Vadim Cherezov The Bridge Institute University of Southern California Biography Publications Institution JoVE Articles Vadim Cherezov has not added a biography. If you are Vadim Cherezov and would like to personalize this page please email our Author Liaison for assistance. Publications Serial Femtosecond Crystallography of Membrane Proteins Advances in Experimental Medicine and Biology. 2016 | Pubmed ID: 27553241 Serial Femtosecond Crystallography Datasets from G Protein-coupled Receptors Scientific Data. 2016 | Pubmed ID: 27479354 X-ray Laser Diffraction for Structure Determination of the Rhodopsin-arrestin Complex Scientific Data. 2016 | Pubmed ID: 27070998 The Fragment Molecular Orbital Method Reveals New Insight into the Chemical Nature of GPCR-Ligand Interactions Journal of Chemical Information and Modeling. Jan, 2016 | Pubmed ID: 26642258 Serial Femtosecond X-ray Diffraction of Enveloped Virus Microcrystals Structural Dynamics (Melville, N.Y.). Jul, 2015 | Pubmed ID: 26798819 Ternary Structure Reveals Mechanism of a Membrane Diacylglycerol Kinase Nature Communications. 2015 | Pubmed ID: 26673816 The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor Structure (London, England : 1993). Dec, 2015 | Pubmed ID: 26526853 Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor The Journal of Biological Chemistry. Dec, 2015 | Pubmed ID: 26420482 Serial Femtosecond Crystallography of Soluble Proteins in Lipidic Cubic Phase IUCrJ. Sep, 2015 | Pubmed ID: 26306196 Crystal Structure of Rhodopsin Bound to Arrestin by Femtosecond X-ray Laser Nature. Jul, 2015 | Pubmed ID: 26200343 A Novel Inert Crystal Delivery Medium for Serial Femtosecond Crystallography IUCrJ. Jul, 2015 | Pubmed ID: 26177184 Fluorescence Recovery After Photobleaching in Lipidic Cubic Phase (LCP-FRAP): A Precrystallization Assay for Membrane Proteins Methods in Enzymology. 2015 | Pubmed ID: 25950976 Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography Cell. May, 2015 | Pubmed ID: 25913193 Lipidic Cubic Phase Serial Millisecond Crystallography Using Synchrotron Radiation IUCrJ. Mar, 2015 | Pubmed ID: 25866654 Two Disparate Ligand-binding Sites in the Human P2Y1 Receptor Nature. Apr, 2015 | Pubmed ID: 25822790 GPCR Structure, Function, Drug Discovery and Crystallography: Report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014 Naunyn-Schmiedeberg's Archives of Pharmacology. Aug, 2015 | Pubmed ID: 25772061 Structural Basis for Bifunctional Peptide Recognition at Human δ-opioid Receptor Nature Structural & Molecular Biology. Mar, 2015 | Pubmed ID: 25686086 Structural Biology. Crystal Structure of the Chemokine Receptor CXCR4 in Complex with a Viral Chemokine Science (New York, N.Y.). Mar, 2015 | Pubmed ID: 25612609 Generic GPCR Residue Numbers - Aligning Topology Maps While Minding the Gaps Trends in Pharmacological Sciences. Jan, 2015 | Pubmed ID: 25541108 Two Classes of Cholesterol Binding Sites for the β2AR Revealed by Thermostability and NMR Biophysical Journal. Nov, 2014 | Pubmed ID: 25418299 Constitutive Phospholipid Scramblase Activity of a G Protein-coupled Receptor Nature Communications. 2014 | Pubmed ID: 25296113 Preparation of Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography Nature Protocols. Sep, 2014 | Pubmed ID: 25122522 Structural Basis for Smoothened Receptor Modulation and Chemoresistance to Anticancer Drugs Nature Communications. 