Thomas A. Waldmann Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute National Institutes of Health Biography Publications Institution JoVE Articles Thomas A. Waldmann has not added a biography. If you are Thomas A. Waldmann and would like to personalize this page please email our Author Liaison for assistance. Publications IL-15 in the Combination Immunotherapy of Cancer Frontiers in Immunology. 2020 | Pubmed ID: 32508818 Bench-to-bedside Translation of Interleukin-15 for Immunotherapy: Principles and Challenges Expert Opinion on Drug Delivery. May, 2020 | Pubmed ID: 32357804 Y-Daclizumab (Anti-CD25), High-Dose Carmustine, Etoposide, Cytarabine, and Melphalan Chemotherapy and Autologous Hematopoietic Stem Cell Transplant Yielded Sustained Complete Remissions in 4 Patients with Recurrent Hodgkin's Lymphoma Cancer Biotherapy & Radiopharmaceuticals. May, 2020 | Pubmed ID: 32275165 NK Cells Prevent T Cell Lymphoma Development in T Cell Receptor-transgenic Mice Cellular Immunology. Jun, 2020 | Pubmed ID: 32143838 -endocytosis of Intact IL-15Rα-IL-15 Complex from Presenting Cells into NK Cells Favors Signaling for Proliferation Proceedings of the National Academy of Sciences of the United States of America. 01, 2020 | Pubmed ID: 31871169 Interleukin-15 (dys)regulation of Lymphoid Homeostasis: Implications for Therapy of Autoimmunity and Cancer The Journal of Experimental Medicine. Jan, 2020 | Pubmed ID: 31821442 Results From a First-in-Human Study of BNZ-1, a Selective Multicytokine Inhibitor Targeting Members of the Common Gamma (γc) Family of Cytokines Journal of Clinical Pharmacology. Feb, 2020 | Pubmed ID: 31465127 Rapid Progression of Adult T-cell Leukemia/lymphoma As Tumor-infiltrating Tregs After PD-1 Blockade Blood. 10, 2019 | Pubmed ID: 31467059 Clinical Trial of a Humanized Anti-IL-2/IL-15 Receptor β Chain in HAM/TSP Annals of Clinical and Translational Neurology. 08, 2019 | Pubmed ID: 31402625 First-in-human Trial of RhIL-15 and Haploidentical Natural Killer Cell Therapy for Advanced Acute Myeloid Leukemia Blood Advances. 07, 2019 | Pubmed ID: 31266741 IL15 by Continuous Intravenous Infusion to Adult Patients with Solid Tumors in a Phase I Trial Induced Dramatic NK-Cell Subset Expansion Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 08, 2019 | Pubmed ID: 31142503 Alternative and Canonical NF-kB Pathways DNA-binding Hierarchies Networks Define Hodgkin Lymphoma and Non-Hodgkin Diffuse Large B Cell Lymphoma Respectively Journal of Cancer Research and Clinical Oncology. Jun, 2019 | Pubmed ID: 30941572 IL-2 and IL-15 Blockade by BNZ-1, an Inhibitor of Selective γ-chain Cytokines, Decreases Leukemic T-cell Viability Leukemia. 05, 2019 | Pubmed ID: 30353031 Minimum Degree of Overlap Between IL-9R and IL-2R on Human T Lymphoma Cells: A Quantitative CLSM and FRET Analysis Cytometry. Part A : the Journal of the International Society for Analytical Cytology. 11, 2018 | Pubmed ID: 30378727 IL-15 Enhanced Antibody-dependent Cellular Cytotoxicity Mediated by NK Cells and Macrophages Proceedings of the National Academy of Sciences of the United States of America. 11, 2018 | Pubmed ID: 30373815 Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma Cancer Cell. 08, 2018 | Pubmed ID: 30057145 Protection by Universal Influenza Vaccine is Mediated by Memory CD4 T Cells Vaccine. 