Thomas Hankemeier Division of Systems Biomedicine and Pharmacology, Department of Analytical BioSciences and Metabolomics Leiden University Biography Publications Institution JoVE Articles Thomas Hankemeier has not added a biography. If you are Thomas Hankemeier and would like to personalize this page please email our Author Liaison for assistance. Publications STATegra, a Comprehensive Multi-omics Dataset of B-cell Differentiation in Mouse Scientific Data. 10, 2019 | Pubmed ID: 31672995 Impaired Serine Metabolism Complements LRRK2-G2019S Pathogenicity in PD Patients Parkinsonism & Related Disorders. Sep, 2019 | Pubmed ID: 31621607 Chemical Diversity and Classification of Secondary Metabolites in Nine Bryophyte Species Metabolites. Oct, 2019 | Pubmed ID: 31614655 Supervised Multidimensional Item Response Theory Modeling of Pediatric Iatrogenic Withdrawal Symptoms CPT: Pharmacometrics & Systems Pharmacology. Oct, 2019 | Pubmed ID: 31612647 Interstitial Flow Recapitulates Gemcitabine Chemoresistance in A 3D Microfluidic Pancreatic Ductal Adenocarcinoma Model by Induction of Multidrug Resistance Proteins International Journal of Molecular Sciences. Sep, 2019 | Pubmed ID: 31546820 Fast LC-ESI-MS/MS Analysis and Influence of Sampling Conditions for Gut Metabolites in Plasma and Serum Scientific Reports. Aug, 2019 | Pubmed ID: 31451722 Intersubject and Intrasubject Variability of Potential Plasma and Urine Metabolite and Protein Biomarkers in Healthy Human Volunteers Clinical Pharmacology and Therapeutics. Aug, 2019 | Pubmed ID: 31400148 LC-MS/MS Analysis of the Central Energy and Carbon Metabolites in Biological Samples Following Derivatization by Dimethylaminophenacyl Bromide Journal of Chromatography. A. Jul, 2019 | Pubmed ID: 31395359 Mechanistic and Quantitative Understanding of Pharmacokinetics in Zebrafish Larvae Through Nanoscale Blood Sampling and Metabolite Modeling of Paracetamol The Journal of Pharmacology and Experimental Therapeutics. Oct, 2019 | Pubmed ID: 31371482 CE-MS for Anionic Metabolic Profiling: An Overview of Methodological Developments Electrophoresis. 09, 2019 | Pubmed ID: 31106868 Assessing the Suitability of Capillary Electrophoresis-mass Spectrometry for Biomarker Discovery in Plasma-based Metabolomics Electrophoresis. 09, 2019 | Pubmed ID: 31025710 Interoperable and Scalable Data Analysis with Microservices: Applications in Metabolomics Bioinformatics (Oxford, England). Oct, 2019 | Pubmed ID: 30851093 Capillary Electrophoresis-Mass Spectrometry for Metabolic Profiling of Biomass-Limited Samples Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30847790 Impact of Post-hatching Maturation on the Pharmacokinetics of Paracetamol in Zebrafish Larvae Scientific Reports. Feb, 2019 | Pubmed ID: 30770889 Automated Microfluidic Cell Culture of Stem Cell Derived Dopaminergic Neurons Scientific Reports. Feb, 2019 | Pubmed ID: 30741972 Discovery of Novel Glycerolated Quinazolinones from Streptomyces Sp. MBT27 Journal of Industrial Microbiology & Biotechnology. Mar, 2019 | Pubmed ID: 30729343 Blood-Based Biomarkers of Quinpirole Pharmacology: Cluster-Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain CPT: Pharmacometrics & Systems Pharmacology. Feb, 2019 | Pubmed ID: 30680960 Activity-Based Protein Profiling Identifies α-Ketoamides As Inhibitors for Phospholipase A2 Group XVI ACS Chemical Biology. 02, 2019 | Pubmed ID: 30620559 Utility of Sheathless Capillary Electrophoresis-mass Spectrometry for Metabolic Profiling of Limited Sample Amounts Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Jan, 2019 | Pubmed ID: 30554093 PhenoMeNal: Processing and Analysis of Metabolomics Data in the Cloud GigaScience. 02, 2019 | Pubmed ID: 30535405 Altered Bile Acid Profile in Mild Cognitive Impairment and Alzheimer's Disease: Relationship to Neuroimaging and CSF Biomarkers Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Feb, 2019 | Pubmed ID: 30337152 Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer's Disease-An Emerging Role for Gut Microbiome Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 01, 2019 | Pubmed ID: 30337151 Role of Amino Acids in Rheumatoid Arthritis Studied by Metabolomics International Journal of Rheumatic Diseases. Jan, 2019 | Pubmed ID: 28328075 The Influence of Neuronal Electrical Activity on the Mammalian Central Clock Metabolome Metabolomics : Official Journal of the Metabolomic Society. 