Timothy C. Chambers

Publications

• Activity of Resveratrol Triesters Against Primary Acute Lymphoblastic Leukemia Cells
  Bioorganic & Medicinal Chemistry Letters. Jun, 2017  |   Pubmed ID: 28499732
• Mitotic Arrest-induced Phosphorylation of Mcl-1 Revisited Using Two-dimensional Gel Electrophoresis and Phosphoproteomics: Nine Phosphorylation Sites Identified
  Oncotarget. Nov, 2016  |   Pubmed ID: 27738316
• Cell Cycle-Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells
  Cancer Research. 06, 2016  |   Pubmed ID: 27197148
• CDK1/2 Toolbox in Need of an Upgrade
  Cell Cycle (Georgetown, Tex.). Jul, 2016  |   Pubmed ID: 27104300
• BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells
  Cancer Research. Apr, 2015  |   Pubmed ID: 25649768
• Cyclin B1 Overexpression Induces Cell Death Independent of Mitotic Arrest
  PloS One. 2014  |   Pubmed ID: 25415322
• Molecular Analysis of Functional Redundancy Among Anti-apoptotic Bcl-2 Proteins and Its Role in Cancer Cell Survival
  Experimental Cell Research. Apr, 2014  |   Pubmed ID: 24556425
• Identification of a Mitotic Death Signature in Cancer Cell Lines
  Cancer Letters. Feb, 2014  |   Pubmed ID: 24099917
• Metabolic Transformation of Antitumor Acridinone C-1305 but Not C-1311 Via Selective Cellular Expression of UGT1A10 Increases Cytotoxic Response: Implications for Clinical Use
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Feb, 2013  |   Pubmed ID: 23160818
• Cyclin-dependent Kinase-1 (Cdk1)/cyclin B1 Dictates Cell Fate After Mitotic Arrest Via Phosphoregulation of Antiapoptotic Bcl-2 Proteins
  The Journal of Biological Chemistry. Nov, 2012  |   Pubmed ID: 22965228
• Cdk1/cyclin B Plays a Key Role in Mitotic Arrest-induced Apoptosis by Phosphorylation of Mcl-1, Promoting Its Degradation and Freeing Bak from Sequestration
  Biochemical Pharmacology. Jan, 2012  |   Pubmed ID: 22024133
• Cyclin-dependent Kinase 1-mediated Bcl-xL/Bcl-2 Phosphorylation Acts As a Functional Link Coupling Mitotic Arrest and Apoptosis
  Molecular and Cellular Biology. Feb, 2010  |   Pubmed ID: 19917720
• Synthesis and Anticancer Activity of Sclerophytin-inspired Hydroisobenzofurans
  Bioorganic & Medicinal Chemistry Letters. Dec, 2009  |   Pubmed ID: 19896844
• Regulation of Bax by C-Jun NH2-terminal Kinase and Bcl-xL in Vinblastine-induced Apoptosis
  Biochemical Pharmacology. Aug, 2009  |   Pubmed ID: 19427996
• P21 Functions in a Post-mitotic Block Checkpoint in the Apoptotic Response to Vinblastine
  Biochemical and Biophysical Research Communications. Mar, 2009  |   Pubmed ID: 19161984
• Identification of the Major Phosphorylation Site in Bcl-xL Induced by Microtubule Inhibitors and Analysis of Its Functional Significance
  The Journal of Biological Chemistry. Dec, 2008  |   Pubmed ID: 18974096
• Key Role for Bak Activation and Bak-Bax Interaction in the Apoptotic Response to Vinblastine
  Molecular Cancer Therapeutics. Jul, 2008  |   Pubmed ID: 18645031
• Distinct Signaling Pathways of Microtubule Inhibitors--vinblastine and Taxol Induce JNK-dependent Cell Death but Through AP-1-dependent and AP-1-independent Mechanisms, Respectively
  The FEBS Journal. Apr, 2008  |   Pubmed ID: 18341588
• Induction of Apoptosis by Vinblastine Via C-Jun Autoamplification and P53-independent Down-regulation of P21WAF1/CIP1
  Molecular Pharmacology. Jan, 2008  |   Pubmed ID: 18094076
• Inducible Overexpression of C-Jun in MCF7 Cells Causes Resistance to Vinblastine Via Inhibition of Drug-induced Apoptosis and Senescence at a Step Subsequent to Mitotic Arrest
  Biochemical Pharmacology. Feb, 2007  |   Pubmed ID: 17126817
• Superhigh-sensitivity Photothermal Monitoring of Individual Cell Response to Antitumor Drug
  Journal of Biomedical Optics. Nov-Dec, 2006  |   Pubmed ID: 17212557
• Vinblastine-induced Apoptosis is Mediated by Discrete Alterations in Subcellular Location, Oligomeric Structure, and Activation Status of Specific Bcl-2 Family Members
  The Journal of Biological Chemistry. Jun, 2006  |   Pubmed ID: 16574665
• Role of C-Jun in Cellular Sensitivity to the Microtubule Inhibitor Vinblastine
  Biochemical and Biophysical Research Communications. Oct, 2005  |   Pubmed ID: 16111654
• Characterization of Vinblastine-induced Bcl-xL and Bcl-2 Phosphorylation: Evidence for a Novel Protein Kinase and a Coordinated Phosphorylation/dephosphorylation Cycle Associated with Apoptosis Induction
  Oncogene. Jan, 2005  |   Pubmed ID: 15531923
• Coordinating Epidermal Growth Factor-induced Motility Promotes Efficient Wound Closure
  American Journal of Physiology. Cell Physiology. Jan, 2005  |   Pubmed ID: 15371256
• Subcellular Localization As a Limiting Factor for Utilization of Decoy Oligonucleotides
  Nucleic Acids Research. Oct, 2004  |   Pubmed ID: 15498923
• Inhibition of Cell Proliferation and Cell Cycle Progression by Specific Inhibition of Basal JNK Activity: Evidence That Mitotic Bcl-2 Phosphorylation is JNK-independent
  The Journal of Biological Chemistry. Mar, 2004  |   Pubmed ID: 14704147
• The JNK, ERK and P53 Pathways Play Distinct Roles in Apoptosis Mediated by the Antitumor Agents Vinblastine, Doxorubicin, and Etoposide
  Biochemical Pharmacology. Aug, 2003  |   Pubmed ID: 12907245
• C-Jun NH2-terminal Kinase-mediated Signaling is Essential for Pseudomonas Aeruginosa ExoS-induced Apoptosis
  Infection and Immunity. Jun, 2003  |   Pubmed ID: 12761120
• Molecular Analysis of the Multidrug Transporter, P-glycoprotein
  Cytotechnology. Sep, 1998  |   Pubmed ID: 19002782