Takahide Nagase Department of Respiratory Medicine The University of Tokyo Hospital Biography Publications Institution JoVE Articles Takahide Nagase has not added a biography. If you are Takahide Nagase and would like to personalize this page please email our Author Liaison for assistance. Publications TIM-3 is Not Essential for Development of Airway Inflammation Induced by House Dust Mite Antigens Allergology International : Official Journal of the Japanese Society of Allergology. May, 2016 | Pubmed ID: 27209052 A Case of Meigs' Syndrome with Preceding Pericardial Effusion in Advance of Pleural Effusion BMC Pulmonary Medicine. 2016 | Pubmed ID: 27160723 Fibroblast VEGF-receptor 1 Expression As Molecular Target in Periodontitis Journal of Clinical Periodontology. Feb, 2016 | Pubmed ID: 26932322 Nonspecific Elevation of Serum Aspergillus Galactomannan Antigen Levels in Patients with Rheumatoid Arthritis Respiratory Investigation. Jan, 2016 | Pubmed ID: 26718144 The Chimeric Transcript RUNX1-GLRX5: a Biomarker for Good Postoperative Prognosis in Stage IA Non-small-cell Lung Cancer Japanese Journal of Clinical Oncology. Feb, 2016 | Pubmed ID: 26685324 Interleukin-17A and Toll-Like Receptor 3 Ligand Poly(I:C) Synergistically Induced Neutrophil Chemoattractant Production by Bronchial Epithelial Cells PloS One. 2015 | Pubmed ID: 26505478 Hippo and TGF-β Interplay in the Lung Field American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2015 | Pubmed ID: 26320155 Histone Methylation-mediated Silencing of MiR-139 Enhances Invasion of Non-small-cell Lung Cancer Cancer Medicine. Oct, 2015 | Pubmed ID: 26256448 Comparison of Clinical Characteristics and Outcomes Between Aspiration Pneumonia and Community-acquired Pneumonia in Patients with Chronic Obstructive Pulmonary Disease BMC Pulmonary Medicine. 2015 | Pubmed ID: 26152178 Oncogenic Activity of BIRC2 and BIRC3 Mutants Independent of Nuclear Factor-κB-activating Potential Cancer Science. Sep, 2015 | Pubmed ID: 26094954 Pulmonary Metastasis of Combined Hepatocellular and Cholangiocarcinoma: A Unique Radiographic Presentation with Air-space Consolidation Masquerading As Pneumonia and Primary Pulmonary Adenocarcinoma Internal Medicine (Tokyo, Japan). 2015 | Pubmed ID: 26027993 Role of α1 and α2 Chains of Type IV Collagen in Early Fibrotic Lesions of Idiopathic Interstitial Pneumonias and Migration of Lung Fibroblasts Laboratory Investigation; a Journal of Technical Methods and Pathology. Aug, 2015 | Pubmed ID: 26006016 Comparison of In-hospital Mortality in Patients with COPD, Asthma and Asthma-COPD Overlap Exacerbations Respirology (Carlton, Vic.). Aug, 2015 | Pubmed ID: 25998444 Ovary-dependent Emphysema Augmentation and Osteopontin Induction in Adult Female Mice Biochemical and Biophysical Research Communications. Jun, 2015 | Pubmed ID: 25912141 Oncogenic TPM3-ALK Activation Requires Dimerization Through the Coiled-coil Structure of TPM3 Biochemical and Biophysical Research Communications. Feb, 2015 | Pubmed ID: 25596129 Clinical Features of 280 Hospitalized Patients with Lymphangioleiomyomatosis in Japan Respirology (Carlton, Vic.). Jan, 2015 | Pubmed ID: 25385157 Paradoxical Association Between Body Mass Index and In-hospital Mortality in Elderly Patients with Chronic Obstructive Pulmonary Disease in Japan International Journal of Chronic Obstructive Pulmonary Disease. 2014 | Pubmed ID: 25525351 Lymphotoxin β Receptor Signaling Induces IL-8 Production in Human Bronchial Epithelial Cells PloS One. 2014 | Pubmed ID: 25501580 Factors Affecting Mortality Following Emergency Admission for Chronic Obstructive Pulmonary Disease BMC Pulmonary Medicine. 2014 | Pubmed ID: 25253449 Differential Knockdown of TGF-β Ligands in a Three-dimensional Co-culture Tumor- Stromal Interaction Model of Lung Cancer BMC Cancer. 