Suzanne A. Eccles Division of Cancer Therapeutics The Institute of Cancer Research Biography Publications Institution JoVE Articles Suzanne A. Eccles has not added a biography. If you are Suzanne A. Eccles and would like to personalize this page please email our Author Liaison for assistance. Publications Discovery of Potent, Orally Bioavailable, Small-molecule Inhibitors of WNT Signaling from a Cell-based Pathway Screen Journal of Medicinal Chemistry. Feb, 2015 | Pubmed ID: 25680029 Exploring the Biomechanical Properties of Brain Malignancies and Their Pathologic Determinants in Vivo with Magnetic Resonance Elastography Cancer Research. Apr, 2015 | Pubmed ID: 25672978 Cancer-associated Fibroblasts Induce High Mobility Group Box 1 and Contribute to Resistance to Doxorubicin in Breast Cancer Cells BMC Cancer. 2014 | Pubmed ID: 25512109 HIF-1α-independent Hypoxia-induced Rapid PTK6 Stabilization is Associated with Increased Motility and Invasion Cancer Biology & Therapy. Oct, 2014 | Pubmed ID: 25019382 Preclinical Evaluation of Imaging Biomarkers for Prostate Cancer Bone Metastasis and Response to Cabozantinib Journal of the National Cancer Institute. Apr, 2014 | Pubmed ID: 24634505 Critical Research Gaps and Translational Priorities for the Successful Prevention and Treatment of Breast Cancer Breast Cancer Research : BCR. 2013 | Pubmed ID: 24286369 Structure-based Design of Orally Bioavailable 1H-pyrrolo[3,2-c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1) Journal of Medicinal Chemistry. Dec, 2013 | Pubmed ID: 24256217 Mode of Cell Death Induced by the HSP90 Inhibitor 17-AAG (tanespimycin) is Dependent on the Expression of Pro-apoptotic BAX Oncotarget. Nov, 2013 | Pubmed ID: 24185264 Dual Blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) Pathways Synergistically Inhibits Rhabdomyosarcoma Cell Growth in Vitro and in Vivo Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2013 | Pubmed ID: 23918606 Kurt Hellmann D. M., D. Phil. Oxon 1922–2013 Clinical & Experimental Metastasis. Jun, 2013 | Pubmed ID: 23844428 A Cyclic Peptide Inhibitor of HIF-1 Heterodimerization That Inhibits Hypoxia Signaling in Cancer Cells Journal of the American Chemical Society. Jul, 2013 | Pubmed ID: 23796364 A Novel Serum Protein Signature Associated with Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Head and Neck Squamous Cell Carcinoma European Journal of Cancer (Oxford, England : 1990). Jul, 2013 | Pubmed ID: 23582742 Tumor Spheroid-based Migration Assays for Evaluation of Therapeutic Agents Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23436417 Two-dimensional Vs. Three-dimensional in Vitro Tumor Migration and Invasion Assays Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23436416 Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles As Selective, Orally Bioavailable CHK1 Inhibitors Journal of Medicinal Chemistry. Nov, 2012 | Pubmed ID: 23082860 Optimization of Imidazo[4,5-b]pyridine-based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor As an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia Journal of Medicinal Chemistry. Oct, 2012 | Pubmed ID: 23043539 CCT244747 is a Novel Potent and Selective CHK1 Inhibitor with Oral Efficacy Alone and in Combination with Genotoxic Anticancer Drugs Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2012 | Pubmed ID: 22929806 Erratum To: Kurt Hellmann D.M., D.Phil. Oxon. A Happy 90th Birthday! Clinical & Experimental Metastasis. Aug, 2012 | Pubmed ID: 22872374 The ALK(F1174L) Mutation Potentiates the Oncogenic Activity of MYCN in Neuroblastoma Cancer Cell. Jul, 2012 | Pubmed ID: 22789543 AT13148 is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2012 | Pubmed ID: 22781553 