09, 2018 | Pubmed ID: 30830420 Global Testing of Shifts in Metabolic Phenotype Metabolomics : Official Journal of the Metabolomic Society. 10, 2018 | Pubmed ID: 30830386 High Fat Diet Increases Circulating Endocannabinoids Accompanied by Increased Synthesis Enzymes in Adipose Tissue Frontiers in Physiology. 2018 | Pubmed ID: 30687125 Covariates in Pharmacometric Repeated Time-to-Event Models: Old and New (Pre)Selection Tools The AAPS Journal. 12, 2018 | Pubmed ID: 30565031 Persistent Metabolic Changes in HIV-infected Patients During the First Year of Combination Antiretroviral Therapy Scientific Reports. 11, 2018 | Pubmed ID: 30446683 Baseline Metabolic Profiles of Early Rheumatoid Arthritis Patients Achieving Sustained Drug-free Remission After Initiating Treat-to-target Tocilizumab, Methotrexate, or the Combination: Insights from Systems Biology Arthritis Research & Therapy. 10, 2018 | Pubmed ID: 30322408 Gene Expression of Endocannabinoid System Components in Skeletal Muscle and Adipose Tissue of South Asians and White Caucasians with Overweight Obesity (Silver Spring, Md.). 08, 2018 | Pubmed ID: 30070030 High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces Coelicolor Journal of Bacteriology. 10, 2018 | Pubmed ID: 30061355 Fusing Metabolomics Data Sets with Heterogeneous Measurement Errors PloS One. 2018 | Pubmed ID: 29698490 Mass Spectrometric Recommendations for Quan/Qual Analysis Using Liquid-chromatography Coupled to Quadrupole Time-of-flight Mass Spectrometry Analytica Chimica Acta. Aug, 2018 | Pubmed ID: 29655429 Strategies to Assess and Optimize Stability of Endogenous Amines During Cerebrospinal Fluid Sampling Metabolomics : Official Journal of the Metabolomic Society. 2018 | Pubmed ID: 29527143 Development and Application of a UHPLC-MS/MS Metabolomics Based Comprehensive Systemic and Tissue-specific Screening Method for Inflammatory, Oxidative and Nitrosative Stress Analytical and Bioanalytical Chemistry. Apr, 2018 | Pubmed ID: 29497765 A Metabolomics Study of Qiliqiangxin in a Rat Model of Heart Failure: a Reverse Pharmacology Approach Scientific Reports. 02, 2018 | Pubmed ID: 29487344 Pharmacological Targeting of ROS Reaction Network in Myeloid Leukemia Cells Monitored by Ultra-weak Photon Emission Oncotarget. Jan, 2018 | Pubmed ID: 29416750 Caloric Restriction Lowers Endocannabinoid Tonus and Improves Cardiac Function in Type 2 Diabetes Nutrition & Diabetes. 01, 2018 | Pubmed ID: 29343706 Circulating Metabolites and General Cognitive Ability and Dementia: Evidence from 11 Cohort Studies Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 06, 2018 | Pubmed ID: 29316447 Therapy Response Testing of Breast Cancer in a 3D High-throughput Perfused Microfluidic Platform BMC Cancer. Nov, 2017 | Pubmed ID: 29096610 The Future of Metabolomics in ELIXIR F1000Research. 2017 | Pubmed ID: 29043062 Blood-based Metabolic Signatures in Alzheimer's Disease Alzheimer's & Dementia (Amsterdam, Netherlands). 2017 | Pubmed ID: 28951883 Cellular Glutathione Levels in HL-60 Cells During Respiratory Burst Are Not Correlated with Ultra-weak Photon Emission Journal of Photochemistry and Photobiology. B, Biology. Oct, 2017 | Pubmed ID: 28926741 A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes Diabetes. 11, 2017 | Pubmed ID: 28847883 Membrane-free Culture and Real-time Barrier Integrity Assessment of Perfused Intestinal Epithelium Tubes Nature Communications. 08, 2017 | Pubmed ID: 28811479 Metabolomics Based Markers Predict Type 2 Diabetes in a 14-year Follow-up Study Metabolomics : Official Journal of the Metabolomic Society. 2017 | Pubmed ID: 28804275 Endocannabinoid Tone is Higher in Healthy Lean South Asian Than White Caucasian Men Scientific Reports. 08, 2017 | Pubmed ID: 28790443 Fetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants The Journal of Infectious Diseases. 08, 2017 | Pubmed ID: 28633455 Activity-based Protein Profiling Reveals Off-target Proteins of the FAAH Inhibitor BIA 10-2474 Science (New York, N.Y.). 06, 2017 | Pubmed ID: 28596366 Towards Personalized Treatment of Pain Using a Quantitative Systems Pharmacology Approach European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Nov, 2017 | Pubmed ID: 28506867 Integrating Clinical Metabolomics-based Biomarker Discovery and Clinical Pharmacology to Enable Precision Medicine European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Nov, 2017 | Pubmed ID: 28502671 Ultra-weak Photon Emission As a Dynamic Tool for Monitoring Oxidative Stress Metabolism Scientific Reports. 