07, 2018 | Pubmed ID: 29887326 Rapid Progression of Adult T-Cell Leukemia-Lymphoma After PD-1 Inhibitor Therapy The New England Journal of Medicine. May, 2018 | Pubmed ID: 29768155 Membrane Potential Distinctly Modulates Mobility and Signaling of IL-2 and IL-15 Receptors in T Cells Biophysical Journal. 05, 2018 | Pubmed ID: 29754714 Gene Regulation and Suppression of Type I Interferon Signaling by STAT3 in Diffuse Large B Cell Lymphoma Proceedings of the National Academy of Sciences of the United States of America. 01, 2018 | Pubmed ID: 29295936 A First-in-Human Phase I Study of Subcutaneous Outpatient Recombinant Human IL15 (rhIL15) in Adults with Advanced Solid Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 04, 2018 | Pubmed ID: 29203590 Cytokines in Cancer Immunotherapy Cold Spring Harbor Perspectives in Biology. 12, 2018 | Pubmed ID: 29101107 Phase I Dose Escalation Study of the Anti-CD2 Monoclonal Antibody, Siplizumab, with DA-EPOCH-R in Aggressive Peripheral T-cell Lymphomas Leukemia & Lymphoma. 06, 2018 | Pubmed ID: 29032710 JAK/STAT Pathway Directed Therapy of T-cell Leukemia/lymphoma: Inspired by Functional and Structural Genomics Molecular and Cellular Endocrinology. 08, 2017 | Pubmed ID: 28214593 Disorders of the JAK/STAT Pathway in T Cell Lymphoma Pathogenesis: Implications for Immunotherapy Annual Review of Immunology. 04, 2017 | Pubmed ID: 28182501 Phase II Study of Alemtuzumab (CAMPATH-1) in Patients with HTLV-1-Associated Adult T-cell Leukemia/lymphoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2017 | Pubmed ID: 27486175 MHC I Expression Regulates Co-clustering and Mobility of Interleukin-2 and -15 Receptors in T Cells Biophysical Journal. Jul, 2016 | Pubmed ID: 27410738 Regulation of Normal B-cell Differentiation and Malignant B-cell Survival by OCT2 Proceedings of the National Academy of Sciences of the United States of America. Apr, 2016 | Pubmed ID: 26993806 Erratum To: 'Mutation of Epigenetic Regulators TET2 and MLL3 in Patients with HTLV-I-induced Acute Adult T-cell Leukemia' Molecular Cancer. Mar, 2016 | Pubmed ID: 26936184 Mutation of Epigenetic Regulators TET2 and MLL3 in Patients with HTLV-I-induced Acute Adult T-cell Leukemia Molecular Cancer. Feb, 2016 | Pubmed ID: 26880370 Augmented Efficacy of Brentuximab Vedotin Combined with Ruxolitinib And/or Navitoclax in a Murine Model of Human Hodgkin's Lymphoma Proceedings of the National Academy of Sciences of the United States of America. Feb, 2016 | Pubmed ID: 26811457 IL15 and T-cell Stemness in T-cell-Based Cancer Immunotherapy Cancer Research. Dec, 2015 | Pubmed ID: 26627006 90Y-daclizumab, an Anti-CD25 Monoclonal Antibody, Provided Responses in 50% of Patients with Relapsed Hodgkin's Lymphoma Proceedings of the National Academy of Sciences of the United States of America. Oct, 2015 | Pubmed ID: 26438866 Selective Targeting of JAK/STAT Signaling is Potentiated by Bcl-xL Blockade in IL-2-dependent Adult T-cell Leukemia Proceedings of the National Academy of Sciences of the United States of America. Oct, 2015 | Pubmed ID: 26396258 IL-21-Driven Neoplasms in SJL Mice Mimic Some Key Features of Human Angioimmunoblastic T-Cell Lymphoma The American Journal of Pathology. Sep, 2015 | Pubmed ID: 26363366 The Shared and Contrasting Roles of IL2 and IL15 in the Life and Death of Normal and Neoplastic Lymphocytes: Implications for Cancer Therapy Cancer Immunology Research. Mar, 2015 | Pubmed ID: 25736261 MiR-155 Augments CD8+ T-cell Antitumor Activity in Lymphoreplete Hosts by Enhancing