Volker Brinkmann Microscopy Core Facility Max Planck Institute for Infection Biology Biography Publications Institution JoVE Articles Volker BrinkmannStaff scientist The publication list contains numerous papers from a scientist with the same name. Publications The Exported Plasmodium Berghei Protein IBIS1 Delineates Membranous Structures in Infected Red Blood Cells Molecular Microbiology. Feb, 2012 | Pubmed ID: 22329949 Critical Role for Heat Shock Protein 20 (HSP20) in Migration of Malarial Sporozoites The Journal of Biological Chemistry. Jan, 2012 | Pubmed ID: 22139844 Therapeutic Dosing of Fingolimod (FTY720) Prevents Cell Infiltration, Rapidly Suppresses Ocular Inflammation, and Maintains the Blood-ocular Barrier The American Journal of Pathology. Feb, 2012 | Pubmed ID: 22119714 Optimal Deconvolution of Transcriptional Profiling Data Using Quadratic Programming with Application to Complex Clinical Blood Samples PloS One. Month, 2011 | Pubmed ID: 22110609 A Mechanistically Novel, First Oral Therapy for Multiple Sclerosis: the Development of Fingolimod (FTY720, Gilenya) Discovery Medicine. Sep, 2011 | Pubmed ID: 21955849 Autophagy-independent Function of MAP-LC3 During Intracellular Propagation of Chlamydia Trachomatis Autophagy. Aug, 2011 | Pubmed ID: 21464618 Sphingosine 1-phosphate (S1P): Physiology and the Effects of S1P Receptor Modulation Neurology. Feb, 2011 | Pubmed ID: 21339489 Impact of Sphingosine 1-phosphate Modulation on Immune Outcomes Neurology. Feb, 2011 | Pubmed ID: 21339486 Fingolimod Provides Long-term Protection in Rodent Models of Cerebral Ischemia Annals of Neurology. Jan, 2011 | Pubmed ID: 21280082 Prevalence of Propionibacterium Acnes in Diseased Prostates and Its Inflammatory and Transforming Activity on Prostate Epithelial Cells International Journal of Medical Microbiology : IJMM. Jan, 2011 | Pubmed ID: 20943438 Angiogenesis is Present in Experimental Autoimmune Encephalomyelitis and Pro-angiogenic Factors Are Increased in Multiple Sclerosis Lesions Journal of Neuroinflammation. Month, 2010 | Pubmed ID: 21176212 Helicobacter Pylori HP0518 Affects Flagellin Glycosylation to Alter Bacterial Motility Molecular Microbiology. Dec, 2010 | Pubmed ID: 21091500 Fingolimod Provides Long-term Protection in Rodent Models of Cerebral Ischemia Annals of Neurology. Nov, 2010 | Pubmed ID: 21077181 Fingolimod (FTY720): Discovery and Development of an Oral Drug to Treat Multiple Sclerosis Nature Reviews. Drug Discovery. Nov, 2010 | Pubmed ID: 21031003 Tyrosine-phosphorylated Caveolin-1 Blocks Bacterial Uptake by Inducing Vav2-RhoA-mediated Cytoskeletal Rearrangements PLoS Biology. Month, 2010 | Pubmed ID: 20808760 Reciprocal Coupling of Coagulation and Innate Immunity Via Neutrophil Serine Proteases Nature Medicine. Aug, 2010 | Pubmed ID: 20676107 A Key Role for Lung-resident Memory Lymphocytes in Protective Immune Responses After BCG Vaccination European Journal of Immunology. Sep, 2010 | Pubmed ID: 20602436 Impairment of Neutrophil Extracellular Trap Degradation is Associated with Lupus Nephritis Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20439745 The Adaptor Molecule CARD9 is Essential for Tuberculosis Control The Journal of Experimental Medicine. Apr, 2010 | Pubmed ID: 20351059 Alpha-GalCer Ameliorates Listeriosis by Accelerating Infiltration of Gr-1+ Cells into the Liver European Journal of Immunology. May, 2010 | Pubmed ID: 20162550 Dynamic T Cell Migration Program Provides Resident Memory Within Intestinal Epithelium The Journal of Experimental Medicine. Mar, 2010 | Pubmed ID: 20156972 Mouse Neutrophil