Todd E. Golde

Publications

• Brain Injection of α-Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2014  |   Pubmed ID: 25209277
• Intramuscular Injection of α-synuclein Induces CNS α-synuclein Pathology and a Rapid-onset Motor Phenotype in Transgenic Mice
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014  |   Pubmed ID: 25002524
• Divergent Effects of the H50Q and G51D SNCA Mutations on the Aggregation of α-synuclein
  Journal of Neurochemistry. Jul, 2014  |   Pubmed ID: 24984882
• NOTCH1 Can Initiate NF-κB Activation Via Cytosolic Interactions with Components of the T Cell Signalosome
  Frontiers in Immunology. 2014  |   Pubmed ID: 24904593
• Amyloidogenic α-synuclein Seeds Do Not Invariably Induce Rapid, Widespread Pathology in Mice
  Acta Neuropathologica. May, 2014  |   Pubmed ID: 24659240
• Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2014  |   Pubmed ID: 24623762
• Complex Relationships Between Substrate Sequence and Sensitivity to Alterations in γ-secretase Processivity Induced by γ-secretase Modulators
  Biochemistry. Apr, 2014  |   Pubmed ID: 24620716
• Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells
  Frontiers in Immunology. 2014  |   Pubmed ID: 24611064
• Open Questions for Alzheimer's Disease Immunotherapy
  Alzheimer's Research & Therapy. 2014  |   Pubmed ID: 24393284
• γ-Secretase Processing and Effects of γ-secretase Inhibitors and Modulators on Long Aβ Peptides in Cells
  The Journal of Biological Chemistry. Feb, 2014  |   Pubmed ID: 24352661
• Induction of CNS α-synuclein Pathology by Fibrillar and Non-amyloidogenic Recombinant α-synuclein
  Acta Neuropathologica Communications. 2013  |   Pubmed ID: 24252149
• Anti-tau Antibodies: Hitting the Target
  Neuron. Oct, 2013  |   Pubmed ID: 24139027
• Accelerated Neurodegeneration Through Chaperone-mediated Oligomerization of Tau
  The Journal of Clinical Investigation. Oct, 2013  |   Pubmed ID: 23999428
• Capsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain
  PloS One. 2013  |   Pubmed ID: 23825679
• γ-Secretase Inhibitors and Modulators
  Biochimica Et Biophysica Acta. Dec, 2013  |   Pubmed ID: 23791707
• Unbiased Screen Reveals Ubiquilin-1 and -2 Highly Associated with Huntingtin Inclusions
  Brain Research. Jun, 2013  |   Pubmed ID: 23774650
• Therapeutic Targeting of NOTCH Signaling Ameliorates Immune-mediated Bone Marrow Failure of Aplastic Anemia
  The Journal of Experimental Medicine. Jul, 2013  |   Pubmed ID: 23733784
• Progress in Alzheimer's Disease Research Circa 2013: Is the Glass Half Empty or Half Full?
  Alzheimer's Research & Therapy. 2013  |   Pubmed ID: 23731836
• Steroids As γ-secretase Modulators
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2013  |   Pubmed ID: 23716494
• Conformational Templating of α-synuclein Aggregates in Neuronal-glial Cultures
  Molecular Neurodegeneration. 2013  |   Pubmed ID: 23714769
• Comment on "ApoE-directed Therapeutics Rapidly Clear β-amyloid and Reverse Deficits in AD Mouse Models"
  Science (New York, N.Y.). May, 2013  |   Pubmed ID: 23704553
• Alzheimer's Disease Risk Alleles in TREM2 Illuminate Innate Immunity in Alzheimer's Disease
  Alzheimer's Research & Therapy. 2013  |   Pubmed ID: 23692967
• Robust Cytoplasmic Accumulation of Phosphorylated TDP-43 in Transgenic Models of Tauopathy
  Acta Neuropathologica. Jul, 2013  |   Pubmed ID: 23666556
• Thinking Laterally About Neurodegenerative Proteinopathies
  The Journal of Clinical Investigation. May, 2013  |   Pubmed ID: 23635781
• Biomarkers for Alzheimer's Disease in Plasma, Serum and Blood - Conceptual and Practical Problems
  Alzheimer's Research & Therapy. 2013  |   Pubmed ID: 23470193
• Reversible Pathologic and Cognitive Phenotypes in an Inducible Model of Alzheimer-amyloidosis
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2013  |   Pubmed ID: 23447589
• Viral Transduction of the Neonatal Brain Delivers Controllable Genetic Mosaicism for Visualising and Manipulating Neuronal Circuits in Vivo
