Véronique Dartois Public Health Research Institute, New Jersey Medical School Rutgers, The State University of New Jersey Biography Publications Institution JoVE Articles Véronique Dartois has not added a biography. If you are Véronique Dartois and would like to personalize this page please email our Author Liaison for assistance. Publications Rifabutin Is Active Against Mycobacterium Abscessus Complex Antimicrobial Agents and Chemotherapy. Apr, 2017 | Pubmed ID: 28396540 In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium Tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1 ACS Infectious Diseases. Mar, 2017 | Pubmed ID: 28271875 Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase As Potential Leads Against Mycobacterium Tuberculosis ACS Infectious Diseases. Jan, 2017 | Pubmed ID: 27704782 New Evidence for the Complexity of the Population Structure of Mycobacterium Tuberculosis Increases the Diagnostic and Biologic Challenges American Journal of Respiratory and Critical Care Medicine. Dec, 2016 | Pubmed ID: 27976945 Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor Synthesis ACS Infectious Diseases. Sep, 2016 | Pubmed ID: 27759369 Prediction of Drug Penetration in Tuberculosis Lesions ACS Infectious Diseases. Aug, 2016 | Pubmed ID: 27626295 Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium Tuberculosis Infected C3HeB/FeJ Mice ACS Infectious Diseases. Apr, 2016 | Pubmed ID: 27227164 Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium Tuberculosis Journal of Medicinal Chemistry. Jul, 2016 | Pubmed ID: 27144688 High Systemic Exposure of Pyrazinoic Acid Has Limited Antituberculosis Activity in Murine and Rabbit Models of Tuberculosis Antimicrobial Agents and Chemotherapy. Jul, 2016 | Pubmed ID: 27139472 Immune Activation of the Host Cell Induces Drug Tolerance in Mycobacterium Tuberculosis Both in Vitro and in Vivo The Journal of Experimental Medicine. May, 2016 | Pubmed ID: 27114608 Inflammatory Signaling in Human Tuberculosis Granulomas is Spatially Organized Nature Medicine. May, 2016 | Pubmed ID: 27043495 Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model EBioMedicine. Feb, 2016 | Pubmed ID: 26981575 Statin Adjunctive Therapy Shortens the Duration of TB Treatment in Mice The Journal of Antimicrobial Chemotherapy. 06, 2016 | Pubmed ID: 26903278 Development and Validation of LC-ESI-MS/MS Method for Analysis of Moxifloxacin and Levofloxacin in Serum of Multidrug-resistant Tuberculosis Patients: Potential Application As Therapeutic Drug Monitoring Tool in Medical Diagnosis Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Jan, 2016 | Pubmed ID: 26730550 Selective Inactivity of Pyrazinamide Against Tuberculosis in C3HeB/FeJ Mice Is Best Explained by Neutral PH of Caseum Antimicrobial Agents and Chemotherapy. Feb, 2016 | Pubmed ID: 26574016 Linezolid Trough Concentrations Correlate with Mitochondrial Toxicity-Related Adverse Events in the Treatment of Chronic Extensively Drug-Resistant Tuberculosis EBioMedicine. Nov, 2015 | Pubmed ID: 26870788 In Silico Evaluation and Exploration of Antibiotic Tuberculosis Treatment Regimens BMC Systems Biology. Nov, 2015 | Pubmed ID: 26578235 Contribution of Oxazolidinones to the Efficacy of Novel Regimens Containing Bedaquiline and Pretomanid in a Mouse Model of Tuberculosis Antimicrobial Agents and Chemotherapy. Oct, 2015 | Pubmed ID: 26503656 The Association Between Sterilizing Activity and Drug Distribution into Tuberculosis Lesions Nature Medicine. Oct, 2015 | Pubmed ID: 26343800 Mass Spectrometry Imaging of Levofloxacin Distribution in TB-infected Pulmonary Lesions by MALDI-MSI and Continuous Liquid Microjunction Surface Sampling International Journal of Mass Spectrometry. Feb, 2015 | Pubmed ID: 26185484 Determination of [11C]rifampin Pharmacokinetics Within Mycobacterium Tuberculosis-infected Mice by Using Dynamic Positron Emission Tomography Bioimaging Antimicrobial Agents and Chemotherapy. Sep, 2015 | Pubmed ID: 26169396 Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives ACS Infectious Diseases. May, 2015 | Pubmed ID: 26086040 A Sterilizing Tuberculosis Treatment Regimen Is Associated with