine Nische Für Blutbildende Stammzellen
  Developmental Cell. Mar, 2005  |   Pubmed ID: 15737932
• Tie2Cre-vermittelte Gen-Ablation Definiert Den Stamm-Zell-Leukämie-Gen (SCL/tal1)-abhängigen Fenster Während Der Hämatopoetischen Stamm-Zell-Entwicklung
  Blood. May, 2005  |   Pubmed ID: 15677556
• Coregulation of GATA Factors by the Friend of GATA (FOG) Family of Multitype Zinc Finger Proteins
  Seminars in Cell & Developmental Biology. Feb, 2005  |   Pubmed ID: 15659346
• Enforced Expression of PU.1 Rescues Osteoclastogenesis from Embryonic Stem Cells Lacking Tal-1
  Stem Cells (Dayton, Ohio). 2005  |   Pubmed ID: 15625130
• Gen-Targeting Und Transgene Strategien Für Die Analyse Von Hämatopoetischen Entwicklung in Der Maus
  Methods in Molecular Medicine. 2005  |   Pubmed ID: 15492385
• Toward Improving Caenorhabditis Elegans Phenome Mapping with an ORFeome-based RNAi Library
  Genome Research. Oct, 2004  |   Pubmed ID: 15489339
• GATA-2 Spielt Zwei Funktionell Unterschiedliche Rollen Während Der Ontogenese Von Hämatopoetischen Stammzellen
  The Journal of Experimental Medicine. Oct, 2004  |   Pubmed ID: 15466621
• Gfi-1 Restricts Proliferation and Preserves Functional Integrity of Haematopoietic Stem Cells
  Nature. Oct, 2004  |   Pubmed ID: 15457180
• A Critical Role for Eosinophils in Allergic Airways Remodeling
  Science (New York, N.Y.). Sep, 2004  |   Pubmed ID: 15375268
• Tel/Etv6 is an Essential and Selective Regulator of Adult Hematopoietic Stem Cell Survival
  Genes & Development. Oct, 2004  |   Pubmed ID: 15371326
• Der Zebrafisch-Gen Kodiert Mondschein Transkriptions-Faktor 1gamma Vermittler, Ein Wesentlicher Regulator Der Hämatopoese
  PLoS Biology. Aug, 2004  |   Pubmed ID: 15314655
• Decoding Hematopoietic Specificity in the Helix-loop-helix Domain of the Transcription Factor SCL/Tal-1
  Molecular and Cellular Biology. Sep, 2004  |   Pubmed ID: 15314159
• Endogenous Oncogenic K-ras(G12D) Stimulates Proliferation and Widespread Neoplastic and Developmental Defects
  Cancer Cell. Apr, 2004  |   Pubmed ID: 15093544
• Transforming Acidic Coiled-coil Protein 3 (TACC3) Controls Friend of GATA-1 (FOG-1) Subcellular Localization and Regulates the Association Between GATA-1 and FOG-1 During Hematopoiesis
  The Journal of Biological Chemistry. May, 2004  |   Pubmed ID: 15037632
• Defective Neural Tube Closure and Anteroposterior Patterning in Mice Lacking the LIM Protein LMO4 or Its Interacting Partner Deaf-1
  Molecular and Cellular Biology. Mar, 2004  |   Pubmed ID: 14966286
• The SWI/SNF Complex--chromatin and Cancer
  Nature Reviews. Cancer. Feb, 2004  |   Pubmed ID: 14964309
• More Than Blood, a Novel Gene Required for Mammalian Postimplantation Development
  Molecular and Cellular Biology. Feb, 2004  |   Pubmed ID: 14729962
• Coregulator-dependent Facilitation of Chromatin Occupancy by GATA-1
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2004  |   Pubmed ID: 14715908
• Functional Overlap of GATA-1 and GATA-2 in Primitive Hematopoietic Development
  Blood. Jan, 2004  |   Pubmed ID: 14504093
• Priming the Hematopoietic Pump
  Immunity. Nov, 2003  |   Pubmed ID: 14614848
• Endothelial Lineage-mediated Loss of the GATA Cofactor Friend of GATA 1 Impairs Cardiac Development
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2003  |   Pubmed ID: 14614148
• Combinatorial Interactions of Serpent, Lozenge, and U-shaped Regulate Crystal Cell Lineage Commitment During Drosophila Hematopoiesis
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2003  |   Pubmed ID: 14504400
