Tony Velkov Department of Biochemistry & Pharmacology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences The University of Melbourne Biography Publications Institution JoVE Articles Tony Velkov has not added a biography. If you are Tony Velkov and would like to personalize this page please email our Author Liaison for assistance. Publications T-2 Toxin and Its Cardiotoxicity: New Insights on the Molecular Mechanisms and Therapeutic Implications Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Sep, 2022 | Pubmed ID: 35792220 Inwardly Rectifying Potassium Channels Mediate Polymyxin-induced Nephrotoxicity Cellular and Molecular Life Sciences : CMLS. May, 2022 | Pubmed ID: 35570209 Mechanisms Underlying Synergistic Killing of Polymyxin B in Combination with Cannabidiol Against : A Metabolomic Study Pharmaceutics. Apr, 2022 | Pubmed ID: 35456620 Colistin-induced Pulmonary Toxicity Involves the Activation of NOX4/TGF-β/mtROS Pathway and the Inhibition of Akt/mTOR Pathway Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. May, 2022 | Pubmed ID: 35378205 An Efficient Approach for the Design and Synthesis of Antimicrobial Peptide-Peptide Nucleic Acid Conjugates Frontiers in Chemistry. 2022 | Pubmed ID: 35372270 A Synthetic Lipopeptide Targeting Top-priority Multidrug-resistant Gram-negative Pathogens Nature Communications. Mar, 2022 | Pubmed ID: 35338128 The Natural Product Curcumin As an Antibacterial Agent: Current Achievements and Problems Antioxidants (Basel, Switzerland). Feb, 2022 | Pubmed ID: 35326110 Unique Mechanistic Insights into Pathways Associated with the Synergistic Activity of Polymyxin B and Caspofungin Against Multidrug-resistant Computational and Structural Biotechnology Journal. 2022 | Pubmed ID: 35284046 P21 Restricts Influenza A Virus by Perturbing the Viral Polymerase Complex and Upregulating Type I Interferon Signaling PLoS Pathogens. Feb, 2022 | Pubmed ID: 35180274 Comparative Metabolomics Revealed Key Pathways Associated with the Synergistic Killing of Multidrug-resistant by a Bacteriophage-polymyxin Combination Computational and Structural Biotechnology Journal. 2022 | Pubmed ID: 35070170 Coarse-grained Simulations Uncover Gram-negative Bacterial Defense Against Polymyxins by the Outer Membrane Computational and Structural Biotechnology Journal. 2021 | Pubmed ID: 34584634 Insights Into Patient Variability During Ivacaftor-Lumacaftor Therapy in Cystic Fibrosis Frontiers in Pharmacology. 2021 | Pubmed ID: 34408649 A Precision Medicine Approach to Optimize Modulator Therapy for Rare CFTR Folding Mutants Journal of Personalized Medicine. Jul, 2021 | Pubmed ID: 34357110 Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury Antioxidants (Basel, Switzerland). Jun, 2021 | Pubmed ID: 34207230 Clinically Relevant Concentrations of Polymyxin B and Meropenem Synergistically Kill Multidrug-Resistant and Minimize Biofilm Formation Antibiotics (Basel, Switzerland). Apr, 2021 | Pubmed ID: 33918040 Synergy of the Polymyxin-Chloramphenicol Combination Against New Delhi Metallo-β-Lactamase-Producing Is Predominately Driven by Chloramphenicol ACS Infectious Diseases. 06, 2021 | Pubmed ID: 33834753 Polymyxins for the Treatment of Lower Respiratory Tract Infections: Lessons Learned from the Integration of Clinical Pharmacokinetic Studies and Clinical Outcomes International Journal of Antimicrobial Agents. Jun, 2021 | Pubmed ID: 33785362 Synchrotron-based X-ray Fluorescence Microscopy Reveals Accumulation of Polymyxins in Single Human Alveolar Epithelial Cells Antimicrobial Agents and Chemotherapy. Mar, 2021 | Pubmed ID: 33649114 Evaluation Strategies for Triple-Drug Combinations Against Carbapenemase-Producing Klebsiella Pneumoniae in an In Vitro Hollow-Fiber Infection Model Clinical Pharmacology and Therapeutics. 04, 2021 | Pubmed ID: 33548079 In Vitro Evaluation of Drug Delivery Behavior for Inhalable Amorphous Nanoparticle Formulations in a Human Lung Epithelial Cell Model International Journal of Pharmaceutics. Mar, 2021 | Pubmed ID: 33486036 DNA Variants Are an Unlikely Explanation for the Changing Quality of Spermatozoa Within the Same Individual Human Fertility (Cambridge, England). Dec, 2021 | Pubmed ID: 31642381 Polymyxin B Combinations with FDA-approved Non-antibiotic Phenothiazine Drugs Targeting Multi-drug Resistance of Gram-negative Pathogens Computational and Structural Biotechnology Journal. 