  The European Journal of Neuroscience. Apr, 2013  |   Pubmed ID: 23347239
• Analysis of Proteolytic Processes and Enzymatic Activities in the Generation of Huntingtin N-terminal Fragments in an HEK293 Cell Model
  PloS One. 2012  |   Pubmed ID: 23236391
• Targeting the ERAD Pathway Via Inhibition of Signal Peptide Peptidase for Antiparasitic Therapeutic Design
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2012  |   Pubmed ID: 23236186
• Cyanobacterial Peptides As a Prototype for the Design of Potent β-secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases
  Journal of Medicinal Chemistry. Dec, 2012  |   Pubmed ID: 23181502
• Retention in Endoplasmic Reticulum 1 (RER1) Modulates Amyloid-β (Aβ) Production by Altering Trafficking of γ-secretase and Amyloid Precursor Protein (APP)
  The Journal of Biological Chemistry. Oct, 2012  |   Pubmed ID: 23043097
• 5-Lipoxygenase Gene Transfer Worsens Memory, Amyloid, and Tau Brain Pathologies in a Mouse Model of Alzheimer Disease
  Annals of Neurology. Sep, 2012  |   Pubmed ID: 23034916
• Aβ Alters the Connectivity of Olfactory Neurons in the Absence of Amyloid Plaques in Vivo
  Nature Communications. 2012  |   Pubmed ID: 22910355
• Alzheimer's β-secretase (BACE1) Regulates the CAMP/PKA/CREB Pathway Independently of β-amyloid
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2012  |   Pubmed ID: 22895721
• Transient Pharmacologic Lowering of Aβ Production Prior to Deposition Results in Sustained Reduction of Amyloid Plaque Pathology
  Molecular Neurodegeneration. 2012  |   Pubmed ID: 22892055
• Hippocampal Expression of Murine IL-4 Results in Exacerbation of Amyloid Deposition
  Molecular Neurodegeneration. 2012  |   Pubmed ID: 22838967
• Overlapping Profiles of Aβ Peptides in the Alzheimer's Disease and Pathological Aging Brains
  Alzheimer's Research & Therapy. 2012  |   Pubmed ID: 22621179
• Shifting a Complex Debate on γ-secretase Cleavage and Alzheimer's Disease
  The EMBO Journal. May, 2012  |   Pubmed ID: 22505028
• Adeno-associated Virus-mediated Brain Delivery of 5-lipoxygenase Modulates the AD-like Phenotype of APP Mice
  Molecular Neurodegeneration. 2012  |   Pubmed ID: 22222029
• Anesthetic Propofol Attenuates the Isoflurane-induced Caspase-3 Activation and Aβ Oligomerization
  PloS One. 2011  |   Pubmed ID: 22069482
• Substrate Sequence Influences γ-secretase Modulator Activity, Role of the Transmembrane Domain of the Amyloid Precursor Protein
  The Journal of Biological Chemistry. Nov, 2011  |   Pubmed ID: 21868380
• Lysine 624 of the Amyloid Precursor Protein (APP) is a Critical Determinant of Amyloid β Peptide Length: Support for a Sequential Model of γ-secretase Intramembrane Proteolysis and Regulation by the Amyloid β Precursor Protein (APP) Juxtamembrane Region
  The Journal of Biological Chemistry. Nov, 2011  |   Pubmed ID: 21868378
• Interferon-γ Induces Progressive Nigrostriatal Degeneration and Basal Ganglia Calcification
  Nature Neuroscience. Jun, 2011  |   Pubmed ID: 21572432
• Right Sizing Funding for Alzheimer's Disease
  Alzheimer's Research & Therapy. 2011  |   Pubmed ID: 21554753
• Robust Amyloid Clearance in a Mouse Model of Alzheimer's Disease Provides Novel Insights into the Mechanism of Amyloid-beta Immunotherapy
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2011  |   Pubmed ID: 21411653
• Hippocampal Expression of Murine TNFα Results in Attenuation of Amyloid Deposition in Vivo
  Molecular Neurodegeneration. 2011  |   Pubmed ID: 21324189
• Anti-aβ Therapeutics in Alzheimer's Disease: the Need for a Paradigm Shift
  Neuron. Jan, 2011  |   Pubmed ID: 21262461
• Reduced Alzheimer's Disease ß-amyloid Deposition in Transgenic Mice Expressing S-palmitoylation-deficient APH1aL and Nicastrin
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2010  |   Pubmed ID: 21123562
• Sorting out Frontotemporal Dementia?
