Suzanne Jackowski

Publications

• Antimalarial Pantothenamide Metabolites Target Acetyl-coenzyme A Biosynthesis in
  Science Translational Medicine. Sep, 2019  |   Pubmed ID: 31534021
• Proposed Therapies for Pantothenate-Kinase-Associated Neurodegeneration
  Journal of Experimental Neuroscience. 2019  |   Pubmed ID: 31205425
• Human Pantothenate Kinase 4 is a Pseudo-pantothenate Kinase
  Protein Science : a Publication of the Protein Society. Jun, 2019  |   Pubmed ID: 30927326
• A Therapeutic Approach to Pantothenate Kinase Associated Neurodegeneration
  Nature Communications. 10, 2018  |   Pubmed ID: 30352999
• Excess Coenzyme A Reduces Skeletal Muscle Performance and Strength in Mice Overexpressing Human PANK2
  Molecular Genetics and Metabolism. 04, 2017  |   Pubmed ID: 28189602
• T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions
  The Journal of Biological Chemistry. Jan, 2017  |   Pubmed ID: 27903651
• Allosteric Regulation of Mammalian Pantothenate Kinase
  The Journal of Biological Chemistry. Oct, 2016  |   Pubmed ID: 27555321
• Correction of a Genetic Deficiency in Pantothenate Kinase 1 Using Phosphopantothenate Replacement Therapy
  Molecular Genetics and Metabolism. Dec, 2015  |   Pubmed ID: 26549575
• Induction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in Mice
  PloS One. 2015  |   Pubmed ID: 26052948
• The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis Without Altering Insulin Sensitivity
  Cell Metabolism. May, 2015  |   Pubmed ID: 25955207
• A High-throughput Screen Reveals New Small-molecule Activators and Inhibitors of Pantothenate Kinases
  Journal of Medicinal Chemistry. Feb, 2015  |   Pubmed ID: 25569308
• Deregulated Coenzyme A, Loss of Metabolic Flexibility and Diabetes
  Biochemical Society Transactions. Aug, 2014  |   Pubmed ID: 25110012
• Physiological Roles of the Pantothenate Kinases
  Biochemical Society Transactions. Aug, 2014  |   Pubmed ID: 25109998
• Coenzyme A and Its Derivatives: Renaissance of a Textbook Classic
  Biochemical Society Transactions. Aug, 2014  |   Pubmed ID: 25109997
• Pank1 Deletion in Leptin-deficient Mice Reduces Hyperglycaemia and Hyperinsulinaemia and Modifies Global Metabolism Without Affecting Insulin Resistance
  Diabetologia. Jul, 2014  |   Pubmed ID: 24781151
• Preface: Phospholipids and Phospholipid Metabolism
  Biochimica Et Biophysica Acta. Mar, 2013  |   Pubmed ID: 23369660
• Phosphatidylcholine and the CDP-choline Cycle
  Biochimica Et Biophysica Acta. Mar, 2013  |   Pubmed ID: 23010477
• Compartmentalization of Mammalian Pantothenate Kinases
  PloS One. 2012  |   Pubmed ID: 23152917
• Germline Deletion of Pantothenate Kinases 1 and 2 Reveals the Key Roles for CoA in Postnatal Metabolism
  PloS One. 2012  |   Pubmed ID: 22815849
• The Specialized Unfolded Protein Response of B Lymphocytes: ATF6α-independent Development of Antibody-secreting B Cells
  Molecular Immunology. Jul, 2012  |   Pubmed ID: 22555069
• Cancer-associated Isocitrate Dehydrogenase Mutations Inactivate NADPH-dependent Reductive Carboxylation
  The Journal of Biological Chemistry. Apr, 2012  |   Pubmed ID: 22442146
• UPR-Mediated Membrane Biogenesis in B Cells
  Biochemistry Research International. 2012  |   Pubmed ID: 22110962
• The Unfolded Protein Response Transducer IRE1α Prevents ER Stress-induced Hepatic Steatosis