2020 | Pubmed ID: 32952938 Simulations of Octapeptin-outer Membrane Interactions Reveal Conformational Flexibility is Linked to Antimicrobial Potency The Journal of Biological Chemistry. 11, 2020 | Pubmed ID: 32913118 Allosteric Folding Correction of F508del and Rare CFTR Mutants by Elexacaftor-tezacaftor-ivacaftor (Trikafta) Combination JCI Insight. 09, 2020 | Pubmed ID: 32853178 Lipid A Profiling and Metabolomics Analysis of Paired Polymyxin-susceptible and -resistant MDR Klebsiella Pneumoniae Clinical Isolates from the Same Patients Before and After Colistin Treatment The Journal of Antimicrobial Chemotherapy. 10, 2020 | Pubmed ID: 32696049 Structure-Activity Relationships of Daptomycin Lipopeptides Journal of Medicinal Chemistry. 11, 2020 | Pubmed ID: 32687352 The Antimicrobial Activity of Cannabinoids Antibiotics (Basel, Switzerland). Jul, 2020 | Pubmed ID: 32668669 Polymyxin-Induced Cell Death of Human Macrophage-Like THP-1 and Neutrophil-Like HL-60 Cells Associated with the Activation of Apoptotic Pathways Antimicrobial Agents and Chemotherapy. 08, 2020 | Pubmed ID: 32660985 Transcriptomic Responses of a New Delhi Metallo-β-lactamase-producing Klebsiella Pneumoniae Isolate to the Combination of Polymyxin B and Chloramphenicol International Journal of Antimicrobial Agents. Aug, 2020 | Pubmed ID: 32574791 Polymyxins-Curcumin Combination Antimicrobial Therapy: Safety Implications and Efficacy for Infection Treatment Antioxidants (Basel, Switzerland). Jun, 2020 | Pubmed ID: 32526966 The Killing Mechanism of Teixobactin Against Methicillin-Resistant Staphylococcus Aureus: an Untargeted Metabolomics Study MSystems. May, 2020 | Pubmed ID: 32457238 Effective Strategy Targeting Polymyxin-Resistant Gram-Negative Pathogens: Polymyxin B in Combination with the Selective Serotonin Reuptake Inhibitor Sertraline ACS Infectious Diseases. 06, 2020 | Pubmed ID: 32427476 Nerve Growth Factor Confers Neuroprotection Against Colistin-Induced Peripheral Neurotoxicity ACS Infectious Diseases. 06, 2020 | Pubmed ID: 32422040 Polymyxin Triple Combinations Against Polymyxin-Resistant, Multidrug-Resistant, KPC-Producing Klebsiella Pneumoniae Antimicrobial Agents and Chemotherapy. 07, 2020 | Pubmed ID: 32393492 Regulating Polymyxin Resistance in Gram-negative Bacteria: Roles of Two-component Systems PhoPQ and PmrAB Future Microbiology. 04, 2020 | Pubmed ID: 32250173 Complete Genome Sequence and Genome-scale Metabolic Modelling of Acinetobacter Baumannii Type Strain ATCC 19606 International Journal of Medical Microbiology : IJMM. Apr, 2020 | Pubmed ID: 32081464 Curcumin Attenuates Colistin-Induced Peripheral Neurotoxicity in Mice ACS Infectious Diseases. 04, 2020 | Pubmed ID: 32037797 Structure of Micelle Bound Cationic Peptides by NMR Spectroscopy Using a Lanthanide Shift Reagent Chemical Communications (Cambridge, England). Mar, 2020 | Pubmed ID: 32037418 Inhalable Liposomal Powder Formulations for Co-delivery of Synergistic Ciprofloxacin and Colistin Against Multi-drug Resistant Gram-negative Lung Infections International Journal of Pharmaceutics. Feb, 2020 | Pubmed ID: 31816354 Synthesis and Structure-activity Relationships of Teixobactin Annals of the New York Academy of Sciences. 01, 2020 | Pubmed ID: 31792983 Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-Resistant Frontiers in Pharmacology. 2019 | Pubmed ID: 31632279 Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin Against Polymyxin-Susceptible and -Resistant Pseudomonas Aeruginosa Antimicrobial Agents and Chemotherapy. 12, 2019 | Pubmed ID: 31611351 An Optimised Cu(0)-RDRP Approach for the Synthesis of Lipidated Oligomeric Vinyl Azlactone: Toward a Versatile Antimicrobial Materials Screening Platform Journal of Materials Chemistry. B. Nov, 2019 | Pubmed ID: 31603181 T-2 Toxin Neurotoxicity: Role of Oxidative Stress and Mitochondrial Dysfunction Archives of Toxicology. 11, 2019 | Pubmed ID: 31570981 The Impact of Backbone N-methylation on the Structure-activity Relationship of Leu -teixobactin Journal of Peptide Science : an Official Publication of the European Peptide Society. Sep, 2019 | Pubmed ID: 31389086 Multifaceted Mechanisms of Colistin Resistance Revealed by Genomic Analysis of Multidrug-resistant Klebsiella Pneumoniae Isolates from Individual Patients Before and After Colistin Treatment The Journal of Infection. 