  Neuron. Nov, 2010  |   Pubmed ID: 21092851
• Phosphorylation Dynamics Regulate Hsp27-mediated Rescue of Neuronal Plasticity Deficits in Tau Transgenic Mice
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2010  |   Pubmed ID: 21084594
• Inhibition of Notch Signaling Reduces the Stem-like Population of Breast Cancer Cells and Prevents Mammosphere Formation
  Anticancer Research. Oct, 2010  |   Pubmed ID: 21036696
• Convection-enhanced Delivery and Systemic Mannitol Increase Gene Product Distribution of AAV Vectors 5, 8, and 9 and Increase Gene Product in the Adult Mouse Brain
  Journal of Neuroscience Methods. Dec, 2010  |   Pubmed ID: 20951738
• IFN-gamma Promotes Complement Expression and Attenuates Amyloid Plaque Deposition in Amyloid Beta Precursor Protein Transgenic Mice
  Journal of Immunology (Baltimore, Md. : 1950). May, 2010  |   Pubmed ID: 20368278
• Massive Gliosis Induced by Interleukin-6 Suppresses Abeta Deposition in Vivo: Evidence Against Inflammation As a Driving Force for Amyloid Deposition
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2010  |   Pubmed ID: 19825975
• Targeting Abeta and Tau in Alzheimer's Disease, an Early Interim Report
  Experimental Neurology. Jun, 2010  |   Pubmed ID: 19716367
• Proteinopathy-induced Neuronal Senescence: a Hypothesis for Brain Failure in Alzheimer's and Other Neurodegenerative Diseases
  Alzheimer's Research & Therapy. 2009  |   Pubmed ID: 19822029
• An NSAID-like Compound, FT-9, Preferentially Inhibits Gamma-secretase Cleavage of the Amyloid Precursor Protein Compared to Its Effect on Amyloid Precursor-like Protein 1
  Biochemistry. Nov, 2009  |   Pubmed ID: 19821615
• Suppression of Hippocampal TRPM7 Protein Prevents Delayed Neuronal Death in Brain Ischemia
  Nature Neuroscience. Oct, 2009  |   Pubmed ID: 19734892
• Generating Differentially Targeted Amyloid-beta Specific Intrabodies As a Passive Vaccination Strategy for Alzheimer's Disease
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2009  |   Pubmed ID: 19638957
• Signal Peptide Peptidases: a Family of Intramembrane-cleaving Proteases That Cleave Type 2 Transmembrane Proteins
  Seminars in Cell & Developmental Biology. Apr, 2009  |   Pubmed ID: 19429495
• Existing Plaques and Neuritic Abnormalities in APP:PS1 Mice Are Not Affected by Administration of the Gamma-secretase Inhibitor LY-411575
  Molecular Neurodegeneration. 2009  |   Pubmed ID: 19419556
• Medicine. Avoiding Unintended Toxicity
  Science (New York, N.Y.). May, 2009  |   Pubmed ID: 19407192
• Aberrant Cleavage of TDP-43 Enhances Aggregation and Cellular Toxicity
  Proceedings of the National Academy of Sciences of the United States of America. May, 2009  |   Pubmed ID: 19383787
• A Small Molecule Inhibitor of Signal Peptide Peptidase Inhibits Plasmodium Development in the Liver and Decreases Malaria Severity
  PloS One. 2009  |   Pubmed ID: 19337374
• Inhibition of Soluble TNF Signaling in a Mouse Model of Alzheimer's Disease Prevents Pre-plaque Amyloid-associated Neuropathology
  Neurobiology of Disease. Apr, 2009  |   Pubmed ID: 19320056
• Identification of Ligand-induced Proteolytic Cleavage and Ectodomain Shedding of VEGFR-1/FLT1 in Leukemic Cancer Cells
  Cancer Research. Mar, 2009  |   Pubmed ID: 19276374
• Quantitative and Mechanistic Studies of Abeta Immunotherapy
  CNS & Neurological Disorders Drug Targets. Mar, 2009  |   Pubmed ID: 19275635
• Notch Regulates Cytolytic Effector Function in CD8+ T Cells
  Journal of Immunology (Baltimore, Md. : 1950). Mar, 2009  |   Pubmed ID: 19265115
