Thomas S. Griffith Department of Urology University of Minnesota Biography Publications Institution JoVE Articles Thomas S. Griffith has not added a biography. If you are Thomas S. Griffith and would like to personalize this page please email our Author Liaison for assistance. Publications Biliary Tract Instillation of a SMAC Mimetic Induces TRAIL-dependent Acute Sclerosing Cholangitis-like Injury in Mice Cell Death & Disease. Jan, 2017 | Pubmed ID: 28055006 Enteric Immunity, the Gut Microbiome, and Sepsis: Rethinking the Germ Theory of Disease Experimental Biology and Medicine (Maywood, N.J.). Jan, 2017 | Pubmed ID: 27633573 Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo Journal of Immunology (Baltimore, Md. : 1950). Dec, 2016 | Pubmed ID: 27798171 Clinical and Experimental Sepsis Impairs CD8 T-Cell-Mediated Immunity Critical Reviews in Immunology. 2016 | Pubmed ID: 27480902 CD8 T Cell-Independent Antitumor Response and Its Potential for Treatment of Malignant Gliomas Cancers. Jul, 2016 | Pubmed ID: 27472363 Gut Microbial Membership Modulates CD4 T Cell Reconstitution and Function After Sepsis Journal of Immunology (Baltimore, Md. : 1950). Sep, 2016 | Pubmed ID: 27448587 Triptolide Enhances the Tumoricidal Activity of TRAIL Against Renal Cell Carcinoma The FEBS Journal. Dec, 2015 | Pubmed ID: 26426449 Therapeutic Applications of TRAIL Receptor Agonists in Cancer and Beyond Pharmacology & Therapeutics. Nov, 2015 | Pubmed ID: 26343199 Exploiting Natural Anti-tumor Immunity for Metastatic Renal Cell Carcinoma Human Vaccines & Immunotherapeutics. 2015 | Pubmed ID: 25996049 Polymicrobial Sepsis Increases Susceptibility to Chronic Viral Infection and Exacerbates CD8+ T Cell Exhaustion Journal of Immunology (Baltimore, Md. : 1950). Jul, 2015 | Pubmed ID: 25980007 The Frequency of Naive and Early-activated Hapten-specific B Cell Subsets Dictates the Efficacy of a Therapeutic Vaccine Against Prescription Opioid Abuse Journal of Immunology (Baltimore, Md. : 1950). Jun, 2015 | Pubmed ID: 25972483 Alterations in Antigen-specific Naive CD4 T Cell Precursors After Sepsis Impairs Their Responsiveness to Pathogen Challenge Journal of Immunology (Baltimore, Md. : 1950). Feb, 2015 | Pubmed ID: 25595784 Immunosuppression After Sepsis: Systemic Inflammation and Sepsis Induce a Loss of Naïve T-cells but No Enduring Cell-autonomous Defects in T-cell Function PloS One. 2014 | Pubmed ID: 25541945 CpG-mediated Modulation of MDSC Contributes to the Efficacy of Ad5-TRAIL Therapy Against Renal Cell Carcinoma Cancer Immunology, Immunotherapy : CII. Nov, 2014 | Pubmed ID: 25143233 Impact of Sepsis on CD4 T Cell Immunity Journal of Leukocyte Biology. Nov, 2014 | Pubmed ID: 24791959 Minimal Changes in the Systemic Immune Response After Nephrectomy of Localized Renal Masses Urologic Oncology. Jul, 2014 | Pubmed ID: 24768357 Effective TRAIL-based Immunotherapy Requires Both Plasmacytoid and CD8α Dendritic Cells Cancer Immunology, Immunotherapy : CII. Jul, 2014 | Pubmed ID: 24711083 GLP-1-mediated Gene Therapy Approaches for Diabetes Treatment Expert Reviews in Molecular Medicine. Mar, 2014 | Pubmed ID: 24666581 Polymicrobial Sepsis Alters Antigen-dependent and -independent Memory CD8 T Cell Functions Journal of Immunology (Baltimore, Md. : 1950). Apr, 2014 | Pubmed ID: 24646738 Cellular Inhibitor of Apoptosis Protein CIAP2 Protects Against Pulmonary Tissue Necrosis During Influenza Virus Infection to Promote Host Survival Cell Host & Microbe. Jan, 2014 | Pubmed ID: 24439895 Intravascular Staining for Discrimination of Vascular and Tissue Leukocytes Nature Protocols. Jan, 2014 | Pubmed ID: 24385150 Clinical Utility of Insulin and Insulin Analogs Islets. Mar-Apr, 2013 | Pubmed ID: 23584214 T-cell-mediated Immunity and the Role of TRAIL in Sepsis-induced Immunosuppression Critical Reviews in Immunology. 