10, 2019 | Pubmed ID: 31374222 Discovery of Novel Polymyxin-Like Antibiotics Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 31364086 Mechanisms of Polymyxin-Induced Nephrotoxicity Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 31364084 Polymyxins: Mode of Action Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 31364070 Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant Frontiers in Pharmacology. 2019 | Pubmed ID: 31333468 The Rise and Spread of Plasmid-mediated Polymyxin Resistance Critical Reviews in Microbiology. Mar, 2019 | Pubmed ID: 31122100 Global Metabolic Analyses of Acinetobacter Baumannii Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30798566 Effects of the Antibiotic Component on In-vitro Bacterial Killing, Physico-chemical Properties, Aerosolization and Dissolution of a Ternary-combinational Inhalation Powder Formulation of Antibiotics for Pan-drug Resistant Gram-negative Lung Infections International Journal of Pharmaceutics. Apr, 2019 | Pubmed ID: 30797863 Novel Polymyxin Combination with the Antiretroviral Zidovudine Exerts Synergistic Killing Against NDM-Producing Multidrug-Resistant Klebsiella Pneumoniae Antimicrobial Agents and Chemotherapy. 04, 2019 | Pubmed ID: 30670431 Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas Aeruginosa MSystems. Jan-Feb, 2019 | Pubmed ID: 30637340 Contemporary Anti-Ebola Drug Discovery Approaches and Platforms ACS Infectious Diseases. 01, 2019 | Pubmed ID: 30516045 Molecular Mechanisms of Neurotoxicity Induced by Polymyxins and Chemoprevention ACS Chemical Neuroscience. 01, 2019 | Pubmed ID: 30362702 Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR Computational and Structural Biotechnology Journal. 2018 | Pubmed ID: 30546859 Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant Frontiers in Microbiology. 2018 | Pubmed ID: 30505298 Chloroquine Ameliorates Carbon Tetrachloride-induced Acute Liver Injury in Mice Via the Concomitant Inhibition of Inflammation and Induction of Apoptosis Cell Death & Disease. 11, 2018 | Pubmed ID: 30478280 Exploiting Macromolecular Design To Optimize the Antibacterial Activity of Alkylated Cationic Oligomers Biomacromolecules. 12, 2018 | Pubmed ID: 30359516 A Comparative Study of Outer Membrane Proteome Between Paired Colistin-Susceptible and Extremely Colistin-Resistant Klebsiella Pneumoniae Strains ACS Infectious Diseases. 12, 2018 | Pubmed ID: 30232886 Lipidomic Analysis of the Outer Membrane Vesicles from Paired Polymyxin-Susceptible and -Resistant Clinical Isolates International Journal of Molecular Sciences. Aug, 2018 | Pubmed ID: 30103446 Composite Particle Formulations of Colistin and Meropenem with Improved In-vitro Bacterial Killing and Aerosolization for Inhalation International Journal of Pharmaceutics. Sep, 2018 | Pubmed ID: 30008433 Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant : A Metabolomic Study Frontiers in Pharmacology. 2018 | Pubmed ID: 29713282 Novel Polymyxin Combination With Antineoplastic Mitotane Improved the Bacterial Killing Against Polymyxin-Resistant Multidrug-Resistant Gram-Negative Pathogens Frontiers in Microbiology. 2018 | Pubmed ID: 29706941 Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas Aeruginosa Antimicrobial Agents and Chemotherapy. 06, 2018 | Pubmed ID: 29632014 Polymyxin B in Combination with Enrofloxacin Exerts Synergistic Killing Against Extensively Drug-Resistant Pseudomonas Aeruginosa Antimicrobial Agents and Chemotherapy. 06, 2018 | Pubmed ID: 29632010 Sputum Active Polymyxin Lipopeptides: Activity Against Cystic Fibrosis Pseudomonas Aeruginosa Isolates and Their Interactions with Sputum Biomolecules ACS Infectious Diseases. 05, 2018 | Pubmed ID: 29566483 The Potentially Beneficial Central Nervous System Activity Profile of Ivacaftor and Its Metabolites ERJ Open Research. Jan, 2018 | Pubmed ID: 29560360 A Proof-of-Concept Study of the Efficacy of Systemically Administered Polymyxins in Mouse Burn Wound Infection Caused by Multidrug-Resistant Gram-Negative Pathogens Antimicrobial Agents and Chemotherapy. 05, 2018 | Pubmed ID: 29439974 T-2 Toxin-induced Toxicity in Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen, Mitochondrial Dysfunction and Inhibition of Nrf2/HO-1 Pathway Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Apr, 2018 | Pubmed ID: 29432840 Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active Against Extensively Drug-Resistant Gram-Negative Bacteria Cell Chemical Biology. 