Val J. Watts

Publications

• Development of a High-throughput Screening Paradigm for the Discovery of Small-molecule Modulators of Adenylyl Cyclase: Identification of an Adenylyl Cyclase 2 Inhibitor
  The Journal of Pharmacology and Experimental Therapeutics. Nov, 2013  |   Pubmed ID: 24008337
• Cell-type Specific Increases in Female Hamster Nucleus Accumbens Spine Density Following Female Sexual Experience
  Brain Structure & Function. Aug, 2013  |   Pubmed ID: 23934655
• Differential Effects of AGS3 Expression on D(2L) Dopamine Receptor-mediated Adenylyl Cyclase Signaling
  Cellular and Molecular Neurobiology. May, 2013  |   Pubmed ID: 23504261
• Bimolecular Fluorescence Complementation Analysis of G Protein-coupled Receptor Dimerization in Living Cells
  Methods in Enzymology. 2013  |   Pubmed ID: 23351744
• Discovery of Antagonists of Tick Dopamine Receptors Via Chemical Library Screening and Comparative Pharmacological Analyses
  Insect Biochemistry and Molecular Biology. Nov, 2012  |   Pubmed ID: 23213654
• Identification of a 2-phenyl-substituted Octahydrobenzo[f]quinoline As a Dopamine D₃ Receptor-selective Full Agonist Ligand
  Bioorganic & Medicinal Chemistry. Nov, 2012  |   Pubmed ID: 23018094
• Dopamine D(2) Receptor-Mediated Heterologous Sensitization of AC5 Requires Signalosome Assembly
  Journal of Signal Transduction. 2012  |   Pubmed ID: 22523680
• Ligand-specific Roles for Transmembrane 5 Serine Residues in the Binding and Efficacy of Dopamine D(1) Receptor Catechol Agonists
  Molecular Pharmacology. May, 2012  |   Pubmed ID: 22334593
• A "genome-to-lead" Approach for Insecticide Discovery: Pharmacological Characterization and Screening of Aedes Aegypti D(1)-like Dopamine Receptors
  PLoS Neglected Tropical Diseases. Jan, 2012  |   Pubmed ID: 22292096
• Comparison of the D₁ Dopamine Full Agonists, Dihydrexidine and Doxanthrine, in the 6-OHDA Rat Model of Parkinson's Disease
  Psychopharmacology. Jul, 2012  |   Pubmed ID: 22222862
• Analogues of Doxanthrine Reveal Differences Between the Dopamine D1 Receptor Binding Properties of Chromanoisoquinolines and Hexahydrobenzo[a]phenanthridines
  European Journal of Medicinal Chemistry. Feb, 2012  |   Pubmed ID: 22204903
• Assessment of Dopamine D₁ Receptor Affinity and Efficacy of Three Tetracyclic Conformationally-restricted Analogs of SKF38393
  Bioorganic & Medicinal Chemistry. Sep, 2011  |   Pubmed ID: 21862338
• Probing the Steric Space at the Floor of the D1 Dopamine Receptor Orthosteric Binding Domain: 7α-, 7β-, 8α-, and 8β-methyl Substituted Dihydrexidine Analogues
  Journal of Medicinal Chemistry. Aug, 2011  |   Pubmed ID: 21714510
• Mapping the Catechol Binding Site in Dopamine D₁ Receptors: Synthesis and Evaluation of Two Parallel Series of Bicyclic Dopamine Analogues
  ChemMedChem. Jun, 2011  |   Pubmed ID: 21538900
• Molecular and Pharmacological Characterization of Two D(1)-like Dopamine Receptors in the Lyme Disease Vector, Ixodes Scapularis
  Insect Biochemistry and Molecular Biology. Aug, 2011  |   Pubmed ID: 21457782
• Fluorescent Protein Complementation Assays: New Tools to Study G Protein-coupled Receptor Oligomerization and GPCR-mediated Signaling
  Molecular and Cellular Endocrinology. Jan, 2011  |   Pubmed ID: 20654687
