Timo L.M. ten Hagen

Publications

• Inhomogeneous Crystal Grain Formation in DPPC-DSPC Based Thermosensitive Liposomes Determines Content Release Kinetics
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Feb, 2017  |   Pubmed ID: 28042084
• High-Resolution Intravital Microscopy of Tumor Angiogenesis
  Methods in Molecular Biology (Clifton, N.J.). 2016  |   Pubmed ID: 27858361
• Melanomas Prevent Endothelial Cell Death Under Restrictive Culture Conditions by Signaling Through AKT and P38 MAPK/ ERK-1/2 Cascades
  Oncoimmunology. 2016  |   Pubmed ID: 27853641
• Lipid Phosphatase SHIP2 Functions As Oncogene in Colorectal Cancer by Regulating PKB Activation
  Oncotarget. Nov, 2016  |   Pubmed ID: 27716613
• Investigation of Particle Accumulation, Chemosensitivity and Thermosensitivity for Effective Solid Tumor Therapy Using Thermosensitive Liposomes and Hyperthermia
  Theranostics. 2016  |   Pubmed ID: 27446503
• EGFR Targeted Thermosensitive Liposomes: A Novel Multifunctional Platform for Simultaneous Tumor Targeted and Stimulus Responsive Drug Delivery
  Colloids and Surfaces. B, Biointerfaces. Oct, 2016  |   Pubmed ID: 27434152
• Targeting Melanoma with Immunoliposomes Coupled to Anti-MAGE A1 TCR-like Single-chain Antibody
  International Journal of Nanomedicine. 2016  |   Pubmed ID: 27022262
• Increased PTP1B Expression and Phosphatase Activity in Colorectal Cancer Results in a More Invasive Phenotype and Worse Patient Outcome
  Oncotarget. Apr, 2016  |   Pubmed ID: 26942883
• Light Fractionation Significantly Increases the Efficacy of Photodynamic Therapy Using BF-200 ALA in Normal Mouse Skin
  PloS One. 2016  |   Pubmed ID: 26872051
• Association of TIMP3 Expression with Vessel Density, Macrophage Infiltration and Prognosis in Human Malignant Melanoma
  European Journal of Cancer (Oxford, England : 1990). Jan, 2016  |   Pubmed ID: 26707830
• Pharmacokinetics, Tissue Distribution and Therapeutic Effect of Cationic Thermosensitive Liposomal Doxorubicin Upon Mild Hyperthermia
  Pharmaceutical Research. Mar, 2016  |   Pubmed ID: 26518763
• Formulation and Optimization of Idarubicin Thermosensitive Liposomes Provides Ultrafast Triggered Release at Mild Hyperthermia and Improves Tumor Response
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2015  |   Pubmed ID: 26541464
• Development of a Novel Cyclic RGD Peptide for Multiple Targeting Approaches of Liposomes to Tumor Region
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2015  |   Pubmed ID: 26526970
• Enhanced Specificity and Drug Delivery in Tumors by CRGD-Anchoring Thermosensitive Liposomes
  Pharmaceutical Research. Dec, 2015  |   Pubmed ID: 26202516
• Cetuximab-oxaliplatin-liposomes for Epidermal Growth Factor Receptor Targeted Chemotherapy of Colorectal Cancer
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Jul, 2015  |   Pubmed ID: 25998052
• Plasma Membrane Targeting by Short Chain Sphingolipids Inserted in Liposomes Improves Anti-tumor Activity of Mitoxantrone in an Orthotopic Breast Carcinoma Xenograft Model
  European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. Aug, 2015  |   Pubmed ID: 25982691
• C8-glycosphingolipids Preferentially Insert into Tumor Cell Membranes and Promote Chemotherapeutic Drug Uptake
  Biochimica Et Biophysica Acta. Aug, 2015  |   Pubmed ID: 25917957
• Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP) Upregulation Mediates Malignant Potential in Colorectal Cancer
  Oncotarget. Apr, 2015  |   Pubmed ID: 25811796
• Short-chain Glycoceramides Promote Intracellular Mitoxantrone Delivery from Novel Nanoliposomes into Breast Cancer Cells
  Pharmaceutical Research. Apr, 2015  |   Pubmed ID: 25319103
• Targeted and Heat-triggered Doxorubicin Delivery to Tumors by Dual Targeted Cationic Thermosensitive Liposomes
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2014  |   Pubmed ID: 25176578
• Somatostatin Analogues for Receptor Targeted Photodynamic Therapy
  PloS One. 2014  |   Pubmed ID: 25111655
• [(111)In-DTPA]octreotide Tumor Uptake in GEPNET Liver Metastases After Intra-arterial Administration: an Overview of Preclinical and Clinical Observations and Implications for Tumor Radiation Dose After Peptide Radionuclide Therapy
  Cancer Biotherapy & Radiopharmaceuticals. May, 2014  |   Pubmed ID: 24820805
• Exposing Endothelial Cells to Tumor Necrosis Factor-α and Peripheral Blood Mononuclear Cells Damage Endothelial Integrity Via Interleukin-1ß by Degradation of Vascular Endothelial-cadherin
  Surgery. Mar, 2014  |   Pubmed ID: 24439748
• Intact Doxil is Taken Up Intracellularly and Released Doxorubicin Sequesters in the Lysosome: Evaluated by in Vitro/in Vivo Live Cell Imaging
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2013  |   Pubmed ID: 24012486