04, 2018 | Pubmed ID: 29396290 Rapamycin Confers Neuroprotection Against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis Through the Activation of Autophagy and MTOR/Akt/CREB Signaling Pathways ACS Chemical Neuroscience. 04, 2018 | Pubmed ID: 29257864 Polymyxin-Induced Lipid A Deacylation in Pseudomonas Aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance ACS Chemical Biology. 01, 2018 | Pubmed ID: 29182311 A Portrait of the Sialyl Glycan Receptor Specificity of the H10 Influenza Virus Hemagglutinin-A Picture of an Avian Virus on the Verge of Becoming a Pandemic? Vaccines. Dec, 2017 | Pubmed ID: 29236069 Design and Evaluation of Novel Polymyxin Fluorescent Probes Sensors (Basel, Switzerland). Nov, 2017 | Pubmed ID: 29137129 Cationic Acrylate Oligomers Comprising Amino Acid Mimic Moieties Demonstrate Improved Antibacterial Killing Efficiency Journal of Materials Chemistry. B, Materials for Biology and Medicine. Jan, 2017 | Pubmed ID: 28966792 Gelofusine Ameliorates Colistin-induced Nephrotoxicity Antimicrobial Agents and Chemotherapy. Sep, 2017 | Pubmed ID: 28923868 Aminoglycoside Concentrations Required for Synergy with Carbapenems Against Pseudomonas Aeruginosa Determined Via Mechanistic Studies and Modeling Antimicrobial Agents and Chemotherapy. Sep, 2017 | Pubmed ID: 28893782 Baicalein Acts As a Nephroprotectant That Ameliorates Colistin-induced Nephrotoxicity by Activating the Antioxidant Defence Mechanism of the Kidneys and Down-regulating the Inflammatory Response The Journal of Antimicrobial Chemotherapy. Sep, 2017 | Pubmed ID: 28859441 The First Total Synthesis and Solution Structure of a Polypeptin, PE2, a Cyclic Lipopeptide with Broad Spectrum Antibiotic Activity Organic & Biomolecular Chemistry. Aug, 2017 | Pubmed ID: 28812779 Polymyxins for CNS Infections: Pharmacology and Neurotoxicity Pharmacology & Therapeutics. Jul, 2017 | Pubmed ID: 28750947 Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes ACS Infectious Diseases. Aug, 2017 | Pubmed ID: 28695731 Hydrolyzable Poly[Poly(Ethylene Glycol) Methyl Ether Acrylate]-Colistin Prodrugs Through Copper-Mediated Photoinduced Living Radical Polymerization Bioconjugate Chemistry. Jul, 2017 | Pubmed ID: 28657722 Deficiency in Outer Dense Fiber 1 is a Marker and Potential Driver of Idiopathic Male Infertility Molecular & Cellular Proteomics : MCP. Jun, 2017 | Pubmed ID: 28572402 Pulsed-voltage Atom Probe Tomography of Low Conductivity and Insulator Materials by Application of Ultrathin Metallic Coating on Nanoscale Specimen Geometry Ultramicroscopy. Oct, 2017 | Pubmed ID: 28558288 Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus Polymyxa ATCC 10401 Journal of Natural Products. May, 2017 | Pubmed ID: 28463513 Pharmacokinetics and Relative Bioavailability of an Oral Amoxicillin-apramycin Combination in Pigs PloS One. 2017 | Pubmed ID: 28426744 Potential Toxicity of Polymyxins in Human Lung Epithelial Cells Antimicrobial Agents and Chemotherapy. Jun, 2017 | Pubmed ID: 28416543 Untargeted Metabolomics Analysis Reveals Key Pathways Responsible for the Synergistic Killing of Colistin and Doripenem Combination Against Acinetobacter Baumannii Scientific Reports. Mar, 2017 | Pubmed ID: 28358014 Antibiotic-non-antibiotic Combinations for Combating Extremely Drug-resistant Gram-negative 'superbugs' Essays in Biochemistry. Feb, 2017 | Pubmed ID: 28258235 The Thermodynamics of Pr55Gag-RNA Interaction Regulate the Assembly of HIV PLoS Pathogens. Feb, 2017 | Pubmed ID: 28222188 Minocycline Attenuates Colistin-induced Neurotoxicity Via Suppression of Apoptosis, Mitochondrial Dysfunction and Oxidative Stress The Journal of Antimicrobial Chemotherapy. Jun, 2017 | Pubmed ID: 28204513 Rediscovering the Octapeptins Natural Product Reports. Mar, 2017 | Pubmed ID: 28180225 A Traceless Reversible Polymeric Colistin Prodrug to Combat Multidrug-resistant (MDR) Gram-negative Bacteria Journal of Controlled Release : Official Journal of the Controlled Release Society. Aug, 2017 | Pubmed ID: 28174100 Plasma Protein Binding Structure-Activity Relationships Related to the N-Terminus of Daptomycin ACS Infectious Diseases. Mar, 2017 | Pubmed ID: 28142234 Pharmacokinetics of the Individual Major Components of Polymyxin B and Colistin in Rats Journal of Natural