Thomas M. Wishart

Publications

• Loss of Glial Neurofascin155 Delays Developmental Synapse Elimination at the Neuromuscular Junction
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2014  |   Pubmed ID: 25232125
• Label-free Quantitative Proteomic Profiling Identifies Disruption of Ubiquitin Homeostasis As a Key Driver of Schwann Cell Defects in Spinal Muscular Atrophy
  Journal of Proteome Research. Nov, 2014  |   Pubmed ID: 25151848
• Increased Levels of UCHL1 Are a Compensatory Response to Disrupted Ubiquitin Homeostasis in Spinal Muscular Atrophy and Do Not Represent a Viable Therapeutic Target
  Neuropathology and Applied Neurobiology. Dec, 2014  |   Pubmed ID: 25041530
• The Rat Striatum Responds to Nigro-striatal Degeneration Via the Increased Expression of Proteins Associated with Growth and Regeneration of Neuronal Circuitry
  Proteome Science. 2014  |   Pubmed ID: 24834013
• A Novel Mouse Model of Warburg Micro Syndrome Reveals Roles for RAB18 in Eye Development and Organisation of the Neuronal Cytoskeleton
  Disease Models & Mechanisms. Apr, 2014  |   Pubmed ID: 24764192
• Dysregulation of Ubiquitin Homeostasis and β-catenin Signaling Promote Spinal Muscular Atrophy
  The Journal of Clinical Investigation. Apr, 2014  |   Pubmed ID: 24590288
• Label-free Proteomics Identifies Calreticulin and GRP75/Mortalin As Peripherally Accessible Protein Biomarkers for Spinal Muscular Atrophy
  Genome Medicine. Oct, 2013  |   Pubmed ID: 24134804
• Total Protein Analysis As a Reliable Loading Control for Quantitative Fluorescent Western Blotting
  PloS One. 2013  |   Pubmed ID: 24023619
• Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration in Vivo
  PLoS Genetics. 2012  |   Pubmed ID: 22952455
• WldS Prevents Axon Degeneration Through Increased Mitochondrial Flux and Enhanced Mitochondrial Ca2+ Buffering
  Current Biology : CB. Apr, 2012  |   Pubmed ID: 22425157
• Using Induced Pluripotent Stem Cells (iPSC) to Model Human Neuromuscular Connectivity: Promise or Reality?
  Journal of Anatomy. Feb, 2012  |   Pubmed ID: 22133357
• Reversible Molecular Pathology of Skeletal Muscle in Spinal Muscular Atrophy
  Human Molecular Genetics. Nov, 2011  |   Pubmed ID: 21840928
• ApoE Isoform-specific Regulation of Regeneration in the Peripheral Nervous System
  Human Molecular Genetics. Jun, 2011  |   Pubmed ID: 21478199
• Induction of Cell Stress in Neurons from Transgenic Mice Expressing Yellow Fluorescent Protein: Implications for Neurodegeneration Research
  PloS One. 2011  |   Pubmed ID: 21408118
• Synaptic Protection in the Brain of WldS Mice Occurs Independently of Age but is Sensitive to Gene-dose
  PloS One. 2010  |   Pubmed ID: 21124744
• SMN Deficiency Disrupts Brain Development in a Mouse Model of Severe Spinal Muscular Atrophy
  Human Molecular Genetics. Nov, 2010  |   Pubmed ID: 20705736
• Expression of the Neuroprotective Slow Wallerian Degeneration (WldS) Gene in Non-neuronal Tissues
  BMC Neuroscience. 2009  |   Pubmed ID: 20015399
• Molecular Correlates of Axonal and Synaptic Pathology in Mouse Models of Batten Disease
  Human Molecular Genetics. Nov, 2009  |   Pubmed ID: 19640925
• Protein Product of CLN6 Gene Responsible for Variant Late-onset Infantile Neuronal Ceroid Lipofuscinosis Interacts with CRMP-2
  Journal of Neuroscience Research. Jul, 2009  |   Pubmed ID: 19235893
• Loss of Translation Elongation Factor (eEF1A2) Expression in Vivo Differentiates Between Wallerian Degeneration and Dying-back Neuronal Pathology
  Journal of Anatomy. Dec, 2008  |   Pubmed ID: 19094180
• Modified Cell Cycle Status in a Mouse Model of Altered Neuronal Vulnerability (slow Wallerian Degeneration; Wlds)
  Genome Biology. 2008  |   Pubmed ID: 18570652
• VCP Binding Influences Intracellular Distribution of the Slow Wallerian Degeneration Protein, Wld(S)
  Molecular and Cellular Neurosciences. Jul, 2008  |   Pubmed ID: 18468455
• Design of a Novel Quantitative PCR (QPCR)-based Protocol for Genotyping Mice Carrying the Neuroprotective Wallerian Degeneration Slow (Wlds) Gene
  Molecular Neurodegeneration. 2007  |   Pubmed ID: 17971231
• 突触蛋白差异蛋白质组学分析标识潜在的细胞目标和突触神经保护所赋予的缓慢沃勒变性 (Wlds) 基因蛋白调解员。
  Molecular & Cellular Proteomics : MCP. Aug, 2007  |   Pubmed ID: 17470424
• Synaptic Vulnerability in Neurodegenerative Disease
  Journal of Neuropathology and Experimental Neurology. Aug, 2006  |   Pubmed ID: 16896307
• Delayed Synaptic Degeneration in the CNS of Wlds Mice After Cortical Lesion
  Brain : a Journal of Neurology. Jun, 2006  |   Pubmed ID: 16738060
• The Neuroprotective WldS Gene Regulates Expression of PTTG1 and Erythroid Differentiation Regulator 1-like Gene in Mice and Human Cells
  Human Molecular Genetics. Feb, 2006  |   Pubmed ID: 16403805
• The Slow Wallerian Degeneration Protein, WldS, Binds Directly to VCP/p97 and Partially Redistributes It Within the Nucleus
  Molecular Biology of the Cell. Mar, 2006  |   Pubmed ID: 16371511
• Progressive Abnormalities in Skeletal Muscle and Neuromuscular Junctions of Transgenic Mice Expressing the Huntington's Disease Mutation
  The European Journal of Neuroscience. Dec, 2004  |   Pubmed ID: 15579164