Thorsten Hoppe Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) University of Cologne Biography Publications Institution JoVE Articles Thorsten Hoppe has not added a biography. If you are Thorsten Hoppe and would like to personalize this page please email our Author Liaison for assistance. Publications Correction To: Build-UPS and Break-downs: Metabolism Impacts on Proteostasis and Aging Cell Death and Differentiation. May, 2021 | Pubmed ID: 33976390 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th Edition) Autophagy. Feb, 2021 | Pubmed ID: 33634751 Build-UPS and Break-downs: Metabolism Impacts on Proteostasis and Aging Cell Death and Differentiation. Feb, 2021 | Pubmed ID: 33398091 The Price of Longevity Aging. 11, 2020 | Pubmed ID: 33253121 Pathogenic Variants in the Myosin Chaperone UNC-45B Cause Progressive Myopathy with Eccentric Cores American Journal of Human Genetics. 12, 2020 | Pubmed ID: 33217308 Ubiquitin-dependent Regulation of a Conserved DMRT Protein Controls Sexually Dimorphic Synaptic Connectivity and Behavior ELife. 10, 2020 | Pubmed ID: 33021200 CHIP Ubiquitylates NOXA and Induces Its Lysosomal Degradation in Response to DNA Damage Cell Death & Disease. 09, 2020 | Pubmed ID: 32913203 Organismal Protein Homeostasis Mechanisms Genetics. 08, 2020 | Pubmed ID: 32759342 Author Correction: Olfaction Regulates Organismal Proteostasis and Longevity Via MicroRNA-dependent Signalling Nature Metabolism. Jan, 2020 | Pubmed ID: 32694680 The Ubiquitin-conjugating Enzyme UBE2K Determines Neurogenic Potential Through Histone H3 in Human Embryonic Stem Cells Communications Biology. 05, 2020 | Pubmed ID: 32451438 Mitochondrial Quality Control Governed by Ubiquitin Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 32391359 Regulation of E3 Ubiquitin Ligases by Homotypic and Heterotypic Assembly F1000Research. 2020 | Pubmed ID: 32076548 Author Correction: The Ubiquitin Ligase UBR5 Suppresses Proteostasis Collapse in Pluripotent Stem Cells from Huntington's Disease Patients Nature Communications. Feb, 2020 | Pubmed ID: 32066719 The Machado-Joseph Disease Deubiquitylase Ataxin-3 Interacts with LC3C/GABARAP and Promotes Autophagy Aging Cell. 01, 2020 | Pubmed ID: 31625269 The Autophagy Receptor P62/SQST-1 Promotes Proteostasis and Longevity in C. Elegans by Inducing Autophagy Nature Communications. 12, 2019 | Pubmed ID: 31827090 Latest Advances in Aging Research and Drug Discovery Aging. 11, 2019 | Pubmed ID: 31770722 Olfaction Regulates Organismal Proteostasis and Longevity Via MicroRNA-dependent Signaling Nature Metabolism. 03, 2019 | Pubmed ID: 31535080 Western Blot Analysis of the Autophagosomal Membrane Protein LGG-1/LC3 in Caenorhabditis Elegans Methods in Enzymology. 2019 | Pubmed ID: 30910027 Hepatic ERAD Takes Control of The organism The EMBO Journal. 11, 2018 | Pubmed ID: 30389670 ERADicate Tumor Progression with Metformin Molecular Cell. 08, 2018 | Pubmed ID: 30118675 The Ubiquitin Ligase UBR5 Suppresses Proteostasis Collapse in Pluripotent Stem Cells from Huntington's Disease Patients Nature Communications. 07, 2018 | Pubmed ID: 30038412 Ub and Down: Ubiquitin Exercise for the Elderly Trends in Cell Biology. 07, 2018 | Pubmed ID: 29704981 Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. 05, 2018 | Pubmed ID: 29611634 Stressed Out: Mitohormesis Is Crossing Borders Trends in Endocrinology and Metabolism: TEM. 08, 2018 | Pubmed ID: 29605660 CHIPped Balance of Proteostasis and Longevity Oncotarget. Nov, 2017 | Pubmed ID: 29228542 Chaperone-directed Ubiquitylation Maintains Proteostasis at the Expense of Longevity Worm. 2017 | Pubmed ID: 28959501 Conserved Cytoplasmic Domains Promote Hrd1 Ubiquitin Ligase Complex Formation for ER-associated Degradation (ERAD) Journal of Cell Science. Oct, 2017 | Pubmed ID: 28827405 Repair or Destruction-an Intimate Liaison Between Ubiquitin Ligases and Molecular Chaperones in Proteostasis FEBS Letters. 09, 2017 | Pubmed ID: 28699655 The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover Cell. 04, 2017 | Pubmed ID: 28431247 Stefan Jentsch (1955-2016)-Maestro of the Ubiquitin Family The EMBO Journal. 