Sven Lang Medical Biochemistry and Molecular Biology Saarland University Biography Publications Institution JoVE Articles Sven Lang has not added a biography. If you are Sven Lang and would like to personalize this page please email our Author Liaison for assistance. Publications Right Portal Vein Ligation Combined With In Situ Splitting Induces Rapid Left Lateral Liver Lobe Hypertrophy Enabling 2-Staged Extended Right Hepatic Resection in Small-for-Size Settings Annals of Surgery. Mar, 2012 | Pubmed ID: 22330038 Oncogenic MST1R Activity in Pancreatic and Gastric Cancer Represents a Valid Target of HSP90 Inhibitors Anticancer Research. Feb, 2012 | Pubmed ID: 22287729 Targeting FGFR/PDGFR/VEGFR Impairs Tumor Growth, Angiogenesis, and Metastasis by Effects on Tumor Cells, Endothelial Cells, and Pericytes in Pancreatic Cancer Molecular Cancer Therapeutics. Nov, 2011 | Pubmed ID: 21885862 Sec62 Protein Level is Crucial for the ER Stress Tolerance of Prostate Cancer The Prostate. Jul, 2011 | Pubmed ID: 21557272 Tumor Development in Murine Ulcerative Colitis Depends on MyD88 Signaling of Colonic F4/80+CD11b(high)Gr1(low) Macrophages The Journal of Clinical Investigation. May, 2011 | Pubmed ID: 21519141 Sec61 Complexes Form Ubiquitous ER Ca2+ Leak Channels Channels (Austin, Tex.). May-Jun, 2011 | Pubmed ID: 21406962 Transforming Growth Factor-beta 2 Gene Silencing with Trabedersen (AP 12009) in Pancreatic Cancer Cancer Science. Jun, 2011 | Pubmed ID: 21366804 Sec62 Protein Level is Crucial for the ER Stress Tolerance of Prostate Cancer The Prostate. Jan, 2011 | Pubmed ID: 21229553 Interaction of Calmodulin with Sec61α Limits Ca2+ Leakage from the Endoplasmic Reticulum The EMBO Journal. Jan, 2011 | Pubmed ID: 21102557 Activating Transcription Factor-3 (ATF3) Functions As a Tumor Suppressor in Colon Cancer and is Up-regulated Upon Heat-shock Protein 90 (Hsp90) Inhibition BMC Cancer. 2010 | Pubmed ID: 21129190 Implication of RICTOR in the MTOR Inhibitor-mediated Induction of Insulin-like Growth Factor-I Receptor (IGF-IR) and Human Epidermal Growth Factor Receptor-2 (Her2) Expression in Gastrointestinal Cancer Cells Biochimica Et Biophysica Acta. Apr, 2010 | Pubmed ID: 20116405 Effect of Heat-shock Protein-90 (HSP90) Inhibition on Human Hepatocytes and on Liver Regeneration in Experimental Models Surgery. May, 2010 | Pubmed ID: 20015528 Results of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis from Colorectal Cancer Journal of Surgical Oncology. Sep, 2009 | Pubmed ID: 19697436 Up-regulation of Krüppel-like Factor 5 in Pancreatic Cancer is Promoted by Interleukin-1beta Signaling and Hypoxia-inducible Factor-1alpha Molecular Cancer Research : MCR. Aug, 2009 | Pubmed ID: 19671674 Lanthanum Ions Inhibit the Mammalian Sec61 Complex in Its Channel Dynamics and Protein Transport Activity FEBS Letters. Jul, 2009 | Pubmed ID: 19555690 Heat-shock Protein 90 (Hsp90) As a Molecular Target for Therapy of Gastrointestinal Cancer Anticancer Research. Jun, 2009 | Pubmed ID: 19528462 Targeting Heat-shock Protein 90 Improves Efficacy of Rapamycin in a Model of Hepatocellular Carcinoma in Mice Hepatology (Baltimore, Md.). Feb, 2009 | Pubmed ID: 19085954 Dual Targeting of Raf and VEGF Receptor 2 Reduces Growth and Metastasis of Pancreatic Cancer Through Direct Effects on Tumor Cells, Endothelial Cells, and Pericytes Molecular Cancer Therapeutics. Nov, 2008 | Pubmed ID: 19001434 ENMD-1198, a Novel Tubulin-binding Agent Reduces HIF-1alpha and STAT3 Activity in Human Hepatocellular Carcinoma(HCC) Cells, and Inhibits Growth and Vascularization in Vivo BMC Cancer. 