Valter D. Longo Andrus Gerontology Center, Department of Biological Sciences, Department of Molecular and Computational Biology University of Southern California, Los Angeles Biography Publications Institution JoVE Articles Valter D. Longo has not added a biography. If you are Valter D. Longo and would like to personalize this page please email our Author Liaison for assistance. Publications Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy Science Translational Medicine. Feb, 2012 | Pubmed ID: 22323820 Chronological Aging in Saccharomyces Cerevisiae Sub-cellular Biochemistry. 2012 | Pubmed ID: 22094419 Intermittent Supplementation with Rapamycin As a Dietary Restriction Mimetic Aging. Nov, 2011 | Pubmed ID: 22147496 Conserved Role of Ras-GEFs in Promoting Aging: from Yeast to Mice Aging. Apr, 2011 | Pubmed ID: 21732566 Lifespan Extension and Paraquat Resistance in a Ubiquinone-deficient Escherichia Coli Mutant Depend on Transcription Factors ArcA and TdcA Aging. Mar, 2011 | Pubmed ID: 21464517 Metabolic Alterations in Yeast Lacking Copper-zinc Superoxide Dismutase Free Radical Biology & Medicine. Jun, 2011 | Pubmed ID: 21397007 Growth Hormone Receptor Deficiency is Associated with a Major Reduction in Pro-aging Signaling, Cancer, and Diabetes in Humans Science Translational Medicine. Feb, 2011 | Pubmed ID: 21325617 Fasting and Differential Chemotherapy Protection in Patients Cell Cycle (Georgetown, Tex.). Nov, 2010 | Pubmed ID: 21088487 Linking Klotho, Nrf2, MAP Kinases and Aging Aging. Oct, 2010 | Pubmed ID: 21076180 Endosomal Protein Sorting and Autophagy Genes Contribute to the Regulation of Yeast Life Span Autophagy. Nov, 2010 | Pubmed ID: 20953148 Genome-wide Screen Identifies Escherichia Coli TCA-cycle-related Mutants with Extended Chronological Lifespan Dependent on Acetate Metabolism and the Hypoxia-inducible Transcription Factor ArcA Aging Cell. Oct, 2010 | Pubmed ID: 20707865 E. Coli Hypoxia-inducible Factor ArcA Mediates Lifespan Extension in a Lipoic Acid Synthase Mutant by Suppressing Acetyl-CoA Synthetase Biological Chemistry. Oct, 2010 | Pubmed ID: 20707605 SIRT1 is Essential for Normal Cognitive Function and Synaptic Plasticity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2010 | Pubmed ID: 20660252 Genome-wide Screen in Saccharomyces Cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and TRNA Methylation Genes Involved in Life Span Regulation PLoS Genetics. Jul, 2010 | Pubmed ID: 20657825 Cell Resilience in Species Life Spans: a Link to Inflammation? Aging Cell. Aug, 2010 | Pubmed ID: 20415721 Extending Healthy Life Span--from Yeast to Humans Science (New York, N.Y.). Apr, 2010 | Pubmed ID: 20395504 Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index Cancer Research. Feb, 2010 | Pubmed ID: 20145127 Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain TheScientificWorldJournal. 2010 | Pubmed ID: 20098959 Calorie Restriction and Cancer Prevention: Metabolic and Molecular Mechanisms Trends in Pharmacological Sciences. Feb, 2010 | Pubmed ID: 20097433 Comparative Analyses of Time-course Gene Expression Profiles of the Long-lived Sch9Delta Mutant Nucleic Acids Research. Jan, 2010 | Pubmed ID: 19880387 Fasting and Cancer Treatment in Humans: A Case Series Report Aging. Dec, 2009 | Pubmed ID: 20157582 Oncogene Homologue Sch9 Promotes Age-dependent Mutations by a Superoxide and Rev1/Polzeta-dependent Mechanism The Journal of Cell Biology. Aug, 2009 | Pubmed ID: 19687253 Tor1/Sch9-regulated Carbon Source Substitution is As Effective As Calorie Restriction in Life Span Extension PLoS Genetics. May, 2009 | Pubmed ID: 19424415 Linking Sirtuins, IGF-I Signaling, and Starvation Experimental Gerontology. Jan-Feb, 2009 | Pubmed ID: 18638538 Turning Anti-ageing Genes Against Cancer Nature Reviews. Molecular Cell Biology. Nov, 2008 | Pubmed ID: 18946478 The Chronological Life Span of Saccharomyces Cerevisiae to Study Mitochondrial Dysfunction and Disease Methods (San