Faster Clearance of Bacteria in Cavitary Lesions in Marmosets Antimicrobial Agents and Chemotherapy. Jul, 2015 | Pubmed ID: 25941223 Heterogeneity in Tuberculosis Pathology, Microenvironments and Therapeutic Responses Immunological Reviews. Mar, 2015 | Pubmed ID: 25703567 Comprehensive Physicochemical, Pharmacokinetic and Activity Profiling of Anti-TB Agents The Journal of Antimicrobial Chemotherapy. Mar, 2015 | Pubmed ID: 25587994 A Computational Tool Integrating Host Immunity with Antibiotic Dynamics to Study Tuberculosis Treatment Journal of Theoretical Biology. Feb, 2015 | Pubmed ID: 25497475 Pharmacokinetic-pharmacodynamic Analysis of Spiroindolone Analogs and KAE609 in a Murine Malaria Model Antimicrobial Agents and Chemotherapy. Feb, 2015 | Pubmed ID: 25487807 PET/CT Imaging Reveals a Therapeutic Response to Oxazolidinones in Macaques and Humans with Tuberculosis Science Translational Medicine. Dec, 2014 | Pubmed ID: 25473035 The Path of Anti-tuberculosis Drugs: from Blood to Lesions to Mycobacterial Cells Nature Reviews. Microbiology. Mar, 2014 | Pubmed ID: 24487820 Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-cell-mediated Killing Cell. Dec, 2013 | Pubmed ID: 24315099 Indolcarboxamide is a Preclinical Candidate for Treating Multidrug-resistant Tuberculosis Science Translational Medicine. Dec, 2013 | Pubmed ID: 24307692 A Medicinal Chemists' Guide to the Unique Difficulties of Lead Optimization for Tuberculosis Bioorganic & Medicinal Chemistry Letters. Sep, 2013 | Pubmed ID: 23910985 Radiologic Responses in Cynomolgus Macaques for Assessing Tuberculosis Chemotherapy Regimens Antimicrobial Agents and Chemotherapy. Sep, 2013 | Pubmed ID: 23796926 Polyamines Inhibit Porin-mediated Fluoroquinolone Uptake in Mycobacteria PloS One. 2013 | Pubmed ID: 23755283 Efficacy and Safety of Metronidazole for Pulmonary Multidrug-resistant Tuberculosis Antimicrobial Agents and Chemotherapy. Aug, 2013 | Pubmed ID: 23733467 Reduced Drug Uptake in Phenotypically Resistant Nutrient-starved Nonreplicating Mycobacterium Tuberculosis Antimicrobial Agents and Chemotherapy. Apr, 2013 | Pubmed ID: 23335744 The Role of Transport Mechanisms in Mycobacterium Tuberculosis Drug Resistance and Tolerance Pharmaceuticals (Basel, Switzerland). Nov, 2012 | Pubmed ID: 24281307 Linezolid for Treatment of Chronic Extensively Drug-resistant Tuberculosis The New England Journal of Medicine. Oct, 2012 | Pubmed ID: 23075177 Comprehensive Analysis of Methods Used for the Evaluation of Compounds Against Mycobacterium Tuberculosis Tuberculosis (Edinburgh, Scotland). Nov, 2012 | Pubmed ID: 22940006 Metronidazole Prevents Reactivation of Latent Mycobacterium Tuberculosis Infection in Macaques Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012 | Pubmed ID: 22826237 Infection Dynamics and Response to Chemotherapy in a Rabbit Model of Tuberculosis Using [¹⁸F]2-fluoro-deoxy-D-glucose Positron Emission Tomography and Computed Tomography Antimicrobial Agents and Chemotherapy. Aug, 2012 | Pubmed ID: 22687508 Mycolic Acids As Diagnostic Markers for Tuberculosis Case Detection in Humans and Drug Efficacy in Mice EMBO Molecular Medicine. Jan, 2012 | Pubmed ID: 22147526 Pharmacokinetic Evaluation of the Penetration of Antituberculosis Agents in Rabbit Pulmonary Lesions Antimicrobial Agents and Chemotherapy. Jan, 2012 | Pubmed ID: 21986820 BCG Induces Protection Against Mycobacterium Tuberculosis Infection in the Wistar Rat Model PloS One. 2011 | Pubmed ID: 22162757 Drug Forgiveness and Interpatient Pharmacokinetic Variability in Tuberculosis The Journal of Infectious Diseases. Dec, 2011 | Pubmed ID: 22021619 Reagent Precoated Targets for Rapid In-tissue Derivatization of the Anti-tuberculosis Drug Isoniazid Followed by MALDI Imaging Mass Spectrometry Journal of the American Society for Mass Spectrometry. Aug, 2011 | Pubmed ID: 21953196 Phosphodiesterase-4 Inhibition Alters Gene Expression and Improves Isoniazid-mediated Clearance of Mycobacterium Tuberculosis in Rabbit Lungs PLoS Pathogens. Sep, 2011 | Pubmed ID: 21949656 Structure-activity Relationships of Antitubercular Nitroimidazoles. 