2014 | Pubmed ID: 25107280 Alternative Polyadenylation is Associated with Lower Expression of PABPN1 and Poor Prognosis in Non-small Cell Lung Cancer Cancer Science. Sep, 2014 | Pubmed ID: 24975429 Novel Swine Model of Transfusion-related Acute Lung Injury Transfusion. Dec, 2014 | Pubmed ID: 24965098 An Integrative Analysis of the Tumorigenic Role of TAZ in Human Non-small Cell Lung Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2014 | Pubmed ID: 24951773 Selective Inhibitors of a PAF Biosynthetic Enzyme Lysophosphatidylcholine Acyltransferase 2 Journal of Lipid Research. Jul, 2014 | Pubmed ID: 24850807 Histamine Induces Human Lung Fibroblast-mediated Collagen Gel Contraction Via Histamine H1 Receptor Experimental Lung Research. Jun, 2014 | Pubmed ID: 24809793 Successful Treatment of Mediastinal Unicentric Castleman's Disease Using Video-Assisted Thoracoscopic Surgery with Preoperative Embolization Case Reports in Medicine. 2013 | Pubmed ID: 24198836 Detection of Novel Paraja Ring Finger 2-fer Tyrosine Kinase MRNA Chimeras is Associated with Poor Postoperative Prognosis in Non-small Cell Lung Cancer Cancer Science. Nov, 2013 | Pubmed ID: 23931849 Effect of Secreted Lymphocyte Antigen-6/urokinase-type Plasminogen Activator Receptor-related Peptide-1 (SLURP-1) on Airway Epithelial Cells Biochemical and Biophysical Research Communications. Aug, 2013 | Pubmed ID: 23876317 [Respiratory Failure] Nihon Rinsho. Japanese Journal of Clinical Medicine. Jun, 2013 | Pubmed ID: 23855209 Infectious Mediastinal Lymphadenopathy After Repeated Transbronchial Needle Aspiration BMJ Case Reports. 2013 | Pubmed ID: 23723103 FER Overexpression is Associated with Poor Postoperative Prognosis and Cancer-cell Survival in Non-small Cell Lung Cancer International Journal of Clinical and Experimental Pathology. 2013 | Pubmed ID: 23573306 An Integrated Expression Profiling Reveals Target Genes of TGF-β and TNF-α Possibly Mediated by MicroRNAs in Lung Cancer Cells PloS One. 2013 | Pubmed ID: 23437179 Differential Effects of a Common Splice Site Polymorphism on the Generation of OAS1 Variants in Human Bronchial Epithelial Cells Human Immunology. Mar, 2013 | Pubmed ID: 23220500 MxA Transcripts with Distinct First Exons and Modulation of Gene Expression Levels by Single-nucleotide Polymorphisms in Human Bronchial Epithelial Cells Immunogenetics. Feb, 2013 | Pubmed ID: 23160781 [Management of Chronic Obstructive Pulmonary Disease in the Elderly] Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. 2012 | Pubmed ID: 23459645 Tumor Necrosis Factor Superfamily Member LIGHT Induces Epithelial-mesenchymal Transition in A549 Human Alveolar Epithelial Cells Biochemical and Biophysical Research Communications. Nov, 2012 | Pubmed ID: 23131560 Characterization of Human Lung Cancer-associated Fibroblasts in Three-dimensional in Vitro Co-culture Model Biochemical and Biophysical Research Communications. Jun, 2012 | Pubmed ID: 22634307 Dynamic Change in Respiratory Resistance During Inspiratory and Expiratory Phases of Tidal Breathing in Patients with Chronic Obstructive Pulmonary Disease International Journal of Chronic Obstructive Pulmonary Disease. 2012 | Pubmed ID: 22589578 Suppressive Effects of a Pyrazole Derivative of Curcumin on Airway Inflammation and Remodeling Experimental and Molecular Pathology. Aug, 2012 | Pubmed ID: 22542791 The Role of CCR7 in Allergic Airway Inflammation Induced by House Dust Mite Exposure Cellular Immunology. Jan-Feb, 2012 | Pubmed ID: 22521241 Oncology Information on the Internet Japanese Journal of Clinical Oncology. May, 2012 | Pubmed ID: 22457324 Pulmonary Venous Invasion, Determined by Chest Computed Tomographic Scan, As a Potential Early Indicator of Zygomycosis Infection: a Case Series Journal of Thoracic Imaging. Jul, 2012 | Pubmed ID: 21912300 Genome Structure-based Screening Identified Epigenetically Silenced MicroRNA Associated with Invasiveness in Non-small-cell Lung Cancer International Journal of Cancer. Jun, 2012 | Pubmed ID: 21702040 [Respiratory Diseases in the Elderly] Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. 