Responsiveness to Homeostatic γc Cytokines Proceedings of the National Academy of Sciences of the United States of America. Jan, 2015 | Pubmed ID: 25548153 Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-human Clinical Trial of Recombinant Human Interleukin-15 in Patients with Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jan, 2015 | Pubmed ID: 25403209 Gain-of-function CCR4 Mutations in Adult T Cell Leukemia/lymphoma The Journal of Experimental Medicine. Dec, 2014 | Pubmed ID: 25488980 Interleukin-15 in the Treatment of Cancer Expert Review of Clinical Immunology. Dec, 2014 | Pubmed ID: 25359408 Distinct Spatial Relationship of the Interleukin-9 Receptor with Interleukin-2 Receptor and Major Histocompatibility Complex Glycoproteins in Human T Lymphoma Cells Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. Dec, 2014 | Pubmed ID: 25297818 Safety, Efficacy, and Pharmacokinetics/pharmacodynamics of Daclizumab (anti-CD25) in Patients with Adult T-cell Leukemia/lymphoma Clinical Immunology (Orlando, Fla.). Dec, 2014 | Pubmed ID: 25267440 Loss of Cytotoxicity and Gain of Cytokine Production in Murine Tumor-activated NK Cells PloS One. 2014 | Pubmed ID: 25101668 IL-15 Adjuvanted Multivalent Vaccinia-based Universal Influenza Vaccine Requires CD4+ T Cells for Heterosubtypic Protection Proceedings of the National Academy of Sciences of the United States of America. Apr, 2014 | Pubmed ID: 24706798 A New Domain in the Toll/IL-1R Domain-containing Adaptor Inducing Interferon-β Factor Protein Amino Terminus is Important for Tumor Necrosis Factor-α Receptor-associated Factor 3 Association, Protein Stabilization and Interferon Signaling Journal of Innate Immunity. 2014 | Pubmed ID: 24577058 The Biology of IL-15: Implications for Cancer Therapy and the Treatment of Autoimmune Disorders The Journal of Investigative Dermatology. Symposium Proceedings. Dec, 2013 | Pubmed ID: 24326545 Insulin-dependent Diabetes Induced by Pancreatic Beta Cell Expression of IL-15 and IL-15Rα Proceedings of the National Academy of Sciences of the United States of America. Aug, 2013 | Pubmed ID: 23904478 Adult T-cell Leukemia Cells Overexpress Wnt5a and Promote Osteoclast Differentiation Blood. Jun, 2013 | Pubmed ID: 23660959 Phase 1 Trial of IL-15 Trans Presentation Blockade Using Humanized Mik-Beta-1 MAb in Patients with T-cell Large Granular Lymphocytic Leukemia Blood. Jan, 2013 | Pubmed ID: 23212516 Paracrine and Transpresentation Functions of IL-15 Are Mediated by Diverse Splice Versions of IL-15Rα in Human Monocytes and Dendritic Cells The Journal of Biological Chemistry. Nov, 2012 | Pubmed ID: 23074221 Burkitt Lymphoma Pathogenesis and Therapeutic Targets from Structural and Functional Genomics Nature. Oct, 2012 | Pubmed ID: 22885699 Radiation Therapy for the Management of Patients with HTLV-1-associated Adult T-cell Leukemia/lymphoma Blood. Aug, 2012 | Pubmed ID: 22730536 Exploiting Synthetic Lethality for the Therapy of ABC Diffuse Large B Cell Lymphoma Cancer Cell. Jun, 2012 | Pubmed ID: 22698399 Augmented IL-15Rα Expression by CD40 Activation is Critical in Synergistic CD8 T Cell-mediated Antitumor Activity of Anti-CD40 Antibody with IL-15 in TRAMP-C2 Tumors in Mice Journal of Immunology (Baltimore, Md. : 1950). Jun, 2012 | Pubmed ID: 22593619 Selective Dependence of H2-M3-restricted CD8 Responses on IL-15 Journal of Immunology (Baltimore, Md. : 1950). Mar, 2012 | Pubmed ID: 