Thomas H Gillingwater

Publications

• SMN-dependent Intrinsic Defects in Schwann Cells in Mouse Models of Spinal Muscular Atrophy
  Human Molecular Genetics. Dec, 2013  |   Pubmed ID: 24301677
• Label-free Proteomics Identifies Calreticulin and GRP75/Mortalin As Peripherally Accessible Protein Biomarkers for Spinal Muscular Atrophy
  Genome Medicine. Oct, 2013  |   Pubmed ID: 24134804
• Executive Deficits, Not Processing Speed Relates to Abnormalities in Distinct Prefrontal Tracts in Amyotrophic Lateral Sclerosis
  Brain : a Journal of Neurology. Nov, 2013  |   Pubmed ID: 24056536
• Total Protein Analysis As a Reliable Loading Control for Quantitative Fluorescent Western Blotting
  PloS One. 2013  |   Pubmed ID: 24023619
• Studying Synapses in Human Brain with Array Tomography and Electron Microscopy
  Nature Protocols. 2013  |   Pubmed ID: 23787894
• Increasing SMN Levels Using the Histone Deacetylase Inhibitor SAHA Ameliorates Defects in Skeletal Muscle Microvasculature in a Mouse Model of Severe Spinal Muscular Atrophy
  Neuroscience Letters. Jun, 2013  |   Pubmed ID: 23583590
• Effect of Limb Lengthening on Internodal Length and Conduction Velocity of Peripheral Nerve
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2013  |   Pubmed ID: 23467369
• Quantitative Tractography and Tract Shape Modeling in Amyotrophic Lateral Sclerosis
  Journal of Magnetic Resonance Imaging : JMRI. Nov, 2013  |   Pubmed ID: 23450730
• Spinal Muscular Atrophy: Going Beyond the Motor Neuron
  Trends in Molecular Medicine. Jan, 2013  |   Pubmed ID: 23228902
• Morphological Characteristics of Motor Neurons Do Not Determine Their Relative Susceptibility to Degeneration in a Mouse Model of Severe Spinal Muscular Atrophy
  PloS One. 2012  |   Pubmed ID: 23285108
• Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration in Vivo
  PLoS Genetics. 2012  |   Pubmed ID: 22952455
• WldS Prevents Axon Degeneration Through Increased Mitochondrial Flux and Enhanced Mitochondrial Ca2+ Buffering
  Current Biology : CB. Apr, 2012  |   Pubmed ID: 22425157
• Altered Maturation of the Primary Somatosensory Cortex in a Mouse Model of Fragile X Syndrome
  Human Molecular Genetics. May, 2012  |   Pubmed ID: 22328088
• Development of a Supported Self-directed Learning Approach for Anatomy Education
  Anatomical Sciences Education. Mar-Apr, 2012  |   Pubmed ID: 22223487
• Using Induced Pluripotent Stem Cells (iPSC) to Model Human Neuromuscular Connectivity: Promise or Reality?
  Journal of Anatomy. Feb, 2012  |   Pubmed ID: 22133357
• Targeting Synaptic Pathology in Multiple Sclerosis: Fingolimod to the Rescue?