04, 2017 | Pubmed ID: 28450732 Metabolic Network Failures in Alzheimer's Disease: A Biochemical Road map Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Sep, 2017 | Pubmed ID: 28341160 Spontaneous Ultra-weak Photon Emission in Correlation to Inflammatory Metabolism and Oxidative Stress in a Mouse Model of Collagen-induced Arthritis Journal of Photochemistry and Photobiology. B, Biology. Mar, 2017 | Pubmed ID: 28199905 Characterization of the Therapeutic Properties of Chinese Herbal Materials by Measuring Delayed Luminescence and Dendritic Cell-based Immunomodulatory Response Journal of Photochemistry and Photobiology. B, Biology. Mar, 2017 | Pubmed ID: 28147303 Feasibility of Ultra-performance Liquid Chromatography-ion Mobility-time-of-flight Mass Spectrometry in Analyzing Oxysterols Journal of Chromatography. A. Mar, 2017 | Pubmed ID: 28118975 Integration of Pharmacometabolomics with Pharmacokinetics and Pharmacodynamics: Towards Personalized Drug Therapy Metabolomics : Official Journal of the Metabolomic Society. 2017 | Pubmed ID: 28058041 Quantitative Profiling of Endocannabinoids and Related -acylethanolamines in Human CSF Using Nano LC-MS/MS Journal of Lipid Research. 03, 2017 | Pubmed ID: 27999147 Measuring Ultra-weak Photon Emission As a Non-invasive Diagnostic Tool for Detecting Early-stage Type 2 Diabetes: A Step Toward Personalized Medicine Journal of Photochemistry and Photobiology. B, Biology. Jan, 2017 | Pubmed ID: 27888740 Classification for Longevity Potential: The Use of Novel Biomarkers Frontiers in Public Health. 2016 | Pubmed ID: 27840811 Differences Between Serum Polar Lipid Profiles of Male and Female Rheumatoid Arthritis Patients in Response to Glucocorticoid Treatment Inflammopharmacology. Dec, 2016 | Pubmed ID: 27682325 Metabolomics Enables Precision Medicine: "A White Paper, Community Perspective" Metabolomics : Official Journal of the Metabolomic Society. 2016 | Pubmed ID: 27642271 Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude Zebrafish. Sep, 2016 | Pubmed ID: 27632065 Exploring the Inflammatory Metabolomic Profile to Predict Response to TNF-α Inhibitors in Rheumatoid Arthritis PloS One. 2016 | Pubmed ID: 27631111 Tracking Biochemical Changes Correlated with Ultra-weak Photon Emission Using Metabolomics Journal of Photochemistry and Photobiology. B, Biology. Oct, 2016 | Pubmed ID: 27597516 Next-generation Capillary Electrophoresis-mass Spectrometry Approaches in Metabolomics Current Opinion in Biotechnology. Jul, 2016 | Pubmed ID: 27455398 Metabolomics Profiling of the Free and Total Oxidised Lipids in Urine by LC-MS/MS: Application in Patients with Rheumatoid Arthritis Analytical and Bioanalytical Chemistry. Sep, 2016 | Pubmed ID: 27405874 Effects of Growth Altitude on Chemical Constituents and Delayed Luminescence Properties in Medicinal Rhubarb Journal of Photochemistry and Photobiology. B, Biology. Sep, 2016 | Pubmed ID: 27327125 Metabolic Characterization of the Natural Progression of Chronic Hepatitis B Genome Medicine. 2016 | Pubmed ID: 27286979 Serum-Based Oxylipins Are Associated with Outcomes in Primary Prevention Implantable Cardioverter Defibrillator Patients PloS One. 2016 | Pubmed ID: 27281224 Bacterial Surface Layer Proteins As a Novel Capillary Coating Material for Capillary Electrophoretic Separations Analytica Chimica Acta. Jun, 2016 | Pubmed ID: 27155306 A Chinese Literature Overview on Ultra-weak Photon Emission As Promising Technology for Studying System-based Diagnostics Complementary Therapies in Medicine. Apr, 2016 | Pubmed ID: 27062943 Discovery of Biochemical Biomarkers for Aggression: A Role for Metabolomics in Psychiatry American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. Jul, 2016 | Pubmed ID: 26913573 Migraine Biomarkers in Cerebrospinal Fluid: A Systematic Review and Meta-analysis Cephalalgia : an International Journal of Headache. Feb, 2016 | Pubmed ID: 26888294 Electroextraction and Electromembrane Extraction: Advances in Hyphenation to Analytical Techniques Electrophoresis. May, 2016 | Pubmed ID: 26864699 Metabolic Effects of a 13-weeks Lifestyle Intervention in Older Adults: The Growing Old Together Study Aging. Jan, 2016 | Pubmed ID: 26824634 