• The Therapeutic Importance of Understanding Mechanisms of Neuronal Cell Death in Neurodegenerative Disease
  Molecular Neurodegeneration. 2009  |   Pubmed ID: 19193222
• "What Kills Neurons in Neurodegenerative Diseases?", a Review Series in an Open Access Journal
  Molecular Neurodegeneration. 2009  |   Pubmed ID: 19193221
• Notch Signaling Mediates G1/S Cell-cycle Progression in T Cells Via Cyclin D3 and Its Dependent Kinases
  Blood. Feb, 2009  |   Pubmed ID: 19001083
• Notch1 and TGFbeta1 Cooperatively Regulate Foxp3 Expression and the Maintenance of Peripheral Regulatory T Cells
  Blood. Sep, 2008  |   Pubmed ID: 18550850
• Substrate-targeting Gamma-secretase Modulators
  Nature. Jun, 2008  |   Pubmed ID: 18548070
• BRI2 (ITM2b) Inhibits Abeta Deposition in Vivo
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2008  |   Pubmed ID: 18524908
• Using Leucine Zipper to Facilitate Alpha-synuclein Assembly
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2008  |   Pubmed ID: 18492724
• Independent Generation of Abeta42 and Abeta38 Peptide Species by Gamma-secretase
  The Journal of Biological Chemistry. Jun, 2008  |   Pubmed ID: 18426795
• Possible Mechanisms of Action of NSAIDs and Related Compounds That Modulate Gamma-secretase Cleavage
  Current Topics in Medicinal Chemistry. 2008  |   Pubmed ID: 18220932
• Notch Signaling is Activated by TLR Stimulation and Regulates Macrophage Functions
  European Journal of Immunology. Jan, 2008  |   Pubmed ID: 18085664
• Off the Beaten Pathway: the Complex Cross Talk Between Notch and NF-kappaB
  Laboratory Investigation; a Journal of Technical Methods and Pathology. Jan, 2008  |   Pubmed ID: 18059366
• Safety, Tolerability, Pharmacokinetics, and Abeta Levels After Short-term Administration of R-flurbiprofen in Healthy Elderly Individuals
  Alzheimer Disease and Associated Disorders. Oct-Dec, 2007  |   Pubmed ID: 18090435
• Epidermal Growth Factor Receptor and Notch Pathways Participate in the Tumor Suppressor Function of Gamma-secretase
  The Journal of Biological Chemistry. Nov, 2007  |   Pubmed ID: 17827153
• Chronic Administration of R-flurbiprofen Attenuates Learning Impairments in Transgenic Amyloid Precursor Protein Mice
  BMC Neuroscience. 2007  |   Pubmed ID: 17650315
• Statins Reduce Amyloid-beta Production Through Inhibition of Protein Isoprenylation
  The Journal of Biological Chemistry. Sep, 2007  |   Pubmed ID: 17646164
• Notch Inhibition in Kaposi's Sarcoma Tumor Cells Leads to Mitotic Catastrophe Through Nuclear Factor-kappaB Signaling
  Molecular Cancer Therapeutics. Jul, 2007  |   Pubmed ID: 17604336
• Novel Rat Alzheimer's Disease Models Based on AAV-mediated Gene Transfer to Selectively Increase Hippocampal Abeta Levels
  Molecular Neurodegeneration. 2007  |   Pubmed ID: 17559680
• The Pathogenesis of Alzheimer's Disease and the Role of Abeta42
  CNS Spectrums. Jan, 2007  |   Pubmed ID: 17192766
• Filling the Gaps in the Abeta Cascade Hypothesis of Alzheimer's Disease
  Current Alzheimer Research. Dec, 2006  |   Pubmed ID: 17168641
• Intracranial Adeno-associated Virus-mediated Delivery of Anti-pan Amyloid Beta, Amyloid Beta40, and Amyloid Beta42 Single-chain Variable Fragments Attenuates Plaque Pathology in Amyloid Precursor Protein Mice
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2006  |   Pubmed ID: 17108166
• Signal Peptide Peptidase (SPP) Dimer Formation As Assessed by Fluorescence Lifetime Imaging Microscopy (FLIM) in Intact Cells
  Molecular Neurodegeneration. 2006  |   Pubmed ID: 17105660
• Disease Modifying Therapy for AD?