2013 | Pubmed ID: 23510024 PMN and Anti-tumor Immunity--the Case of Bladder Cancer Immunotherapy Seminars in Cancer Biology. Jun, 2013 | Pubmed ID: 23410637 Sustained and Incomplete Recovery of Naive CD8+ T Cell Precursors After Sepsis Contributes to Impaired CD8+ T Cell Responses to Infection Journal of Immunology (Baltimore, Md. : 1950). Mar, 2013 | Pubmed ID: 23355736 Activation of Systemic Antitumor Immunity Via TRAIL-induced Apoptosis Oncoimmunology. Oct, 2012 | Pubmed ID: 23170271 TNF-related Apoptosis-inducing Ligand (TRAIL) Exerts Therapeutic Efficacy for the Treatment of Pneumococcal Pneumonia in Mice The Journal of Experimental Medicine. Oct, 2012 | Pubmed ID: 23071253 Insulin Gene Therapy from Design to Beta Cell Generation Expert Reviews in Molecular Medicine. Oct, 2012 | Pubmed ID: 23062285 Therapeutic Potential of VIP Vs PACAP in Diabetes Journal of Molecular Endocrinology. Dec, 2012 | Pubmed ID: 22991228 Diet-induced Obesity Alters Dendritic Cell Function in the Presence and Absence of Tumor Growth Journal of Immunology (Baltimore, Md. : 1950). Aug, 2012 | Pubmed ID: 22745381 Eradication of Metastatic Renal Cell Carcinoma After Adenovirus-encoded TNF-related Apoptosis-inducing Ligand (TRAIL)/CpG Immunotherapy PloS One. 2012 | Pubmed ID: 22312440 Effect of Combined Locally Delivered Growth Factors and Systemic Sildenafil Citrate on Microrecanalization in Biodegradable Conduit for Vas Deferens Reconstruction Urology. Jan, 2012 | Pubmed ID: 22285175 Advances in Viral Vector-Based TRAIL Gene Therapy for Cancer Cancers. Feb, 2011 | Pubmed ID: 24212631 Cell Death in the Maintenance and Abrogation of Tolerance: the Five Ws of Dying Cells Immunity. Oct, 2011 | Pubmed ID: 22035838 The Plasticity of Regulatory T Cell Function Journal of Immunology (Baltimore, Md. : 1950). Nov, 2011 | Pubmed ID: 22013112 The Magnitude of the T Cell Response to a Clinically Significant Dose of Influenza Virus is Regulated by TRAIL Journal of Immunology (Baltimore, Md. : 1950). Nov, 2011 | Pubmed ID: 21940678 Clinical Significance of TRAIL and TRAIL Receptors in Patients with Head and Neck Cancer Head & Neck. Sep, 2011 | Pubmed ID: 21837697 Description of a Novel Murine Model for Ileocystoplasty and Early Histologic Changes TheScientificWorldJournal. Jul, 2011 | Pubmed ID: 21789468 Immune Unresponsiveness to Secondary Heterologous Bacterial Infection After Sepsis Induction is TRAIL Dependent Journal of Immunology (Baltimore, Md. : 1950). Sep, 2011 | Pubmed ID: 21788440 Tracing of Islet Graft Survival by Way of in Vivo Fluorescence Imaging Diabetes/metabolism Research and Reviews. Sep, 2011 | Pubmed ID: 21584921 Systemic Immunological Tolerance to Ocular Antigens is Mediated by TRAIL-expressing CD8+ T Cells Journal of Immunology (Baltimore, Md. : 1950). Jan, 2011 | Pubmed ID: 21169546 Sensitization of Human Bladder Tumor Cells to TNF-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis with a Small Molecule IAP Antagonist Apoptosis : an International Journal on Programmed Cell Death. Jan, 2011 | Pubmed ID: 20734142 NF-κB Targeting by Way of IKK Inhibition Sensitizes Lung Cancer Cells to Adenovirus Delivery of TRAIL BMC Cancer. Oct, 2010 | Pubmed ID: 20977779 TRAIL-expressing CD8+ T Cells Mediate Tolerance Following Soluble Peptide-induced