Delayed Luminescence: an Experimental Protocol for Chinese Herbal Medicines Luminescence : the Journal of Biological and Chemical Luminescence. Sep, 2016 | Pubmed ID: 26818567 Weight Loss Predictability by Plasma Metabolic Signatures in Adults with Obesity and Morbid Obesity of the DiOGenes Study Obesity (Silver Spring, Md.). Feb, 2016 | Pubmed ID: 26813527 Sheathless Capillary Electrophoresis-mass Spectrometry for Anionic Metabolic Profiling Electrophoresis. Apr, 2016 | Pubmed ID: 26593113 Quantitative Profiling of Oxylipins in Plasma and Atherosclerotic Plaques of Hypercholesterolemic Rabbits Analytical and Bioanalytical Chemistry. Jan, 2016 | Pubmed ID: 26511226 Serum Amine-based Metabolites and Their Association with Outcomes in Primary Prevention Implantable Cardioverter-defibrillator Patients Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. Sep, 2016 | Pubmed ID: 26498162 Collagen Induced Arthritis in DBA/1J Mice Associates with Oxylipin Changes in Plasma Mediators of Inflammation. 2015 | Pubmed ID: 26604432 Oxylipid Profile of Low-Dose Aspirin Exposure: A Pharmacometabolomics Study Journal of the American Heart Association. Oct, 2015 | Pubmed ID: 26504148 COordination of Standards in MetabOlomicS (COSMOS): Facilitating Integrated Metabolomics Data Access Metabolomics : Official Journal of the Metabolomic Society. 2015 | Pubmed ID: 26491418 Effects of Metformin on Metabolite Profiles and LDL Cholesterol in Patients with Type 2 Diabetes Diabetes Care. Oct, 2015 | Pubmed ID: 26251408 First-Trimester Serum Acylcarnitine Levels to Predict Preeclampsia: A Metabolomics Approach Disease Markers. 2015 | Pubmed ID: 26146448 Microfluidic 3D Cell Culture: from Tools to Tissue Models Current Opinion in Biotechnology. Dec, 2015 | Pubmed ID: 26094109 Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons Journal of the American Chemical Society. Jul, 2015 | Pubmed ID: 26083464 P53 Attenuates AKT Signaling by Modulating Membrane Phospholipid Composition Oncotarget. Aug, 2015 | Pubmed ID: 26061814 Matrix Effect Compensation in Small-Molecule Profiling for an LC-TOF Platform Using Multicomponent Postcolumn Infusion Analytical Chemistry. Jun, 2015 | Pubmed ID: 25965142 Differentiation of Neuroepithelial Stem Cells into Functional Dopaminergic Neurons in 3D Microfluidic Cell Culture Lab on a Chip. Jun, 2015 | Pubmed ID: 25902196 Individualization of Treatments with Drugs Metabolized by CES1: Combining Genetics and Metabolomics Pharmacogenomics. 2015 | Pubmed ID: 25896426 A Mutasynthesis Approach with a Penicillium Chrysogenum ΔroqA Strain Yields New Roquefortine D Analogues Chembiochem : a European Journal of Chemical Biology. Apr, 2015 | Pubmed ID: 25766600 Testing Tuberculosis Drug Efficacy in a Zebrafish High-throughput Translational Medicine Screen Antimicrobial Agents and Chemotherapy. Feb, 2015 | Pubmed ID: 25385118 Lab-on-a-Chip Hyphenation with Mass Spectrometry: Strategies for Bioanalytical Applications Current Opinion in Biotechnology. Feb, 2015 | Pubmed ID: 25232996 Systematic Evaluation of Commercially Available Ultra-high Performance Liquid Chromatography Columns for Drug Metabolite Profiling: Optimization of Chromatographic Peak Capacity Journal of Chromatography. A. Dec, 2014 | Pubmed ID: 25435462 Roux-en-Y Gastric Bypass Surgery, but Not Calorie Restriction, Reduces Plasma Branched-chain Amino Acids in Obese Women Independent of Weight Loss or the Presence of Type 2 Diabetes Diabetes Care. Dec, 2014 | Pubmed ID: 25315204 Gas Pressure Assisted Microliquid-liquid Extraction Coupled Online to Direct Infusion Mass Spectrometry: a New Automated Screening Platform for Bioanalysis Analytical Chemistry. Oct, 2014 | Pubmed ID: 25243401 Analysis of Oxysterols and Vitamin D Metabolites in Mouse Brain and Cell Line Samples by Ultra-high-performance Liquid Chromatography-atmospheric Pressure Photoionization-mass Spectrometry Journal of Chromatography. A. Oct, 2014 | Pubmed ID: 25204266 Metabolic Phenotyping Reveals a Lipid Mediator Response to Ionizing Radiation Journal of Proteome Research. Sep, 2014 | Pubmed ID: 25126707 Phaseguides As Tunable Passive Microvalves for Liquid Routing in Complex Microfluidic Networks Lab on a Chip. Sep, 2014 | Pubmed ID: 24989781 Continuous-flow Microelectroextraction for Enrichment of Low Abundant Compounds Analytical Chemistry. Aug, 2014 | Pubmed ID: 24892382 Enhanced