22312130 The Role of Interleukin-15 in Inflammation and Immune Responses to Infection: Implications for Its Therapeutic Use Microbes and Infection. Mar, 2012 | Pubmed ID: 22064066 IL-15 Administered by Continuous Infusion to Rhesus Macaques Induces Massive Expansion of CD8+ T Effector Memory Population in Peripheral Blood Blood. Dec, 2011 | Pubmed ID: 22067383 A Role for Interleukin-2 Trans-presentation in Dendritic Cell-mediated T Cell Activation in Humans, As Revealed by Daclizumab Therapy Nature Medicine. May, 2011 | Pubmed ID: 21532597 Safety (toxicity), Pharmacokinetics, Immunogenicity, and Impact on Elements of the Normal Immune System of Recombinant Human IL-15 in Rhesus Macaques Blood. May, 2011 | Pubmed ID: 21385847 Development of an IL-15-autocrine CD8 T-cell Leukemia in IL-15-transgenic Mice Requires the Cis Expression of IL-15Rα Blood. Apr, 2011 | Pubmed ID: 21304101 CP-690,550, a Therapeutic Agent, Inhibits Cytokine-mediated Jak3 Activation and Proliferation of T Cells from Patients with ATL and HAM/TSP Blood. Feb, 2011 | Pubmed ID: 21106989 Development of a Highly Efficacious Vaccinia-based Dual Vaccine Against Smallpox and Anthrax, Two Important Bioterror Entities Proceedings of the National Academy of Sciences of the United States of America. Oct, 2010 | Pubmed ID: 20921397 Notch Signaling Contributes to Proliferation and Tumor Formation of Human T-cell Leukemia Virus Type 1-associated Adult T-cell Leukemia Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20823234 Transient and Persistent Effects of IL-15 on Lymphocyte Homeostasis in Nonhuman Primates Blood. Oct, 2010 | Pubmed ID: 20631381 Highly Persistent and Effective Prime/boost Regimens Against Tuberculosis That Use a Multivalent Modified Vaccine Virus Ankara-based Tuberculosis Vaccine with Interleukin-15 As a Molecular Adjuvant Clinical and Vaccine Immunology : CVI. May, 2010 | Pubmed ID: 20357059 Interleukin-15 and Its Receptor Augment Dendritic Cell Vaccination Against the Neu Oncogene Through the Induction of Antibodies Partially Independent of CD4 Help Cancer Research. Feb, 2010 | Pubmed ID: 20086176 Preclinical Evaluation of an Anti-CD25 Monoclonal Antibody, 7G7/B6, Armed with the Beta-emitter, Yttrium-90, As a Radioimmunotherapeutic Agent for Treating Lymphoma Cancer Biotherapy & Radiopharmaceuticals. Jun, 2009 | Pubmed ID: 19538052 Plasmid-encoded Interleukin-15 Receptor Alpha Enhances Specific Immune Responses Induced by a DNA Vaccine in Vivo Human Gene Therapy. Oct, 2009 | Pubmed ID: 19530914 Interleukin-15 Combined with an Anti-CD40 Antibody Provides Enhanced Therapeutic Efficacy for Murine Models of Colon Cancer Proceedings of the National Academy of Sciences of the United States of America. May, 2009 | Pubmed ID: 19383782 Effect of Anti-CD25 Antibody Daclizumab in the Inhibition of Inflammation and Stabilization of Disease Progression in Multiple Sclerosis Archives of Neurology. Apr, 2009 | Pubmed ID: 19364933 A Multi-valent Vaccinia Virus-based Tuberculosis Vaccine Molecularly Adjuvanted with Interleukin-15 Induces Robust Immune Responses in Mice Vaccine. Mar, 2009 | Pubmed ID: 19356615 Vaccinia Virus-based Multivalent H5N1 Avian Influenza Vaccines Adjuvanted with IL-15 Confer Sterile Cross-clade Protection in Mice Journal of Immunology (Baltimore, Md. : 1950). Mar, 2009 | Pubmed ID: 19234203 Gene Expression Profiling of ATL Patients: Compilation of Disease-related Genes and Evidence