Peripheral T Cell Deletion Journal of Leukocyte Biology. Dec, 2010 | Pubmed ID: 20807702 Micro-recanalization in a Biodegradable Graft for Reconstruction of the Vas Deferens is Enhanced by Sildenafil Citrate Asian Journal of Andrology. Nov, 2010 | Pubmed ID: 20639908 Conatumumab, a Fully Human MAb Against Death Receptor 5 for the Treatment of Cancer Current Opinion in Investigational Drugs (London, England : 2000). Jun, 2010 | Pubmed ID: 20496264 Sepsis-induced Apoptosis Leads to Active Suppression of Delayed-type Hypersensitivity by CD8+ Regulatory T Cells Through a TRAIL-dependent Mechanism Journal of Immunology (Baltimore, Md. : 1950). Jun, 2010 | Pubmed ID: 20483771 In Vivo Fluorescence Imaging is Well-suited for the Monitoring of Adenovirus Directed Transgene Expression in Living Organisms Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Jun, 2010 | Pubmed ID: 19789926 Bacillus Calmette-Guerin Immunotherapy for Urothelial Carcinoma of the Bladder Immunotherapy. Mar, 2009 | Pubmed ID: 20046960 The Role of Neutrophils and TNF-related Apoptosis-inducing Ligand (TRAIL) in Bacillus Calmette-Guérin (BCG) Immunotherapy for Urothelial Carcinoma of the Bladder Cancer Metastasis Reviews. Dec, 2009 | Pubmed ID: 19967427 TRAIL-deficient Mice Exhibit Delayed Regression of Retinal Neovascularization The American Journal of Pathology. Dec, 2009 | Pubmed ID: 19893042 Activation-induced CD154 Expression Abrogates Tolerance Induced by Apoptotic Cells Journal of Immunology (Baltimore, Md. : 1950). Nov, 2009 | Pubmed ID: 19841180 TNF-related Apoptosis-inducing Ligand (TRAIL): a New Path to Anti-cancer Therapies European Journal of Pharmacology. Dec, 2009 | Pubmed ID: 19836385 Adenovirus-mediated TRAIL Gene (Ad5hTRAIL) Delivery into Pancreatic Islets Prolongs Normoglycemia in Streptozotocin-induced Diabetic Rats Human Gene Therapy. Oct, 2009 | Pubmed ID: 19572802 Induction of Tumor Cell Apoptosis by TRAIL Gene Therapy Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19565910 [Not Available] Journal of Oncology. 2009 | Pubmed ID: 19547714 Early Microrecanalization of Vas Deferens Following Biodegradable Graft Implantation in Bilaterally Vasectomized Rats Asian Journal of Andrology. May, 2009 | Pubmed ID: 19349949 TRAIL Gene Therapy: from Preclinical Development to Clinical Application Current Gene Therapy. Feb, 2009 | Pubmed ID: 19275567 The Use of Immunofluorescence in Microdissection Testicular Sperm Extraction Journal of Andrology. Sep-Oct, 2009 | Pubmed ID: 19234316 High TRAIL Death Receptor 4 and Decoy Receptor 2 Expression Correlates with Significant Cell Death in Pancreatic Ductal Adenocarcinoma Patients Pancreas. Mar, 2009 | Pubmed ID: 18981952 CD8 T Cells Utilize TRAIL to Control Influenza Virus Infection Journal of Immunology (Baltimore, Md. : 1950). Oct, 2008 | Pubmed ID: 18802095 Influenza-induced Expression of Functional Tumor Necrosis Factor-related Apoptosis-inducing Ligand on Human Peripheral Blood Mononuclear Cells Human Immunology. Oct, 2008 | Pubmed ID: 18723061 Role of Neutrophils in BCG Immunotherapy for Bladder Cancer Urologic Oncology. Jul-Aug, 2008 | Pubmed ID: 18593617 High Levels of Endogenous Tumor Necrosis Factor-related Apoptosis-inducing Ligand Expression Correlate with Increased Cell Death in Human Pancreas Pancreas. May, 2008 | Pubmed ID: 18437085 Tumor Necrosis Factor-related Apoptosis Inducing Ligand-R4 Decoy Receptor Expression is Correlated with High Gleason Scores, Prostate-specific Antigen Recurrence, and Decreased Survival in Patients with Prostate Carcinoma Urologic