Timothy Block Drexel University College of Medicine Biography Publications Institution JoVE Articles Timothy Block has not added a biography. If you are Timothy Block and would like to personalize this page please email our Author Liaison for assistance. Publications Enhancing the Antiviral Potency of ER α-glucosidase Inhibitor IHVR-19029 Against Hemorrhagic Fever Viruses in Vitro and in Vivo Antiviral Research. 02, 2018 | Pubmed ID: 29253498 Interferon-inducible Ribonuclease ISG20 Inhibits Hepatitis B Virus Replication Through Directly Binding to the Epsilon Stem-loop Structure of Viral RNA PLoS Pathogens. Apr, 2017 | Pubmed ID: 28399146 The Doylestown Algorithm: A Test to Improve the Performance of AFP in the Detection of Hepatocellular Carcinoma Cancer Prevention Research (Philadelphia, Pa.). Feb, 2016 | Pubmed ID: 26712941 Data Supporting Updating Estimates of the Prevalence of Chronic Hepatitis B and C in the United States Hepatology (Baltimore, Md.). Nov, 2015 | Pubmed ID: 26239816 Comprehensive DNA Methylation Analysis of Hepatitis B Virus Genome in Infected Liver Tissues Scientific Reports. May, 2015 | Pubmed ID: 26000761 Glycosylation and Liver Cancer Advances in Cancer Research. 2015 | Pubmed ID: 25727150 STING Agonists Induce an Innate Antiviral Immune Response Against Hepatitis B Virus Antimicrobial Agents and Chemotherapy. Feb, 2015 | Pubmed ID: 25512416 Differential Methylation of the Promoter and First Exon of the RASSF1A Gene in Hepatocarcinogenesis Hepatology Research : the Official Journal of the Japan Society of Hepatology. Nov, 2015 | Pubmed ID: 25382672 Inhibition of Endoplasmic Reticulum-resident Glucosidases Impairs Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63 Spike Protein-mediated Entry by Altering the Glycan Processing of Angiotensin I-converting Enzyme 2 Antimicrobial Agents and Chemotherapy. Jan, 2015 | Pubmed ID: 25348530 Viral Resistance of MOGS-CDG Patients Implies a Broad-spectrum Strategy Against Acute Virus Infections Antiviral Therapy. 2015 | Pubmed ID: 25318123 An Interferon-beta Promoter Reporter Assay for High Throughput Identification of Compounds Against Multiple RNA Viruses Antiviral Research. Jul, 2014 | Pubmed ID: 24792753 Interferon Induction of IFITM Proteins Promotes Infection by Human Coronavirus OC43 Proceedings of the National Academy of Sciences of the United States of America. May, 2014 | Pubmed ID: 24753610 Imino Sugar Glucosidase Inhibitors As Broadly Active Anti-filovirus Agents Emerging Microbes & Infections. Nov, 2013 | Pubmed ID: 26038444 Alpha-interferon Suppresses Hepadnavirus Transcription by Altering Epigenetic Modification of CccDNA Minichromosomes PLoS Pathogens. Sep, 2013 | Pubmed ID: 24068929 Total Serum Glycan Analysis is Superior to Lectin-FLISA for the Early Detection of Hepatocellular Carcinoma Proteomics. Clinical Applications. Oct, 2013 | Pubmed ID: 23857719 Inhibition of Hepatitis B Virus Replication by the Host Zinc Finger Antiviral Protein PLoS Pathogens. 2013 | Pubmed ID: 23853601 A Southern Blot Assay for Detection of Hepatitis B Virus Covalently Closed Circular DNA from Cell Cultures Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23821267 Antiviral Therapies Targeting Host ER Alpha-glucosidases: Current Status and Future Directions Antiviral Research. Sep, 2013 | Pubmed ID: 23816430 Altered Functionality of Anti-bacterial Antibodies in Patients with Chronic Hepatitis C Virus Infection PloS One. 2013 | Pubmed ID: 23750224 Small Molecule Inhibitors of ER α-glucosidases Are Active Against Multiple Hemorrhagic Fever Viruses Antiviral Research. Jun, 2013 | Pubmed ID: 23578725 Sulfamoylbenzamide Derivatives Inhibit the Assembly