Products. Jan, 2017 | Pubmed ID: 28080060 Functional Characterization of the Unique Terminal Thioesterase Domain from Polymyxin Synthetase Biochemistry. Jan, 2017 | Pubmed ID: 28071053 From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative "Superbugs" Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor Modulators Microbial Drug Resistance (Larchmont, N.Y.). Jul, 2017 | Pubmed ID: 27935770 A Hydrogel-Based Localized Release of Colistin for Antimicrobial Treatment of Burn Wound Infection Macromolecular Bioscience. Feb, 2017 | Pubmed ID: 27619320 Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells Via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis Molecular Neurobiology. Dec, 2016 | Pubmed ID: 27957686 Pharmacokinetics/pharmacodynamics of Colistin and Polymyxin B: Are We There Yet? International Journal of Antimicrobial Agents. Dec, 2016 | Pubmed ID: 27793510 Development of HPLC and LC-MS/MS Methods for the Analysis of Ivacaftor, Its Major Metabolites and Lumacaftor in Plasma and Sputum of Cystic Fibrosis Patients Treated with ORKAMBI or KALYDECO Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Dec, 2016 | Pubmed ID: 27792891 Deficiency in Outer Dense Fiber 1 Is a Marker and Potential Driver of Idiopathic Male Infertility Molecular & Cellular Proteomics : MCP. 12, 2016 | Pubmed ID: 27770032 The Plasma Protein Binding Proteome of Ertapenem: A Novel Compound-Centric Proteomic Approach for Elucidating Drug-Plasma Protein Binding Interactions ACS Chemical Biology. 12, 2016 | Pubmed ID: 27682196 Near-Atomic Three-Dimensional Mapping for Site-Specific Chemistry of 'Superbugs' Nano Letters. Nov, 2016 | Pubmed ID: 27650306 A Novel Chemical Biology Approach for Mapping of Polymyxin Lipopeptide Antibody Binding Epitopes ACS Infectious Diseases. May, 2016 | Pubmed ID: 27627202 An "Unlikely" Pair: The Antimicrobial Synergy of Polymyxin B in Combination with the Cystic Fibrosis Transmembrane Conductance Regulator Drugs KALYDECO and ORKAMBI ACS Infectious Diseases. Jul, 2016 | Pubmed ID: 27626100 Transcriptomic Analysis of the Activity of a Novel Polymyxin Against Staphylococcus Aureus MSphere. Jul-Aug, 2016 | Pubmed ID: 27471750 Polymyxins: a New Hope in Combating Gram-negative Superbugs? Future Medicinal Chemistry. Jun, 2016 | Pubmed ID: 27328129 Pharmacokinetics of Levobupivacaine Following Infant Spinal Anesthesia Paediatric Anaesthesia. Jun, 2016 | Pubmed ID: 27061607 Antibacterial Low Molecular Weight Cationic Polymers: Dissecting the Contribution of Hydrophobicity, Chain Length and Charge to Activity RSC Advances. Jan, 2016 | Pubmed ID: 26998253 Global Metabolic Analyses Identify Key Differences in Metabolite Levels Between Polymyxin-susceptible and Polymyxin-resistant Acinetobacter Baumannii Scientific Reports. Feb, 2016 | Pubmed ID: 26924392 Quantitation of Polymyxin-Lipopolysaccharide Interactions Using an Image-Based Fluorescent Probe Journal of Pharmaceutical Sciences. Feb, 2016 | Pubmed ID: 26869441 Anthelmintic Closantel Enhances Bacterial Killing of Polymyxin B Against Multidrug-resistant Acinetobacter Baumannii The Journal of Antibiotics. Jun, 2016 | Pubmed ID: 26669752 Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species, Mitochondrial Dysfunction, and Autophagy Molecular Neurobiology. Sep, 2016 | Pubmed ID: 26316077 Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-line Antibiotics Against Multidrug-Resistant Gram-negative Bacteria ACS Infectious Diseases. Nov, 2015 | Pubmed ID: 27525307 Cold Adaptation Generates Mutations Associated with the Growth of Influenza B Vaccine Viruses Vaccine. Oct, 2015 | Pubmed ID: 26407922 Cellular Uptake and Localization of Polymyxins in Renal Tubular Cells Using Rationally Designed Fluorescent Probes Antimicrobial Agents and Chemotherapy. Dec, 2015 | Pubmed ID: 26392495 Molecular Characterisation of the Haemagglutinin Glycan-Binding Specificity of Egg-Adapted Vaccine Strains of the Pandemic 2009 H1N1 Swine Influenza A Virus Molecules (Basel, Switzerland). Jun, 2015 | Pubmed ID: 26056814 Synergistic Killing of NDM-producing MDR Klebsiella Pneumoniae by Two 'old' Antibiotics-polymyxin B and Chloramphenicol The Journal of Antimicrobial Chemotherapy. Sep, 2015 | Pubmed ID: 26023209 Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner The Journal of Biological Chemistry. May, 2015 | Pubmed ID: 25847235 Drug-drug Plasma