Tobias Krojer Structural Genomics Consortium University of Oxford Biography Publications Institution JoVE Articles Tobias Krojer has not added a biography. If you are Tobias Krojer and would like to personalize this page please email our Author Liaison for assistance. Publications Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking Science Advances. 04, 2021 | Pubmed ID: 33853786 Structure and Activation Mechanism of the Human Liver-type Glutaminase GLS2 Biochimie. Jun, 2021 | Pubmed ID: 33746066 Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia ACS Chemical Biology. 04, 2021 | Pubmed ID: 33724769 The Low-cost Shifter Microscope Stage Transforms the Speed and Robustness of Protein Crystal Harvesting Acta Crystallographica. Section D, Structural Biology. Jan, 2021 | Pubmed ID: 33404526 Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking BioRxiv : the Preprint Server for Biology. Nov, 2020 | Pubmed ID: 33269349 Discovery of Allosteric Binding Sites by Crystallographic Fragment Screening Current Opinion in Structural Biology. 12, 2020 | Pubmed ID: 33171388 Crystallographic and Electrophilic Fragment Screening of the SARS-CoV-2 Main Protease Nature Communications. 10, 2020 | Pubmed ID: 33028810 Deliberately Losing Control of C-H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism ChemMedChem. Dec, 2020 | Pubmed ID: 32812371 Aspartate/asparagine-β-hydroxylase Crystal Structures Reveal an Unexpected Epidermal Growth Factor-like Domain Substrate Disulfide Pattern Nature Communications. 10, 2019 | Pubmed ID: 31659163 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening Journal of the American Chemical Society. 06, 2019 | Pubmed ID: 31060360 A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase ACS Catalysis. Apr, 2019 | Pubmed ID: 30984471 Achieving a Good Crystal System for Crystallographic X-Ray Fragment Screening Methods in Enzymology. 2018 | Pubmed ID: 30390801 A Multi-crystal Method for Extracting Obscured Crystallographic States from Conventionally Uninterpretable Electron Density Nature Communications. 04, 2017 | Pubmed ID: 28436492 Partial-occupancy Binders Identified by the Pan-Dataset Density Analysis Method Offer New Chemical Opportunities and Reveal Cryptic Binding Sites Structural Dynamics (Melville, N.Y.). May, 2017 | Pubmed ID: 28345007 The XChemExplorer Graphical Workflow Tool for Routine or Large-scale Protein-ligand Structure Determination Acta Crystallographica. Section D, Structural Biology. 03, 2017 | Pubmed ID: 28291762 Proper Modelling of Ligand Binding Requires an Ensemble of Bound and Unbound States Acta Crystallographica. Section D, Structural Biology. 03, 2017 | Pubmed ID: 28291761 Gentle, Fast and Effective Crystal Soaking by Acoustic Dispensing Acta Crystallographica. Section D, Structural Biology. 03, 2017 | Pubmed ID: 28291760 Structure and Inhibitor Specificity of the PCTAIRE-family Kinase CDK16 The Biochemical Journal. 02, 2017 | Pubmed ID: 28057719 A Poised Fragment Library Enables Rapid Synthetic Expansion Yielding the First Reported Inhibitors of PHIP(2), an Atypical Bromodomain Chemical Science. Mar, 2016 | Pubmed ID: 29910922 Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin Cell Reports. 12, 2016 | Pubmed ID: 27926874 A Generic Protocol for Protein Crystal Dehydration Using the HC1b Humidity Controller Acta Crystallographica. Section D, Structural Biology. 