for TCF4 Involvement in BIRC5 Gene Expression and Cell Viability Blood. Apr, 2009 | Pubmed ID: 19131553 IL-15 Serves As a Costimulator in Determining the Activity of Autoreactive CD8 T Cells in an Experimental Mouse Model of Graft-versus-host-like Disease Journal of Immunology (Baltimore, Md. : 1950). Jul, 2008 | Pubmed ID: 18606663 High-dose Humanized Anti-IL-2 Receptor Alpha Antibody (daclizumab) for the Treatment of Active, Non-infectious Uveitis Journal of Autoimmunity. Sep, 2008 | Pubmed ID: 18571896 IL-15 Expands Unconventional CD8alphaalphaNK1.1+ T Cells but Not Valpha14Jalpha18+ NKT Cells Journal of Immunology (Baltimore, Md. : 1950). Jun, 2008 | Pubmed ID: 18490727 IL-15 As a Mediator of CD4+ Help for CD8+ T Cell Longevity and Avoidance of TRAIL-mediated Apoptosis Proceedings of the National Academy of Sciences of the United States of America. Apr, 2008 | Pubmed ID: 18362335 Preassociation of IL-15 with IL-15R Alpha-IgG1-Fc Enhances Its Activity on Proliferation of NK and CD8+/CD44high T Cells and Its Antitumor Action Journal of Immunology (Baltimore, Md. : 1950). Feb, 2008 | Pubmed ID: 18250415 Effective Therapy of Murine Models of Human Leukemia and Lymphoma with Radiolabeled Anti-CD30 Antibody, HeFi-1 Proceedings of the National Academy of Sciences of the United States of America. May, 2007 | Pubmed ID: 17488826 The IL-15/IL-15Ralpha on Cell Surfaces Enables Sustained IL-15 Activity and Contributes to the Long Survival of CD8 Memory T Cells Proceedings of the National Academy of Sciences of the United States of America. Jan, 2007 | Pubmed ID: 17202253 ITK and IL-15 Support Two Distinct Subsets of CD8+ T Cells Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006 | Pubmed ID: 16880398 The Biology of Interleukin-2 and Interleukin-15: Implications for Cancer Therapy and Vaccine Design Nature Reviews. Immunology. Aug, 2006 | Pubmed ID: 16868550 Preparation and in Vivo Evaluation of a Novel Stabilized Linker for 211At Labeling of Protein Nuclear Medicine and Biology. May, 2006 | Pubmed ID: 16720238 Regulatory CD56(bright) Natural Killer Cells Mediate Immunomodulatory Effects of IL-2Ralpha-targeted Therapy (daclizumab) in Multiple Sclerosis Proceedings of the National Academy of Sciences of the United States of America. Apr, 2006 | Pubmed ID: 16585503 Effective Treatment of a Murine Model of Adult T-cell Leukemia Using 211At-7G7/B6 and Its Combination with Unmodified Anti-Tac (daclizumab) Directed Toward CD25 Blood. Aug, 2006 | Pubmed ID: 16569769 Persistent Inhibition of Telomerase Reprograms Adult T-cell Leukemia to P53-dependent Senescence Blood. Aug, 2006 | Pubmed ID: 16569765 Effective Therapy for a Murine Model of Human Anaplastic Large-cell Lymphoma with the Anti-CD30 Monoclonal Antibody, HeFi-1, Does Not Require Activating Fc Receptors Blood. Jul, 2006 | Pubmed ID: 16551968 Familial Hypercatabolic Hypoproteinemia Caused by Deficiency of the Neonatal Fc Receptor, FcRn, Due to a Mutant Beta2-microglobulin Gene Proceedings of the National Academy of Sciences of the United States of America. Mar, 2006 | Pubmed ID: 16549777 Effective Cancer Therapy Through Immunomodulation Annual Review of Medicine. 