2011 | Pubmed ID: 22323022 [Pathophysiology of Peripheral Airway Obstruction Underlying COPD] Nihon Rinsho. Japanese Journal of Clinical Medicine. Oct, 2011 | Pubmed ID: 22073561 CpG Island Methylation of MicroRNAs is Associated with Tumor Size and Recurrence of Non-small-cell Lung Cancer Cancer Science. Dec, 2011 | Pubmed ID: 21917081 Pulmonary Features Associated with Being Underweight in Older Men Journal of the American Geriatrics Society. Aug, 2011 | Pubmed ID: 21848827 Polymerase Reaction Without Primers Throughout for the Reconstruction of Full-length CDNA from Products of Rapid Amplification of CDNA Ends (RACE) Biotechnology Letters. Jul, 2011 | Pubmed ID: 21384194 Suppression of Transforming Growth Factor β1 in Lung Alveolar Epithelium-derived Cells Using Adeno-associated Virus Type 2/5 Vectors to Carry Short Hairpin RNA Experimental Lung Research. Apr, 2011 | Pubmed ID: 21269064 Simultaneous Stimulation with TGF-β1 and TNF-α Induces Epithelial Mesenchymal Transition in Bronchial Epithelial Cells International Archives of Allergy and Immunology. 2011 | Pubmed ID: 21196756 [Case of Sarcoidosis with Squamous Cell Carcinoma Which Originated from Solitary Bronchial Papilloma] Nihon Kokyūki Gakkai Zasshi = the Journal of the Japanese Respiratory Society. Nov, 2010 | Pubmed ID: 21141059 Treatment of PCR Products with Exonuclease I and Heat-labile Alkaline Phosphatase Improves the Visibility of Combined Bisulfite Restriction Analysis Biochemical and Biophysical Research Communications. Aug, 2010 | Pubmed ID: 20674551 Down-regulation of Secreted Lymphocyte Antigen-6/urokinase-type Plasminogen Activator Receptor-related Peptide-1 (SLURP-1), an Endogenous Allosteric Alpha7 Nicotinic Acetylcholine Receptor Modulator, in Murine and Human Asthmatic Conditions Biochemical and Biophysical Research Communications. Aug, 2010 | Pubmed ID: 20621062 [Clinical and Radiological Features of Tuberculous Pneumonia in Patients with Emphysema] Kekkaku : [Tuberculosis]. May, 2010 | Pubmed ID: 20560400 Tumor Necrosis Factor-alpha Enhances Both Epithelial-mesenchymal Transition and Cell Contraction Induced in A549 Human Alveolar Epithelial Cells by Transforming Growth Factor-beta1 Experimental Lung Research. Feb, 2010 | Pubmed ID: 20128678 Amino Acid Residues Critical for Endoplasmic Reticulum Export and Trafficking of Platelet-activating Factor Receptor The Journal of Biological Chemistry. Feb, 2010 | Pubmed ID: 20007715 Histamine Stimulates Human Lung Fibroblast Migration Molecular and Cellular Biochemistry. Apr, 2010 | Pubmed ID: 19851834 Identification of G0S2 As a Gene Frequently Methylated in Squamous Lung Cancer by Combination of in Silico and Experimental Approaches International Journal of Cancer. Apr, 2010 | Pubmed ID: 19816938 [The Effects of Macrolides (EM900, Clarithromycin and Azithromycin) on IL-17-induced IL-8 Production by Airway Epithelial Cells] The Japanese Journal of Antibiotics. Mar, 2009 | Pubmed ID: 22452048 Impact of DNA Demethylation of the G0S2 Gene on the Transcription of G0S2 in Squamous Lung Cancer Cell Lines with or Without Nuclear Receptor Agonists Biochemical and Biophysical Research Communications. Dec, 2009 | Pubmed ID: 19878646 Procaterol Inhibits Lung Fibroblast Migration Inflammation. Dec, 2009 | Pubmed ID: 19728063 