of Hepatitis B Virus Nucleocapsids Journal of Virology. Jun, 2013 | Pubmed ID: 23576513 Chronic Hepatitis B: What Should Be the Goal for New Therapies? Antiviral Research. Apr, 2013 | Pubmed ID: 23391846 Suppression of AKT Anti-Apoptotic Signaling by a Novel Drug Candidate Results in Growth Arrest and Apoptosis of Hepatocellular Carcinoma Cells PloS One. 2013 | Pubmed ID: 23355882 Improved Biomarker Performance for the Detection of Hepatocellular Carcinoma by Inclusion of Clinical Parameters Proceedings. IEEE International Conference on Bioinformatics and Biomedicine. Dec, 2012 | Pubmed ID: 24307972 Interleukin-6 and Oncostatin M Are Elevated in Liver Disease in Conjunction with Candidate Hepatocellular Carcinoma Biomarker GP73 Cancer Biomarkers : Section A of Disease Markers. 2012 | Pubmed ID: 23144154 The Innate Immune Response to Hepatitis B Virus Infection: Implications for Pathogenesis and Therapy Antiviral Research. Dec, 2012 | Pubmed ID: 23072881 RO 90-7501 Enhances TLR3 and RLR Agonist Induced Antiviral Response PloS One. 2012 | Pubmed ID: 23056170 Substance Abuse, HIV-1 and Hepatitis Current HIV Research. Oct, 2012 | Pubmed ID: 22973853 Characterization of the Host Factors Required for Hepadnavirus Covalently Closed Circular (ccc) DNA Formation PloS One. 2012 | Pubmed ID: 22912842 Design, Synthesis, and Biological Evaluation of N-alkylated Deoxynojirimycin (DNJ) Derivatives for the Treatment of Dengue Virus Infection Journal of Medicinal Chemistry. Jul, 2012 | Pubmed ID: 22712544 Identification of Disubstituted Sulfonamide Compounds As Specific Inhibitors of Hepatitis B Virus Covalently Closed Circular DNA Formation Antimicrobial Agents and Chemotherapy. Aug, 2012 | Pubmed ID: 22644022 Direct Evidence That HSV DNA Damaged by Ultraviolet (UV) Irradiation Can Be Repaired in a Cell Type-dependent Manner Journal of Neurovirology. Jun, 2012 | Pubmed ID: 22581427 Impact of the Location of CpG Methylation Within the GSTP1 Gene on Its Specificity As a DNA Marker for Hepatocellular Carcinoma PloS One. 2012 | Pubmed ID: 22536438 Increased Levels of Tetra-antennary N-linked Glycan but Not Core Fucosylation Are Associated with Hepatocellular Carcinoma Tissue Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. May, 2012 | Pubmed ID: 22490318 Detection of Hypermethylated Vimentin in Urine of Patients with Colorectal Cancer The Journal of Molecular Diagnostics : JMD. Mar, 2012 | Pubmed ID: 22251609 Quantitative Dynamics of Hepatitis B Basal Core Promoter and Precore Mutants Before and After HBeAg Seroconversion Journal of Hepatology. Apr, 2012 | Pubmed ID: 22173170 Methylation of the CpG Sites Only on the Sense Strand of the APC Gene is Specific for Hepatocellular Carcinoma PloS One. 2011 | Pubmed ID: 22073196 Immunology. Dec, 2011 | Pubmed ID: 22043941 A Ubiquitin Independent Degradation Pathway Utilized by a Hepatitis B Virus Envelope Protein to Limit Antigen Presentation PloS One. 2011 | Pubmed ID: 21969857 Development of Recombinant Aleuria Aurantia Lectins with Altered Binding Specificities to Fucosylated Glycans Biochemical and Biophysical Research Communications. Oct, 2011 | Pubmed ID: 21945439 Competitive Inhibitor of Cellular α-glucosidases Protects Mice from Lethal Dengue Virus Infection Antiviral Research. Nov, 2011 | Pubmed ID: 21854808 Design, Synthesis, and Biological Evaluation of Triazolo-pyrimidine Derivatives As Novel Inhibitors of Hepatitis B Virus Surface Antigen (HBsAg) Secretion Journal of Medicinal Chemistry. Aug, 2011 | Pubmed ID: 21786803 A Locked Nucleic Acid Clamp-mediated PCR Assay for Detection of a P53 Codon 249 Hotspot Mutation in Urine The Journal of Molecular Diagnostics : JMD. Sep, 2011 | Pubmed ID: 21726666 Quantification of Complex Precore Mutations of Hepatitis B Virus by SimpleProbe Real Time PCR and Dual Melting Analysis Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology. Aug, 2011 | Pubmed ID: 21665530 Ultrasensitive Quantification of Hepatitis B Virus A1762T/G1764A Mutant by a SimpleProbe PCR Using a Wild-type-selective PCR Blocker and a Primer-blocker-probe Partial-overlap Approach Journal of Clinical Microbiology. Jul, 2011 | Pubmed ID: 21562108 International Journal of Oncology. Jul, 2011 | Pubmed ID: 21503570 Novel Changes in Glycosylation of Serum Apo-J in Patients with Hepatocellular Carcinoma Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Jun, 2011 | Pubmed ID: 21467232 Inhibitors of Endoplasmic Reticulum Alpha-glucosidases Potently Suppress Hepatitis C Virus Virion Assembly and Release Antimicrobial Agents and Chemotherapy. Mar, 2011 | Pubmed ID: 21173177 Alkylated Porphyrins Have Broad Antiviral Activity Against Hepadnaviruses, Flaviviruses, Filoviruses, and Arenaviruses Antimicrobial Agents and Chemotherapy. Feb, 2011 | Pubmed ID: 21135183 Indoleamine 2,3-dioxygenase Mediates the Antiviral Effect of Gamma Interferon Against Hepatitis B Virus in Human Hepatocyte-derived Cells Journal of Virology. Jan, 2011 | Pubmed ID: 21084489 Combination of α-glucosidase Inhibitor and Ribavirin for the Treatment of Dengue Virus Infection in Vitro and in Vivo Antiviral Research. Jan, 2011 | Pubmed ID: 21073903 Hepatocellular Carcinoma of the Liver Cancer Biomarkers : Section A of Disease Markers. 2010 | Pubmed ID: 22112485 Cancer Biomarkers : Section A of Disease Markers. 2010 | Pubmed ID: 21694465 Interferon-induced Cell Membrane Proteins, IFITM3 and Tetherin, Inhibit Vesicular Stomatitis Virus Infection Via Distinct Mechanisms Journal of Virology. Dec, 2010 | Pubmed ID: 20943977 Evidence That Herpes Simplex Virus DNA Derived from Quiescently Infected Cells in Vitro, and Latently Infected Cells in Vivo, is Physically Damaged Journal of Neurovirology. Oct, 2010 | Pubmed ID: 20874012 Linkage Specific Fucosylation of Alpha-1-antitrypsin in Liver Cirrhosis and Cancer Patients: Implications for a Biomarker of Hepatocellular Carcinoma PloS One. 2010 | Pubmed ID: 20811639 Glucosidase Inhibition Enhances Presentation of De-N-glycosylated Hepatitis B Virus Epitopes by Major Histocompatibility Complex Class I in Vitro and in Woodchucks Hepatology (Baltimore, Md.). Oct, 2010 | Pubmed ID: 20658465 Interferons Accelerate Decay of Replication-competent Nucleocapsids of Hepatitis B Virus Journal of Virology. Sep, 2010 | Pubmed ID: 20610715 Identification of Five Interferon-induced Cellular Proteins That Inhibit West Nile Virus and Dengue Virus Infections Journal of Virology. Aug, 2010 | Pubmed ID: 20534863 Production and Function of the Cytoplasmic Deproteinized Relaxed Circular DNA of Hepadnaviruses Journal of Virology. Jan, 2010 | Pubmed ID: 19864387 Journal of Virology. Jan, 2010 | Pubmed ID: 19864383 Antiviral Effect of Interferon Lambda Against West Nile Virus Antiviral Research. Jul, 2009 | Pubmed ID: 19501257 Antiviral Activity of Geneticin Against Dengue Virus Antiviral Research. Jul, 2009 | Pubmed ID: 19501253 Novel Fucosylated Biomarkers for the Early Detection of Hepatocellular Carcinoma Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Jun, 2009 | Pubmed ID: 19454616 Journal of Clinical Microbiology. Jun, 2009 | Pubmed ID: 19386849 Novel Imino Sugar Derivatives Demonstrate Potent Antiviral Activity Against Flaviviruses Antimicrobial Agents and Chemotherapy. Apr, 2009 | Pubmed ID: 19223639 Rapid and Sensitive Detection of Hepatitis B Virus 1762T/1764A Double Mutation from Hepatocellular