• Facile Synthesis of Octahydrobenzo[h]isoquinolines: Novel and Highly Potent D1 Dopamine Agonists
  Bioorganic & Medicinal Chemistry. Sep, 2010  |   Pubmed ID: 20709559
• Visualization of G Protein-coupled Receptor (GPCR) Interactions in Living Cells Using Bimolecular Fluorescence Complementation (BiFC)
  Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [et Al.]. Apr, 2010  |   Pubmed ID: 20373507
• Ligand-induced Regulation and Localization of Cannabinoid CB1 and Dopamine D2L Receptor Heterodimers
  The Journal of Pharmacology and Experimental Therapeutics. Mar, 2010  |   Pubmed ID: 20016021
• The Intracellular II-III Loops of Cav1.2 and Cav1.3 Uncouple L-type Voltage-gated Ca2+ Channels from Glucagon-like Peptide-1 Potentiation of Insulin Secretion in INS-1 Cells Via Displacement from Lipid Rafts
  The Journal of Pharmacology and Experimental Therapeutics. Jul, 2009  |   Pubmed ID: 19351867
• Fluorescent and Bioluminescent Protein-fragment Complementation Assays in the Study of G Protein-coupled Receptor Oligomerization and Signaling
  Molecular Pharmacology. Apr, 2009  |   Pubmed ID: 19141658
• Comparison of the Enantiomers of (+/-)-doxanthrine, a High Efficacy Full Dopamine D(1) Receptor Agonist, and a Reversal of Enantioselectivity at D(1) Versus Alpha(2C) Adrenergic Receptors
  European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. Feb, 2009  |   Pubmed ID: 19028082
• Adenosine A(2A) Receptors Assemble into Higher-order Oligomers at the Plasma Membrane
  FEBS Letters. Dec, 2008  |   Pubmed ID: 19013155
• A Point Mutation to Galphai Selectively Blocks GoLoco Motif Binding: Direct Evidence for Galpha.GoLoco Complexes in Mitotic Spindle Dynamics
  The Journal of Biological Chemistry. Dec, 2008  |   Pubmed ID: 18984596
• Ligand-dependent Oligomerization of Dopamine D(2) and Adenosine A(2A) Receptors in Living Neuronal Cells
  Molecular Pharmacology. Sep, 2008  |   Pubmed ID: 18524886
• Adenylyl Cyclase 5: a New Clue in the Search for the "fountain of Youth"?
  Science's STKE : Signal Transduction Knowledge Environment. Nov, 2007  |   Pubmed ID: 18029912
• Adenylyl Cyclase Isoforms As Novel Therapeutic Targets: an Exciting Example of Excitotoxicity Neuroprotection
  Molecular Interventions. Apr, 2007  |   Pubmed ID: 17468386
• Trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: Synthesis, Resolution, and Preliminary Pharmacological Characterization of a New Dopamine D1 Receptor Full Agonist
  Journal of Medicinal Chemistry. Nov, 2006  |   Pubmed ID: 17154515
• WAY-100635 is a Potent Dopamine D4 Receptor Agonist
  Psychopharmacology. Oct, 2006  |   Pubmed ID: 16915381
• Repeated Quinpirole Treatments Produce Neurochemical Sensitization and Associated Behavioral Changes in Female Hamsters
  Psychopharmacology. Sep, 2006  |   Pubmed ID: 16850118
• Regulatory Properties of Adenylate Cyclases Type 5 and 6: A Progress Report
  European Journal of Pharmacology. Mar, 2006  |   Pubmed ID: 16527269
• Dexamethasone-induced Ras Protein 1 Negatively Regulates Protein Kinase C Delta: Implications for Adenylyl Cyclase 2 Signaling
  Molecular Pharmacology. May, 2006  |   Pubmed ID: 16489124
• D2 Dopamine Receptor-induced Sensitization of Adenylyl Cyclase Type 1 is G Alpha(s) Independent
  Neuropharmacology. Apr, 2006  |   Pubmed ID: 16376953