Transcriptional Coactivator with PDZ-binding Motif is Essential for Normal Alveolarization in Mice American Journal of Respiratory and Critical Care Medicine. Aug, 2009 | Pubmed ID: 19498055 Thyroid Transcription Factor-1 Inhibits Transforming Growth Factor-beta-mediated Epithelial-to-mesenchymal Transition in Lung Adenocarcinoma Cells Cancer Research. Apr, 2009 | Pubmed ID: 19293183 C-reactive Protein Modulates Human Lung Fibroblast Migration Experimental Lung Research. Feb, 2009 | Pubmed ID: 19191104 Hyperoxia Exaggerates Bacterial Dissemination and Lethality in Pseudomonas Aeruginosa Pneumonia Pulmonary Pharmacology & Therapeutics. Aug, 2009 | Pubmed ID: 19162211 [Chronic Obstructive Pulmonary Disease (COPD)] Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. Sep, 2008 | Pubmed ID: 19057095 Clarithromycin Inhibits Fibroblast Migration Respiratory Medicine. Dec, 2008 | Pubmed ID: 18701271 Sequential and Quantitative Analysis of a Murine Model of Elastase-induced Emphysema Biological & Pharmaceutical Bulletin. Jul, 2008 | Pubmed ID: 18591788 Effect of Dexamethasone on Voltage-gated Na+ Channel in Cultured Human Bronchial Smooth Muscle Cells Life Sciences. Jun, 2008 | Pubmed ID: 18485418 Non-infectious Bronchiolitis As an Early Pulmonary Complication of Hematopoietic Stem Cell Transplantation Internal Medicine (Tokyo, Japan). 2008 | Pubmed ID: 18176008 Multiple Renal Cysts, Urinary Concentration Defects, and Pulmonary Emphysematous Changes in Mice Lacking TAZ American Journal of Physiology. Renal Physiology. Mar, 2008 | Pubmed ID: 18172001 [Clinical Management of the Aged Patients with COPD] Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. Sep, 2007 | Pubmed ID: 18049002 Calcitonin Gene-related Peptide Mediates Acid-induced Lung Injury in Mice Respirology (Carlton, Vic.). Nov, 2007 | Pubmed ID: 17986107 A Template for Informed Consent Forms in Medical Examination and Treatment: an Intervention Study Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. Aug, 2007 | Pubmed ID: 17660733 Prevention of Postextubation Laryngeal Oedema Lancet (London, England). Jul, 2007 | Pubmed ID: 17617262 The Induction of H3K9 Methylation by PIWIL4 at the P16Ink4a Locus Biochemical and Biophysical Research Communications. Aug, 2007 | Pubmed ID: 17544373 Adrenomedullin Insufficiency Increases Allergen-induced Airway Hyperresponsiveness in Mice Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2007 | Pubmed ID: 17332272 Beta-defensin Overexpression Induces Progressive Muscle Degeneration in Mice American Journal of Physiology. Cell Physiology. Jun, 2007 | Pubmed ID: 17215327 [How to Activate Clinical Management of the Aged Patients Using COPD Guidelines?] Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. Sep, 2006 | Pubmed ID: 17073287 [Respiratory Disorders in the Aged: in the Present and Future] Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. Sep, 2005 | Pubmed ID: 16248412 Betaine Improved Restriction Digestion Biochemical and Biophysical Research Communications. Dec, 2005 | Pubmed ID: 16216219 Absence of Leukotriene B4 Receptor 1 Confers Resistance to Airway Hyperresponsiveness and Th2-type Immune Responses Journal of Immunology (Baltimore, Md. : 1950). Oct, 2005 | Pubmed ID: 16177061 Leukotriene D4 Potentiates Fibronectin-induced Migration of Human Lung Fibroblasts Clinical Immunology (Orlando, Fla.). Nov, 2005 | Pubmed ID: 16109507 Acute and Chronic Effects of Eicosapentaenoic Acid on Voltage-gated Sodium Channel Expressed in Cultured Human Bronchial Smooth Muscle Cells Biochemical and Biophysical Research Communications. Jun, 2005 | Pubmed ID: 15883037 [Recent Progress in Leukotriene Research] Arerugī = [Allergy]. Dec, 2004 | Pubmed ID: 15799303 [Lipid Mediators and