Torben Heick Jensen

Publications

• A Two-Layered Targeting Mechanism Underlies Nuclear RNA Sorting by the Human Exosome
  Cell Reports. Feb, 2020  |   Pubmed ID: 32075771
• The Human ZC3H3 and RBM26/27 Proteins Are Critical for PAXT-mediated Nuclear RNA Decay
  Nucleic Acids Research. 03, 2020  |   Pubmed ID: 31950173
• Global Identification of Human Exosome Substrates Using RNA Interference and RNA Sequencing
  Methods in Molecular Biology (Clifton, N.J.). 2020  |   Pubmed ID: 31768975
• Nuclear Sorting of RNA
  Wiley Interdisciplinary Reviews. RNA. Mar, 2020  |   Pubmed ID: 31713323
• The Nuclear RNA Exosome and Its Cofactors
  Advances in Experimental Medicine and Biology. 2019  |   Pubmed ID: 31811632
• A Functional Link Between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2
  Cell Reports. Nov, 2019  |   Pubmed ID: 31722198
• The Long Noncoding RNA is Seemingly Dispensable for Normal Tissue Homeostasis and Cancer Cell Growth
  RNA (New York, N.Y.). 12, 2019  |   Pubmed ID: 31551298
• The MTR4 Helicase Recruits Nuclear Adaptors of the Human RNA Exosome Using Distinct Arch-interacting Motifs
  Nature Communications. 07, 2019  |   Pubmed ID: 31358741
• Preparation of RNA 3' End Sequencing Libraries of Total and 4-thiouracil Labeled RNA for Simultaneous Measurement of Transcription, RNA Synthesis and Decay in
  Bio-protocol. Mar, 2019  |   Pubmed ID: 30931349
• Escaping Nuclear Decay: the Significance of MRNA Export for Gene Expression
  Current Genetics. Apr, 2019  |   Pubmed ID: 30515529
• The Multitasking PolyA Tail: Nuclear RNA Maturation, Degradation and Export
  Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 11, 2018  |   Pubmed ID: 30397105
• Box C/D SnoRNP Autoregulation by a Cis-Acting SnoRNA in the NOP56 Pre-mRNA
  Molecular Cell. 10, 2018  |   Pubmed ID: 30220559
• The RNA Exosome Contributes to Gene Expression Regulation During Stem Cell Differentiation
  Nucleic Acids Research. 11, 2018  |   Pubmed ID: 30212902
• Simultaneous Measurement of Transcriptional and Post-transcriptional Parameters by 3' End RNA-Seq
  Cell Reports. 08, 2018  |   Pubmed ID: 30157438
• A Nuclear Export Block Triggers the Decay of Newly Synthesized Polyadenylated RNA
  Cell Reports. Aug, 2018  |   Pubmed ID: 30157437
• Diminished Nuclear RNA Decay Upon Infection Upregulates Antibacterial Noncoding RNAs
  The EMBO Journal. 07, 2018  |   Pubmed ID: 29880601
• The RNA Exosome Adaptor ZFC3H1 Functionally Competes with Nuclear Export Activity to Retain Target Transcripts
  Cell Reports. 05, 2018  |   Pubmed ID: 29768216
• Controlling Nuclear RNA Levels
  Nature Reviews. Genetics. 08, 2018  |   Pubmed ID: 29748575
• Transcription Start Site Analysis Reveals Widespread Divergent Transcription in D. Melanogaster and Core Promoter-encoded Enhancer Activities
  Nucleic Acids Research. 06, 2018  |   Pubmed ID: 29659982
• Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions
  Cell Reports. 01, 2018  |   Pubmed ID: 29298432
• Characterising -regulatory Variation in the Transcriptome of Histologically Normal and Tumour-derived Pancreatic Tissues
  Gut. 03, 2018  |   Pubmed ID: 28634199
• ARS2 is a General Suppressor of Pervasive Transcription
  Nucleic Acids Research. Sep, 2017  |   Pubmed ID: 28973446
• Polo-like Kinase 2 Modulates α-synuclein Protein Levels by Regulating Its MRNA Production
  Neurobiology of Disease. Oct, 2017  |   Pubmed ID: 28648742
• Targeting the Nuclear RNA Exosome: Poly(A) Binding Proteins Enter the Stage
  RNA Biology. 07, 2017  |   Pubmed ID: 28421898
• Mutually Exclusive CBC-Containing Complexes Contribute to RNA Fate
  Cell Reports. 03, 2017  |   Pubmed ID: 28297668
• Nuclear Decay Factors Crack Up MRNA
  Molecular Cell. Mar, 2017  |   Pubmed ID: 28257696
• Lariat Capping As a Tool to Manipulate the 5' End of Individual Yeast MRNA Species in Vivo