  Journal of Neurochemistry. Nov, 2006  |   Pubmed ID: 17076654
• Insights into the Mechanisms of Action of Anti-Abeta Antibodies in Alzheimer's Disease Mouse Models
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2006  |   Pubmed ID: 17068112
• Sortilin, SorCS1b, and SorLA Vps10p Sorting Receptors, Are Novel Gamma-secretase Substrates
  Molecular Neurodegeneration. 2006  |   Pubmed ID: 16930450
• Intramembrane Proteolytic Cleavage by Human Signal Peptide Peptidase Like 3 and Malaria Signal Peptide Peptidase
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2006  |   Pubmed ID: 16873890
• Interleukin-1 Receptor 1 Knockout Has No Effect on Amyloid Deposition in Tg2576 Mice and Does Not Alter Efficacy Following Abeta Immunotherapy
  Journal of Neuroinflammation. 2006  |   Pubmed ID: 16872492
• Signal Peptide Peptidase: Biochemical Properties and Modulation by Nonsteroidal Antiinflammatory Drugs
  Biochemistry. Jul, 2006  |   Pubmed ID: 16834339
• Inclusion-body Myositis and Alzheimer Disease: Two Sides of the Same Coin, or Different Currencies Altogether?
  Neurology. Jan, 2006  |   Pubmed ID: 16432148
• Detection of Presenilin-1 Homodimer Formation in Intact Cells Using Fluorescent Lifetime Imaging Microscopy
  Biochemical and Biophysical Research Communications. Feb, 2006  |   Pubmed ID: 16376853
• Anti-Abeta42- and Anti-Abeta40-specific MAbs Attenuate Amyloid Deposition in an Alzheimer Disease Mouse Model
  The Journal of Clinical Investigation. Jan, 2006  |   Pubmed ID: 16341263
• Efficient Neuronal Gene Transfer with AAV8 Leads to Neurotoxic Levels of Tau or Green Fluorescent Proteins
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2006  |   Pubmed ID: 16325474
• Notch1 Augments NF-kappaB Activity by Facilitating Its Nuclear Retention
  The EMBO Journal. Jan, 2006  |   Pubmed ID: 16319921
• C-terminal PAL Motif of Presenilin and Presenilin Homologues Required for Normal Active Site Conformation
  Journal of Neurochemistry. Jan, 2006  |   Pubmed ID: 16305624
• Inhibitors of Rho-kinase Modulate Amyloid-beta (Abeta) Secretion but Lack Selectivity for Abeta42
  Journal of Neurochemistry. Jan, 2006  |   Pubmed ID: 16300630
• Inhibitors of Gamma-secretase Block in Vivo and in Vitro T Helper Type 1 Polarization by Preventing Notch Upregulation of Tbx21
  Nature Immunology. Jul, 2005  |   Pubmed ID: 15991363
• Gamma Secretase Inhibitor Blocks Notch Activation and Induces Apoptosis in Kaposi's Sarcoma Tumor Cells
  Oncogene. Sep, 2005  |   Pubmed ID: 15940249
• Bringing Amyloid into Focus
  Nature Biotechnology. May, 2005  |   Pubmed ID: 15877070
• Diverse Compounds Mimic Alzheimer Disease-causing Mutations by Augmenting Abeta42 Production
  Nature Medicine. May, 2005  |   Pubmed ID: 15834426
• The Abeta Hypothesis: Leading Us to Rationally-designed Therapeutic Strategies for the Treatment or Prevention of Alzheimer Disease
  Brain Pathology (Zurich, Switzerland). Jan, 2005  |   Pubmed ID: 15779241
• Homing in on Intracellular Abeta?