Lipid Isomer Separation in Human Plasma Using Reversed-phase UPLC with Ion-mobility/high-resolution MS Detection Journal of Lipid Research. Aug, 2014 | Pubmed ID: 24891331 A Non-canonical NRPS is Involved in the Synthesis of Fungisporin and Related Hydrophobic Cyclic Tetrapeptides in Penicillium Chrysogenum PloS One. 2014 | Pubmed ID: 24887561 Metabolomics Profiling for Identification of Novel Potential Markers in Early Prediction of Preeclampsia PloS One. 2014 | Pubmed ID: 24873829 Simple Capillary Electrophoresis-mass Spectrometry Method for Complex Glycan Analysis Using a Flow-through Microvial Interface Analytical Chemistry. Jul, 2014 | Pubmed ID: 24873509 Phaseguide Assisted Liquid Lamination for Magnetic Particle-based Assays Lab on a Chip. Jul, 2014 | Pubmed ID: 24832933 A Protective Lipidomic Biosignature Associated with a Balanced Omega-6/omega-3 Ratio in Fat-1 Transgenic Mice PloS One. 2014 | Pubmed ID: 24760204 Isotachophoretic Phenomena in Electric Field Gradient Focusing: Perspectives for Sample Preparation and Bioassays Analytical Chemistry. May, 2014 | Pubmed ID: 24670194 Novel Hollow Microneedle Technology for Depth-controlled Microinjection-mediated Dermal Vaccination: a Study with Polio Vaccine in Rats Pharmaceutical Research. Jul, 2014 | Pubmed ID: 24469907 Capillary Electrophoresis-mass Spectrometry Using a Flow-through Microvial Interface for Cationic Metabolome Analysis Electrophoresis. May, 2014 | Pubmed ID: 24375112 Postprandial Fatty Acid Specific Changes in Circulating Oxylipins in Lean and Obese Men After High-fat Challenge Tests Molecular Nutrition & Food Research. Mar, 2014 | Pubmed ID: 24127338 Combined LC/MS-platform for Analysis of All Major Stratum Corneum Lipids, and the Profiling of Skin Substitutes Biochimica Et Biophysica Acta. Jan, 2014 | Pubmed ID: 24120918 The Potential of Electrophoretic Sample Pretreatment Techniques and New Instrumentation for Bioanalysis, with a Focus on Peptidomics and Metabolomics Bioanalysis. Nov, 2013 | Pubmed ID: 24256359 Novel Key Metabolites Reveal Further Branching of the Roquefortine/meleagrin Biosynthetic Pathway The Journal of Biological Chemistry. Dec, 2013 | Pubmed ID: 24225953 Elastomeric Microvalves As Tunable Nanochannels for Concentration Polarization Lab on a Chip. Dec, 2013 | Pubmed ID: 24158567 A New Approach to Untargeted Integration of High Resolution Liquid Chromatography-mass Spectrometry Data Analytica Chimica Acta. Nov, 2013 | Pubmed ID: 24139572 Microfluidic Titer Plate for Stratified 3D Cell Culture Lab on a Chip. Sep, 2013 | Pubmed ID: 23887749 Human Metabolomics: Strategies to Understand Biology Current Opinion in Chemical Biology. Oct, 2013 | Pubmed ID: 23849548 A Branched Biosynthetic Pathway is Involved in Production of Roquefortine and Related Compounds in Penicillium Chrysogenum PloS One. 2013 | Pubmed ID: 23776469 Three-phase Electroextraction: a New (online) Sample Purification and Enrichment Method for Bioanalysis Analytical Chemistry. Aug, 2013 | Pubmed ID: 23724849 Solvent Exchange Module for LC-NMR Hyphenation Using Machine Vision-Controlled Droplet Evaporation Analytical Chemistry. Jun, 2013 | Pubmed ID: 23679001 Pre-processing Liquid Chromatography/high-resolution Mass Spectrometry Data: Extracting Pure Mass Spectra by Deconvolution from the Invariance of Isotopic Distribution Rapid Communications in Mass Spectrometry : RCM. May, 2013 | Pubmed ID: 23592192 Lipidomics of Familial Longevity Aging Cell. Jun, 2013 | Pubmed ID: 23451766 Automated Pipeline for De Novo Metabolite Identification Using Mass-spectrometry-based Metabolomics Analytical Chemistry. Apr, 2013 | Pubmed ID: 23368721 How Do Metabolites Differ from Their Parent Molecules and How Are They Excreted? Journal of Chemical Information and Modeling. Feb, 2013 | Pubmed ID: 23351040 Hierarchical Clustering Analysis of Blood Plasma Lipidomics Profiles from Mono- and Dizygotic Twin Families European Journal of Human Genetics : EJHG. Jan, 2013 | Pubmed ID: 22713803 Assessing the Metabolic Effects of Prednisolone in Healthy Volunteers Using Urine Metabolic Profiling Genome Medicine. 