• A Bifunctional Galphai/Galphas Modulatory Peptide That Attenuates Adenylyl Cyclase Activity
  FEBS Letters. Oct, 2005  |   Pubmed ID: 16225870
• Structure of Galpha(i1) Bound to a GDP-selective Peptide Provides Insight into Guanine Nucleotide Exchange
  Structure (London, England : 1993). Jul, 2005  |   Pubmed ID: 16004878
• Sensitization of Adenylate Cyclase by Galpha I/o-coupled Receptors
  Pharmacology & Therapeutics. Jun, 2005  |   Pubmed ID: 15922020
• Dexras1 Blocks Receptor-mediated Heterologous Sensitization of Adenylyl Cyclase 1
  Biochemical and Biophysical Research Communications. Jul, 2005  |   Pubmed ID: 15913563
• Galphaq-coupled Receptor Signaling Enhances Adenylate Cyclase Type 6 Activation
  Biochemical Pharmacology. Jul, 2005  |   Pubmed ID: 15885660
• Galphaq Potentiation of Adenylate Cyclase Type 9 Activity Through a Ca2+/calmodulin-dependent Pathway
  Biochemical Pharmacology. Apr, 2005  |   Pubmed ID: 15794946
• Activation of a Novel PKC Isoform Synergistically Enhances D2L Dopamine Receptor-mediated Sensitization of Adenylate Cyclase Type 6
  Cellular Signalling. May, 2005  |   Pubmed ID: 15683739
• Protein Kinase C and Epidermal Growth Factor Stimulation of Raf1 Potentiates Adenylyl Cyclase Type 6 Activation in Intact Cells
  Molecular Pharmacology. Jan, 2005  |   Pubmed ID: 15470083
• Using Molecular Tools to Dissect the Role of Galphas in Sensitization of AC1
  Molecular Pharmacology. Dec, 2004  |   Pubmed ID: 15361543
• Sexual Experience Alters D1 Receptor-mediated Cyclic AMP Production in the Nucleus Accumbens of Female Syrian Hamsters
  Synapse (New York, N.Y.). Jul, 2004  |   Pubmed ID: 15150737
• Differentiation-induced Alterations in Cyclic AMP Signaling in the Cath.a Differentiated (CAD) Neuronal Cell Line
  Journal of Neurochemistry. Mar, 2004  |   Pubmed ID: 15009651
• Novel Regulatory Properties of Human Type 9 Adenylate Cyclase
  The Journal of Pharmacology and Experimental Therapeutics. Jul, 2004  |   Pubmed ID: 14996950
• Sensitization of Neuronal A2A Adenosine Receptors After Persistent D2 Dopamine Receptor Activation
  The Journal of Pharmacology and Experimental Therapeutics. Jan, 2004  |   Pubmed ID: 14566008
• Sensitization of Adenylate Cyclase by Short-term Activation of 5-HT1A Receptors
  Cellular Signalling. Dec, 2003  |   Pubmed ID: 14575866
• Sensitization of Adenylate Cyclase: a General Mechanism of Neuroadaptation to Persistent Activation of Galpha(i/o)-coupled Receptors?
  Life Sciences. Oct, 2003  |   Pubmed ID: 14519441
• A Complex Signaling Cascade Links the Serotonin2A Receptor to Phospholipase A2 Activation: the Involvement of MAP Kinases
  Journal of Neurochemistry. Aug, 2003  |   Pubmed ID: 12887695
• Serotonin 5-hydroxytryptamine 2A Receptor-coupled Phospholipase C and Phospholipase A2 Signaling Pathways Have Different Receptor Reserves
  The Journal of Pharmacology and Experimental Therapeutics. Jan, 2003  |   Pubmed ID: 12490596
• Heterologous Sensitization of Adenylate Cyclase is Protein Kinase A-dependent in Cath.a Differentiated (CAD)-D2L Cells
  Journal of Neurochemistry. Sep, 2002  |   Pubmed ID: 12358756
• Molecular Mechanisms for Heterologous Sensitization of Adenylate Cyclase
  The Journal of Pharmacology and Experimental Therapeutics. Jul, 2002  |   Pubmed ID: 12065693