Oncology. Mar-Apr, 2008 | Pubmed ID: 18312935 Molecular Mechanisms of Death Ligand-mediated Immune Modulation: a Gene Therapy Model to Prolong Islet Survival in Type 1 Diabetes Journal of Cellular Biochemistry. Jun, 2008 | Pubmed ID: 18247339 TNF-related Apoptosis-inducing Ligand (TRAIL) is Expressed Throughout Myeloid Development, Resulting in a Broad Distribution Among Neutrophil Granules Journal of Leukocyte Biology. Mar, 2008 | Pubmed ID: 18063697 Activation of Tumor-specific CD8+ T Cells After Intratumoral Ad5-TRAIL/CpG Oligodeoxynucleotide Combination Therapy Cancer Research. Dec, 2007 | Pubmed ID: 18089829 Cytomegalovirus and the Role of Interferon in the Expression of Tumor Necrosis Factor-related Apoptosis-inducing Ligand in the Placenta American Journal of Obstetrics and Gynecology. Dec, 2007 | Pubmed ID: 18060949 Predicting Bacillus Calmette-Guerin Immunotherapy Effectiveness The Journal of Urology. Dec, 2007 | Pubmed ID: 17936825 Neutrophils and TRAIL: Insights into BCG Immunotherapy for Bladder Cancer Immunologic Research. 2007 | Pubmed ID: 17917057 TRAIL Death Receptor-4 Expression Positively Correlates with the Tumor Grade in Breast Cancer Patients with Invasive Ductal Carcinoma International Journal of Radiation Oncology, Biology, Physics. Nov, 2007 | Pubmed ID: 17512128 Apoptotic Cells Induce Tolerance by Generating Helpless CD8+ T Cells That Produce TRAIL Journal of Immunology (Baltimore, Md. : 1950). Mar, 2007 | Pubmed ID: 17312109 The Role of Fas Ligand and TNF-related Apoptosis-inducing Ligand (TRAIL) in the Ocular Immune Response Chemical Immunology and Allergy. 2007 | Pubmed ID: 17264490 Histone Deacetylase Inhibitors Enhance Ad5-TRAIL Killing of TRAIL-resistant Prostate Tumor Cells Through Increased Caspase-2 Activity Apoptosis : an International Journal on Programmed Cell Death. Mar, 2007 | Pubmed ID: 17195089 Identification of the Mycobacterial Subcomponents Involved in the Release of Tumor Necrosis Factor-related Apoptosis-inducing Ligand from Human Neutrophils Infection and Immunity. Mar, 2007 | Pubmed ID: 17194806 Induction of Protective Immunity to RM-1 Prostate Cancer Cells with ALVAC-IL-2/IL-12/TNF-alpha Combination Therapy International Journal of Cancer. Dec, 2006 | Pubmed ID: 16991124 A Vision of Cell Death: Fas Ligand and Immune Privilege 10 Years Later Immunological Reviews. Oct, 2006 | Pubmed ID: 16972907 Survivin Inhibits Apoptosis Induced by TRAIL, and the Ratio Between Survivin and TRAIL Receptors is Predictive of Recurrent Disease in Neuroblastoma Journal of Pediatric Surgery. Aug, 2006 | Pubmed ID: 16863850 TRAIL Deficiency Delays, but Does Not Prevent, Erosion in the Quality of "helpless" Memory CD8 T Cells Journal of Immunology (Baltimore, Md. : 1950). Jul, 2006 | Pubmed ID: 16818756 Neisseria Gonorrhoeae Delays the Onset of Apoptosis in Polymorphonuclear Leukocytes Cellular Microbiology. Nov, 2006 | Pubmed ID: 16803582 Histone Deacetylase Inhibitors Modulate the Sensitivity of Tumor Necrosis Factor-related Apoptosis-inducing Ligand-resistant Bladder Tumor Cells Cancer Research. Jan, 2006 | Pubmed ID: 16397266 Histone Deacetylase Inhibitors Modulate Renal Cell Carcinoma Sensitivity to TRAIL/Apo-2L-induced Apoptosis by Enhancing TRAIL-R2 Expression Cancer Biology & Therapy. Oct, 2005 | Pubmed ID: 16096370 Neutrophil Stimulation with Mycobacterium Bovis Bacillus Calmette-Guerin (BCG) Results in the Release of Functional Soluble TRAIL/Apo-2L Blood. Nov, 2005 | Pubmed ID: 16037389 Depsipeptide (FR901228) Enhances the Cytotoxic Activity of TRAIL by Redistributing TRAIL