2012 | Pubmed ID: 23199229 Increase in Short-chain Ceramides Correlates with an Altered Lipid Organization and Decreased Barrier Function in Atopic Eczema Patients Journal of Lipid Research. Dec, 2012 | Pubmed ID: 23024286 Tunable Ionic Mobility Filter for Depletion Zone Isotachophoresis Analytical Chemistry. Nov, 2012 | Pubmed ID: 23013213 Feasibility of Electroextraction As Versatile Sample Preconcentration for Fast and Sensitive Analysis of Urine Metabolites, Demonstrated on Acylcarnitines Electrophoresis. Oct, 2012 | Pubmed ID: 23001993 OMG: Open Molecule Generator Journal of Cheminformatics. 2012 | Pubmed ID: 22985496 Characterization of Rheumatoid Arthritis Subtypes Using Symptom Profiles, Clinical Chemistry and Metabolomics Measurements PloS One. 2012 | Pubmed ID: 22984493 Fragmentation Trees for the Structural Characterisation of Metabolites Rapid Communications in Mass Spectrometry : RCM. Oct, 2012 | Pubmed ID: 22956319 MetiTree: a Web Application to Organize and Process High-resolution Multi-stage Mass Spectrometry Metabolomics Data Bioinformatics (Oxford, England). Oct, 2012 | Pubmed ID: 22851531 Instrument and Process Independent Binning and Baseline Correction Methods for Liquid Chromatography-high Resolution-mass Spectrometry Deconvolution Analytica Chimica Acta. Aug, 2012 | Pubmed ID: 22840645 Quantitative Profiling of Oxylipins Through Comprehensive LC-MS/MS Analysis: Application in Cardiac Surgery Analytical and Bioanalytical Chemistry. Sep, 2012 | Pubmed ID: 22814969 On-line Large-volume Electroextraction Coupled to Liquid Chromatography-mass Spectrometry to Improve Detection of Peptides Journal of Chromatography. A. Aug, 2012 | Pubmed ID: 22749583 Limits of Miniaturization: Assessing ITP Performance in Sub-micron and Nanochannels Lab on a Chip. Aug, 2012 | Pubmed ID: 22691967 Metabolite Identification Using Automated Comparison of High-resolution Multistage Mass Spectral Trees Analytical Chemistry. Jul, 2012 | Pubmed ID: 22612383 Metabolomics of Cerebrospinal Fluid Reveals Changes in the Central Nervous System Metabolism in a Rat Model of Multiple Sclerosis Metabolomics : Official Journal of the Metabolomic Society. Apr, 2012 | Pubmed ID: 22448154 Lipidomics Reveals Multiple Pathway Effects of a Multi-components Preparation on Lipid Biochemistry in ApoE*3Leiden.CETP Mice PloS One. 2012 | Pubmed ID: 22291936 An Efficient Hydrophilic Interaction Liquid Chromatography Separation of 7 Phospholipid Classes Based on a Diol Column Journal of Chromatography. A. Jan, 2012 | Pubmed ID: 22169191 Enrichment of Viable Bacteria in a Micro-volume by Free-flow Electrophoresis Lab on a Chip. Feb, 2012 | Pubmed ID: 22008897 Understanding and Classifying Metabolite Space and Metabolite-likeness PloS One. 2011 | Pubmed ID: 22194963 [An Ultra Performance Liquid Chromatography-time-of-flight-mass Spectrometric Method for Fast Analysis of Ginsenosides in Panax Ginseng Root] Se Pu = Chinese Journal of Chromatography / Zhongguo Hua Xue Hui. Jun, 2011 | Pubmed ID: 22032158 The Impact of Delayed Storage on the Measured Proteome and Metabolome of Human Cerebrospinal Fluid Clinical Chemistry. Dec, 2011 | Pubmed ID: 21998343 Localization of Fatty Acyl and Double Bond Positions in Phosphatidylcholines Using a Dual Stage CID Fragmentation Coupled with Ion Mobility Mass Spectrometry Journal of the American Society for Mass Spectrometry. Sep, 2011 | Pubmed ID: 21953258 Sub-typing of Rheumatic Diseases Based on a Systems Diagnosis Questionnaire PloS One. 2011 | Pubmed ID: 21949766 Quantitative Metabolomics Based on Gas Chromatography Mass Spectrometry: Status and Perspectives Metabolomics : Official Journal of the Metabolomic Society. Sep, 2011 | Pubmed ID: 21949491 Linking Biological Activity with Herbal Constituents by Systems Biology-based Approaches: Effects of Panax Ginseng in Type 2 Diabetic Goto-Kakizaki Rats Molecular BioSystems. Nov, 2011 | Pubmed ID: 21901208 Single-electrolyte Isotachophoresis Using a Nanochannel-induced Depletion Zone Analytical Chemistry. Oct, 2011 | Pubmed ID: 21861489 Anacetrapib Promotes Reverse Cholesterol Transport and Bulk Cholesterol Excretion in Syrian Golden Hamsters Journal of Lipid Research. Nov, 2011 | Pubmed ID: 21841206 ApoB SiRNA-induced Liver Steatosis is Resistant to Clearance by the Loss of Fatty Acid Transport Protein 5 (Fatp5) Lipids. Nov, 2011 | Pubmed ID: 21826528 Attenuation of Slc27a5 Gene Expression Followed by LC-MS Measurement of Bile Acid Reconjugation Using Metabolomics and a Stable Isotope Tracer Strategy Journal of Proteome Research. Oct, 2011 | Pubmed ID: 21819150 Elemental Composition Determination Based on MS(n) Bioinformatics (Oxford, England). Sep, 2011 | Pubmed ID: 21757467 Identifying Static and Kinetic Lipid Phenotypes by High Resolution UPLC-MS: Unraveling Diet-induced Changes in Lipid Homeostasis by Coupling Metabolomics and Fluxomics Journal of Proteome Research. Sep, 2011 | Pubmed ID: 21744776 Plasma and Liver Lipidomics Response to an Intervention of Rimonabant in ApoE*3Leiden.CETP Transgenic Mice PloS One. 2011 | Pubmed ID: 21611179 Traditional Processing Strongly Affects Metabolite Composition by Hydrolysis in Rehmannia Glutinosa Roots Chemical & Pharmaceutical Bulletin. 