  RNA (New York, N.Y.). 05, 2017  |   Pubmed ID: 28159804
• Structure of the RBM7-ZCCHC8 Core of the NEXT Complex Reveals Connections to Splicing Factors
  Nature Communications. Dec, 2016  |   Pubmed ID: 27905398
• Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts
  Molecular Cell. Nov, 2016  |   Pubmed ID: 27871484
• A Conserved Virus-induced Cytoplasmic TRAMP-like Complex Recruits the Exosome to Target Viral RNA for Degradation
  Genes & Development. 07, 2016  |   Pubmed ID: 27474443
• Principles for RNA Metabolism and Alternative Transcription Initiation Within Closely Spaced Promoters
  Nature Genetics. 09, 2016  |   Pubmed ID: 27455346
• Purification and Analysis of Endogenous Human RNA Exosome Complexes
  RNA (New York, N.Y.). Sep, 2016  |   Pubmed ID: 27402899
• Relationships Between PROMPT and Gene Expression
  RNA Biology. 2016  |   Pubmed ID: 26574648
• Human Gene Promoters Are Intrinsically Bidirectional
  Molecular Cell. Nov, 2015  |   Pubmed ID: 26545074
• Nonsense-mediated MRNA Decay: an Intricate Machinery That Shapes Transcriptomes
  Nature Reviews. Molecular Cell Biology. Nov, 2015  |   Pubmed ID: 26397022
• The Nuclear PolyA-Binding Protein Nab2p Is Essential for MRNA Production
  Cell Reports. Jul, 2015  |   Pubmed ID: 26119729
• Rapid, Optimized Interactomic Screening
  Nature Methods. Jun, 2015  |   Pubmed ID: 25938370
• The Human Nuclear Exosome Targeting Complex is Loaded Onto Newly Synthesized RNA to Direct Early Ribonucleolysis
  Cell Reports. Jan, 2015  |   Pubmed ID: 25578728
• Human Nonsense-mediated RNA Decay Initiates Widely by Endonucleolysis and Targets SnoRNA Host Genes
  Genes & Development. Nov, 2014  |   Pubmed ID: 25403180
• SnapShot: Nuclear RNAPII Transcript Modification
  Cell. May, 2014  |   Pubmed ID: 24855955
• Rat1p Maintains RNA Polymerase II CTD Phosphorylation Balance
  RNA (New York, N.Y.). Apr, 2014  |   Pubmed ID: 24501251
• The Human Cap-binding Complex is Functionally Connected to the Nuclear RNA Exosome
  Nature Structural & Molecular Biology. Dec, 2013  |   Pubmed ID: 24270879
• Dealing with Pervasive Transcription
  Molecular Cell. Nov, 2013  |   Pubmed ID: 24267449
• Mutational Analysis of the Yeast RNA Helicase Sub2p Reveals Conserved Domains Required for Growth, MRNA Export, and Genomic Stability
  RNA (New York, N.Y.). Oct, 2013  |   Pubmed ID: 23962665
• Polyadenylation Site-induced Decay of Upstream Transcripts Enforces Promoter Directionality
  Nature Structural & Molecular Biology. Aug, 2013  |   Pubmed ID: 23851456
• Exonuclease HDIS3L2 Specifies an Exosome-independent 3'-5' Degradation Pathway of Human Cytoplasmic MRNA
  The EMBO Journal. Jul, 2013  |   Pubmed ID: 23756462
• Making Ends Meet: Coordination Between RNA 3'-end Processing and Transcription Initiation
  Wiley Interdisciplinary Reviews. RNA. May-Jun, 2013  |   Pubmed ID: 23450686
• Transcription-associated Quality Control of MRNP
  Biochimica Et Biophysica Acta. Jan, 2013  |   Pubmed ID: 22982197
• Biochemistry and Function of RNA Exosomes
  The Enzymes. 2012  |   Pubmed ID: 27166438
• MRN1 Implicates Chromatin Remodeling Complexes and Architectural Factors in MRNA Maturation
  PloS One. 2012  |   Pubmed ID: 23028530
• Promoter-proximal Polyadenylation Sites Reduce Transcription Activity
  Genes & Development. Oct, 2012  |   Pubmed ID: 23028143
• Nuclear Retention Prevents Premature Cytoplasmic Appearance of MRNA
  Molecular Cell. Oct, 2012  |   Pubmed ID: 22921936
• Rrp6p Controls MRNA Poly(A) Tail Length and Its Decoration with Poly(A) Binding Proteins
  Molecular Cell. Jul, 2012  |   Pubmed ID: 22683267
• Improved Methodology for the Affinity Isolation of Human Protein Complexes Expressed at Near Endogenous Levels
  BioTechniques. May, 2012  |   Pubmed ID: 22668517