Receptor to Membrane Lipid Rafts Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2005 | Pubmed ID: 15771957 CD4+ T-cell Help Controls CD8+ T-cell Memory Via TRAIL-mediated Activation-induced Cell Death Nature. Mar, 2005 | Pubmed ID: 15744305 Immunostimulatory Oligodeoxynucleotides Induce Apoptosis of B Cell Chronic Lymphocytic Leukemia Cells Journal of Leukocyte Biology. Mar, 2005 | Pubmed ID: 15582984 Expression of TNF-related Apoptosis-inducing Ligand (TRAIL) in Megakaryocytes and Platelets Experimental Hematology. Nov, 2004 | Pubmed ID: 15539085 Inhibition of the NF-kappaB Pathway Enhances TRAIL-mediated Apoptosis in Neuroblastoma Cells Cancer Gene Therapy. Oct, 2004 | Pubmed ID: 15332116 Human B Cells Express Functional TRAIL/Apo-2 Ligand After CpG-containing Oligodeoxynucleotide Stimulation Journal of Immunology (Baltimore, Md. : 1950). Jul, 2004 | Pubmed ID: 15240676 Tumor Necrosis Factor-related Apoptosis-inducing Ligand: a Novel Mechanism for Bacillus Calmette-Guérin-induced Antitumor Activity Cancer Research. May, 2004 | Pubmed ID: 15150089 Structure/function Analysis of the Murine CD95L Promoter Reveals the Identification of a Novel Transcriptional Repressor and Functional CD28 Response Element The Journal of Biological Chemistry. Sep, 2003 | Pubmed ID: 12855690 Plasmacytoid Dendritic Cell-derived IFN-alpha Induces TNF-related Apoptosis-inducing Ligand/Apo-2L-mediated Antitumor Activity by Human Monocytes Following CpG Oligodeoxynucleotide Stimulation Journal of Immunology (Baltimore, Md. : 1950). Jul, 2003 | Pubmed ID: 12817000 The Topoisomerase I Inhibitor Topotecan Increases the Sensitivity of Prostate Tumor Cells to TRAIL/Apo-2L-induced Apoptosis Cancer Chemotherapy and Pharmacology. Sep, 2003 | Pubmed ID: 12811515 Apoptosis, Tolerance, and Regulatory T Cells--old Wine, New Wineskins Immunological Reviews. Jun, 2003 | Pubmed ID: 12752676 Induction of Glioblastoma Apoptosis Using Neural Stem Cell-mediated Delivery of Tumor Necrosis Factor-related Apoptosis-inducing Ligand Cancer Research. Dec, 2002 | Pubmed ID: 12499252 Cell Death and Immune Privilege International Reviews of Immunology. Mar-Jun, 2002 | Pubmed ID: 12424841 TRAIL: a Mechanism of Tumor Surveillance in an Immune Privileged Site Journal of Immunology (Baltimore, Md. : 1950). Nov, 2002 | Pubmed ID: 12391182 Induction and Regulation of Tumor Necrosis Factor-related Apoptosis-inducing Ligand/Apo-2 Ligand-mediated Apoptosis in Renal Cell Carcinoma Cancer Research. Jun, 2002 | Pubmed ID: 12036919 Uptake of Apoptotic Antigen-coupled Cells by Lymphoid Dendritic Cells and Cross-priming of CD8(+) T Cells Produce Active Immune Unresponsiveness Journal of Immunology (Baltimore, Md. : 1950). Jun, 2002 | Pubmed ID: 12023355 A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies Katherine A. Murphy*1,2, Britnie R. James*1,2,3, Andrew Wilber4,5, Thomas S. Griffith1,2,3 1Department of Urology, University of Minnesota, 2Masonic Cancer Center, University of Minnesota, 3Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota, 4Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 5Simmons Cancer Institute JoVE 55080 Cancer Research
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies Katherine A. Murphy*1,2, Britnie R. James*1,2,3, Andrew Wilber4,5, Thomas S. Griffith1,2,3 1Department of Urology, University of Minnesota, 2Masonic Cancer Center, University of Minnesota, 3Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota, 4Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 5Simmons Cancer Institute JoVE 55080 Cancer Research
