Sudarshan Rajagopal

Publications

• The β-arrestins: Multifunctional Regulators of G Protein-coupled Receptors
  The Journal of Biological Chemistry. Mar, 2016  |   Pubmed ID: 26984408
• Safety and Tolerability of High-dose Inhaled Treprostinil in Pulmonary Hypertension
  Journal of Cardiovascular Pharmacology. Apr, 2016  |   Pubmed ID: 26828324
• Use of Outcome Measures in Pulmonary Hypertension Clinical Trials
  American Heart Journal. Sep, 2015  |   Pubmed ID: 26385024
• The Influence of Angle of Insonation and Target Depth on Speckle-tracking Strain
  Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography. May, 2015  |   Pubmed ID: 25655402
• What is Biased Efficacy? Defining the Relationship Between Intrinsic Efficacy and Free Energy Coupling
  Trends in Pharmacological Sciences. Dec, 2014  |   Pubmed ID: 25448316
• Monitoring Protein Conformational Changes and Dynamics Using Stable-isotope Labeling and Mass Spectrometry
  Nature Protocols. 2014  |   Pubmed ID: 24810039
• Comprehensive Assessment of Right Ventricular Function in Patients with Pulmonary Hypertension with Global Longitudinal Peak Systolic Strain Derived from Multiple Right Ventricular Views
  Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography. Jun, 2014  |   Pubmed ID: 24656881
• Right Ventricular Mechanics Using a Novel Comprehensive Three-view Echocardiographic Strain Analysis in a Normal Population
  Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography. Apr, 2014  |   Pubmed ID: 24508364
• Biased Agonism As a Mechanism for Differential Signaling by Chemokine Receptors
  The Journal of Biological Chemistry. Oct, 2013  |   Pubmed ID: 24145037
• Quantifying Biased Agonism: Understanding the Links Between Affinity and Efficacy
  Nature Reviews. Drug Discovery. Jun, 2013  |   Pubmed ID: 23681006
• Distinct Phosphorylation Sites on the β(2)-adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-arrestin
  Science Signaling. Aug, 2011  |   Pubmed ID: 21868357
• A Stress Response Pathway Regulates DNA Damage Through β2-adrenoreceptors and β-arrestin-1
  Nature. Sep, 2011  |   Pubmed ID: 21857681
• Multiple Ligand-specific Conformations of the β2-adrenergic Receptor
  Nature Chemical Biology. Oct, 2011  |   Pubmed ID: 21857662
• Quantifying Ligand Bias at Seven-transmembrane Receptors
  Molecular Pharmacology. Sep, 2011  |   Pubmed ID: 21610196
• Therapeutic Potential of β-arrestin- and G Protein-biased Agonists
  Trends in Molecular Medicine. Mar, 2011  |   Pubmed ID: 21183406
• Global Phosphorylation Analysis of Beta-arrestin-mediated Signaling Downstream of a Seven Transmembrane Receptor (7TMR)
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2010  |   Pubmed ID: 20686112
• Teaching Old Receptors New Tricks: Biasing Seven-transmembrane Receptors
  Nature Reviews. Drug Discovery. May, 2010  |   Pubmed ID: 20431569
• Beta-arrestin- but Not G Protein-mediated Signaling by the "decoy" Receptor CXCR7
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2010  |   Pubmed ID: 20018651
• Total Chemical Synthesis and Biophysical Characterization of the Minimal Isoform of the KChIP2 Potassium Channel Regulatory Subunit
  Protein Science : a Publication of the Protein Society. Sep, 2007  |   Pubmed ID: 17660260
• Visualizing Reaction Pathways in Photoactive Yellow Protein from Nanoseconds to Seconds
  Proceedings of the National Academy of Sciences of the United States of America. May, 2005  |   Pubmed ID: 15870207
• A Structural Pathway for Signaling in the E46Q Mutant of Photoactive Yellow Protein
  Structure (London, England : 1993). Jan, 2005  |   Pubmed ID: 15642261
• Purification and Initial Characterization of a Putative Blue Light-regulated Phosphodiesterase from Escherichia Coli
  Photochemistry and Photobiology. Nov-Dec, 2004  |   Pubmed ID: 15453820
• Analytical Trapping: Extraction of Time-independent Structures from Time-dependent Crystallographic Data
  Journal of Structural Biology. Sep, 2004  |   Pubmed ID: 15450291
• Chromophore Conformation and the Evolution of Tertiary Structural Changes in Photoactive Yellow Protein
  Structure (London, England : 1993). Jun, 2004  |   Pubmed ID: 15274923
• Analysis of Experimental Time-resolved Crystallographic Data by Singular Value Decomposition
  Acta Crystallographica. Section D, Biological Crystallography. May, 2004  |   Pubmed ID: 15103131
• Protein Kinetics: Structures of Intermediates and Reaction Mechanism from Time-resolved X-ray Data
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2004  |   Pubmed ID: 15041745
• Application of Singular Value Decomposition to the Analysis of Time-resolved Macromolecular X-ray Data
  Biophysical Journal. Mar, 2003  |   Pubmed ID: 12609912
• Crystal Structure of a Photoactive Yellow Protein from a Sensor Histidine Kinase: Conformational Variability and Signal Transduction
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2003  |   Pubmed ID: 12563032
• The LOV Domain Family: Photoresponsive Signaling Modules Coupled to Diverse Output Domains
  Biochemistry. Jan, 2003  |   Pubmed ID: 12515534