2006 | Pubmed ID: 16409137 Preclinical and Phase I Clinical Trial of Blockade of IL-15 Using Mikbeta1 Monoclonal Antibody in T Cell Large Granular Lymphocyte Leukemia Proceedings of the National Academy of Sciences of the United States of America. Jan, 2006 | Pubmed ID: 16387851 Detection of Lymph Node Involvement in Hematologic Malignancies Using Micromagnetic Resonance Lymphangiography with a Gadolinum-labeled Dendrimer Nanoparticle Neoplasia (New York, N.Y.). Nov, 2005 | Pubmed ID: 16331884 Central Memory Self/tumor-reactive CD8+ T Cells Confer Superior Antitumor Immunity Compared with Effector Memory T Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2005 | Pubmed ID: 15980149 Survival Adjustment of Mature Dendritic Cells by IL-15 Proceedings of the National Academy of Sciences of the United States of America. Jun, 2005 | Pubmed ID: 15932944 Combination Therapy for Adult T-cell Leukemia-xenografted Mice: Flavopiridol and Anti-CD25 Monoclonal Antibody Blood. Feb, 2005 | Pubmed ID: 15383455 Role of Trans-cellular IL-15 Presentation in the Activation of NK Cell-mediated Killing, Which Leads to Enhanced Tumor Immunosurveillance Blood. Jan, 2005 | Pubmed ID: 15367431 Preparation and in Vivo Evaluation of Novel Linkers for 211At Labeling of Proteins Nuclear Medicine and Biology. Nov, 2004 | Pubmed ID: 15607488 IL-15/IL-15Ralpha-mediated Avidity Maturation of Memory CD8+ T Cells Proceedings of the National Academy of Sciences of the United States of America. Oct, 2004 | Pubmed ID: 15477598 IL-2 and IL-15 Receptor Alpha-subunits Are Coexpressed in a Supramolecular Receptor Cluster in Lipid Rafts of T Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2004 | Pubmed ID: 15263076 Targeting the Interleukin-15/interleukin-15 Receptor System in Inflammatory Autoimmune Diseases Arthritis Research & Therapy. 2004 | Pubmed ID: 15225362 Elevated Serum-soluble Interleukin-2 Receptor Levels in Patients with Anaplastic Large Cell Lymphoma Blood. Nov, 2004 | Pubmed ID: 15205267 Humanized Anti-CD25 (daclizumab) Inhibits Disease Activity in Multiple Sclerosis Patients Failing to Respond to Interferon Beta Proceedings of the National Academy of Sciences of the United States of America. Jun, 2004 | Pubmed ID: 15161974 Lymphatic Drainage Imaging of Breast Cancer in Mice by Micro-magnetic Resonance Lymphangiography Using a Nano-size Paramagnetic Contrast Agent Journal of the National Cancer Institute. May, 2004 | Pubmed ID: 15126607 Micro-MRI Methods to Detect Renal Cysts in Mice Kidney International. Apr, 2004 | Pubmed ID: 15086495 Systemic Radioimmunotherapy Using a Monoclonal Antibody, Anti-Tac Directed Toward the Alpha Subunit of the IL-2 Receptor Armed with the Alpha-emitting Radionuclides (212)Bi or (211)At Nuclear Medicine and Biology. Apr, 2004 | Pubmed ID: 15028248 IL-15 Enhances the in Vivo Antitumor Activity of Tumor-reactive CD8+ T Cells Proceedings of the National Academy of Sciences of the United States of America. Feb, 2004 | Pubmed ID: 14762166 IL-15 in the Life and Death of Lymphocytes: Immunotherapeutic Implications Trends in Molecular Medicine. Dec, 2003 | Pubmed ID: 14659465 Distinct Pathways Involving the FK506-binding Proteins 12 and 12.6 Underlie IL-2-versus IL-15-mediated Proliferation of T Cells Proceedings of the National Academy of Sciences of the United States of America. Nov, 2003 | Pubmed ID: 14605212 A Novel Means of Favorably Tipping the Balance Between Cytopathic and Regulatory T Cells Immunity. Oct, 2003 | Pubmed ID: 14563310 Comparison of Dendrimer-based Macromolecular Contrast Agents for Dynamic Micro-magnetic Resonance Lymphangiography Magnetic Resonance in Medicine. Oct, 2003 | Pubmed ID: 14523962 Activated