  The EMBO Journal. Apr, 2011  |   Pubmed ID: 21407177
• Modulation of Pantothenate Kinase 3 Activity by Small Molecules That Interact with the Substrate/allosteric Regulatory Domain
  Chemistry & Biology. Aug, 2010  |   Pubmed ID: 20797618
• Pantothenate Kinase 1 is Required to Support the Metabolic Transition from the Fed to the Fasted State
  PloS One. Jun, 2010  |   Pubmed ID: 20559429
• Phosphatidylcholine Biosynthesis During Neuronal Differentiation and Its Role in Cell Fate Determination
  The Journal of Biological Chemistry. Aug, 2010  |   Pubmed ID: 20525991
• Pantothenate Kinase from the Thermoacidophilic Archaeon Picrophilus Torridus
  Journal of Bacteriology. Jan, 2010  |   Pubmed ID: 19854913
• Elimination of the CDP-ethanolamine Pathway Disrupts Hepatic Lipid Homeostasis
  The Journal of Biological Chemistry. Oct, 2009  |   Pubmed ID: 19666474
• ATF6alpha Induces XBP1-independent Expansion of the Endoplasmic Reticulum
  Journal of Cell Science. May, 2009  |   Pubmed ID: 19420237
• CTP:phosphocholine Cytidylyltransferase Alpha is Required for B-cell Proliferation and Class Switch Recombination
  The Journal of Biological Chemistry. Mar, 2009  |   Pubmed ID: 19139091
• Membrane Phospholipid Synthesis and Endoplasmic Reticulum Function
  Journal of Lipid Research. Apr, 2009  |   Pubmed ID: 18952570
• Cytokine Secretion Requires Phosphatidylcholine Synthesis
  The Journal of Cell Biology. Jun, 2008  |   Pubmed ID: 18559668
• Biosynthesis of Pantothenic Acid and Coenzyme A
  EcoSal Plus. Apr, 2007  |   Pubmed ID: 26443589
• Localization and Regulation of Mouse Pantothenate Kinase 2
  FEBS Letters. Oct, 2007  |   Pubmed ID: 17825826
• Probucol Therapy Overcomes the Reproductive Defect in CTP: Phosphocholine Cytidylyltransferase Beta2 Knockout Mice
  Biochimica Et Biophysica Acta. Jul, 2007  |   Pubmed ID: 17560827
• Chemical Knockout of Pantothenate Kinase Reveals the Metabolic and Genetic Program Responsible for Hepatic Coenzyme A Homeostasis
  Chemistry & Biology. Mar, 2007  |   Pubmed ID: 17379144
• Structure of the Type III Pantothenate Kinase from Bacillus Anthracis at 2.0 A Resolution: Implications for Coenzyme A-dependent Redox Biology
  Biochemistry. Mar, 2007  |   Pubmed ID: 17323930
• Activation of Human Mitochondrial Pantothenate Kinase 2 by Palmitoylcarnitine
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2007  |   Pubmed ID: 17242360
• Phospholipid Biosynthesis Program Underlying Membrane Expansion During B-lymphocyte Differentiation
  The Journal of Biological Chemistry. Mar, 2007  |   Pubmed ID: 17213195
• Role of Phosphocholine Cytidylyltransferase Alpha in Lung Development
  Molecular and Cellular Biology. Feb, 2007  |   Pubmed ID: 17130238
• Placental Thrombosis and Spontaneous Fetal Death in Mice Deficient in Ethanolamine Kinase 2
  The Journal of Biological Chemistry. Sep, 2006  |   Pubmed ID: 16861741
• Biochemical Properties of Human Pantothenate Kinase 2 Isoforms and Mutations Linked to Pantothenate Kinase-associated Neurodegeneration
  The Journal of Biological Chemistry. Jan, 2006  |   Pubmed ID: 16272150
• Feedback Regulation of Murine Pantothenate Kinase 3 by Coenzyme A and Coenzyme A Thioesters
  The Journal of Biological Chemistry. Sep, 2005  |   Pubmed ID: 16040613