Carcinomas Using LNA-mediated PCR Clamping and Hybridization Probes Journal of Virological Methods. Jun, 2009 | Pubmed ID: 19187787 Journal of Proteome Research. Feb, 2009 | Pubmed ID: 19099421 Inhibition of Cellular Alpha-glucosidases Results in Increased Presentation of Hepatitis B Virus Glycoprotein-derived Peptides by MHC Class I Virology. Feb, 2009 | Pubmed ID: 19091367 Mycopathologia. Apr, 2009 | Pubmed ID: 19015951 Activation of Pattern Recognition Receptor-mediated Innate Immunity Inhibits the Replication of Hepatitis B Virus in Human Hepatocyte-derived Cells Journal of Virology. Jan, 2009 | Pubmed ID: 18971270 Fucosylated Glycoproteins As Markers of Liver Disease Disease Markers. 2008 | Pubmed ID: 19126969 Annals of the New York Academy of Sciences. Aug, 2008 | Pubmed ID: 18837947 Annals of the New York Academy of Sciences. Aug, 2008 | Pubmed ID: 18837929 Journal of Clinical Microbiology. Nov, 2008 | Pubmed ID: 18799703 Journal of Clinical Microbiology. Oct, 2008 | Pubmed ID: 18753347 Liver-specific MicroRNA MiR-122 Enhances the Replication of Hepatitis C Virus in Nonhepatic Cells Journal of Virology. Aug, 2008 | Pubmed ID: 18550664 Gastroenterology. Jul, 2008 | Pubmed ID: 18457674 Apoptosis : an International Journal on Programmed Cell Death. Apr, 2008 | Pubmed ID: 18347987 The Degree of Readiness of Selected Biomarkers for the Early Detection of Hepatocellular Carcinoma: Notes from a Recent Workshop Cancer Biomarkers : Section A of Disease Markers. 2008 | Pubmed ID: 18334731 Identification of Three Interferon-inducible Cellular Enzymes That Inhibit the Replication of Hepatitis C Virus Journal of Virology. Feb, 2008 | Pubmed ID: 18077728 Increased Levels of Galactose-deficient Anti-Gal Immunoglobulin G in the Sera of Hepatitis C Virus-infected Individuals with Fibrosis and Cirrhosis Journal of Virology. Feb, 2008 | Pubmed ID: 18045939 N-linked Glycosylation of the Liver Cancer Biomarker GP73 Journal of Cellular Biochemistry. May, 2008 | Pubmed ID: 18004786 Molecular Virology of Hepatitis B Virus for Clinicians Clinics in Liver Disease. Nov, 2007 | Pubmed ID: 17981225 Alpha Interferon-induced Antiviral Response Noncytolytically Reduces Replication Defective Adenovirus DNA in MDBK Cells Antiviral Research. Dec, 2007 | Pubmed ID: 17897730 A Substituted Tetrahydro-tetrazolo-pyrimidine is a Specific and Novel Inhibitor of Hepatitis B Virus Surface Antigen Secretion Antimicrobial Agents and Chemotherapy. Dec, 2007 | Pubmed ID: 17875990 Journal of Neurovirology. Aug, 2007 | Pubmed ID: 17849314 Characterization of the Intracellular Deproteinized Relaxed Circular DNA of Hepatitis B Virus: an Intermediate of Covalently Closed Circular DNA Formation Journal of Virology. Nov, 2007 | Pubmed ID: 17804499 Journal of Clinical Microbiology. Nov, 2007 | Pubmed ID: 17728479 The Degradation Pathway for the HBV Envelope Proteins Involves Proteolysis Prior to Degradation Via the Cytosolic Proteasome Virology. Dec, 2007 | Pubmed ID: 17716702 Regulation of Hepatitis B Virus Replication by the Phosphatidylinositol 3-kinase-akt Signal Transduction Pathway Journal of Virology. Sep, 2007 | Pubmed ID: 17609269 The Role of the Downstream Signal Sequences in the Maturation of the HBV Middle Surface Glycoprotein: Development of a Novel Therapeutic Vaccine Candidate Virology. Aug, 2007 | Pubmed ID: 17462693 Antiviral Chemistry & Chemotherapy. 2007 | Pubmed ID: 17354651 Molecular Cancer Therapeutics. Jan, 2007 | Pubmed ID: 17237271 Antiviral Chemistry & Chemotherapy. 