Protein Binding Interactions of Ivacaftor Journal of Molecular Recognition : JMR. Jun, 2015 | Pubmed ID: 25707701 Defining the Mechanisms by Which the Reactive Oxygen Species By-product, 4-hydroxynonenal, Affects Human Sperm Cell Function Biology of Reproduction. Apr, 2015 | Pubmed ID: 25673561 Two Mechanisms of Killing of Pseudomonas Aeruginosa by Tobramycin Assessed at Multiple Inocula Via Mechanism-based Modeling Antimicrobial Agents and Chemotherapy. Apr, 2015 | Pubmed ID: 25645838 Major Pathways of Polymyxin-induced Apoptosis in Rat Kidney Proximal Tubular Cells Antimicrobial Agents and Chemotherapy. Apr, 2015 | Pubmed ID: 25624331 Significant Accumulation of Polymyxin in Single Renal Tubular Cells: a Medicinal Chemistry and Triple Correlative Microscopy Approach Analytical Chemistry. Feb, 2015 | Pubmed ID: 25553489 Lycopene Attenuates Colistin-Induced Nephrotoxicity in Mice Via Activation of the Nrf2/HO-1 Pathway Antimicrobial Agents and Chemotherapy. Jan, 2015 | Pubmed ID: 25385104 The Carbohydrate-binding Promiscuity of Euonymus Europaeus Lectin is Predicted to Involve a Single Binding Site Glycobiology. Jan, 2015 | Pubmed ID: 25209582 Methotrexate-conjugated PEGylated Dendrimers Show Differential Patterns of Deposition and Activity in Tumour-burdened Lymph Nodes After Intravenous and Subcutaneous Administration in Rats Molecular Pharmaceutics. Dec, 2014 | Pubmed ID: 25485615 Inhaled Anti-infective Chemotherapy for Respiratory Tract Infections: Successes, Challenges and the Road Ahead Advanced Drug Delivery Reviews. Nov, 2014 | Pubmed ID: 25446140 Analysis of Protein Thiol Changes Occurring During Rat Sperm Epididymal Maturation Biology of Reproduction. Nov, 2014 | Pubmed ID: 25411390 Imaging the Distribution of Polymyxins in the Kidney The Journal of Antimicrobial Chemotherapy. Nov, 2014 | Pubmed ID: 25377569 In Situ Probing the Interior of Single Bacterial Cells at Nanometer Scale Nanotechnology. Oct, 2014 | Pubmed ID: 25257833 Measuring Polymyxin Uptake by Renal Tubular Cells: is BODIPY-polymyxin B an Appropriate Probe? Antimicrobial Agents and Chemotherapy. Oct, 2014 | Pubmed ID: 25225340 Colistin and Polymyxin B: Peas in a Pod, or Chalk and Cheese? Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. May, 2014 | Pubmed ID: 24700659 Probing the Penetration of Antimicrobial Polymyxin Lipopeptides into Gram-negative Bacteria Bioconjugate Chemistry. Apr, 2014 | Pubmed ID: 24635310 Teaching 'old' Polymyxins New Tricks: New-generation Lipopeptides Targeting Gram-negative 'superbugs' ACS Chemical Biology. May, 2014 | Pubmed ID: 24601489 Nanoscale Focused Ion Beam Tomography of Single Bacterial Cells for Assessment of Antibiotic Effects Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. Apr, 2014 | Pubmed ID: 24589280 A Secondary Mode of Action of Polymyxins Against Gram-negative Bacteria Involves the Inhibition of NADH-quinone Oxidoreductase Activity The Journal of Antibiotics. Feb, 2014 | Pubmed ID: 24169795 The RNA-dependent-RNA Polymerase, an Emerging Antiviral Drug Target for the Hendra Virus Current Drug Targets. Jan, 2014 | Pubmed ID: 24102407 Surface Changes and Polymyxin Interactions with a Resistant Strain of Klebsiella Pneumoniae Innate Immunity. May, 2014 | Pubmed ID: 23887184 Polymyxins and Analogues Bind to Ribosomal RNA and Interfere with Eukaryotic Translation in Vitro Chembiochem : a European Journal of Chemical Biology. Nov, 2013 | Pubmed ID: 24105917 The Specificity of the Influenza B Virus Hemagglutinin Receptor Binding Pocket: What Does It Bind To? Journal of Molecular Recognition : JMR. Oct, 2013 | Pubmed ID: 23996486 The Antigenic Architecture of the Hemagglutinin of Influenza H5N1 Viruses Molecular Immunology. Dec, 2013 | Pubmed ID: 23933511 PK/PD Models in Antibacterial Development Current Opinion in Microbiology. Oct, 2013 | Pubmed ID: 23871724 Interaction of Phthalates and Phenoxy Acid Herbicide Environmental Pollutants with Intestinal Intracellular Lipid Binding Proteins Chemical Research in Toxicology. Aug, 2013 | Pubmed ID: 23841907 Polymyxin B Induces Apoptosis in Kidney Proximal Tubular Cells Antimicrobial Agents and Chemotherapy. Jun, 2013 | Pubmed ID: 23796937 Pharmacokinetics of Four Different Brands of Colistimethate and Formed Colistin in Rats The Journal of Antimicrobial Chemotherapy. Oct, 2013 | Pubmed ID: 23749953 Pharmacology of Polymyxins: New Insights into an 'old' Class of Antibiotics Future Microbiology. Jun, 2013 | Pubmed ID: 23701329 Interactions Between Human Liver Fatty Acid Binding Protein and Peroxisome Proliferator Activated Receptor Selective Drugs PPAR Research. 