05, 2016 | Pubmed ID: 27139626 Outcome of the First WwPDB/CCDC/D3R Ligand Validation Workshop Structure (London, England : 1993). Apr, 2016 | Pubmed ID: 27050687 An Overview of Heavy-atom Derivatization of Protein Crystals Acta Crystallographica. Section D, Structural Biology. Mar, 2016 | Pubmed ID: 26960118 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors Journal of Medicinal Chemistry. Feb, 2016 | Pubmed ID: 26741168 Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors Journal of Medicinal Chemistry. Feb, 2016 | Pubmed ID: 26699912 Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation Chemistry & Biology. Dec, 2015 | Pubmed ID: 26687144 Structural Basis of Glycogen Branching Enzyme Deficiency and Pharmacologic Rescue by Rational Peptide Design Human Molecular Genetics. Oct, 2015 | Pubmed ID: 26199317 Optimisation of a Triazolopyridine Based Histone Demethylase Inhibitor Yields a Potent and Selective KDM2A (FBXL11) Inhibitor MedChemComm. Dec, 2014 | Pubmed ID: 26682034 Lysine Methylation-dependent Binding of 53BP1 to the PRb Tumor Suppressor Proceedings of the National Academy of Sciences of the United States of America. Aug, 2014 | Pubmed ID: 25049398 Ribosomal Oxygenases Are Structurally Conserved from Prokaryotes to Humans Nature. Jun, 2014 | Pubmed ID: 24814345 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor Which Causes Iron Translocation Chemical Science. Aug, 2013 | Pubmed ID: 26682036 Crystal Structures of Malonyl-coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-causing Mutations Structure (London, England : 1993). Jul, 2013 | Pubmed ID: 23791943 Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases The Journal of Biological Chemistry. Mar, 2013 | Pubmed ID: 23349464 Plant Growth Regulator Daminozide is a Selective Inhibitor of Human KDM2/7 Histone Demethylases Journal of Medicinal Chemistry. Jul, 2012 | Pubmed ID: 22724510 Structure of MMACHC Reveals an Arginine-rich Pocket and a Domain-swapped Dimer for Its B12 Processing Function Biochemistry. Jun, 2012 | Pubmed ID: 22642810 Assessment of Radiation Damage Behaviour in a Large Collection of Empirically Optimized Datasets Highlights the Importance of Unmeasured Complicating Effects Journal of Synchrotron Radiation. May, 2011 | Pubmed ID: 21525647 Crystal Structures of the Endoplasmic Reticulum Aminopeptidase-1 (ERAP1) Reveal the Molecular Basis for N-terminal Peptide Trimming Proceedings of the National Academy of Sciences of the United States of America. May, 2011 | Pubmed ID: 21508329 Structural and Mechanistic Studies on γ-butyrobetaine Hydroxylase Chemistry & Biology. Dec, 2010 | Pubmed ID: 21168767 Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6 Journal of Molecular Biology. May, 2010 | Pubmed ID: 20685276 Crystal Structure of the 2-oxoglutarate- and Fe(II)-dependent Lysyl Hydroxylase JMJD6 Journal of Molecular Biology. Aug, 2010 | Pubmed ID: 20684070 Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source Alice Douangamath*1,2, Ailsa Powell*1,2, Daren Fearon*1,2, Patrick M. Collins1,2, Romain Talon1,2,3, Tobias Krojer3,4, Rachael Skyner1,2, Jose Brandao-Neto1,2, Louise Dunnett1,2, Alexandre Dias1,2, Anthony Aimon1,2,3, Nicholas M. Pearce1,3, Conor Wild3,5, Tyler Gorrie-Stone1, Frank von Delft1,2,3,4,6 1Diamond Light Source Ltd, Harwell Science and Innovation Campus, 2Research Complex at Harwell, Harwell Science and Innovation Campus, 3Structural Genomics Consortium, University of Oxford, 4Centre for Medicines Discovery, University of Oxford, 5Oxford Protein Informatics Group, Department of Statistics, Oxford University, 6Department of Biochemistry, University of Johannesburg JoVE 62414 Chemistry
Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source Alice Douangamath*1,2, Ailsa Powell*1,2, Daren Fearon*1,2, Patrick M. Collins1,2, Romain Talon1,2,3, Tobias Krojer3,4, Rachael Skyner1,2, Jose Brandao-Neto1,2, Louise Dunnett1,2, Alexandre Dias1,2, Anthony Aimon1,2,3, Nicholas M. Pearce1,3, Conor Wild3,5, Tyler Gorrie-Stone1, Frank von Delft1,2,3,4,6 1Diamond Light Source Ltd, Harwell Science and Innovation Campus, 2Research Complex at Harwell, Harwell Science and Innovation Campus, 3Structural Genomics Consortium, University of Oxford, 4Centre for Medicines Discovery, University of Oxford, 5Oxford Protein Informatics Group, Department of Statistics, Oxford University, 6Department of Biochemistry, University of Johannesburg JoVE 62414 Chemistry