Clearance of a Biotinylated Macromolecular MRI Contrast Agent from the Blood Pool Using an Avidin Chase Bioconjugate Chemistry. Sep-Oct, 2003 | Pubmed ID: 13129410 Coadministration of HIV Vaccine Vectors with Vaccinia Viruses Expressing IL-15 but Not IL-2 Induces Long-lasting Cellular Immunity Proceedings of the National Academy of Sciences of the United States of America. Mar, 2003 | Pubmed ID: 12626740 Immunotherapy: Past, Present and Future Nature Medicine. Mar, 2003 | Pubmed ID: 12612576 Pretarget Radiotherapy with an Anti-CD25 Antibody-streptavidin Fusion Protein Was Effective in Therapy of Leukemia/lymphoma Xenografts Proceedings of the National Academy of Sciences of the United States of America. Feb, 2003 | Pubmed ID: 12569172 The Meandering 45-year Odyssey of a Clinical Immunologist Annual Review of Immunology. 2003 | Pubmed ID: 12359737 IL-15Ralpha Recycles and Presents IL-15 In Trans to Neighboring Cells Immunity. Nov, 2002 | Pubmed ID: 12433361 Pretargeting Radioimmunotherapy of a Murine Model of Adult T-cell Leukemia with the Alpha-emitting Radionuclide, Bismuth 213 Blood. Jul, 2002 | Pubmed ID: 12070029 IFN Regulatory Factor 4 Participates in the Human T Cell Lymphotropic Virus Type I-mediated Activation of the IL-15 Receptor Alpha Promoter Journal of Immunology (Baltimore, Md. : 1950). Jun, 2002 | Pubmed ID: 12023365 IL-15 Plays a Major Role in the Persistence of Tax-specific CD8 Cells in HAM/TSP Patients Proceedings of the National Academy of Sciences of the United States of America. Dec, 2001 | Pubmed ID: 11717409 Onset of Natural Killer Cell Lymphomas in Transgenic Mice Carrying a Truncated HMGI-C Gene by the Chronic Stimulation of the IL-2 and IL-15 Pathway Proceedings of the National Academy of Sciences of the United States of America. Jul, 2001 | Pubmed ID: 11427729 IL-2-induced Activation-induced Cell Death is Inhibited in IL-15 Transgenic Mice Proceedings of the National Academy of Sciences of the United States of America. Oct, 2000 | Pubmed ID: 11016962 Viral Activation of Interleukin-15 (IL-15): Characterization of a Virus-inducible Element in the IL-15 Promoter Region Journal of Virology. Aug, 2000 | Pubmed ID: 10906187 Treatment of Noninfectious Intermediate and Posterior Uveitis with the Humanized Anti-Tac MAb: a Phase I/II Clinical Trial Proceedings of the National Academy of Sciences of the United States of America. Jun, 1999 | Pubmed ID: 10377437 Activation of Human Monocytes Induces Differential Resistance to Apoptosis with Rapid Down Regulation of Caspase-8/FLICE Proceedings of the National Academy of Sciences of the United States of America. Nov, 1998 | Pubmed ID: 9826696 Epitope Blocking: Positive and Negative Effects on the Biodistribution of 125I-labeled Anti-Tac Disulfide-stabilized Fv Fragment of Two Antibodies Against Different Epitopes of the Circulating Antigen Japanese Journal of Cancer Research : Gann. Apr, 1998 | Pubmed ID: 9617350 Recruitment of SH2-containing Protein Tyrosine Phosphatase SHP-1 to the Interleukin 2 Receptor; Loss of SHP-1 Expression in Human T-lymphotropic Virus Type I-transformed T Cells Proceedings of the National Academy of Sciences of the United States of America. Mar, 1998 | Pubmed ID: 9520455 Human T Cell Lymphotropic Virus Type I Tax Protein Trans-activates Interleukin 15 Gene Transcription Through an NF-kappaB Site Proceedings of the National Academy of Sciences of the United States of America. Mar, 