Tomasz Sosinowski

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Biocheck Inc. South San Francisco, CA

Tomasz Sosinowski
Senior Scientist and R&D Manager

Tomasz Sosinowski is the Senior Scientist and the R&D Manager of the CAR-T Cell Laboratory at the Biocheck Inc. in South San Francisco, California. He received his B.S degree with honors in Molecular and Cellular Biology from the University of Michigan in Ann Arbor, MI, and a Ph.D. degree in Microbiology and Immunology from the University of California in San Francisco (UCSF), CA.

During his training, Dr. Sosinowski developed broad expertise in T cell biology. As part of his graduate work, he studied T Cell Receptor (TCR) signaling and thymocyte development in the laboratory of Dr. Arthur Weiss at UCSF. During his post-doctoral training he generated a murine model for studying biology of Interleukin-15 in the laboratory of Drs. Philippa Marrack and John Kappler at the National Jewish Health and the University of Colorado Denver. He then moved to the laboratory of Dr. Laurent Gapin, also at the University of Colorado, to study molecular interactions between the TCR and the peptide-MHC complexes in the mouse model of type-1 diabetes (T1D). In 2011 he was recruited by Dr. George Eisenbarth to the faculty of the Barbara Davis Center (BDC) for Diabetes at the Anschutz Medical Campus of the University of Colorado. At BDC, Dr. Sosinowski developed a method for enumerating insulin-specific CD4+ T cells present in blood of T1D patients.

In 2017 Dr. Sosinowski enthusiastically joint the field of CAR T cells by becoming the Senior Scientist and R&D Manager at Biocheck Inc. His current focus includes generating CAR T cells targeting hematological malignancies and identifying molecular targets for CAR T cells in solid tumors.


High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

1Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 2Department of Medicine, Endocrinology, Diabetes & Metabolism, Baylor College of Medicine, 3Scientific Center, Shandong Provincial Hospital affiliated to Shandong University

JoVE 59985

 Immunology and Infection