2008 | Pubmed ID: 18651980 Inhibition of Insulin-like Growth Factor-I Receptor (IGF-IR) Using NVP-AEW541, a Small Molecule Kinase Inhibitor, Reduces Orthotopic Pancreatic Cancer Growth and Angiogenesis European Journal of Cancer (Oxford, England : 1990). Jul, 2008 | Pubmed ID: 18445520 Dual Inhibition of Raf and VEGFR2 Reduces Growth and Vascularization of Hepatocellular Carcinoma in an Experimental Model Langenbeck's Archives of Surgery / Deutsche Gesellschaft Für Chirurgie. May, 2008 | Pubmed ID: 18297306 Blocking Heat Shock Protein-90 Inhibits the Invasive Properties and Hepatic Growth of Human Colon Cancer Cells and Improves the Efficacy of Oxaliplatin in P53-deficient Colon Cancer Tumors in Vivo Molecular Cancer Therapeutics. Nov, 2007 | Pubmed ID: 18025273 Targeting Heat Shock Protein 90 in Pancreatic Cancer Impairs Insulin-like Growth Factor-I Receptor Signaling, Disrupts an Interleukin-6/signal-transducer and Activator of Transcription 3/hypoxia-inducible Factor-1alpha Autocrine Loop, and Reduces Orthotopic Tumor Growth Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2007 | Pubmed ID: 17975158 The Direct Effects of Anti-vascular Endothelial Growth Factor Therapy on Tumor Cells Clinical Colorectal Cancer. Jul, 2007 | Pubmed ID: 17681102 Inhibition of Heat Shock Protein 90 Impairs Epidermal Growth Factor-mediated Signaling in Gastric Cancer Cells and Reduces Tumor Growth and Vascularization in Vivo Molecular Cancer Therapeutics. Mar, 2007 | Pubmed ID: 17363505 Mycophenolate Mofetil Inhibits Tumor Growth and Angiogenesis in Vitro but Has Variable Antitumor Effects in Vivo, Possibly Related to Bioavailability Transplantation. Mar, 2007 | Pubmed ID: 17353782 Mammalian Target of Rapamycin is Activated in Human Gastric Cancer and Serves As a Target for Therapy in an Experimental Model International Journal of Cancer. Journal International Du Cancer. Apr, 2007 | Pubmed ID: 17230506 Sirolimus Promotes Tolerance for Donor and Recipient Antigens After MHC Class II Disparate Bone Marrow Transplantation in Rats Experimental Hematology. Jan, 2007 | Pubmed ID: 17198885 No Contribution of Multipotent Mesenchymal Stromal Cells to Liver Regeneration in a Rat Model of Prolonged Hepatic Injury Stem Cells (Dayton, Ohio). Mar, 2007 | Pubmed ID: 17110617 CDKN2A Germline Mutations in Familial Pancreatic Cancer Annals of Surgery. Dec, 2002 | Pubmed ID: 12454511 P16INK4a is a Prognostic Marker in Resected Ductal Pancreatic Cancer: an Analysis of P16INK4a, P53, MDM2, an Rb Annals of Surgery. Jan, 2002 | Pubmed ID: 11753042 Imagens ao vivo de cálcio celular Combinado com siRNA silenciamento gênico mediado Identifica Ca 2 + Canais de vazamento na membrana ER e seus mecanismos de regulação Sven Lang*1, Nico Schäuble*1, Adolfo Cavalié2, Richard Zimmermann1 1Medical Biochemistry and Molecular Biology, Saarland University, 2Experimental and Clinical Pharmacology and Toxicology, Saarland University JoVE 2730 Biology
Imagens ao vivo de cálcio celular Combinado com siRNA silenciamento gênico mediado Identifica Ca 2 + Canais de vazamento na membrana ER e seus mecanismos de regulação Sven Lang*1, Nico Schäuble*1, Adolfo Cavalié2, Richard Zimmermann1 1Medical Biochemistry and Molecular Biology, Saarland University, 2Experimental and Clinical Pharmacology and Toxicology, Saarland University JoVE 2730 Biology