Toshihide Kurihara Department of Ophthalmology Keio University School of Medicine Biography Publications Institution JoVE Articles Toshihide Kurihara Toshihide Kurihara is an Assistant Professor of Ophthalmology and a Principal Investigator in the Laboratory of Photobiology at Keio University School of Medicine, Tokyo, Japan. He received his M.D. degree from the Faculty of Medicine, University of Tsukuba, Ibaraki, Japan in 2001. He completed his ophthalmology residency at Keio University Hospital in 2005, and obtained his Ph.D. degree under the supervision of Professor Kazuo Tsubota from Keio University Graduate School of Medicine in 2009. Dr. Kurihara did his postdoctoral training under the mentorship of Professor Martin Friedlander at the Scripps Research Institute in La Jolla, California, USA. His research interest is hypoxia responses in development, physiology, and pathophysiology of the retina. Currently, he also conducts research focusing on visual restoration utilizing optogenetic technology and molecular mechanism of myopia development and progression. Publications KW3110 Prevents Blue Light-Induced Inflammation and Degeneration in the Retina Nutrients. Dec, 2018 | Pubmed ID: 30558320 A Highly Efficient Murine Model of Experimental Myopia Scientific Reports. 02, 2018 | Pubmed ID: 29391484 Development and Pathological Changes of Neurovascular Unit Regulated by Hypoxia Response in the Retina Progress in Brain Research. Month, 2016 | Pubmed ID: 27130417 Blue Light-induced Inflammatory Marker Expression in the Retinal Pigment Epithelium-choroid of Mice and the Protective Effect of a Yellow Intraocular Lens Material In vivo Experimental Eye Research. Jan, 2015 | Pubmed ID: 25576667 Neurons Limit Angiogenesis by Titrating VEGF in Retina Cell. Oct, 2014 | Pubmed ID: 25417109 Intraoperative and Fluorescein Angiographic Findings of a Secondary Macular Hole Associated with Age-related Macular Degeneration Treated by Pars Plana Vitrectomy BMC Ophthalmology. Month, 2014 | Pubmed ID: 25270019 Local Acting Sticky-trap Inhibits Vascular Endothelial Growth Factor Dependent Pathological Angiogenesis in the Eye EMBO Molecular Medicine. May, 2014 | Pubmed ID: 24705878 Utilizing Stem Cell-derived RPE Cells As a Therapeutic Intervention for Age-related Macular Degeneration Advances in Experimental Medicine and Biology. Month, 2014 | Pubmed ID: 24664714 Hypoxia-inducible Factor (HIF)/vascular Endothelial Growth Factor (VEGF) Signaling in the Retina Advances in Experimental Medicine and Biology. Month, 2014 | Pubmed ID: 24664708 Ras Pathway Inhibition Prevents Neovascularization by Repressing Endothelial Cell Sprouting The Journal of Clinical Investigation. Nov, 2013 | Pubmed ID: 24084735 Targeted Deletion of Vegfa in Adult Mice Induces Vision Loss The Journal of Clinical Investigation. Nov, 2012 | Pubmed ID: 23093773 Using Flow Cytometry to Compare the Dynamics of Photoreceptor Outer Segment Phagocytosis in IPS-derived RPE Cells Investigative Ophthalmology & Visual Science. Month, 2012 | Pubmed ID: 22871841 Renin-Angiotensin System Hyperactivation Can Induce Inflammation and Retinal Neural Dysfunction International Journal of Inflammation. Month, 2012 | Pubmed ID: 22536545 Generation of Retinal Pigment Epithelial Cells from Small Molecules and OCT4 Reprogrammed Human Induced Pluripotent Stem Cells Stem Cells Translational Medicine. Feb, 2012 | Pubmed ID: 