2006 | Pubmed ID: 17176630 Journal of Neurovirology. Oct, 2006 | Pubmed ID: 17065130 Journal of Virology. Dec, 2006 | Pubmed ID: 16987974 Antiviral Research. Nov, 2006 | Pubmed ID: 16780964 Molecular & Cellular Proteomics : MCP. Oct, 2006 | Pubmed ID: 16760258 Antiviral Research. Jun, 2006 | Pubmed ID: 16724398 Does Rapid Oligomerization of Hepatitis B Envelope Proteins Play a Role in Resistance to Proteasome Degradation and Enhance Chronicity? DNA and Cell Biology. Mar, 2006 | Pubmed ID: 16569195 Proteomic Analysis of Serum Associated Fucosylated Glycoproteins in the Development of Primary Hepatocellular Carcinoma Journal of Proteome Research. Feb, 2006 | Pubmed ID: 16457596 Cancer Biomarkers : Section A of Disease Markers. 2005 | Pubmed ID: 17192038 Advances in Experimental Medicine and Biology. 2005 | Pubmed ID: 16400797 Hepatitis B Virus Large and Middle Glycoproteins Are Degraded by a Proteasome Pathway in Glucosidase-inhibited Cells but Not in Cells with Functional Glucosidase Enzyme Journal of Virology. Oct, 2005 | Pubmed ID: 16188993 Journal of Hepatology. Dec, 2005 | Pubmed ID: 16137783 International Journal of Medical Sciences. 2005 | Pubmed ID: 15968337 Hepatology (Baltimore, Md.). Mar, 2005 | Pubmed ID: 15726646 Journal of Virological Methods. Mar, 2005 | Pubmed ID: 15664065 Journal of the American Chemical Society. Jan, 2005 | Pubmed ID: 15643858 Proceedings of the National Academy of Sciences of the United States of America. Jan, 2005 | Pubmed ID: 15642945 Surrogate Markers of Efficacy for Medical Treatment of Viral Hepatitis Biotechnology Healthcare. Oct, 2004 | Pubmed ID: 23396674 Defining the Value Proposition of Biotech Therapies Biotechnology Healthcare. May, 2004 | Pubmed ID: 23372498 International Journal of Medical Sciences. 2004 | Pubmed ID: 15912187 Journal of Virology. Nov, 2004 | Pubmed ID: 15507596 Annals of the New York Academy of Sciences. Jun, 2004 | Pubmed ID: 15251944 Antimicrobial Agents and Chemotherapy. Jun, 2004 | Pubmed ID: 15155204 Journal of Virological Methods. Jul, 2004 | Pubmed ID: 15109821 The Journal of Molecular Diagnostics : JMD. May, 2004 | Pubmed ID: 15096565 Proteomics. Mar, 2004 | Pubmed ID: 14997503 Methods in Molecular Medicine. 2004 | Pubmed ID: 14762271 Clinical Chemistry. Jan, 2004 | Pubmed ID: 14709652 Journal of Virology. Nov, 2003 | Pubmed ID: 14581530 Oncogene. Aug, 2003 | Pubmed ID: 12910247 Molecular & Cellular Proteomics : MCP. Apr, 2003 | Pubmed ID: 12754305 Proteomics. May, 2003 | Pubmed ID: 12748940 Journal of Virology. May, 2003 | Pubmed ID: 12692252 Antiviral Chemistry & Chemotherapy. Sep, 2002 | Pubmed ID: 12630678 The Journal of General Virology. Dec, 2002 | Pubmed ID: 12466470 Antimicrobial Agents and Chemotherapy. Dec, 2002 | Pubmed ID: 12435712 Journal of Virology. Oct, 2002 | Pubmed ID: 12208938 Antiviral Research. Sep, 2002 | Pubmed ID: 12206880 The Journal of General Virology. Jul, 2002 | Pubmed ID: 12075077 Virology. Mar, 2002 | Pubmed ID: 12033761 रासायनिक अवरुद्ध जटिल नमूने में मल्टिप्लेक्स उच्च throughput विशिष्ट प्रोटीन ग्लाइकोसिलेशन की रूपरेखा के लिए एंटीबॉडी माइक्रोएरे Chen Lu1, Joshua L. Wonsidler1, Jianwei Li2, Yanming Du1, Timothy Block3, Brian Haab4, Songming Chen1 1Institute for Hepatitis and Virus Research, 2Department of Microbiology and Immunology, Thomas Jefferson University, 3Drexel University College of Medicine, 4Van Andel Research Institute JoVE 3791 Biology
रासायनिक अवरुद्ध जटिल नमूने में मल्टिप्लेक्स उच्च throughput विशिष्ट प्रोटीन ग्लाइकोसिलेशन की रूपरेखा के लिए एंटीबॉडी माइक्रोएरे Chen Lu1, Joshua L. Wonsidler1, Jianwei Li2, Yanming Du1, Timothy Block3, Brian Haab4, Songming Chen1 1Institute for Hepatitis and Virus Research, 2Department of Microbiology and Immunology, Thomas Jefferson University, 3Drexel University College of Medicine, 4Van Andel Research Institute JoVE 3791 Biology