1998 | Pubmed ID: 9482906 Generation of Secretable and Nonsecretable Interleukin 15 Isoforms Through Alternate Usage of Signal Peptides Proceedings of the National Academy of Sciences of the United States of America. Dec, 1997 | Pubmed ID: 9405632 Preassembly of Interleukin 2 (IL-2) Receptor Subunits on Resting Kit 225 K6 T Cells and Their Modulation by IL-2, IL-7, and IL-15: a Fluorescence Resonance Energy Transfer Study Proceedings of the National Academy of Sciences of the United States of America. Nov, 1997 | Pubmed ID: 9371812 The Mechanism of Intestinal Uptake and Transcellular Transport of IgG in the Neonatal Rat The Journal of Clinical Investigation. Nov, 1972 | Pubmed ID: 5080417 The Renal Handling of Low Molecular Weight Proteins. II. Disorders of Serum Protein Catabolism in Patients with Tubular Proteinuria, the Nephrotic Syndrome, or Uremia The Journal of Clinical Investigation. Aug, 1972 | Pubmed ID: 5054468 Immunoglobulin E in Immunologic Deficiency Diseases. I. Relation of IgE and IgA to Respiratory Tract Disease in Isolated IgE Deficiency, IgA Deficiency, and Ataxia Telangiectasia The Journal of Clinical Investigation. Feb, 1972 | Pubmed ID: 5009116 Impaired Lymphocyte Transformation in Intestinal Lymphangiectasia: Evidence for at Least Two Functionally Distinct Lymphocyte Populations in Man The Journal of Clinical Investigation. Jun, 1972 | Pubmed ID: 4554185 Hypercatabolism of IgG, IgA, IgM, and Albumin in the Wiskott-Aldrich Syndrome. A Unique Disorder of Serum Protein Metabolism The Journal of Clinical Investigation. Nov, 1971 | Pubmed ID: 5096517 Renal Handling of Low Molecular Weight Proteins. I. L-Chain Metabolism in Experimental Renal Disease The Journal of Clinical Investigation. Apr, 1971 | Pubmed ID: 4100686 Metabolic Properties of IgG Subclasses in Man The Journal of Clinical Investigation. Apr, 1970 | Pubmed ID: 5443170 The Effect of Hydrocortisone on Immunoglobulin Metabolism The Journal of Clinical Investigation. Sep, 1970 | Pubmed ID: 4194767 Direct Measurement of the Rates of Synthesis of Plasma Proteins in Control Subjects and Patients with Gastrointestinal Protein Loss The Journal of Clinical Investigation. May, 1968 | Pubmed ID: 5239039 Immunoglobulin Metabolism in Ataxia Telangiectasia The Journal of Clinical Investigation. Aug, 1968 | Pubmed ID: 4174353 Measurement of Gastrointestinal Protein Loss Using Ceruloplasmin Labeled with Copper The Journal of Clinical Investigation. Jan, 1967 | Pubmed ID: 6018743 The Mechanism of Appearance of Immunoglobulin A in Nasal Secretions in Man The Journal of Clinical Investigation. Dec, 1967 | Pubmed ID: 4169362 The Role of the Kidney in the Catabolism of Bence Jones Proteins and Immunoglobulin Fragments The Journal of Experimental Medicine. Aug, 1967 | Pubmed ID: 4165739 Анализ естественного метаболизма клеток-убийц человека Javier Traba1,2, Thomas A. Waldmann3, Olga M. Anton3 1Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 2Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), 3Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health JoVE 61466 Immunology and Infection
Анализ естественного метаболизма клеток-убийц человека Javier Traba1,2, Thomas A. Waldmann3, Olga M. Anton3 1Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 2Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), 3Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health JoVE 61466 Immunology and Infection