2011 | Pubmed ID: 21532190 Semi-automated Non-target Processing in GC × GC-MS Metabolomics Analysis: Applicability for Biomedical Studies Metabolomics : Official Journal of the Metabolomic Society. Mar, 2011 | Pubmed ID: 21461033 LC/MS Analysis of Stratum Corneum Lipids: Ceramide Profiling and Discovery Journal of Lipid Research. Jun, 2011 | Pubmed ID: 21444759 In Vivo D2O Labeling to Quantify Static and Dynamic Changes in Cholesterol and Cholesterol Esters by High Resolution LC/MS Journal of Lipid Research. Jan, 2011 | Pubmed ID: 20884843 Online Capillary Liquid-liquid Electroextraction of Peptides As Fast Pre-concentration Prior to LC-MS Electrophoresis. Dec, 2010 | Pubmed ID: 21064141 Systems Biology-based Diagnostic Principles As Pillars of the Bridge Between Chinese and Western Medicine Planta Medica. Dec, 2010 | Pubmed ID: 20979015 Quantitative Proteomics and Metabolomics Analysis of Normal Human Cerebrospinal Fluid Samples Molecular & Cellular Proteomics : MCP. Sep, 2010 | Pubmed ID: 20811074 Comparative Transcriptional Profiling and Preliminary Study on Heterosis Mechanism of Super-hybrid Rice Molecular Plant. Nov, 2010 | Pubmed ID: 20729474 Comprehensive LC-MS E Lipidomic Analysis Using a Shotgun Approach and Its Application to Biomarker Detection and Identification in Osteoarthritis Patients Journal of Proteome Research. May, 2010 | Pubmed ID: 20355720 Equating, or Correction for Between-block Effects with Application to Body Fluid LC-MS and NMR Metabolomics Data Sets Analytical Chemistry. Feb, 2010 | Pubmed ID: 20052990 Metabolic Profiling of Ultrasmall Sample Volumes with GC/MS: from Microliter to Nanoliter Samples Analytical Chemistry. Jan, 2010 | Pubmed ID: 19947586 Systems Toxicology Study of Doxorubicin on Rats Using Ultra Performance Liquid Chromatography Coupled with Mass Spectrometry Based Metabolomics Metabolomics : Official Journal of the Metabolomic Society. Dec, 2009 | Pubmed ID: 20046867 Mass-spectrometry-based Metabolomics: Limitations and Recommendations for Future Progress with Particular Focus on Nutrition Research Metabolomics : Official Journal of the Metabolomic Society. Dec, 2009 | Pubmed ID: 20046865 The Effect of Preanalytical Factors on Stability of the Proteome and Selected Metabolites in Cerebrospinal Fluid (CSF) Journal of Proteome Research. Dec, 2009 | Pubmed ID: 19845411 Feasibility of Electrodialysis As a Fast and Selective Sample Preparation Method for the Profiling of Low-abundant Peptides in Biofluids Electrophoresis. Jul, 2009 | Pubmed ID: 19569123 Analytical Strategies in Lipidomics and Applications in Disease Biomarker Discovery Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Sep, 2009 | Pubmed ID: 19233743 Alkaloid Profiling of the Chinese Herbal Medicine Fuzi by Combination of Matrix-assisted Laser Desorption Ionization Mass Spectrometry with Liquid Chromatography-mass Spectrometry Journal of Chromatography. A. Mar, 2009 | Pubmed ID: 19095240 Bioconversion of Red Ginseng Saponins in the Gastro-intestinal Tract in Vitro Model Studied by High-performance Liquid Chromatography-high Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Journal of Chromatography. A. Mar, 2009 | Pubmed ID: 19041979 RPLC-ion-trap-FTMS Method for Lipid Profiling of Plasma: Method Validation and Application to P53 Mutant Mouse Model Journal of Proteome Research. Nov, 2008 | Pubmed ID: 18841877 Solution Titration by Wall Deprotonation During Capillary Filling of Silicon Oxide Nanochannels Analytical Chemistry. Nov, 2008 | Pubmed ID: 18826247 Lipidomic Approach to Evaluate Rosuvastatin and Atorvastatin at Various Dosages: Investigating Differential Effects Among Statins Current Medical Research and Opinion. Sep, 2008 | Pubmed ID: 18655752 Comprehensive Analysis of the Metabolome of Pseudomonas Putida S12 Grown on Different