Kurt Hellmann D.M., D.Phil. Oxon. A Happy 90th Birthday! Clinical & Experimental Metastasis. Aug, 2012 | Pubmed ID: 22695808 Dependence of Wilms Tumor Cells on Signaling Through Insulin-like Growth Factor 1 in an Orthotopic Xenograft Model Targetable by Specific Receptor Inhibition Proceedings of the National Academy of Sciences of the United States of America. May, 2012 | Pubmed ID: 22529373 Dual Targeting of ErbB2 and MUC1 in Breast Cancer Using Chimeric Antigen Receptors Engineered to Provide Complementary Signaling Journal of Clinical Immunology. Oct, 2012 | Pubmed ID: 22526592 The HSP90 Inhibitor NVP-AUY922 Radiosensitizes by Abrogation of Homologous Recombination Resulting in Mitotic Entry with Unresolved DNA Damage PloS One. 2012 | Pubmed ID: 22523597 Advances in Establishment and Analysis of Three-dimensional Tumor Spheroid-based Functional Assays for Target Validation and Drug Evaluation BMC Biology. 2012 | Pubmed ID: 22439642 Epigenetic Disruption of Cadherin-11 in Human Cancer Metastasis The Journal of Pathology. Feb, 2012 | Pubmed ID: 22374749 Flexible Targeting of ErbB Dimers That Drive Tumorigenesis by Using Genetically Engineered T Cells Molecular Medicine (Cambridge, Mass.). 2012 | Pubmed ID: 22354215 Non-invasive in Vivo Imaging of Vessel Calibre in Orthotopic Prostate Tumour Xenografts International Journal of Cancer. Journal International Du Cancer. Mar, 2012 | Pubmed ID: 21469141 Preclinical Drug Development for Childhood Cancer Expert Opinion on Drug Discovery. Jan, 2011 | Pubmed ID: 22646826 The Epidermal Growth Factor Receptor/Erb-B/HER Family in Normal and Malignant Breast Biology The International Journal of Developmental Biology. 2011 | Pubmed ID: 22161825 Structure-guided Evolution of Potent and Selective CHK1 Inhibitors Through Scaffold Morphing Journal of Medicinal Chemistry. Dec, 2011 | Pubmed ID: 22111927 Quantitative Chemical Proteomics Reveals New Potential Drug Targets in Head and Neck Cancer Molecular & Cellular Proteomics : MCP. Dec, 2011 | Pubmed ID: 21955398 The Aurora Kinase Inhibitor CCT137690 Downregulates MYCN and Sensitizes MYCN-amplified Neuroblastoma in Vivo Molecular Cancer Therapeutics. Nov, 2011 | Pubmed ID: 21885865 Ca2+ Influx Through Reverse Mode Na+/Ca2+ Exchange is Critical for Vascular Endothelial Growth Factor-mediated Extracellular Signal-regulated Kinase (ERK) 1/2 Activation and Angiogenic Functions of Human Endothelial Cells The Journal of Biological Chemistry. Nov, 2011 | Pubmed ID: 21873429 Simple Experimental and Spontaneous Metastasis Assays in Mice Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21748685 Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β Molecular Cancer Therapeutics. Aug, 2011 | Pubmed ID: 21659463 Angiogenic Functions of Voltage-gated Na+ Channels in Human Endothelial Cells: Modulation of Vascular Endothelial Growth Factor (VEGF) Signaling The Journal of Biological Chemistry. May, 2011 | Pubmed ID: 21385874 Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930 Molecular Cancer Therapeutics. Feb, 2011 | Pubmed ID: 21191045 Metastasis and the Tumor Microenvironment: A Joint Metastasis Research Society-AACR Conference - Research on Metastasis: Part 2 IDrugs : the Investigational Drugs Journal. Nov, 2010 | Pubmed ID: 21046523 Metastasis and the Tumor Microenvironment: A Joint Metastasis Research Society-AACR Conference - Research on Metastasis: Part 1 IDrugs : the Investigational Drugs Journal. Nov, 2010 | Pubmed ID: 21046522 Bayesian Estimation of Changes in Transverse Relaxation Rates Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Sep, 2010 | Pubmed ID: 20806382 Tumour-microenvironmental Interactions: Paths to Progression and Targets for