  British Journal of Pharmacology. Feb, 2012  |   Pubmed ID: 21806598
• Morphologic and Functional Correlates of Synaptic Pathology in the Cathepsin D Knockout Mouse Model of Congenital Neuronal Ceroid Lipofuscinosis
  Journal of Neuropathology and Experimental Neurology. Dec, 2011  |   Pubmed ID: 22082660
• Reversible Molecular Pathology of Skeletal Muscle in Spinal Muscular Atrophy
  Human Molecular Genetics. Nov, 2011  |   Pubmed ID: 21840928
• The Contribution of Mouse Models to Understanding the Pathogenesis of Spinal Muscular Atrophy
  Disease Models & Mechanisms. Jul, 2011  |   Pubmed ID: 21708901
• ApoE Isoform-specific Regulation of Regeneration in the Peripheral Nervous System
  Human Molecular Genetics. Jun, 2011  |   Pubmed ID: 21478199
• Induction of Cell Stress in Neurons from Transgenic Mice Expressing Yellow Fluorescent Protein: Implications for Neurodegeneration Research
  PloS One. 2011  |   Pubmed ID: 21408118
• The Response of Neuromuscular Junctions to Injury is Developmentally Regulated
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2011  |   Pubmed ID: 21228222
• Synaptic Protection in the Brain of WldS Mice Occurs Independently of Age but is Sensitive to Gene-dose
  PloS One. 2010  |   Pubmed ID: 21124744
• SMN Deficiency Disrupts Brain Development in a Mouse Model of Severe Spinal Muscular Atrophy
  Human Molecular Genetics. Nov, 2010  |   Pubmed ID: 20705736
• Age-related Motor Neuron Degeneration in DNA Repair-deficient Ercc1 Mice
  Acta Neuropathologica. Oct, 2010  |   Pubmed ID: 20602234
• Pre-symptomatic Development of Lower Motor Neuron Connectivity in a Mouse Model of Severe Spinal Muscular Atrophy
  Human Molecular Genetics. Feb, 2010  |   Pubmed ID: 19884170
• Murine Cathepsin D Deficiency is Associated with Dysmyelination/myelin Disruption and Accumulation of Cholesteryl Esters in the Brain
  Journal of Neurochemistry. Jan, 2010  |   Pubmed ID: 19845830
• Alternative Splicing Events Are a Late Feature of Pathology in a Mouse Model of Spinal Muscular Atrophy
  PLoS Genetics. Dec, 2009  |   Pubmed ID: 20019802
• Expression of the Neuroprotective Slow Wallerian Degeneration (WldS) Gene in Non-neuronal Tissues
  BMC Neuroscience. 2009  |   Pubmed ID: 20015399
• Molecular Correlates of Axonal and Synaptic Pathology in Mouse Models of Batten Disease
  Human Molecular Genetics. Nov, 2009  |   Pubmed ID: 19640925
• Transcriptional Regulation of the AP-1 and Nrf2 Target Gene Sulfiredoxin
  Molecules and Cells. Mar, 2009  |   Pubmed ID: 19326073
• Protein Product of CLN6 Gene Responsible for Variant Late-onset Infantile Neuronal Ceroid Lipofuscinosis Interacts with CRMP-2
  Journal of Neuroscience Research. Jul, 2009  |   Pubmed ID: 19235893
• The Importance of Exposure to Human Material in Anatomical Education: a Philosophical Perspective
  Anatomical Sciences Education. Nov-Dec, 2008  |   Pubmed ID: 19109856
• Loss of Translation Elongation Factor (eEF1A2) Expression in Vivo Differentiates Between Wallerian Degeneration and Dying-back Neuronal Pathology
  Journal of Anatomy. Dec, 2008  |   Pubmed ID: 19094180
• MGluR5 Regulates Glutamate-dependent Development of the Mouse Somatosensory Cortex
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2008  |   Pubmed ID: 19052194
• Identity, Developmental Restriction and Reactivity of Extralaminar Cells Capping Mammalian Neuromuscular Junctions
  Journal of Cell Science. Dec, 2008  |   Pubmed ID: 19001504
• Modified Cell Cycle Status in a Mouse Model of Altered Neuronal Vulnerability (slow Wallerian Degeneration; Wlds)
  Genome Biology. 2008  |   Pubmed ID: 18570652
• Rapid Loss of Motor Nerve Terminals Following Hypoxia-reperfusion Injury Occurs Via Mechanisms Distinct from Classic Wallerian Degeneration
  Journal of Anatomy. Jun, 2008  |   Pubmed ID: 18510509
• VCP Binding Influences Intracellular Distribution of the Slow Wallerian Degeneration Protein, Wld(S)
  Molecular and Cellular Neurosciences. Jul, 2008  |   Pubmed ID: 18468455
