Suzanne A. Eccles

Publications

• Discovery of Potent, Orally Bioavailable, Small-molecule Inhibitors of WNT Signaling from a Cell-based Pathway Screen
  Journal of Medicinal Chemistry. Feb, 2015  |   Pubmed ID: 25680029
• Exploring the Biomechanical Properties of Brain Malignancies and Their Pathologic Determinants in Vivo with Magnetic Resonance Elastography
  Cancer Research. Apr, 2015  |   Pubmed ID: 25672978
• Cancer-associated Fibroblasts Induce High Mobility Group Box 1 and Contribute to Resistance to Doxorubicin in Breast Cancer Cells
  BMC Cancer. 2014  |   Pubmed ID: 25512109
• HIF-1α-independent Hypoxia-induced Rapid PTK6 Stabilization is Associated with Increased Motility and Invasion
  Cancer Biology & Therapy. Oct, 2014  |   Pubmed ID: 25019382
• Preclinical Evaluation of Imaging Biomarkers for Prostate Cancer Bone Metastasis and Response to Cabozantinib
  Journal of the National Cancer Institute. Apr, 2014  |   Pubmed ID: 24634505
• Critical Research Gaps and Translational Priorities for the Successful Prevention and Treatment of Breast Cancer
  Breast Cancer Research : BCR. 2013  |   Pubmed ID: 24286369
• Structure-based Design of Orally Bioavailable 1H-pyrrolo[3,2-c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)
  Journal of Medicinal Chemistry. Dec, 2013  |   Pubmed ID: 24256217
• Mode of Cell Death Induced by the HSP90 Inhibitor 17-AAG (tanespimycin) is Dependent on the Expression of Pro-apoptotic BAX
  Oncotarget. Nov, 2013  |   Pubmed ID: 24185264
• Dual Blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) Pathways Synergistically Inhibits Rhabdomyosarcoma Cell Growth in Vitro and in Vivo
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2013  |   Pubmed ID: 23918606
• Kurt Hellmann D. M., D. Phil. Oxon 1922–2013
  Clinical & Experimental Metastasis. Jun, 2013  |   Pubmed ID: 23844428
• A Cyclic Peptide Inhibitor of HIF-1 Heterodimerization That Inhibits Hypoxia Signaling in Cancer Cells
  Journal of the American Chemical Society. Jul, 2013  |   Pubmed ID: 23796364
• A Novel Serum Protein Signature Associated with Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Head and Neck Squamous Cell Carcinoma
  European Journal of Cancer (Oxford, England : 1990). Jul, 2013  |   Pubmed ID: 23582742
• Tumor Spheroid-based Migration Assays for Evaluation of Therapeutic Agents
  Methods in Molecular Biology (Clifton, N.J.). 2013  |   Pubmed ID: 23436417
• Two-dimensional Vs. Three-dimensional in Vitro Tumor Migration and Invasion Assays
  Methods in Molecular Biology (Clifton, N.J.). 2013  |   Pubmed ID: 23436416
• Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles As Selective, Orally Bioavailable CHK1 Inhibitors
  Journal of Medicinal Chemistry. Nov, 2012  |   Pubmed ID: 23082860
• Optimization of Imidazo[4,5-b]pyridine-based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor As an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia
  Journal of Medicinal Chemistry. Oct, 2012  |   Pubmed ID: 23043539
• CCT244747 is a Novel Potent and Selective CHK1 Inhibitor with Oral Efficacy Alone and in Combination with Genotoxic Anticancer Drugs
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2012  |   Pubmed ID: 22929806
• Erratum To: Kurt Hellmann D.M., D.Phil. Oxon. A Happy 90th Birthday!
  Clinical & Experimental Metastasis. Aug, 2012  |   Pubmed ID: 22872374
• The ALK(F1174L) Mutation Potentiates the Oncogenic Activity of MYCN in Neuroblastoma
  Cancer Cell. Jul, 2012  |   Pubmed ID: 22789543
• AT13148 is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2012  |   Pubmed ID: 22781553
• Kurt Hellmann D.M., D.Phil. Oxon. A Happy 90th Birthday!