22532929 The Formation of an Angiogenic Astrocyte Template is Regulated by the Neuroretina in a HIF-1-dependent Manner Developmental Biology. Mar, 2012 | Pubmed ID: 22226979 Biological Role of Lutein in the Light-induced Retinal Degeneration The Journal of Nutritional Biochemistry. May, 2012 | Pubmed ID: 21658930 Neural Degeneration in the Retina of the Streptozotocin-induced Type 1 Diabetes Model Experimental Diabetes Research. Month, 2011 | Pubmed ID: 22144984 Astrocyte PVHL and HIF-α Isoforms Are Required for Embryonic-to-adult Vascular Transition in the Eye The Journal of Cell Biology. Nov, 2011 | Pubmed ID: 22084310 Roles of AMP-activated Protein Kinase in Diabetes-induced Retinal Inflammation Investigative Ophthalmology & Visual Science. Month, 2011 | Pubmed ID: 22058332 Retinal Ganglion Cell Loss in Superoxide Dismutase 1 Deficiency Investigative Ophthalmology & Visual Science. Jun, 2011 | Pubmed ID: 21421868 Regulation of Posttranscriptional Modification As a Possible Therapeutic Approach for Retinal Neuroprotection Journal of Ophthalmology. Month, 2011 | Pubmed ID: 21076532 Hydrogen and N-acetyl-L-cysteine Rescue Oxidative Stress-induced Angiogenesis in a Mouse Corneal Alkali-burn Model Investigative Ophthalmology & Visual Science. Jan, 2011 | Pubmed ID: 20847117 Resveratrol Prevents Light-induced Retinal Degeneration Via Suppressing Activator Protein-1 Activation The American Journal of Pathology. Oct, 2010 | Pubmed ID: 20709795 Astrocyte Hypoxic Response is Essential for Pathological but Not Developmental Angiogenesis of the Retina Glia. Aug, 2010 | Pubmed ID: 20544853 Von Hippel-Lindau Protein Regulates Transition from the Fetal to the Adult Circulatory System in Retina Development (Cambridge, England). May, 2010 | Pubmed ID: 20388654 Bilateral Acute Functional Disturbance in the Retina Following Placental Abruption Japanese Journal of Ophthalmology. Nov, 2009 | Pubmed ID: 20020254 Retinal Phototoxicity in a Novel Murine Model of Intraocular Lens Implantation Molecular Vision. Month, 2009 | Pubmed ID: 20019883 New Retractor Capable of Aspirating Fluids During Scleral Buckling Surgery Retina (Philadelphia, Pa.). Nov-Dec, 2009 | Pubmed ID: 19898190 Involvement of Hyaluronan and Its Receptor CD44 with Choroidal Neovascularization Investigative Ophthalmology & Visual Science. Sep, 2009 | Pubmed ID: 19339747 Prevention of Ocular Inflammation in Endotoxin-induced Uveitis with Resveratrol by Inhibiting Oxidative Damage and Nuclear Factor-kappaB Activation Investigative Ophthalmology & Visual Science. Jul, 2009 | Pubmed ID: 19279313 Neuroprotective Effect of an Antioxidant, Lutein, During Retinal Inflammation Investigative Ophthalmology & Visual Science. Mar, 2009 | Pubmed ID: 18997089 Roles of STAT3/SOCS3 Pathway in Regulating the Visual Function and Ubiquitin-proteasome-dependent Degradation of Rhodopsin During Retinal Inflammation The Journal of Biological Chemistry. Sep, 2008 | Pubmed ID: 18614536 Angiotensin II Type 1 Receptor Signaling Contributes to Synaptophysin Degradation and Neuronal Dysfunction in the Diabetic Retina Diabetes. Aug, 2008 | Pubmed ID: 18487452 Retinal Dysfunction and Progressive Retinal Cell Death in SOD1-deficient Mice The American Journal of Pathology. May, 2008 | Pubmed ID: 18372426 Suppression of Choroidal Neovascularization by Dendritic Cell Vaccination Targeting VEGFR2 Investigative Ophthalmology & Visual