Treatment Seminars in Cancer Biology. Jun, 2010 | Pubmed ID: 20599506 Imidazo[4,5-b]pyridine Derivatives As Inhibitors of Aurora Kinases: Lead Optimization Studies Toward the Identification of an Orally Bioavailable Preclinical Development Candidate Journal of Medicinal Chemistry. Jul, 2010 | Pubmed ID: 20565112 Mechanistic Evaluation of the Novel HSP90 Inhibitor NVP-AUY922 in Adult and Pediatric Glioblastoma Molecular Cancer Therapeutics. May, 2010 | Pubmed ID: 20457619 Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt) Journal of Medicinal Chemistry. Mar, 2010 | Pubmed ID: 20151677 The Preclinical Pharmacology and Therapeutic Activity of the Novel CHK1 Inhibitor SAR-020106 Molecular Cancer Therapeutics. Jan, 2010 | Pubmed ID: 20053762 An Open Letter to the FDA and Other Regulatory Agencies: Preclinical Drug Development Must Consider the Impact on Metastasis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2009 | Pubmed ID: 25278743 Brk Protects Breast Cancer Cells from Autophagic Cell Death Induced by Loss of Anchorage The American Journal of Pathology. Sep, 2009 | Pubmed ID: 19661439 Combining Hit Identification Strategies: Fragment-based and in Silico Approaches to Orally Active 2-aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone Journal of Medicinal Chemistry. Aug, 2009 | Pubmed ID: 19610616 Biological Properties of Potent Inhibitors of Class I Phosphatidylinositide 3-kinases: from PI-103 Through PI-540, PI-620 to the Oral Agent GDC-0941 Molecular Cancer Therapeutics. Jul, 2009 | Pubmed ID: 19584227 Changes in Choline Metabolism As Potential Biomarkers of Phospholipase C{gamma}1 Inhibition in Human Prostate Cancer Cells Molecular Cancer Therapeutics. May, 2009 | Pubmed ID: 19417158 The Identification of Novel PLC-gamma Inhibitors Using Virtual High Throughput Screening Bioorganic & Medicinal Chemistry. Apr, 2009 | Pubmed ID: 19303309 In Vitro Assays for Endothelial Cell Functions Related to Angiogenesis: Proliferation, Motility, Tubular Differentiation, and Proteolysis Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19301670 Determinants of Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition in Squamous Cell Carcinoma of the Head and Neck The Journal of Pathology. May, 2009 | Pubmed ID: 19197951 Molecular Pharmacology of Phosphatidylinositol 3-kinase Inhibition in Human Glioma Cell Cycle (Georgetown, Tex.). Feb, 2009 | Pubmed ID: 19177002 A MicroRNA DNA Methylation Signature for Human Cancer Metastasis Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008 | Pubmed ID: 18768788 The Identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) As a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer Journal of Medicinal Chemistry. Sep, 2008 | Pubmed ID: 18754654 CHR-2797: an Antiproliferative Aminopeptidase Inhibitor That Leads to Amino Acid Deprivation in Human Leukemic Cells Cancer Research. Aug, 2008 | Pubmed ID: 18701491 NVP-AUY922: a Novel Heat Shock Protein 90 Inhibitor Active Against Xenograft Tumor Growth, Angiogenesis, and Metastasis Cancer Research. Apr, 2008 | Pubmed ID: 18413753 An in Vitro and in Vivo Study of the Combination of the Heat Shock Protein Inhibitor 17-allylamino-17-demethoxygeldanamycin and Carboplatin in Human Ovarian Cancer Models Cancer Chemotherapy and Pharmacology. Oct, 2008 | Pubmed ID: 18193424 4,5-diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer Journal of Medicinal Chemistry. Jan, 2008 | Pubmed ID: 18020435 The Bcl-2/Bcl-XL Family Inhibitor ABT-737 Sensitizes Ovarian Cancer Cells to Carboplatin Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2007 | Pubmed ID: 18056200 AACR-NCI-EORTC--19th Symposium. Molecular Targets and Cancer Therapeutics--Part 4 IDrugs : the Investigational Drugs Journal. Dec, 2007 | Pubmed ID: 18041676 Plexin-B1 Mutations in Prostate Cancer Proceedings of the National Academy of Sciences of the United States of America. Nov, 2007 | Pubmed ID: 18024597 Application of Meso Scale Technology for the Measurement of Phosphoproteins in Human Tumor Xenografts Assay and Drug Development Technologies. Jun, 2007 | Pubmed ID: 17638539 Metastasis: Recent Discoveries and Novel Treatment Strategies Lancet. May, 2007 | Pubmed ID: 17512859 The Phosphoinositide-specific Phospholipase C Inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) Spontaneously Forms Conjugates with Common Components of Cell Culture Medium Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jul, 2007 | Pubmed ID: 17403917 The Vascular Targeting Property of Paclitaxel is Enhanced by SU6668, a Receptor Tyrosine Kinase Inhibitor, Causing Apoptosis of Endothelial Cells and Inhibition of Angiogenesis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2006 | Pubmed ID: 16551869 Benzoquinone Ansamycin Heat Shock Protein 90 Inhibitors Modulate Multiple Functions Required for Tumor Angiogenesis Molecular Cancer Therapeutics. Mar, 2006 | Pubmed ID: 16546966 Identification of Magnetic Resonance Detectable Metabolic Changes Associated with Inhibition of Phosphoinositide 3-kinase Signaling in Human Breast Cancer Cells Molecular Cancer Therapeutics. Jan, 2006 | Pubmed ID: 16432178 Cell Migration/invasion Assays and Their Application in Cancer Drug Discovery Biotechnology Annual Review. 2005 | Pubmed ID: 16216785 The Phosphoinositide 3-kinase Signalling Pathway As a Therapeutic Target in Squamous Cell Carcinoma of the Head and Neck Expert Opinion on Therapeutic Targets. Aug, 2005 | Pubmed ID: 16083342 PLCgamma1 is Essential for Early Events in Integrin Signalling Required for Cell Motility Journal of Cell Science. Jun, 2005 | Pubmed ID: 15944397 Biological Significance of C-erbB Family Oncogenes in Head and Neck Cancer Cancer Metastasis Reviews. Jan, 2005 | Pubmed ID: 15785872 Breast Cancer Metastasis: When, Where, How? Lancet. Mar 19-25, 2005 | Pubmed ID: 15781080 Targeting Key Steps in Metastatic Tumour Progression Current Opinion in Genetics & Development. Feb, 2005 | Pubmed ID: 15661537 Parallels in Invasion and Angiogenesis Provide Pivotal Points for Therapeutic Intervention The International Journal of Developmental Biology. 2004 | Pubmed ID: 15349833 Combination Epidermal Growth Factor Receptor Inhibition and Radical Radiotherapy for NSCLC Expert Review of Anticancer Therapy. Aug, 2004 | Pubmed ID: 15270661 Signaling Pathways Required for Matrix Metalloproteinase-9 Induction by Betacellulin in Head-and-neck Squamous Carcinoma Cells International Journal of Cancer. Journal International Du Cancer. Aug, 2004 | Pubmed ID: 15197768 Phosphoinositide 3-kinase Signalling Pathways in Tumor Progression, Invasion and Angiogenesis Tumori. Jan-Feb, 2004 | Pubmed ID: 15143962 Use of Plasma MMP-2 and MMP-9 Levels As a Surrogate for Tumour Expression in Colorectal Cancer Patients International Journal of Cancer. Journal International Du Cancer. Nov, 2003 | Pubmed ID: 14520690 The Role of C-erbB Receptors and Ligands in Head and Neck Squamous Cell Carcinoma Oral Oncology. Oct, 2002 | Pubmed ID: 12167415 3 차원 (3D) 종양 회전 타원체 침공 분석 Maria Vinci1,2, Carol Box2, Suzanne A. Eccles2 1Division of Molecular Pathology, The Institute of Cancer Research, 2Division of Cancer Therapeutics, The Institute of Cancer Research Medicine
3 차원 (3D) 종양 회전 타원체 침공 분석 Maria Vinci1,2, Carol Box2, Suzanne A. Eccles2 1Division of Molecular Pathology, The Institute of Cancer Research, 2Division of Cancer Therapeutics, The Institute of Cancer Research Medicine