  Neuron. Mar, 2005  |   Pubmed ID: 15748837
• Presenilin Regulates Capacitative Calcium Entry Dependently and Independently of Gamma-secretase Activity
  Biochemical and Biophysical Research Communications. Oct, 2004  |   Pubmed ID: 15336962
• A Signal Peptide Peptidase (SPP) Reporter Activity Assay Based on the Cleavage of Type II Membrane Protein Substrates Provides Further Evidence for an Inverted Orientation of the SPP Active Site Relative to Presenilin
  The Journal of Biological Chemistry. Oct, 2004  |   Pubmed ID: 15252014
• Signal Peptide Peptidase Forms a Homodimer That is Labeled by an Active Site-directed Gamma-secretase Inhibitor
  The Journal of Biological Chemistry. Apr, 2004  |   Pubmed ID: 14704149
• Amyloid-beta Immunization Effectively Reduces Amyloid Deposition in FcRgamma-/- Knock-out Mice
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2003  |   Pubmed ID: 13679422
• Intramembrane-cleaving Aspartic Proteases and Disease: Presenilins, Signal Peptide Peptidase and Their Homologs
  Human Molecular Genetics. Oct, 2003  |   Pubmed ID: 12966028
• TCR-mediated Notch Signaling Regulates Proliferation and IFN-gamma Production in Peripheral T Cells
  Journal of Immunology (Baltimore, Md. : 1950). Sep, 2003  |   Pubmed ID: 12960327
• Immune Responses Against Abeta1-42 in HLA Class II Transgenic Mice: Implications for Abeta1-42 Immune-mediated Therapies
  Neurobiology of Aging. Nov, 2003  |   Pubmed ID: 12928057
• NSAIDs and Enantiomers of Flurbiprofen Target Gamma-secretase and Lower Abeta 42 in Vivo
  The Journal of Clinical Investigation. Aug, 2003  |   Pubmed ID: 12897211
• Triple-transgenic Model of Alzheimer's Disease with Plaques and Tangles: Intracellular Abeta and Synaptic Dysfunction
  Neuron. Jul, 2003  |   Pubmed ID: 12895417
• Evidence That Nonsteroidal Anti-inflammatory Drugs Decrease Amyloid Beta 42 Production by Direct Modulation of Gamma-secretase Activity
  The Journal of Biological Chemistry. Aug, 2003  |   Pubmed ID: 12805356
• The Non-cyclooxygenase Targets of Non-steroidal Anti-inflammatory Drugs, Lipoxygenases, Peroxisome Proliferator-activated Receptor, Inhibitor of Kappa B Kinase, and NF Kappa B, Do Not Reduce Amyloid Beta 42 Production
  The Journal of Biological Chemistry. Aug, 2003  |   Pubmed ID: 12805355
• Abeta42-lowering Nonsteroidal Anti-inflammatory Drugs Preserve Intramembrane Cleavage of the Amyloid Precursor Protein (APP) and ErbB-4 Receptor and Signaling Through the APP Intracellular Domain
  The Journal of Biological Chemistry. Aug, 2003  |   Pubmed ID: 12777371
• Peptide-based, Irreversible Inhibitors of Gamma-secretase Activity
  Biochemical and Biophysical Research Communications. Jun, 2003  |   Pubmed ID: 12763025
• Overexpression of Nicastrin Increases Abeta Production
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2003  |   Pubmed ID: 12692078
• Physiologic and Pathologic Events Mediated by Intramembranous and Juxtamembranous Proteolysis
  Science's STKE : Signal Transduction Knowledge Environment. Mar, 2003  |   Pubmed ID: 12621149
• Alzheimer Disease Therapy: Can the Amyloid Cascade Be Halted?
  The Journal of Clinical Investigation. Jan, 2003  |   Pubmed ID: 12511580
• Open Peer Commentary Regarding Abeta Immunization and CNS Inflammation by Pasinetti Et Al
  Neurobiology of Aging. Sep-Oct, 2002  |   Pubmed ID: 12392769
• Inflammation Takes on Alzheimer Disease
  Nature Medicine. Sep, 2002  |   Pubmed ID: 12205453
• Identification of a Novel Family of Presenilin Homologues
  Human Molecular Genetics. May, 2002  |   Pubmed ID: 11978763
• Inclusion Body Myositis-like Phenotype Induced by Transgenic Overexpression of Beta APP in Skeletal Muscle
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2002  |   Pubmed ID: 11972038
• FAD-linked Mutations in Presenilin 1 Alter the Length of Abeta Peptides Derived from BetaAPP Transmembrane Domain Mutants
  Biochimica Et Biophysica Acta. Mar, 2002  |   Pubmed ID: 11959461
• A Physiologic Signaling Role for the Gamma -secretase-derived Intracellular Fragment of APP
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2002  |   Pubmed ID: 11917117
• A Presenilin 1 Mutation Associated with Familial Frontotemporal Dementia Inhibits Gamma-secretase Cleavage of APP and Notch
  Neurobiology of Disease. Mar, 2002  |   Pubmed ID: 11895378
• Cholesterol-dependent Gamma-secretase Activity in Buoyant Cholesterol-rich Membrane Microdomains
  Neurobiology of Disease. Feb, 2002  |   Pubmed ID: 11848681