Science. Oct, 2007 | Pubmed ID: 17898306 Eicosapentaenoic Acid is Anti-inflammatory in Preventing Choroidal Neovascularization in Mice Investigative Ophthalmology & Visual Science. Sep, 2007 | Pubmed ID: 17724224 Interleukin-6 Receptor-mediated Activation of Signal Transducer and Activator of Transcription-3 (STAT3) Promotes Choroidal Neovascularization The American Journal of Pathology. Jun, 2007 | Pubmed ID: 17525280 SOCS3 is Required to Temporally Fine-tune Photoreceptor Cell Differentiation Developmental Biology. Mar, 2007 | Pubmed ID: 17198696 Neuroprotective Effects of Angiotensin II Type 1 Receptor (AT1R) Blocker, Telmisartan, Via Modulating AT1R and AT2R Signaling in Retinal Inflammation Investigative Ophthalmology & Visual Science. Dec, 2006 | Pubmed ID: 17122147 Pars Plana Vitrectomy with Internal Limiting Membrane Removal for Macular Hole Associated with Proliferative Diabetic Retinopathy Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Jul, 2005 | Pubmed ID: 15657774 Ein murines Modell der ischämischen Netzhautverletzung induziert durch transiente bilaterale gemeinsame Carotis ArterieNverschluss Deokho Lee*1,2, Yukihiro Miwa*1,2,3, Heonuk Jeong1,2, Shin-ichi Ikeda1,2, Yusaku Katada1,2, Kazuo Tsubota1,2,4, Toshihide Kurihara1,2 1Laboratory of Photobiology, Keio University School of Medicine, 2Department of Ophthalmology, Keio University School of Medicine, 3Animal eye care, Tokyo Animal Eye Clinic, 4Tsubota Laboratory, Inc. JoVE 61865 Medicine Anreiz und Auswertung von einem Mausmodell der experimentellen Myopie Xiaoyan Jiang1,2, Toshihide Kurihara1,2, Shin-ichi Ikeda1,2, Hiromitsu Kunimi1,2, Kiwako Mori1,2, Hidemasa Torii1,2, Kazuo Tsubota2 1Laboratory of Photobiology, Keio University School of Medicine, 2Department of Ophthalmology, Keio University School of Medicine JoVE 58822 Neuroscience Darstellende Subretinale Injektionen in Nagetiere zu retinalen Pigmentepithelzellen in Suspension liefern Peter D. Westenskow1,2, Toshihide Kurihara1, Stephen Bravo1, Daniel Feitelberg1, Zack A. Sedillo2, Edith Aguilar1, Martin Friedlander1,2 1Department of Cell and Molecular Biology, The Scripps Research Institute, 2Lowy Medical Research Institute Medicine
Ein murines Modell der ischämischen Netzhautverletzung induziert durch transiente bilaterale gemeinsame Carotis ArterieNverschluss Deokho Lee*1,2, Yukihiro Miwa*1,2,3, Heonuk Jeong1,2, Shin-ichi Ikeda1,2, Yusaku Katada1,2, Kazuo Tsubota1,2,4, Toshihide Kurihara1,2 1Laboratory of Photobiology, Keio University School of Medicine, 2Department of Ophthalmology, Keio University School of Medicine, 3Animal eye care, Tokyo Animal Eye Clinic, 4Tsubota Laboratory, Inc. JoVE 61865 Medicine
Anreiz und Auswertung von einem Mausmodell der experimentellen Myopie Xiaoyan Jiang1,2, Toshihide Kurihara1,2, Shin-ichi Ikeda1,2, Hiromitsu Kunimi1,2, Kiwako Mori1,2, Hidemasa Torii1,2, Kazuo Tsubota2 1Laboratory of Photobiology, Keio University School of Medicine, 2Department of Ophthalmology, Keio University School of Medicine JoVE 58822 Neuroscience
Darstellende Subretinale Injektionen in Nagetiere zu retinalen Pigmentepithelzellen in Suspension liefern Peter D. Westenskow1,2, Toshihide Kurihara1, Stephen Bravo1, Daniel Feitelberg1, Zack A. Sedillo2, Edith Aguilar1, Martin Friedlander1,2 1Department of Cell and Molecular Biology, The Scripps Research Institute, 2Lowy Medical Research Institute Medicine