• Coenzyme A: Back in Action
  Progress in Lipid Research. Mar-May, 2005  |   Pubmed ID: 15893380
• Early Embryonic Lethality in Mice with Targeted Deletion of the CTP:phosphocholine Cytidylyltransferase Alpha Gene (Pcyt1a)
  Molecular and Cellular Biology. Apr, 2005  |   Pubmed ID: 15798219
• A Pantothenate Kinase from Staphylococcus Aureus Refractory to Feedback Regulation by Coenzyme A
  The Journal of Biological Chemistry. Feb, 2005  |   Pubmed ID: 15548531
• CTP: Phosphocholine Cytidylyltransferase: Paving the Way from Gene to Membrane
  The Journal of Biological Chemistry. Jan, 2005  |   Pubmed ID: 15536089
• XBP1: a Link Between the Unfolded Protein Response, Lipid Biosynthesis, and Biogenesis of the Endoplasmic Reticulum
  The Journal of Cell Biology. Oct, 2004  |   Pubmed ID: 15466483
• Acyl Carrier Protein is a Cellular Target for the Antibacterial Action of the Pantothenamide Class of Pantothenate Antimetabolites
  The Journal of Biological Chemistry. Dec, 2004  |   Pubmed ID: 15459190
• Bacterial Inhibition of Phosphatidylcholine Synthesis Triggers Apoptosis in the Brain
  The Journal of Experimental Medicine. Jul, 2004  |   Pubmed ID: 15238609
• Disruption of CCTbeta2 Expression Leads to Gonadal Dysfunction
  Molecular and Cellular Biology. Jun, 2004  |   Pubmed ID: 15143167
• The Structure of the Pantothenate Kinase.ADP.pantothenate Ternary Complex Reveals the Relationship Between the Binding Sites for Substrate, Allosteric Regulator, and Antimetabolites
  The Journal of Biological Chemistry. Aug, 2004  |   Pubmed ID: 15136582
• PPARalpha Controls the Intracellular Coenzyme A Concentration Via Regulation of PANK1alpha Gene Expression
  Journal of Lipid Research. Jan, 2004  |   Pubmed ID: 14523052
• Gene Structure, Expression and Identification of a New CTP:phosphocholine Cytidylyltransferase Beta Isoform
  Biochimica Et Biophysica Acta. Jul, 2003  |   Pubmed ID: 12842190
• Role of Feedback Regulation of Pantothenate Kinase (CoaA) in Control of Coenzyme A Levels in Escherichia Coli
  Journal of Bacteriology. Jun, 2003  |   Pubmed ID: 12754240
• The Murine Pantothenate Kinase (Pank1) Gene Encodes Two Differentially Regulated Pantothenate Kinase Isozymes
  Gene. May, 2002  |   Pubmed ID: 12095677
• Forty Years of Bacterial Fatty Acid Synthesis
  Biochemical and Biophysical Research Communications. Apr, 2002  |   Pubmed ID: 11969206
• A Missense Mutation in the FabB (beta-ketoacyl-acyl Carrier Protein Synthase I) Gene Confers Tiolactomycin Resistance to Escherichia Coli
  Antimicrobial Agents and Chemotherapy. May, 2002  |   Pubmed ID: 11959552
• Structure and Mechanism of CTP:phosphocholine Cytidylyltransferase (LicC) from Streptococcus Pneumoniae
  The Journal of Biological Chemistry. Feb, 2002  |   Pubmed ID: 11706035
• The LicC Gene of Streptococcus Pneumoniae Encodes a CTP:phosphocholine Cytidylyltransferase
  Journal of Bacteriology. Aug, 2001  |   Pubmed ID: 11466299
• Modulation of CTP:phosphocholine Cytidylyltransferase by Membrane Curvature Elastic Stress
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2000  |   Pubmed ID: 10908674
• Activity of the Phosphatidylcholine Biosynthetic Pathway Modulates the Distribution of Fatty Acids into Glycerolipids in Proliferating Cells
  Biochimica Et Biophysica Acta. Jan, 2000  |   Pubmed ID: 10666565