3. Exploration of the Linker and Lipophilic Tail of ((s)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-amino PA-824) Journal of Medicinal Chemistry. Aug, 2011 | Pubmed ID: 21755942 Imidazolopiperazines: Hit to Lead Optimization of New Antimalarial Agents Journal of Medicinal Chemistry. Jul, 2011 | Pubmed ID: 21644570 Mycobacterium Tuberculosis Infection Induces Hypoxic Lung Lesions in the Rat Tuberculosis (Edinburgh, Scotland). Jul, 2011 | Pubmed ID: 21636324 T Cell Monitoring of Chemotherapy in Experimental Rat Tuberculosis Antimicrobial Agents and Chemotherapy. Aug, 2011 | Pubmed ID: 21628535 Experimental Tuberculosis in the Wistar Rat: a Model for Protective Immunity and Control of Infection PloS One. Apr, 2011 | Pubmed ID: 21533270 High-sensitivity MALDI-MRM-MS Imaging of Moxifloxacin Distribution in Tuberculosis-infected Rabbit Lungs and Granulomatous Lesions Analytical Chemistry. Mar, 2011 | Pubmed ID: 21332183 A Chemical Genetic Screen in Mycobacterium Tuberculosis Identifies Carbon-source-dependent Growth Inhibitors Devoid of in Vivo Efficacy Nature Communications. Aug, 2010 | Pubmed ID: 20975714 Spiroindolones, a Potent Compound Class for the Treatment of Malaria Science (New York, N.Y.). Sep, 2010 | Pubmed ID: 20813948 Spirotetrahydro Beta-carbolines (spiroindolones): a New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria Journal of Medicinal Chemistry. Jul, 2010 | Pubmed ID: 20568778 Inhibition of Dengue Virus by an Ester Prodrug of an Adenosine Analog Antimicrobial Agents and Chemotherapy. Aug, 2010 | Pubmed ID: 20516277 Preclinical Evaluation of the Antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, As an Antimalarial Drug Candidate Antimicrobial Agents and Chemotherapy. Jun, 2010 | Pubmed ID: 20350951 Clinical Pharmacology and Lesion Penetrating Properties of Second- and Third-line Antituberculous Agents Used in the Management of Multidrug-resistant (MDR) and Extensively-drug Resistant (XDR) Tuberculosis Current Clinical Pharmacology. May, 2010 | Pubmed ID: 20156156 An Adenosine Nucleoside Inhibitor of Dengue Virus Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009 | Pubmed ID: 19918064 The Spectrum of Latent Tuberculosis: Rethinking the Biology and Intervention Strategies Nature Reviews. Microbiology. Dec, 2009 | Pubmed ID: 19855401 Lipiarmycin Targets RNA Polymerase and Has Good Activity Against Multidrug-resistant Strains of Mycobacterium Tuberculosis The Journal of Antimicrobial Chemotherapy. Oct, 2008 | Pubmed ID: 18587134 Phenolic Acid-mediated Regulation of the PadC Gene, Encoding the Phenolic Acid Decarboxylase of Bacillus Subtilis Journal of Bacteriology. May, 2008 | Pubmed ID: 18326577 Peptide Deformylase Inhibitors As Potent Antimycobacterial Agents Antimicrobial Agents and Chemotherapy. Nov, 2006 | Pubmed ID: 16966397 Systemic Antibacterial Activity of Novel Synthetic Cyclic Peptides Antimicrobial Agents and Chemotherapy. Aug, 2005 | Pubmed ID: 16048940 Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry (LCM-LC/MS) Matthew Zimmerman1, Landry Blanc1, Pei-Yu Chen1, Véronique Dartois1, Brendan Prideaux1 1Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey JoVE 57402 Medicine An In Vitro Caseum Binding Assay that Predicts Drug Penetration in Tuberculosis Lesions Jansy P. Sarathy1, Hsin-pin Ho Liang1, Danielle Weiner2, Jacqueline Gonzales2, Laura E. Via2, Véronique Dartois1 1Public Health Research Institute Centre, New Jersey Medical School, Rutgers, 2Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, NIAID, NIH JoVE 55559 Immunology and Infection
Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry (LCM-LC/MS) Matthew Zimmerman1, Landry Blanc1, Pei-Yu Chen1, Véronique Dartois1, Brendan Prideaux1 1Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey JoVE 57402 Medicine
An In Vitro Caseum Binding Assay that Predicts Drug Penetration in Tuberculosis Lesions Jansy P. Sarathy1, Hsin-pin Ho Liang1, Danielle Weiner2, Jacqueline Gonzales2, Laura E. Via2, Véronique Dartois1 1Public Health Research Institute Centre, New Jersey Medical School, Rutgers, 2Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, NIAID, NIH JoVE 55559 Immunology and Infection