Extracellular Traps in Microbial Infections Journal of Innate Immunity. Month, 2009 | Pubmed ID: 20375576 Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense Against Candida Albicans PLoS Pathogens. Oct, 2009 | Pubmed ID: 19876394 Bacterial Porin Disrupts Mitochondrial Membrane Potential and Sensitizes Host Cells to Apoptosis PLoS Pathogens. Oct, 2009 | Pubmed ID: 19851451 Rab6 and Rab11 Regulate Chlamydia Trachomatis Development and Golgin-84-dependent Golgi Fragmentation PLoS Pathogens. Oct, 2009 | Pubmed ID: 19816566 FTY720 (fingolimod) in Multiple Sclerosis: Therapeutic Effects in the Immune and the Central Nervous System British Journal of Pharmacology. Nov, 2009 | Pubmed ID: 19814729 Restoration of NET Formation by Gene Therapy in CGD Controls Aspergillosis Blood. Sep, 2009 | Pubmed ID: 19541821 The Potent Protein Kinase C-selective Inhibitor AEB071 (sotrastaurin) Represents a New Class of Immunosuppressive Agents Affecting Early T-cell Activation The Journal of Pharmacology and Experimental Therapeutics. Sep, 2009 | Pubmed ID: 19491325 Netting Neutrophils in Autoimmune Small-vessel Vasculitis Nature Medicine. Jun, 2009 | Pubmed ID: 19448636 Identifying Activated T Cells in Reconstituted RAG Deficient Mice Using Retrovirally Transduced Pax5 Deficient Pro-B Cells PloS One. Month, 2009 | Pubmed ID: 19340306 Bim and Bmf Synergize to Induce Apoptosis in Neisseria Gonorrhoeae Infection PLoS Pathogens. Mar, 2009 | Pubmed ID: 19300516 Chlamydia Causes Fragmentation of the Golgi Compartment to Ensure Reproduction Nature. Feb, 2009 | Pubmed ID: 19060882 Real-time Imaging of Leishmania Mexicana-infected Early Phagosomes: a Study Using Primary Macrophages Generated from Green Fluorescent Protein-Rab5 Transgenic Mice FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2009 | Pubmed ID: 18927250 Sphingosine 1-phosphate Receptor Agonism Impairs Skin Dendritic Cell Migration and Homing to Secondary Lymphoid Tissue: Association with Prolonged Allograft Survival Transplant Immunology. Nov, 2008 | Pubmed ID: 18694829 Infection at the Cellular Level Methods in Cell Biology. Month, 2008 | Pubmed ID: 18617048 Transgenic, Fluorescent Leishmania Mexicana Allow Direct Analysis of the Proteome of Intracellular Amastigotes Molecular & Cellular Proteomics : MCP. Sep, 2008 | Pubmed ID: 18474515 Anticancer Activity of FTY720: Phosphorylated FTY720 Inhibits Autotaxin, a Metastasis-enhancing and Angiogenic Lysophospholipase D Cancer Letters. Aug, 2008 | Pubmed ID: 18378389 Delay of Phagosome Maturation by a Mycobacterial Lipid is Reversed by Nitric Oxide Cellular Microbiology. Jul, 2008 | Pubmed ID: 18363878 Modulation of T Cell Homeostasis and Alloreactivity Under Continuous FTY720 Exposure International Immunology. May, 2008 | Pubmed ID: 18343890 Role of Interleukin-12 in Determining Differential Kinetics of Invariant Natural Killer T Cells in Response to Differential Burden of Listeria Monocytogenes Microbes and Infection / Institut Pasteur. Mar, 2008 | Pubmed ID: 18321748 Long-term Effects of Natural Amino Acids on Infection with Chlamydia Trachomatis Microbial Pathogenesis. May, 2008 | Pubmed ID: 18222624 Requirement of Secondary Lymphoid Tissues for the Induction of Primary and Secondary T Cell Responses Against Listeria Monocytogenes European Journal of Immunology. Jan, 2008 | Pubmed ID: 18050270 A Small Non-coding RNA of the Invasion Gene Island (SPI-1) Represses Outer Membrane Protein Synthesis from the Salmonella Core Genome Molecular Microbiology. Dec, 2007 | Pubmed ID: 17971080 Beneficial Suicide: Why Neutrophils Die to Make NETs Nature