2013 | Pubmed ID: 23476633 Head and Flagella Subcompartmental Proteomic Analysis of Human Spermatozoa Proteomics. Jan, 2013 | Pubmed ID: 23161668 Reverse Engineering the Antigenic Architecture of the Haemagglutinin from Influenza H5N1 Clade 1 and 2.2 Viruses with Fine Epitope Mapping Using Monoclonal Antibodies Molecular Immunology. Apr, 2013 | Pubmed ID: 23127859 Molecular Basis for the Increased Polymyxin Susceptibility of Klebsiella Pneumoniae Strains with Under-acylated Lipid A Innate Immunity. Jun, 2013 | Pubmed ID: 23008349 Molecular Characterization of Lipopolysaccharide Binding to Human α-1-Acid Glycoprotein Journal of Lipids. 2012 | Pubmed ID: 23316371 Drug-binding Energetics of Human α-1-acid Glycoprotein Assessed by Isothermal Titration Calorimetry and Molecular Docking Simulations Journal of Molecular Recognition : JMR. Dec, 2012 | Pubmed ID: 23192962 Analysis of Phosphopeptide Changes As Spermatozoa Acquire Functional Competence in the Epididymis Demonstrates Changes in the Post-translational Modification of Izumo1 Journal of Proteome Research. Nov, 2012 | Pubmed ID: 22954305 The Combination of Colistin and Doripenem is Synergistic Against Klebsiella Pneumoniae at Multiple Inocula and Suppresses Colistin Resistance in an in Vitro Pharmacokinetic/pharmacodynamic Model Antimicrobial Agents and Chemotherapy. Oct, 2012 | Pubmed ID: 22802247 Structure-activity Relationships for the Binding of Polymyxins with Human α-1-acid Glycoprotein Biochemical Pharmacology. May, 2012 | Pubmed ID: 22587817 Characterization of the N-methyltransferase Activities of the Multifunctional Polypeptide Cyclosporin Synthetase Chemistry & Biology. Apr, 2011 | Pubmed ID: 21513883 Design, Synthesis, and Evaluation of a New Fluorescent Probe for Measuring Polymyxin-lipopolysaccharide Binding Interactions Analytical Biochemistry. Feb, 2011 | Pubmed ID: 21050838 Developing an Anion Host for Lipid A Binding and Antibacterial Activity Chemical Communications (Cambridge, England). May, 2010 | Pubmed ID: 20424772 Self-assembly Behavior of Colistin and Its Prodrug Colistin Methanesulfonate: Implications for Solution Stability and Solubilization The Journal of Physical Chemistry. B. Apr, 2010 | Pubmed ID: 20302384 Structure--activity Relationships of Polymyxin Antibiotics Journal of Medicinal Chemistry. Mar, 2010 | Pubmed ID: 19874036 Ligand-enhanced Expression and In-cell Assay of Human Peroxisome Proliferator-activated Receptor Alpha Ligand Binding Domain Protein Expression and Purification. Apr, 2010 | Pubmed ID: 19782138 Probing the Fibrate Binding Specificity of Rat Liver Fatty Acid Binding Protein Journal of Medicinal Chemistry. Sep, 2009 | Pubmed ID: 19663428 Thermodynamics of Lipophilic Drug Binding to Intestinal Fatty Acid Binding Protein and Permeation Across Membranes Molecular Pharmaceutics. Mar-Apr, 2009 | Pubmed ID: 19265444 Characterization of Lipophilic Drug Binding to Rat Intestinal Fatty Acid Binding Protein Molecular and Cellular Biochemistry. Jun, 2009 | Pubmed ID: 19160019 Ni2+-based Immobilized Metal Ion Affinity Chromatography of Lactose Operon Repressor Protein from Escherichia Coli Preparative Biochemistry & Biotechnology. 2008 | Pubmed ID: 18800304 Structural and Biochemical Characterization of the Oxidoreductase NmDsbA3 from Neisseria Meningitidis The Journal of Biological Chemistry. Nov, 2008 | Pubmed ID: 18715864 Characterization of the Drug Binding Specificity of Rat Liver Fatty Acid Binding Protein Journal of Medicinal Chemistry. Jul, 2008 | Pubmed ID: 18533710 A Protocol for the Combined Sub-fractionation and Delipidation of Lipid Binding Proteins Using Hydrophobic Interaction Chromatography Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. May, 2008 | Pubmed ID: 18456580 Probing the Flexibility of the DsbA Oxidoreductase from Vibrio Cholerae--a 15N - 1H Heteronuclear NMR Relaxation Analysis of Oxidized and Reduced Forms of DsbA Journal of Molecular Biology. Aug, 2007 | Pubmed ID: 17585933 Examination of the Role of Intestinal Fatty Acid-binding Protein in Drug Absorption Using a Parallel Artificial Membrane Permeability Assay Chemistry & Biology. Apr, 