Carbon Sources Molecular BioSystems. Apr, 2008 | Pubmed ID: 18354785 Similarities and Differences in Lipidomics Profiles Among Healthy Monozygotic Twin Pairs Omics : a Journal of Integrative Biology. Mar, 2008 | Pubmed ID: 18266560 Higher Mass Loadability in Comprehensive Two-dimensional Gas Chromatography-mass Spectrometry for Improved Analytical Performance in Metabolomics Analysis Journal of Chromatography. A. Apr, 2008 | Pubmed ID: 18155223 Recent Methodology in the Phytochemical Analysis of Ginseng Phytochemical Analysis : PCA. Jan-Feb, 2008 | Pubmed ID: 18058794 Proposed Minimum Reporting Standards for Chemical Analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI) Metabolomics : Official Journal of the Metabolomic Society. Sep, 2007 | Pubmed ID: 24039616 Profiling of Endogenous Peptides in Human Synovial Fluid by NanoLC-MS: Method Validation and Peptide Identification Journal of Proteome Research. Nov, 2007 | Pubmed ID: 17929855 Microbial Metabolomics: Toward a Platform with Full Metabolome Coverage Analytical Biochemistry. Nov, 2007 | Pubmed ID: 17765195 CE-ESI-MS of Biological Anions in Plastic Capillaries at High PH Electrophoresis. Mar, 2007 | Pubmed ID: 17300131 Metabolomics-based Systems Biology and Personalized Medicine: Moving Towards N = 1 Clinical Trials? Pharmacogenomics. Oct, 2006 | Pubmed ID: 17054418 Metabolite Profiling of Human Urine by CE-ESI-MS Using Separation Electrolytes at Low PH Electrophoresis. Nov, 2006 | Pubmed ID: 17054083 Simultaneous Quantitative Analysis of Metabolites Using Ion-pair Liquid Chromatography-electrospray Ionization Mass Spectrometry Analytical Chemistry. Sep, 2006 | Pubmed ID: 16970336 Hyphenation of Infrared Spectroscopy to Liquid Chromatography for Qualitative and Quantitative Polymer Analysis: Degradation of Poly(bisphenol A)carbonate Journal of Chromatography. A. Oct, 2006 | Pubmed ID: 16735038 Effects of Growth Conditions and Processing on Rehmannia Glutinosa Using Fingerprint Strategy Planta Medica. Apr, 2006 | Pubmed ID: 16557461 Microbial Metabolomics with Gas Chromatography/mass Spectrometry Analytical Chemistry. Feb, 2006 | Pubmed ID: 16478122 Typical Diffusion Behaviour in Packaging Polymers - Application to Functional Barriers Food Additives and Contaminants. Feb, 2006 | Pubmed ID: 16449064 Sign Constraints Improve the Detection of Differences Between Complex Spectral Data Sets: LC-IR As an Example Analytical Chemistry. Dec, 2005 | Pubmed ID: 16351148 Microbial Metabolomics: Replacing Trial-and-error by the Unbiased Selection and Ranking of Targets Journal of Industrial Microbiology & Biotechnology. Jun, 2005 | Pubmed ID: 15895265 Ensaio padronizado e escalável para estudar perfundido 3D Angiogênico Sprouting de células endotelias derivadas do iPSC in vitro Vincent van Duinen1,2, Wendy Stam1, Viola Borgdorff3, Arie Reijerkerk3, Valeria Orlova4, Paul Vulto5, Thomas Hankemeier2, Anton Jan van Zonneveld1 1Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, 2Division of Systems Biomedicine and Pharmacology, Department of Analytical BioSciences and Metabolomics, Leiden University, 3Ncardia, 4Department of Anatomy and Embryology, Leiden University Medical Center, 5Mimetas JoVE 59678 Bioengineering Sheathless Eletroforese Capilar-Espectrometria de Massa para Metabolic Profiling de amostras biológicas Wei Zhang1, M. Can Gulersonmez1, Thomas Hankemeier1, Rawi Ramautar1 1Division of Analytical Biosciences, Leiden Academic Center for Drug Research, Leiden University JoVE 54535 Biochemistry
Ensaio padronizado e escalável para estudar perfundido 3D Angiogênico Sprouting de células endotelias derivadas do iPSC in vitro Vincent van Duinen1,2, Wendy Stam1, Viola Borgdorff3, Arie Reijerkerk3, Valeria Orlova4, Paul Vulto5, Thomas Hankemeier2, Anton Jan van Zonneveld1 1Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, 2Division of Systems Biomedicine and Pharmacology, Department of Analytical BioSciences and Metabolomics, Leiden University, 3Ncardia, 4Department of Anatomy and Embryology, Leiden University Medical Center, 5Mimetas JoVE 59678 Bioengineering
Sheathless Eletroforese Capilar-Espectrometria de Massa para Metabolic Profiling de amostras biológicas Wei Zhang1, M. Can Gulersonmez1, Thomas Hankemeier1, Rawi Ramautar1 1Division of Analytical Biosciences, Leiden Academic Center for Drug Research, Leiden University JoVE 54535 Biochemistry