  Clinical & Experimental Metastasis. Aug, 2012  |   Pubmed ID: 22695808
• Dependence of Wilms Tumor Cells on Signaling Through Insulin-like Growth Factor 1 in an Orthotopic Xenograft Model Targetable by Specific Receptor Inhibition
  Proceedings of the National Academy of Sciences of the United States of America. May, 2012  |   Pubmed ID: 22529373
• Dual Targeting of ErbB2 and MUC1 in Breast Cancer Using Chimeric Antigen Receptors Engineered to Provide Complementary Signaling
  Journal of Clinical Immunology. Oct, 2012  |   Pubmed ID: 22526592
• The HSP90 Inhibitor NVP-AUY922 Radiosensitizes by Abrogation of Homologous Recombination Resulting in Mitotic Entry with Unresolved DNA Damage
  PloS One. 2012  |   Pubmed ID: 22523597
• Advances in Establishment and Analysis of Three-dimensional Tumor Spheroid-based Functional Assays for Target Validation and Drug Evaluation
  BMC Biology. 2012  |   Pubmed ID: 22439642
• Epigenetic Disruption of Cadherin-11 in Human Cancer Metastasis
  The Journal of Pathology. Feb, 2012  |   Pubmed ID: 22374749
• Flexible Targeting of ErbB Dimers That Drive Tumorigenesis by Using Genetically Engineered T Cells
  Molecular Medicine (Cambridge, Mass.). 2012  |   Pubmed ID: 22354215
• Non-invasive in Vivo Imaging of Vessel Calibre in Orthotopic Prostate Tumour Xenografts
  International Journal of Cancer. Journal International Du Cancer. Mar, 2012  |   Pubmed ID: 21469141
• Preclinical Drug Development for Childhood Cancer
  Expert Opinion on Drug Discovery. Jan, 2011  |   Pubmed ID: 22646826
• The Epidermal Growth Factor Receptor/Erb-B/HER Family in Normal and Malignant Breast Biology
  The International Journal of Developmental Biology. 2011  |   Pubmed ID: 22161825
• Structure-guided Evolution of Potent and Selective CHK1 Inhibitors Through Scaffold Morphing
  Journal of Medicinal Chemistry. Dec, 2011  |   Pubmed ID: 22111927
• Quantitative Chemical Proteomics Reveals New Potential Drug Targets in Head and Neck Cancer
  Molecular & Cellular Proteomics : MCP. Dec, 2011  |   Pubmed ID: 21955398
• The Aurora Kinase Inhibitor CCT137690 Downregulates MYCN and Sensitizes MYCN-amplified Neuroblastoma in Vivo
  Molecular Cancer Therapeutics. Nov, 2011  |   Pubmed ID: 21885865
• Ca2+ Influx Through Reverse Mode Na+/Ca2+ Exchange is Critical for Vascular Endothelial Growth Factor-mediated Extracellular Signal-regulated Kinase (ERK) 1/2 Activation and Angiogenic Functions of Human Endothelial Cells
  The Journal of Biological Chemistry. Nov, 2011  |   Pubmed ID: 21873429
• Simple Experimental and Spontaneous Metastasis Assays in Mice
  Methods in Molecular Biology (Clifton, N.J.). 2011  |   Pubmed ID: 21748685
• Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
  Molecular Cancer Therapeutics. Aug, 2011  |   Pubmed ID: 21659463
• Angiogenic Functions of Voltage-gated Na+ Channels in Human Endothelial Cells: Modulation of Vascular Endothelial Growth Factor (VEGF) Signaling
  The Journal of Biological Chemistry. May, 2011  |   Pubmed ID: 21385874
• Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930
  Molecular Cancer Therapeutics. Feb, 2011  |   Pubmed ID: 21191045
• Metastasis and the Tumor Microenvironment: A Joint Metastasis Research Society-AACR Conference - Research on Metastasis: Part 2
  IDrugs : the Investigational Drugs Journal. Nov, 2010  |   Pubmed ID: 21046523
• Metastasis and the Tumor Microenvironment: A Joint Metastasis Research Society-AACR Conference - Research on Metastasis: Part 1
  IDrugs : the Investigational Drugs Journal. Nov, 2010  |   Pubmed ID: 21046522
• Bayesian Estimation of Changes in Transverse Relaxation Rates
  Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Sep, 2010  |   Pubmed ID: 20806382
• Tumour-microenvironmental Interactions: Paths to Progression and Targets for Treatment
  Seminars in Cancer Biology. Jun, 2010  |   Pubmed ID: 20599506
• Imidazo[4,5-b]pyridine Derivatives As Inhibitors of Aurora Kinases: Lead Optimization Studies Toward the Identification of an Orally Bioavailable Preclinical Development Candidate
  Journal of Medicinal Chemistry. Jul, 2010  |   Pubmed ID: 20565112
• Mechanistic Evaluation of the Novel HSP90 Inhibitor NVP-AUY922 in Adult and Pediatric Glioblastoma
  Molecular Cancer Therapeutics. May, 2010  |   Pubmed ID: 20457619
• Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)
  Journal of Medicinal Chemistry. Mar, 2010  |   Pubmed ID: 20151677
• The Preclinical Pharmacology and Therapeutic Activity of the Novel CHK1 Inhibitor SAR-020106
  Molecular Cancer Therapeutics. Jan, 2010  |   Pubmed ID: 20053762
• An Open Letter to the FDA and Other Regulatory Agencies: Preclinical Drug Development Must Consider the Impact on Metastasis
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2009  |   Pubmed ID: 25278743
• Brk Protects Breast Cancer Cells from Autophagic Cell Death Induced by Loss of Anchorage
  The American Journal of Pathology. Sep, 2009  |   Pubmed ID: 19661439
• Combining Hit Identification Strategies: Fragment-based and in Silico Approaches to Orally Active 2-aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone
  Journal of Medicinal Chemistry. Aug, 2009  |   Pubmed ID: 19610616
• Biological Properties of Potent Inhibitors of Class I Phosphatidylinositide 3-kinases: from PI-103 Through PI-540, PI-620 to the Oral Agent GDC-0941
  Molecular Cancer Therapeutics. Jul, 2009  |   Pubmed ID: 19584227
• Changes in Choline Metabolism As Potential Biomarkers of Phospholipase C{gamma}1 Inhibition in Human Prostate Cancer Cells
  Molecular Cancer Therapeutics. May, 2009  |   Pubmed ID: 19417158
• The Identification of Novel PLC-gamma Inhibitors Using Virtual High Throughput Screening
  Bioorganic & Medicinal Chemistry. Apr, 2009  |   Pubmed ID: 19303309
• In Vitro Assays for Endothelial Cell Functions Related to Angiogenesis: Proliferation, Motility, Tubular Differentiation, and Proteolysis
  Methods in Molecular Biology (Clifton, N.J.). 2009  |   Pubmed ID: 19301670
• Determinants of Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition in Squamous Cell Carcinoma of the Head and Neck
  The Journal of Pathology. May, 2009  |   Pubmed ID: 19197951
• Molecular Pharmacology of Phosphatidylinositol 3-kinase Inhibition in Human Glioma
  Cell Cycle (Georgetown, Tex.). Feb, 2009  |   Pubmed ID: 19177002
• A MicroRNA DNA Methylation Signature for Human Cancer Metastasis
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008  |   Pubmed ID: 18768788
• The Identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) As a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer
  Journal of Medicinal Chemistry. Sep, 2008  |   Pubmed ID: 18754654
• CHR-2797: an Antiproliferative Aminopeptidase Inhibitor That Leads to Amino Acid Deprivation in Human Leukemic Cells
  Cancer Research. Aug, 2008  |   Pubmed ID: 18701491
• NVP-AUY922: a Novel Heat Shock Protein 90 Inhibitor Active Against Xenograft Tumor Growth, Angiogenesis, and Metastasis
  Cancer Research. Apr, 2008  |   Pubmed ID: 18413753
• An in Vitro and in Vivo Study of the Combination of the Heat Shock Protein Inhibitor 17-allylamino-17-demethoxygeldanamycin and Carboplatin in Human Ovarian Cancer Models
  Cancer Chemotherapy and Pharmacology. Oct, 2008  |   Pubmed ID: 18193424
• 4,5-diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer
  Journal of Medicinal Chemistry. Jan, 2008  |   Pubmed ID: 18020435
• The Bcl-2/Bcl-XL Family Inhibitor ABT-737 Sensitizes Ovarian Cancer Cells to Carboplatin
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2007  |   Pubmed ID: 18056200
• AACR-NCI-EORTC--19th Symposium. Molecular Targets and Cancer Therapeutics--Part 4
  IDrugs : the Investigational Drugs Journal. Dec, 2007  |   Pubmed ID: 18041676
• Plexin-B1 Mutations in Prostate Cancer
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2007  |   Pubmed ID: 18024597
• Application of Meso Scale Technology for the Measurement of Phosphoproteins in Human Tumor Xenografts
  Assay and Drug Development Technologies. Jun, 2007  |   Pubmed ID: 17638539
• Metastasis: Recent Discoveries and Novel Treatment Strategies
  Lancet. May, 2007  |   Pubmed ID: 17512859
• The Phosphoinositide-specific Phospholipase C Inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) Spontaneously Forms Conjugates with Common Components of Cell Culture Medium
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jul, 2007  |   Pubmed ID: 17403917
• The Vascular Targeting Property of Paclitaxel is Enhanced by SU6668, a Receptor Tyrosine Kinase Inhibitor, Causing Apoptosis of Endothelial Cells and Inhibition of Angiogenesis
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2006  |   Pubmed ID: 16551869
• Benzoquinone Ansamycin Heat Shock Protein 90 Inhibitors Modulate Multiple Functions Required for Tumor Angiogenesis
  Molecular Cancer Therapeutics. Mar, 2006  |   Pubmed ID: 16546966
• Identification of Magnetic Resonance Detectable Metabolic Changes Associated with Inhibition of Phosphoinositide 3-kinase Signaling in Human Breast Cancer Cells
  Molecular Cancer Therapeutics. Jan, 2006  |   Pubmed ID: 16432178
• Cell Migration/invasion Assays and Their Application in Cancer Drug Discovery
  Biotechnology Annual Review. 2005  |   Pubmed ID: 16216785
• The Phosphoinositide 3-kinase Signalling Pathway As a Therapeutic Target in Squamous Cell Carcinoma of the Head and Neck
  Expert Opinion on Therapeutic Targets. Aug, 2005  |   Pubmed ID: 16083342
• PLCgamma1 is Essential for Early Events in Integrin Signalling Required for Cell Motility
  Journal of Cell Science. Jun, 2005  |   Pubmed ID: 15944397
• Biological Significance of C-erbB Family Oncogenes in Head and Neck Cancer
  Cancer Metastasis Reviews. Jan, 2005  |   Pubmed ID: 15785872
• Breast Cancer Metastasis: When, Where, How?
  Lancet. Mar 19-25, 2005  |   Pubmed ID: 15781080
• Targeting Key Steps in Metastatic Tumour Progression
  Current Opinion in Genetics & Development. Feb, 2005  |   Pubmed ID: 15661537
• Parallels in Invasion and Angiogenesis Provide Pivotal Points for Therapeutic Intervention
  The International Journal of Developmental Biology. 2004  |   Pubmed ID: 15349833
• Combination Epidermal Growth Factor Receptor Inhibition and Radical Radiotherapy for NSCLC
  Expert Review of Anticancer Therapy. Aug, 2004  |   Pubmed ID: 15270661
• Signaling Pathways Required for Matrix Metalloproteinase-9 Induction by Betacellulin in Head-and-neck Squamous Carcinoma Cells
  International Journal of Cancer. Journal International Du Cancer. Aug, 2004  |   Pubmed ID: 15197768
• Phosphoinositide 3-kinase Signalling Pathways in Tumor Progression, Invasion and Angiogenesis
  Tumori. Jan-Feb, 2004  |   Pubmed ID: 15143962
• Use of Plasma MMP-2 and MMP-9 Levels As a Surrogate for Tumour Expression in Colorectal Cancer Patients
  International Journal of Cancer. Journal International Du Cancer. Nov, 2003  |   Pubmed ID: 14520690
• The Role of C-erbB Receptors and Ligands in Head and Neck Squamous Cell Carcinoma
  Oral Oncology. Oct, 2002  |   Pubmed ID: 12167415