• Saccharomyces Cerevisiae Ngl3p is an Active 3'-5' Exonuclease with a Specificity Towards Poly-A RNA Reminiscent of Cellular Deadenylases
  Nucleic Acids Research. Jan, 2012  |   Pubmed ID: 21965533
• Implication of Ccr4-Not Complex Function in MRNA Quality Control in Saccharomyces Cerevisiae
  RNA (New York, N.Y.). Oct, 2011  |   Pubmed ID: 21862638
• Interaction Profiling Identifies the Human Nuclear Exosome Targeting Complex
  Molecular Cell. Aug, 2011  |   Pubmed ID: 21855801
• PROMoter UPstream Transcripts Share Characteristics with MRNAs and Are Produced Upstream of All Three Major Types of Mammalian Promoters
  Nucleic Acids Research. Sep, 2011  |   Pubmed ID: 21596787
• T-body Formation Precedes Virus-like Particle Maturation in S. Cerevisiae
  RNA Biology. Mar-Apr, 2011  |   Pubmed ID: 21358276
• The Eukaryotic RNA Exosome: Same Scaffold but Variable Catalytic Subunits
  RNA Biology. Jan-Feb, 2011  |   Pubmed ID: 21289487
• Nuclear Quality Control of RNA Polymerase II Transcripts
  Wiley Interdisciplinary Reviews. RNA. Nov-Dec, 2010  |   Pubmed ID: 21956943
• RNA Exosome. Preface
  Advances in Experimental Medicine and Biology. 2010  |   Pubmed ID: 21618869
• A Pause to Splice
  Molecular Cell. Nov, 2010  |   Pubmed ID: 21095579
• Translation by Remote Control
  Cell. Nov, 2010  |   Pubmed ID: 21074041
• Crosstalk Between MRNA 3' End Processing and Transcription Initiation
  Molecular Cell. Nov, 2010  |   Pubmed ID: 21070967
• The Human Core Exosome Interacts with Differentially Localized Processive RNases: HDIS3 and HDIS3L
  The EMBO Journal. Jul, 2010  |   Pubmed ID: 20531386
• The Yeast 5'-3' Exonuclease Rat1p Functions During Transcription Elongation by RNA Polymerase II
  Molecular Cell. Feb, 2010  |   Pubmed ID: 20188675
• Assembly of an Export-competent MRNP is Needed for Efficient Release of the 3'-end Processing Complex After Polyadenylation
  Molecular and Cellular Biology. Oct, 2009  |   Pubmed ID: 19635808
• Assembly of Export-competent MRNP: It's All About Being Connected
  Molecular Cell. Jan, 2009  |   Pubmed ID: 19187754
• RNA Exosome Depletion Reveals Transcription Upstream of Active Human Promoters
  Science (New York, N.Y.). Dec, 2008  |   Pubmed ID: 19056938
• Exonucleolysis is Required for Nuclear MRNA Quality Control in Yeast THO Mutants
  RNA (New York, N.Y.). Nov, 2008  |   Pubmed ID: 18824516
• The T Body, a New Cytoplasmic RNA Granule in Saccharomyces Cerevisiae
  Molecular and Cellular Biology. Oct, 2008  |   Pubmed ID: 18678648
• Nuclear MRNA Surveillance in THO/sub2 Mutants is Triggered by Inefficient Polyadenylation
  Molecular Cell. Jul, 2008  |   Pubmed ID: 18614048
• Dissecting Mechanisms of Nuclear MRNA Surveillance in THO/sub2 Complex Mutants
  The EMBO Journal. May, 2007  |   Pubmed ID: 17410208
• A Novel Plasmid-based Microarray Screen Identifies Suppressors of Rrp6Delta in Saccharomyces Cerevisiae
  Molecular and Cellular Biology. Feb, 2007  |   Pubmed ID: 17101774
• The Role of the Brr5/Ysh1 C-terminal Domain and Its Homolog Syc1 in MRNA 3'-end Processing in Saccharomyces Cerevisiae
  RNA (New York, N.Y.). Mar, 2006  |   Pubmed ID: 16431986
• Dramatically Improved RNA in Situ Hybridization Signals Using LNA-modified Probes
  RNA (New York, N.Y.). Nov, 2005  |   Pubmed ID: 16177135
• Modulation of Transcription Affects MRNP Quality
  Molecular Cell. Oct, 2004  |   Pubmed ID: 15494310
• Localization of Nuclear Retained MRNAs in Saccharomyces Cerevisiae
  RNA (New York, N.Y.). Sep, 2003  |   Pubmed ID: 12923254
• Early Formation of MRNP: License for Export or Quality Control?
  Molecular Cell. May, 2003  |   Pubmed ID: 12769839
• Interactions Between MRNA Export Commitment, 3'-end Quality Control, and Nuclear Degradation
  Molecular and Cellular Biology. Dec, 2002  |   Pubmed ID: 12417728