• The αVβ3/αVβ5 Integrin Inhibitor Cilengitide Augments Tumor Response to Melphalan Isolated Limb Perfusion in a Sarcoma Model
  International Journal of Cancer. Jun, 2013  |   Pubmed ID: 23152080
• Multimodality Imaging of Somatostatin Receptor-positive Tumors with Nuclear and Bioluminescence Imaging
  Molecular Imaging. Feb, 2012  |   Pubmed ID: 22418025
• Changes of Ferritin and CRP Levels in Melanoma Patients Treated with Adjuvant Interferon-α (EORTC 18952) and Prognostic Value on Treatment Outcome
  Melanoma Research. Aug, 2011  |   Pubmed ID: 21546857
• Local ATP Generation by Brain-type Creatine Kinase (CK-B) Facilitates Cell Motility
  PloS One. 2009  |   Pubmed ID: 19333390
• Laboratory Models of Regional Chemotherapy
  International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. May, 2008  |   Pubmed ID: 18393006
• Tumor Necrosis Factor-mediated Interactions Between Inflammatory Response and Tumor Vascular Bed
  Immunological Reviews. Apr, 2008  |   Pubmed ID: 18364010
• TNF and Manipulation of the Tumor Cell-stromal Interface: "ways to Make Chemotherapy Effective"
  Frontiers in Bioscience : a Journal and Virtual Library. Jan, 2008  |   Pubmed ID: 17981776
• Tumor Necrosis Factor Alpha Mediates Homogeneous Distribution of Liposomes in Murine Melanoma That Contributes to a Better Tumor Response
  Cancer Research. Oct, 2007  |   Pubmed ID: 17909055
• Vasoactive Peptides Upregulate MRNA Expression and Secretion of Vascular Endothelial Growth Factor in Human Airway Smooth Muscle Cells
  Cell Biochemistry and Biophysics. 2007  |   Pubmed ID: 17406064
• Synergistic Antitumor Effects of Histamine Plus Melphalan in Isolated Hepatic Perfusion for Liver Metastases
  Annals of Surgical Oncology. Feb, 2007  |   Pubmed ID: 17096052
• Decreased Response Rates by the Combination of Histamine and IL-2 in Melphalan-based Isolated Limb Perfusion
  Cancer Immunology, Immunotherapy : CII. Apr, 2007  |   Pubmed ID: 16896966
• EMAP-II Facilitates TNF-R1 Apoptotic Signalling in Endothelial Cells and Induces TRADD Mobilization
  Apoptosis : an International Journal on Programmed Cell Death. Dec, 2006  |   Pubmed ID: 17051333
• Early Destruction of Tumor Vasculature in Tumor Necrosis Factor-alpha-based Isolated Limb Perfusion is Responsible for Tumor Response
  Anti-cancer Drugs. Sep, 2006  |   Pubmed ID: 16940805
• Differential Effects of Matrix and Growth Factors on Endothelial and Fibroblast Motility: Application of a Modified Cell Migration Assay
  Journal of Cellular Biochemistry. Dec, 2006  |   Pubmed ID: 16817234
• Changing the Pathophysiology of Solid Tumours: the Potential of TNF and Other Vasoactive Agents
  International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. May, 2006  |   Pubmed ID: 16754345
• Intratumoural Expression of TNF-R1 and EMAP-II in Relation to Response of Patients Treated with TNF-based Isolated Limb Perfusion
  International Journal of Cancer. Sep, 2006  |   Pubmed ID: 16615114
• TNF-alpha in Cancer Treatment: Molecular Insights, Antitumor Effects, and Clinical Utility
  The Oncologist. Apr, 2006  |   Pubmed ID: 16614236
• Technology Insight: Utility of TNF-alpha-based Isolated Limb Perfusion to Avoid Amputation of Irresectable Tumors of the Extremities
  Nature Clinical Practice. Oncology. Feb, 2006  |   Pubmed ID: 16462850
• MR Angiography of Tumor-related Vasculature: from the Clinic to the Micro-environment
  Radiographics : a Review Publication of the Radiological Society of North America, Inc. Oct, 2005  |   Pubmed ID: 16227499
• Histamine Combined with Melphalan in Isolated Limb Perfusion for the Treatment of Locally Advanced Soft Tissue Sarcomas: Preclinical Studies in Rats
  Acta Cirurgica Brasileira. Jul-Aug, 2005  |   Pubmed ID: 16186945
• Addition of Low-dose Tumor Necrosis Factor-alpha to Systemic Treatment with STEALTH Liposomal Doxorubicin (Doxil) Improved Anti-tumor Activity in Osteosarcoma-bearing Rats
  Anti-cancer Drugs. Jul, 2005  |   Pubmed ID: 15930896
• Synergistic Antitumor Response of Interleukin 2 with Melphalan in Isolated Limb Perfusion in Soft Tissue Sarcoma-bearing Rats
  Cancer Research. May, 2005  |   Pubmed ID: 15899822
• Effect of Low-dose Tumor Necrosis Factor-alpha in Combination with STEALTH Liposomal Cisplatin (SPI-077) on Soft-tissue- and Osteosarcoma-bearing Rats
  Anticancer Research. Mar-Apr, 2005  |   Pubmed ID: 15868905
• Synergistic Antitumor Activity of Histamine Plus Melphalan in Isolated Limb Perfusion: Preclinical Studies
  Journal of the National Cancer Institute. Nov, 2004  |   Pubmed ID: 15523089
• Lack of Efficacy of Doxil in TNF-alpha-based Isolated Limb Perfusion in Sarcoma-bearing Rats
  British Journal of Cancer. May, 2004  |   Pubmed ID: 15208623
• Solid Tumor Therapy: Manipulation of the Vasculature with TNF
  Technology in Cancer Research & Treatment. Jun, 2003  |   Pubmed ID: 12779350