Diego, Calif.). Dec, 2008 | Pubmed ID: 18930829 SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons Cell Metabolism. Jul, 2008 | Pubmed ID: 18590691 Chronological Aging-induced Apoptosis in Yeast Biochimica Et Biophysica Acta. Jul, 2008 | Pubmed ID: 18445486 Starvation-dependent Differential Stress Resistance Protects Normal but Not Cancer Cells Against High-dose Chemotherapy Proceedings of the National Academy of Sciences of the United States of America. Jun, 2008 | Pubmed ID: 18378900 Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9 PLoS Genetics. Jan, 2008 | Pubmed ID: 18225956 Longevity Mutation in SCH9 Prevents Recombination Errors and Premature Genomic Instability in a Werner/Bloom Model System The Journal of Cell Biology. Jan, 2008 | Pubmed ID: 18195102 Significant and Systematic Expression Differentiation in Long-lived Yeast Strains PloS One. 2007 | Pubmed ID: 17971858 The Chronological Life Span of Saccharomyces Cerevisiae Methods in Molecular Biology (Clifton, N.J.). 2007 | Pubmed ID: 17634576 Inference of Transcription Modification in Long-live Yeast Strains from Their Expression Profiles BMC Genomics. 2007 | Pubmed ID: 17617911 Sirtuins in Aging and Age-related Disease Cell. Jul, 2006 | Pubmed ID: 16873059 Aging As a Mitochondria-mediated Atavistic Program: Can Aging Be Switched Off? Annals of the New York Academy of Sciences. Dec, 2005 | Pubmed ID: 16399892 Programmed and Altruistic Ageing Nature Reviews. Genetics. Nov, 2005 | Pubmed ID: 16304601 Sir2 Blocks Extreme Life-span Extension Cell. Nov, 2005 | Pubmed ID: 16286010 Analysis of Gene Expression Profile in Yeast Aging Chronologically Mechanisms of Ageing and Development. Jan, 2005 | Pubmed ID: 15610757 Ras: the Other Pro-aging Pathway Science of Aging Knowledge Environment : SAGE KE. Sep, 2004 | Pubmed ID: 15456908 Superoxide is a Mediator of an Altruistic Aging Program in Saccharomyces Cerevisiae The Journal of Cell Biology. Sep, 2004 | Pubmed ID: 15452146 Superoxide Inhibits 4Fe-4S Cluster Enzymes Involved in Amino Acid Biosynthesis. Cross-compartment Protection by CuZn-superoxide Dismutase The Journal of Biological Chemistry. Jul, 2004 | Pubmed ID: 15166213 Search for Methuselah Genes Heats Up Science of Aging Knowledge Environment : SAGE KE. Feb, 2004 | Pubmed ID: 14960761 Biodemographic Trajectories of Age-specific Reproliferation from Stationary Phase in the Yeast Saccharomyces Cerevisiae Seem Multiphasic Mechanisms of Ageing and Development. Dec, 2003 | Pubmed ID: 14659594 The Chronological Life Span of Saccharomyces Cerevisiae Aging Cell. Apr, 2003 | Pubmed ID: 12882320 The Ras and Sch9 Pathways Regulate Stress Resistance and Longevity Experimental Gerontology. Jul, 2003 | Pubmed ID: 12855292 Evolutionary Medicine: from Dwarf Model Systems to Healthy Centenarians? Science (New York, N.Y.). Feb, 2003 | Pubmed ID: 12610293 SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast Genetics. Jan, 2003 | Pubmed ID: 12586694 Oxygen? No Thanks, I'm on a Diet Science of Aging Knowledge Environment : SAGE KE. Jun, 2002 | Pubmed ID: 14602992 Genetics of Aging and Diseases: from Rare Mutations and Model Systems to Disease Prevention Archives of Neurology. Nov, 2002 | Pubmed ID: 12433254 Peroxynitrite Mediates Neurotoxicity of Amyloid Beta-peptide1-42- and Lipopolysaccharide-activated Microglia The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2002 | Pubmed ID: 11978825 Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model Min Wei1, Federica Madia1, Valter D. Longo1 1Andrus Gerontology Center, Department of Biological Sciences, Department of Molecular and Computational Biology, University of Southern California, Los Angeles JoVE 3030 Biology
Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model Min Wei1, Federica Madia1, Valter D. Longo1 1Andrus Gerontology Center, Department of Biological Sciences, Department of Molecular and Computational Biology, University of Southern California, Los Angeles JoVE 3030 Biology