• Wesentliche Rolle Für Die Peroxiredoxin Prdx1 in Erythrozyten Antioxidative Abwehr Und Unterdrückung Von Tumoren
  Nature. Jul, 2003  |   Pubmed ID: 12891360
• GATA-1 As a Regulator of Mast Cell Differentiation Revealed by the Phenotype of the GATA-1low Mouse Mutant
  The Journal of Experimental Medicine. Feb, 2003  |   Pubmed ID: 12566412
• Hämatopoetischen Stammzellen Behalten Langfristige Bestandsauffüllung Aktivität Und Multipotenz in Abwesenheit Des Stamm-Zell-Leukämie SCL/tal-1 Gen
  Nature. Jan, 2003  |   Pubmed ID: 12540851
• Intrinsic Requirement for Zinc Finger Transcription Factor Gfi-1 in Neutrophil Differentiation
  Immunity. Jan, 2003  |   Pubmed ID: 12530980
• The Zinc Finger Transcription Factor Gfi1, Implicated in Lymphomagenesis, is Required for Inner Ear Hair Cell Differentiation and Survival
  Development (Cambridge, England). Jan, 2003  |   Pubmed ID: 12441305
• Die Expression Von CD41 Markiert Den Beginn Der Definitiven Hämatopoese in Der Maus-Embryo
  Blood. Jan, 2003  |   Pubmed ID: 12393529
• Highly Penetrant, Rapid Tumorigenesis Through Conditional Inversion of the Tumor Suppressor Gene Snf5
  Cancer Cell. Nov, 2002  |   Pubmed ID: 12450796
• The SCL Complex Regulates C-kit Expression in Hematopoietic Cells Through Functional Interaction with Sp1
  Blood. Oct, 2002  |   Pubmed ID: 12239153
• Gonadal Differentiation, Sex Determination and Normal Sry Expression in Mice Require Direct Interaction Between Transcription Partners GATA4 and FOG2
  Development (Cambridge, England). Oct, 2002  |   Pubmed ID: 12223418
• Dysregulation of Protein Modification by ISG15 Results in Brain Cell Injury
  Genes & Development. Sep, 2002  |   Pubmed ID: 12208842
• X-linked Thrombocytopenia with Thalassemia from a Mutation in the Amino Finger of GATA-1 Affecting DNA Binding Rather Than FOG-1 Interaction
  Blood. Sep, 2002  |   Pubmed ID: 12200364
• Stem-cell Competition
  Nature. Jul, 2002  |   Pubmed ID: 12097889
• GATA-factor Dependence of the Multitype Zinc-finger Protein FOG-1 for Its Essential Role in Megakaryopoiesis
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2002  |   Pubmed ID: 12077323
• The Use of Altered Specificity Mutants to Probe Specific Protein-protein Interactions Involved in the Activation of GATA-1 Target Genes
  Methods (San Diego, Calif.). Jan, 2002  |   Pubmed ID: 12054907
• Targeted Deletion of a High-affinity GATA-binding Site in the GATA-1 Promoter Leads to Selective Loss of the Eosinophil Lineage in Vivo
  The Journal of Experimental Medicine. Jun, 2002  |   Pubmed ID: 12045237
• Transcriptional Regulation of Erythropoiesis: an Affair Involving Multiple Partners
  Oncogene. May, 2002  |   Pubmed ID: 12032775
• Distinct Domains of the GATA-1 Cofactor FOG-1 Differentially Influence Erythroid Versus Megakaryocytic Maturation
  Molecular and Cellular Biology. Jun, 2002  |   Pubmed ID: 12024038
• Interaction Between FOG-1 and the Corepressor C-terminal Binding Protein is Dispensable for Normal Erythropoiesis in Vivo
  Molecular and Cellular Biology. May, 2002  |   Pubmed ID: 11940669
• Hämatopoese Und Stammzellen: Plastizität Im Vergleich Zu Entwicklungs-Heterogenität
  Nature Immunology. Apr, 2002  |   Pubmed ID: 11919568
• Die Suche Nach Dem Hämangioblast
  Journal of Hematotherapy & Stem Cell Research. Feb, 2002  |   Pubmed ID: 11847000
• The Zinc-finger Proto-oncogene Gfi-1b is Essential for Development of the Erythroid and Megakaryocytic Lineages
  Genes & Development. Feb, 2002  |   Pubmed ID: 11825872