• VAPB Interacts with and Modulates the Activity of ATF6
  Human Molecular Genetics. Jun, 2008  |   Pubmed ID: 18263603
• A Neurological Phenotype in Mice with DNA Repair Gene Ercc1 Deficiency
  DNA Repair. Feb, 2008  |   Pubmed ID: 18221731
• Synaptic Changes in the Thalamocortical System of Cathepsin D-deficient Mice: a Model of Human Congenital Neuronal Ceroid-lipofuscinosis
  Journal of Neuropathology and Experimental Neurology. Jan, 2008  |   Pubmed ID: 18091563
• Selective Vulnerability of Motor Neurons and Dissociation of Pre- and Post-synaptic Pathology at the Neuromuscular Junction in Mouse Models of Spinal Muscular Atrophy
  Human Molecular Genetics. Apr, 2008  |   Pubmed ID: 18065780
• Design of a Novel Quantitative PCR (QPCR)-based Protocol for Genotyping Mice Carrying the Neuroprotective Wallerian Degeneration Slow (Wlds) Gene
  Molecular Neurodegeneration. 2007  |   Pubmed ID: 17971231
• Differential Proteomics Analysis of Synaptic Proteins Identifies Potential Cellular Targets and Protein Mediators of Synaptic Neuroprotection Conferred by the Slow Wallerian Degeneration (Wlds) Gene
  Molecular & Cellular Proteomics : MCP. Aug, 2007  |   Pubmed ID: 17470424
• Synaptic Vulnerability in Neurodegenerative Disease
  Journal of Neuropathology and Experimental Neurology. Aug, 2006  |   Pubmed ID: 16896307
• Delayed Synaptic Degeneration in the CNS of Wlds Mice After Cortical Lesion
  Brain : a Journal of Neurology. Jun, 2006  |   Pubmed ID: 16738060
• Involvement of Protein Kinase A in Patterning of the Mouse Somatosensory Cortex
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2006  |   Pubmed ID: 16707791
• Synaptic Ras GTPase Activating Protein Regulates Pattern Formation in the Trigeminal System of Mice
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2006  |   Pubmed ID: 16452659
• The Neuroprotective WldS Gene Regulates Expression of PTTG1 and Erythroid Differentiation Regulator 1-like Gene in Mice and Human Cells
  Human Molecular Genetics. Feb, 2006  |   Pubmed ID: 16403805
• Progressive Loss of Motor Neuron Function in Wasted Mice: Effects of a Spontaneous Null Mutation in the Gene for the EEF1 A2 Translation Factor
  Journal of Neuropathology and Experimental Neurology. Apr, 2005  |   Pubmed ID: 15835265
• A Rat Model of Slow Wallerian Degeneration (WldS) with Improved Preservation of Neuromuscular Synapses
  The European Journal of Neuroscience. Jan, 2005  |   Pubmed ID: 15654865
• The Slow Wallerian Degeneration Gene, WldS, Inhibits Axonal Spheroid Pathology in Gracile Axonal Dystrophy Mice
  Brain : a Journal of Neurology. Feb, 2005  |   Pubmed ID: 15644421
• Progressive Abnormalities in Skeletal Muscle and Neuromuscular Junctions of Transgenic Mice Expressing the Huntington's Disease Mutation
  The European Journal of Neuroscience. Dec, 2004  |   Pubmed ID: 15579164
• Myo-GDNF Increases Non-functional Polyinnervation of Reinnervated Mouse Muscle
  Neuroreport. Jan, 2004  |   Pubmed ID: 15106825
• Axotomy-dependent and -independent Synapse Elimination in Organ Cultures of Wld(s) Mutant Mouse Skeletal Muscle
  Journal of Neuroscience Research. Apr, 2004  |   Pubmed ID: 15048930
• Neuroprotection After Transient Global Cerebral Ischemia in Wld(s) Mutant Mice
  Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jan, 2004  |   Pubmed ID: 14688617
• The Relationship of Neuromuscular Synapse Elimination to Synaptic Degeneration and Pathology: Insights from WldS and Other Mutant Mice
  Journal of Neurocytology. Jun-Sep, 2003  |   Pubmed ID: 15034273
• Ultrastructural Correlates of Synapse Withdrawal at Axotomized Neuromuscular Junctions in Mutant and Transgenic Mice Expressing the Wld Gene
  Journal of Anatomy. Sep, 2003  |   Pubmed ID: 14529044
• Age-dependent Synapse Withdrawal at Axotomised Neuromuscular Junctions in Wld(s) Mutant and Ube4b/Nmnat Transgenic Mice
  The Journal of Physiology. Sep, 2002  |   Pubmed ID: 12231635