Terrance G. Johns

Publications

• Phosphorylation of Dedicator of Cytokinesis 1 (Dock180) at Tyrosine Residue Y722 by Src Family Kinases Mediates EGFRvIII-driven Glioblastoma Tumorigenesis
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012  |   Pubmed ID: 22323579
• Activation of Src Induces Mitochondrial Localisation of De2-7EGFR (EGFRvIII) in Glioma Cells: Implications for Glucose Metabolism
  Journal of Cell Science. Sep, 2011  |   Pubmed ID: 21878501
• Tumor Heterogeneity is an Active Process Maintained by a Mutant EGFR-induced Cytokine Circuit in Glioblastoma
  Genes & Development. Aug, 2010  |   Pubmed ID: 20713517
• MAb 806 Enhances the Efficacy of Ionizing Radiation in Glioma Xenografts Expressing the De2-7 Epidermal Growth Factor Receptor
  International Journal of Radiation Oncology, Biology, Physics. Oct, 2010  |   Pubmed ID: 20638193
• Immuno-PET Quantitation of De2-7 Epidermal Growth Factor Receptor Expression in Glioma Using 124I-IMP-R4-labeled Antibody Ch806
  Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jun, 2010  |   Pubmed ID: 20484439
• Fyn and SRC Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients
  Cancer Research. Sep, 2009  |   Pubmed ID: 19690143
• Targeting a Unique EGFR Epitope with Monoclonal Antibody 806 Activates NF-kappaB and Initiates Tumour Vascular Normalization
  Journal of Cellular and Molecular Medicine. Sep, 2009  |   Pubmed ID: 19432811
• The Plasticity of Oncogene Addiction: Implications for Targeted Therapies Directed to Receptor Tyrosine Kinases
  Neoplasia (New York, N.Y.). May, 2009  |   Pubmed ID: 19412429
• A Truncated Soluble Epidermal Growth Factor Receptor-Fc Fusion Ligand Trap Displays Anti-tumour Activity in Vivo
  Growth Factors (Chur, Switzerland). Jun, 2009  |   Pubmed ID: 19333814
• Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009  |   Pubmed ID: 19289842
• Heparin-binding Epidermal Growth Factor-like Growth Factor Signaling in Flow-induced Arterial Remodeling
  Circulation Research. May, 2008  |   Pubmed ID: 18436796
• Internalization, Intracellular Trafficking, and Biodistribution of Monoclonal Antibody 806: a Novel Anti-epidermal Growth Factor Receptor Antibody
  Neoplasia (New York, N.Y.). Dec, 2007  |   Pubmed ID: 18084617
• Unligated Epidermal Growth Factor Receptor Forms Higher Order Oligomers Within Microclusters on A431 Cells That Are Sensitive to Tyrosine Kinase Inhibitor Binding
  Biochemistry. Apr, 2007  |   Pubmed ID: 17381163
• The Efficacy of Epidermal Growth Factor Receptor-specific Antibodies Against Glioma Xenografts is Influenced by Receptor Levels, Activation Status, and Heterodimerization
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2007  |   Pubmed ID: 17363548
• A Phase I Clinical Trial with Monoclonal Antibody Ch806 Targeting Transitional State and Mutant Epidermal Growth Factor Receptors
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2007  |   Pubmed ID: 17360479
• The Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor AG1478 Increases the Formation of Inactive Untethered EGFR Dimers. Implications for Combination Therapy with Monoclonal Antibody 806
  The Journal of Biological Chemistry. Feb, 2007  |   Pubmed ID: 17092939
• Epidermal Growth Factor Receptor Activation: an Upstream Signal for Transition of Quiescent Astrocytes into Reactive Astrocytes After Neural Injury
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2006  |   Pubmed ID: 16837601
• An Automated Peptide and Protein Thiazolidine Coupling Chemistry for Biosensor Immobilization Giving a Unique N-terminal Orientation
  Analytical Biochemistry. Jan, 2006  |   Pubmed ID: 16310754
• Functional Effects of Glycosylation at Asn-579 of the Epidermal Growth Factor Receptor
  Biochemistry. Nov, 2005  |   Pubmed ID: 16274239
• Enhanced Efficacy of Radioimmunotherapy with 90Y-CHX-A''-DTPA-hu3S193 by Inhibition of Epidermal Growth Factor Receptor (EGFR) Signaling with EGFR Tyrosine Kinase Inhibitor AG1478
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2005  |   Pubmed ID: 16203806
• Treatment of Human Tumor Xenografts with Monoclonal Antibody 806 in Combination with a Prototypical Epidermal Growth Factor Receptor-specific Antibody Generates Enhanced Antitumor Activity
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2005  |   Pubmed ID: 16144944
• The Antitumor Monoclonal Antibody 806 Recognizes a High-mannose Form of the EGF Receptor That Reaches the Cell Surface when Cells Over-express the Receptor
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2005  |   Pubmed ID: 15774576
• Immunological Effects of Chimeric Anti-GD3 Monoclonal Antibody KM871 in Patients with Metastatic Melanoma
  Cancer Immunity : a Journal of the Academy of Cancer Immunology. Feb, 2005  |   Pubmed ID: 15723450
• The Tumor-specific De2-7 Epidermal Growth Factor Receptor (EGFR) Promotes Cells Survival and Heterodimerizes with the Wild-type EGFR
  Oncogene. Aug, 2004  |   Pubmed ID: 15221011
• Identification of the Epitope for the Epidermal Growth Factor Receptor-specific Monoclonal Antibody 806 Reveals That It Preferentially Recognizes an Untethered Form of the Receptor
  The Journal of Biological Chemistry. Jul, 2004  |   Pubmed ID: 15075331
• CR1/CR2 Interactions Modulate the Functions of the Cell Surface Epidermal Growth Factor Receptor
  The Journal of Biological Chemistry. May, 2004  |   Pubmed ID: 15016810
• Antitumor Efficacy of Cytotoxic Drugs and the Monoclonal Antibody 806 is Enhanced by the EGF Receptor Inhibitor AG1478
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2003  |   Pubmed ID: 14676326
• Generation of Anti-idiotype Antibodies for Application in Clinical Immunotherapy Laboratory Analyses
  Hybridoma and Hybridomics. Aug, 2003  |   Pubmed ID: 14511567
• The Crystal Structure of Myelin Oligodendrocyte Glycoprotein, a Key Autoantigen in Multiple Sclerosis
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2003  |   Pubmed ID: 12960396
• Novel Monoclonal Antibody Specific for the De2-7 Epidermal Growth Factor Receptor (EGFR) That Also Recognizes the EGFR Expressed in Cells Containing Amplification of the EGFR Gene
  International Journal of Cancer. Journal International Du Cancer. Mar, 2002  |   Pubmed ID: 11920591