2007 | Pubmed ID: 17462580 Generation of Mutant Leukaemia Inhibitory Factor (LIF)-IgG Heavy Chain Fusion Proteins As Bivalent Antagonists of LIF Journal of Immunological Methods. May, 2007 | Pubmed ID: 17408687 An Improved Purification Procedure for Cyclosporin Synthetase Protein Expression and Purification. Feb, 2006 | Pubmed ID: 16139518 An Improved Method for the Purification of Rat Liver-type Fatty Acid Binding Protein from Escherichia Coli Protein Expression and Purification. Nov, 2005 | Pubmed ID: 15914028 The Interaction of Lipophilic Drugs with Intestinal Fatty Acid-binding Protein The Journal of Biological Chemistry. May, 2005 | Pubmed ID: 15722357 Non-ribosomal Peptide Synthetases As Technological Platforms for the Synthesis of Highly Modified Peptide Bioeffectors--Cyclosporin Synthetase As a Complex Example Biotechnology Annual Review. 2003 | Pubmed ID: 14650927 Photoaffinity Labeling of the N-methyltransferase Domains of Cyclosporin Synthetase Photochemistry and Photobiology. Feb, 2003 | Pubmed ID: 12785050 Mapping and Molecular Modeling of S-adenosyl-L-methionine Binding Sites in N-methyltransferase Domains of the Multifunctional Polypeptide Cyclosporin Synthetase The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12399454 Rat Burn Model om cutane thermische verbranding en infectie van volledige dikte te bestuderen Rajnikant Sharma1, Shekhar Yeshwante1, Quentin Vallé1, Maytham Hussein2, Varsha Thombare2, Sean Michael McCann1, Robert Maile3,4,5, Jian Li6, Tony Velkov2, Gauri Rao1 1UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 2Department of Biochemistry & Pharmacology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, 3Department of Microbiology & Immunology, University of North Carolina School of Medicine, 4Department of Surgery, University of North Carolina at Chapel Hill, 5Curriculum in Toxicology and Environmental Medicine, University of North Carolina at Chapel Hill, 6Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University JoVE 64345 Immunology and Infection Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study JoVE 63540 Neuroscience Geoptimaliseerde LC-MS/MS methode voor de analyse van de High-throughput van klinische monsters van Ivacaftor, de belangrijkste metabolieten daarvan en Lumacaftor in biologische vloeistoffen van Cystic Fibrosis patiënten Elena K. Schneider1, Felisa Reyes-Ortega1, Jian Li1,2, Tony Velkov1 1Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 2Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University JoVE 56084 Medicine Fosfopeptide Analyse van knaagdieren Epididymal Spermatozoa Mark A. Baker1, Louise Hetherington1, Anita Weinberg1, Tony Velkov2 1School of Environmental and Life Science, University of Newcastle, 2Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University Biology
Rat Burn Model om cutane thermische verbranding en infectie van volledige dikte te bestuderen Rajnikant Sharma1, Shekhar Yeshwante1, Quentin Vallé1, Maytham Hussein2, Varsha Thombare2, Sean Michael McCann1, Robert Maile3,4,5, Jian Li6, Tony Velkov2, Gauri Rao1 1UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 2Department of Biochemistry & Pharmacology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, 3Department of Microbiology & Immunology, University of North Carolina School of Medicine, 4Department of Surgery, University of North Carolina at Chapel Hill, 5Curriculum in Toxicology and Environmental Medicine, University of North Carolina at Chapel Hill, 6Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University JoVE 64345 Immunology and Infection
Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study JoVE 63540 Neuroscience
Geoptimaliseerde LC-MS/MS methode voor de analyse van de High-throughput van klinische monsters van Ivacaftor, de belangrijkste metabolieten daarvan en Lumacaftor in biologische vloeistoffen van Cystic Fibrosis patiënten Elena K. Schneider1, Felisa Reyes-Ortega1, Jian Li1,2, Tony Velkov1 1Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 2Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University JoVE 56084 Medicine
Fosfopeptide Analyse van knaagdieren Epididymal Spermatozoa Mark A. Baker1, Louise Hetherington1, Anita Weinberg1, Tony Velkov2 1School of Environmental and Life Science, University of Newcastle, 2Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University Biology