Pulmonary Diseases] Nihon Naika Gakkai Zasshi. The Journal of the Japanese Society of Internal Medicine. Jun, 2004 | Pubmed ID: 15227836 Voltage-gated Sodium Channel Expressed in Cultured Human Smooth Muscle Cells: Involvement of SCN9A FEBS Letters. Jun, 2004 | Pubmed ID: 15178348 Platelet-activating Factor Receptor Develops Airway Hyperresponsiveness Independently of Airway Inflammation in a Murine Asthma Model Journal of Immunology (Baltimore, Md. : 1950). Jun, 2004 | Pubmed ID: 15153532 New Therapeutic Key for Cystic Fibrosis: a Role for Lipoxins Nature Immunology. Apr, 2004 | Pubmed ID: 15052263 A Potent Inhibitor of Cytosolic Phospholipase A2, Arachidonyl Trifluoromethyl Ketone, Attenuates LPS-induced Lung Injury in Mice American Journal of Physiology. Lung Cellular and Molecular Physiology. May, 2003 | Pubmed ID: 12505870 Effects of Obstructive Sleep Apnea on Circulating ICAM-1, IL-8, and MCP-1 Journal of Applied Physiology (Bethesda, Md. : 1985). Jan, 2003 | Pubmed ID: 12391099 Platelet-activating Factor Receptor Prostaglandins & Other Lipid Mediators. Aug, 2002 | Pubmed ID: 12432946 Molecular Mechanisms Underlying Human Beta-defensin-2 Gene Expression in a Human Airway Cell Line (LC2/ad) Respirology (Carlton, Vic.). Dec, 2002 | Pubmed ID: 12421237 Attenuation of Antigen-induced Airway Hyperresponsiveness in CGRP-deficient Mice American Journal of Physiology. Lung Cellular and Molecular Physiology. Nov, 2002 | Pubmed ID: 12376349 Identification of Multiple Novel Epididymis-specific Beta-defensin Isoforms in Humans and Mice Journal of Immunology (Baltimore, Md. : 1950). Sep, 2002 | Pubmed ID: 12193721 A Pivotal Role of Cytosolic Phospholipase A(2) in Bleomycin-induced Pulmonary Fibrosis Nature Medicine. May, 2002 | Pubmed ID: 11984592 Airway Hyperresponsiveness in Transgenic Mice Overexpressing Platelet Activating Factor Receptor is Mediated by an Atropine-sensitive Pathway American Journal of Respiratory and Critical Care Medicine. Jan, 2002 | Pubmed ID: 11790655 Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition Yu Mikami1,2, Hirotaka Matsuzaki2, Hideyuki Takeshima2, Kosuke Makita2, Yasuhiro Yamauchi2, Takahide Nagase2 1Department of Clinical Laboratory, The University of Tokyo Hospital, 2Department of Respiratory Medicine, The University of Tokyo Hospital JoVE 53974 Developmental Biology Three-dimensional Co-culture Model for Tumor-stromal Interaction Masafumi Horie1,2, Akira Saito1,3, Yoko Yamaguchi4, Mitsuhiro Ohshima5, Takahide Nagase1 1Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, 2Department of Clinical Laboratory, Graduate School of Medicine, The University of Tokyo, 3Division for Health Service Promotion, The University of Tokyo, 4Department of Biochemistry, Nihon University School of Dentistry, 5Department of Biochemistry, Ohu University School of Pharmaceutical Sciences JoVE 52469 Medicine
Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition Yu Mikami1,2, Hirotaka Matsuzaki2, Hideyuki Takeshima2, Kosuke Makita2, Yasuhiro Yamauchi2, Takahide Nagase2 1Department of Clinical Laboratory, The University of Tokyo Hospital, 2Department of Respiratory Medicine, The University of Tokyo Hospital JoVE 53974 Developmental Biology
Three-dimensional Co-culture Model for Tumor-stromal Interaction Masafumi Horie1,2, Akira Saito1,3, Yoko Yamaguchi4, Mitsuhiro Ohshima5, Takahide Nagase1 1Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, 2Department of Clinical Laboratory, Graduate School of Medicine, The University of Tokyo, 3Division for Health Service Promotion, The University of Tokyo, 4Department of Biochemistry, Nihon University School of Dentistry, 5Department of Biochemistry, Ohu University School of Pharmaceutical Sciences JoVE 52469 Medicine