2014 | Pubmed ID: 25008467 Femtosecond Crystallography of Membrane Proteins in the Lipidic Cubic Phase Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Jul, 2014 | Pubmed ID: 24914147 Agonist-bound Structure of the Human P2Y12 Receptor Nature. May, 2014 | Pubmed ID: 24784220 Allosteric Sodium in Class A GPCR Signaling Trends in Biochemical Sciences. May, 2014 | Pubmed ID: 24767681 Structure of the Human P2Y12 Receptor in Complex with an Antithrombotic Drug Nature. May, 2014 | Pubmed ID: 24670650 Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator Science (New York, N.Y.). Apr, 2014 | Pubmed ID: 24603153 Lipidic Cubic Phase Injector Facilitates Membrane Protein Serial Femtosecond Crystallography Nature Communications. 2014 | Pubmed ID: 24525480 Molecular Control of δ-opioid Receptor Signalling Nature. Feb, 2014 | Pubmed ID: 24413399 Functional Assay for T4 Lysozyme-engineered G Protein-coupled Receptors with an Ion Channel Reporter Structure (London, England : 1993). Jan, 2014 | Pubmed ID: 24268646 Serial Femtosecond Crystallography of G Protein-coupled Receptors Science (New York, N.Y.). Dec, 2013 | Pubmed ID: 24357322 The Role of a Sodium Ion Binding Site in the Allosteric Modulation of the A(2A) Adenosine G Protein-coupled Receptor Structure (London, England : 1993). Dec, 2013 | Pubmed ID: 24210756 Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex Science (New York, N.Y.). Sep, 2013 | Pubmed ID: 24030490 Structure-based Ligand Discovery Targeting Orthosteric and Allosteric Pockets of Dopamine Receptors Molecular Pharmacology. Dec, 2013 | Pubmed ID: 24021214 Structure of the Human Glucagon Class B G-protein-coupled Receptor Nature. Jul, 2013 | Pubmed ID: 23863937 Integrated Nonlinear Optical Imaging Microscope for On-axis Crystal Detection and Centering at a Synchrotron Beamline Journal of Synchrotron Radiation. Jul, 2013 | Pubmed ID: 23765294 Hydrogen Bonding of Cholesterol in the Lipidic Cubic Phase Langmuir : the ACS Journal of Surfaces and Colloids. Jun, 2013 | Pubmed ID: 23763339 Structure of the Human Smoothened Receptor Bound to an Antitumour Agent Nature. May, 2013 | Pubmed ID: 23636324 Towards Protein-crystal Centering Using Second-harmonic Generation (SHG) Microscopy Acta Crystallographica. Section D, Biological Crystallography. May, 2013 | Pubmed ID: 23633594 Structural Features for Functional Selectivity at Serotonin Receptors Science (New York, N.Y.). May, 2013 | Pubmed ID: 23519215 Structural Basis for Molecular Recognition at Serotonin Receptors Science (New York, N.Y.). May, 2013 | Pubmed ID: 23519210 The GPCR Network: a Large-scale Collaboration to Determine Human GPCR Structure and Function Nature Reviews. Drug Discovery. Jan, 2013 | Pubmed ID: 23237917 Structure-function of the G Protein-coupled Receptor Superfamily Annual Review of Pharmacology and Toxicology. 2013 | Pubmed ID: 23140243 Crystal Structure of a Voltage-gated K+ Channel Pore Module in a Closed State in Lipid Membranes The Journal of Biological Chemistry. Dec, 2012 | Pubmed ID: 23095758 Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions Science (New York, N.Y.). Jul, 2012 | Pubmed ID: 22798613 Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-coupled Receptors Structure (London, England : 1993). Jun, 2012 | Pubmed ID: 22681902 Crystal Structures of the Outer Membrane Domain of Intimin and Invasin from Enterohemorrhagic E. Coli and Enteropathogenic Y. Pseudotuberculosis Structure (London, England : 1993). Jul, 2012 | Pubmed ID: 22658748 Structure of the Nociceptin/orphanin FQ Receptor in Complex with a Peptide Mimetic Nature. 