01, 2017 | Pubmed ID: 27974363 E4 Ligase-specific Ubiquitination Hubs Coordinate DNA Double-strand-break Repair and Apoptosis Nature Structural & Molecular Biology. Nov, 2016 | Pubmed ID: 27669035 It's All About Talking: Two-way Communication Between Proteasomal and Lysosomal Degradation Pathways Via Ubiquitin American Journal of Physiology. Cell Physiology. 08, 2016 | Pubmed ID: 27225656 Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin Frontiers in Genetics. 2016 | Pubmed ID: 27200082 Chromatin-associated Degradation is Defined by UBXN-3/FAF1 to Safeguard DNA Replication Fork Progression Nature Communications. Feb, 2016 | Pubmed ID: 26842564 Double-edged Alliance: Mitochondrial Surveillance by the UPS and Autophagy Current Opinion in Cell Biology. Dec, 2015 | Pubmed ID: 26343990 Regulation of the DNA Damage Response by Ubiquitin Conjugation Frontiers in Genetics. 2015 | Pubmed ID: 25806049 Challenging Muscle Homeostasis Uncovers Novel Chaperone Interactions in Caenorhabditis Elegans Frontiers in Molecular Biosciences. 2014 | Pubmed ID: 25988162 MicroRNAs Meet Calcium: Joint Venture in ER Proteostasis Science Signaling. Nov, 2014 | Pubmed ID: 25372053 The Ubiquitin-selective Chaperone Cdc48/p97 Associates with Ubx3 to Modulate Monoubiquitylation of Histone H2B Nucleic Acids Research. 2014 | Pubmed ID: 25183520 Limited Proteolysis: DisRUPting Proteasomal Inhibition Current Biology : CB. Aug, 2014 | Pubmed ID: 25093561 Reversible 26S Proteasome Disassembly Upon Mitochondrial Stress Cell Reports. Jun, 2014 | Pubmed ID: 24857655 Activation of the Endoplasmic Reticulum Unfolded Protein Response by Lipid Disequilibrium Without Disturbed Proteostasis in Vivo Proceedings of the National Academy of Sciences of the United States of America. Jun, 2014 | Pubmed ID: 24843123 Pathogenesis of Human Mitochondrial Diseases is Modulated by Reduced Activity of the Ubiquitin/proteasome System Cell Metabolism. Apr, 2014 | Pubmed ID: 24703696 Ubiquitin Sets the Timer: Impacts on Aging and Longevity Nature Structural & Molecular Biology. Apr, 2014 | Pubmed ID: 24699075 Hexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong Life Cell. Mar, 2014 | Pubmed ID: 24630720 Create and Preserve: Proteostasis in Development and Aging is Governed by Cdc48/p97/VCP Biochimica Et Biophysica Acta. Jan, 2014 | Pubmed ID: 23583830 Role of Sirtuins in Lifespan Regulation is Linked to Methylation of Nicotinamide Nature Chemical Biology. Nov, 2013 | Pubmed ID: 24077178 DNA Damage in Germ Cells Induces an Innate Immune Response That Triggers Systemic Stress Resistance Nature. Sep, 2013 | Pubmed ID: 23975097 A Novel Interaction Between Aging and ER Overload in a Protein Conformational Dementia Genetics. Mar, 2013 | Pubmed ID: 23335331 The Myosin Chaperone UNC-45 is Organized in Tandem Modules to Support Myofilament Formation in C. Elegans Cell. Jan, 2013 | Pubmed ID: 23332754 Deficiency for the Ubiquitin Ligase UBE3B in a Blepharophimosis-ptosis-intellectual-disability Syndrome American Journal of Human Genetics. Dec, 2012 | Pubmed ID: 23200864 Analysis of Ubiquitin-dependent Proteolysis in Caenorhabditis Elegans Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22350911 CDC-48/p97 Coordinates CDT-1 Degradation with GINS Chromatin Dissociation to Ensure Faithful DNA Replication Molecular Cell. Oct, 2011 | Pubmed ID: 21981920 A Screenable in Vivo Assay to Study Proteostasis Networks in Caenorhabditis Elegans Genetics. Apr, 2011 | Pubmed ID: 21288877 Life and Destruction: Ubiquitin-mediated Proteolysis in Aging and Longevity F1000 Biology Reports. Nov, 2010 | Pubmed ID: 21151840 Think Locally: Control of Ubiquitin-dependent Protein Degradation in Neurons EMBO Reports. Jan, 2009 | Pubmed ID: 19079132 In Vitro Analysis of E3 Ubiquitin Ligase Function Leonie Müller1, Carl Elias Kutzner1,2, Vishnu Balaji1, Thorsten Hoppe1,2 1Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, 2Center for Molecular Medicine Cologne, University of Cologne JoVE 62393 Biology
In Vitro Analysis of E3 Ubiquitin Ligase Function Leonie Müller1, Carl Elias Kutzner1,2, Vishnu Balaji1, Thorsten Hoppe1,2 1Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, 2Center for Molecular Medicine Cologne, University of Cologne JoVE 62393 Biology