2012 | Pubmed ID: 22596163 Structure of the Human κ-opioid Receptor in Complex with JDTic Nature. May, 2012 | Pubmed ID: 22437504 Diversity and Modularity of G Protein-coupled Receptor Structures Trends in Pharmacological Sciences. Jan, 2012 | Pubmed ID: 22032986 GPCR Stabilization Using the Bicelle-like Architecture of Mixed Sterol-detergent Micelles Methods (San Diego, Calif.). Dec, 2011 | Pubmed ID: 22041719 Characterization of Lipid Matrices for Membrane Protein Crystallization by High-throughput Small Angle X-ray Scattering Methods (San Diego, Calif.). Dec, 2011 | Pubmed ID: 21903166 High Resolution Structure of the Ba3 Cytochrome C Oxidase from Thermus Thermophilus in a Lipidic Environment PloS One. 2011 | Pubmed ID: 21814577 Lipidic Cubic Phase Technologies for Membrane Protein Structural Studies Current Opinion in Structural Biology. Aug, 2011 | Pubmed ID: 21775127 Structure of the Human Histamine H1 Receptor Complex with Doxepin Nature. Jul, 2011 | Pubmed ID: 21697825 Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases Crystal Growth & Design. Apr, 2011 | Pubmed ID: 21660116 Structure of an Agonist-bound Human A2A Adenosine Receptor Science (New York, N.Y.). Apr, 2011 | Pubmed ID: 21393508 Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist Science (New York, N.Y.). Nov, 2010 | Pubmed ID: 21097933 Structures of the CXCR4 Chemokine GPCR with Small-molecule and Cyclic Peptide Antagonists Science (New York, N.Y.). Nov, 2010 | Pubmed ID: 20929726 Conserved Binding Mode of Human Beta2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography Journal of the American Chemical Society. Aug, 2010 | Pubmed ID: 20669948 Recent Progress in the Structure Determination of GPCRs, a Membrane Protein Family with High Potential As Pharmaceutical Targets Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20665265 LCP-Tm: an Assay to Measure and Understand Stability of Membrane Proteins in a Membrane Environment Biophysical Journal. Apr, 2010 | Pubmed ID: 20409473 Nonlinear Optical Imaging of Integral Membrane Protein Crystals in Lipidic Mesophases Analytical Chemistry. Jan, 2010 | Pubmed ID: 20025250 Rastering Strategy for Screening and Centring of Microcrystal Samples of Human Membrane Proteins with a Sub-10 Microm Size X-ray Synchrotron Beam Journal of the Royal Society, Interface / the Royal Society. Oct, 2009 | Pubmed ID: 19535414 Crystallizing Membrane Proteins Using Lipidic Mesophases Nature Protocols. 2009 | Pubmed ID: 19390528 Analysis of Full and Partial Agonists Binding to Beta2-adrenergic Receptor Suggests a Role of Transmembrane Helix V in Agonist-specific Conformational Changes Journal of Molecular Recognition : JMR. Jul-Aug, 2009 | Pubmed ID: 19353579 LCP-FRAP Assay for Pre-Screening Membrane Proteins for in Meso Crystallization Crystal Growth & Design. 2008 | Pubmed ID: 19234616 The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist Science (New York, N.Y.). Nov, 2008 | Pubmed ID: 18832607 Insights into the Mode of Action of a Putative Zinc Transporter CzrB in Thermus Thermophilus Structure (London, England : 1993). Sep, 2008 | Pubmed ID: 18786400 A Specific Cholesterol Binding Site is Established by the 2.8 A Structure of the Human Beta2-adrenergic Receptor Structure (London, England : 1993). Jun, 2008 | Pubmed ID: 18547522 In Meso Crystal Structure and Docking Simulations Suggest an Alternative Proteoglycan Binding Site in the OpcA Outer Membrane Adhesin Proteins. Apr, 2008 | Pubmed ID: 18076035 High-resolution Crystal Structure of an Engineered Human Beta2-adrenergic G Protein-coupled Receptor Science (New York, N.Y.). Nov, 2007 | Pubmed ID: 17962520 GPCR Engineering Yields High-resolution Structural Insights into Beta2-adrenergic Receptor Function Science (New York, N.Y.). Nov, 2007 | Pubmed ID: 17962519 Membrane Protein Crystallization in Lipidic Mesophases. A Mechanism Study Using X-ray Microdiffraction Faraday Discussions. 2007 | Pubmed ID: 17955811 Crystallization and Preliminary X-ray Diffraction Analysis of a Soluble Domain of the Putative Zinc Transporter CzrB from Thermus Thermophilus Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Aug, 2007 | Pubmed ID: 17671365 Controlling the Passage of Light Through Metal Microchannels by Nanocoatings of Phospholipids The Journal of Physical Chemistry. B. Nov, 2006 | Pubmed ID: 17064131 Molecular Organization of Cholesterol in Unsaturated Phosphatidylethanolamines: X-ray Diffraction and Solid State 2H NMR Reveal Differences with Phosphatidylcholines Journal of the American Chemical Society. Apr, 2006 | Pubmed ID: 16620109 Room to Move: Crystallizing Membrane Proteins in Swollen Lipidic Mesophases Journal of Molecular Biology. Apr, 2006 | Pubmed ID: 16490208 Membrane Protein Crystallization in Lipidic Mesophases with Tailored Bilayers Structure (London, England : 1993). Dec, 2004 | Pubmed ID: 15576026 Order from Disorder, Corralling Cholesterol with Chaotic Lipids. The Role of Polyunsaturated Lipids in Membrane Raft Formation Chemistry and Physics of Lipids. Nov, 2004 | Pubmed ID: 15530450 Rational Design of Lipid for Membrane Protein Crystallization Journal of Structural Biology. Nov, 2004 | Pubmed ID: 15477097 A Robotic System for Crystallizing Membrane and Soluble Proteins in Lipidic Mesophases Acta Crystallographica. Section D, Biological Crystallography. Oct, 2004 | Pubmed ID: 15388926 Interaction of Cholesterol with a Docosahexaenoic Acid-containing Phosphatidylethanolamine: Trigger for Microdomain/raft Formation? Biochemistry. Oct, 2003 | Pubmed ID: 14556634 Membrane Protein Crystallization in Meso: Lipid Type-tailoring of the Cubic Phase Biophysical Journal. Dec, 2002 | Pubmed ID: 12496106 Too Hot to Handle? Synchrotron X-ray Damage of Lipid Membranes and Mesophases Journal of Synchrotron Radiation. Nov, 2002 | Pubmed ID: 12409619 Controlling Membrane Cholesterol Content. A Role for Polyunsaturated (docosahexaenoate) Phospholipids Biochemistry. Oct, 2002 | Pubmed ID: 12369842 Biophysical and Transfection Studies of the DiC(14)-amidine/DNA Complex Biophysical Journal. Jun, 2002 | Pubmed ID: 12023234 Molecular Organization of Cholesterol in Polyunsaturated Membranes: Microdomain Formation Biophysical Journal. Jan, 2002 | Pubmed ID: 11751316 Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography Andrii Ishchenko1,2, Vadim Cherezov1,2, Wei Liu3 1The Bridge Institute, University of Southern California, 2Department of Chemistry, University of Southern California, 3School of Molecular Sciences, Center for Applied Structural Discovery at the Biodesign Institute, Arizona State University JoVE 54463 Biochemistry Crystallization of Membrane Proteins in Lipidic Mesophases Wei Liu1, Vadim Cherezov1 1Molecular Biology, The Scripps Research Institute JoVE 2501 Biology
Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography Andrii Ishchenko1,2, Vadim Cherezov1,2, Wei Liu3 1The Bridge Institute, University of Southern California, 2Department of Chemistry, University of Southern California, 3School of Molecular Sciences, Center for Applied Structural Discovery at the Biodesign Institute, Arizona State University JoVE 54463 Biochemistry
Crystallization of Membrane Proteins in Lipidic Mesophases Wei Liu1, Vadim Cherezov1 1Molecular Biology, The Scripps Research Institute JoVE 2501 Biology