Reviews. Microbiology. Aug, 2007 | Pubmed ID: 17632569 Insights into the Mechanism of FTY720 and Compatibility with Regulatory T Cells for the Inhibition of Graft-versus-host Disease (GVHD) Blood. Nov, 2007 | Pubmed ID: 17606761 Sphingosine 1-phosphate Receptors in Health and Disease: Mechanistic Insights from Gene Deletion Studies and Reverse Pharmacology Pharmacology & Therapeutics. Jul, 2007 | Pubmed ID: 17561264 FTY720, an Immunomodulatory Sphingolipid Mimetic: Translation of a Novel Mechanism into Clinical Benefit in Multiple Sclerosis Expert Opinion on Investigational Drugs. Mar, 2007 | Pubmed ID: 17302523 FTY720, a Synthetic Sphingosine 1 Phosphate Analogue, Inhibits Development of Atherosclerosis in Low-density Lipoprotein Receptor-deficient Mice Circulation. Jan, 2007 | Pubmed ID: 17242282 The Helicobacter Pylori CagA Protein Disrupts Matrix Adhesion of Gastric Epithelial Cells by Dephosphorylation of Vinculin Cellular Microbiology. May, 2007 | Pubmed ID: 17217431 Novel Cell Death Program Leads to Neutrophil Extracellular Traps The Journal of Cell Biology. Jan, 2007 | Pubmed ID: 17210947 Sphingosine-1-phosphate Stimulates the Functional Capacity of Progenitor Cells by Activation of the CXCR4-dependent Signaling Pathway Via the S1P3 Receptor Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2007 | Pubmed ID: 17158356 Critical Role of Methylglyoxal and AGE in Mycobacteria-induced Macrophage Apoptosis and Activation PloS One. Month, 2006 | Pubmed ID: 17183656 FTY720 Preferentially Depletes Naive T Cells from Peripheral and Lymphoid Organs International Immunopharmacology. Dec, 2006 | Pubmed ID: 17161343 A Monoselective Sphingosine-1-phosphate Receptor-1 Agonist Prevents Allograft Rejection in a Stringent Rat Heart Transplantation Model Chemistry & Biology. Nov, 2006 | Pubmed ID: 17114004 Naturally Occurring Amino Acids Differentially Influence the Development of Chlamydia Trachomatis and Chlamydia (Chlamydophila) Pneumoniae Journal of Medical Microbiology. Jul, 2006 | Pubmed ID: 16772415 Pulmonary and Vascular Pharmacology of Sphingosine 1-phosphate Current Opinion in Pharmacology. Jun, 2006 | Pubmed ID: 16563863 Neutrophil Extracellular Traps Capture and Kill Candida Albicans Yeast and Hyphal Forms Cellular Microbiology. Apr, 2006 | Pubmed ID: 16548892 Apoptotic Vesicles Crossprime CD8 T Cells and Protect Against Tuberculosis Immunity. Jan, 2006 | Pubmed ID: 16413927 A Novel Low Molecular Weight Inhibitor of Dendritic Cells and B Cells Blocks Allergic Inflammation American Journal of Respiratory and Critical Care Medicine. Mar, 2006 | Pubmed ID: 16387807 Novel Insights into the Mechanism of Action of FTY720 in a Transgenic Model of Allograft Rejection: Implications for Therapy of Chronic Rejection Journal of Immunology (Baltimore, Md. : 1950). Jan, 2006 | Pubmed ID: 16365393 The Sphingosine 1-phosphate Receptor Agonist FTY720 Differentially Affects the Sequestration of CD4+/CD25+ T-regulatory Cells and Enhances Their Functional Activity Journal of Immunology (Baltimore, Md. : 1950). Dec, 2005 | Pubmed ID: 16339533 Human Neutrophils Kill Bacillus Anthracis PLoS Pathogens. Nov, 2005 | Pubmed ID: 16292357 Transient T Cell Accumulation in Lymph Nodes and Sustained Lymphopenia in Mice Treated with FTY720 European Journal of Immunology. Dec, 2005 | Pubmed ID: 16285007 The Sphingosine-1-phosphate Receptor Agonist FTY720 Modulates Dendritic Cell Trafficking in Vivo American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Nov, 2005 | Pubmed ID: 16212624 Increased Vaccine Efficacy Against Tuberculosis of Recombinant Mycobacterium Bovis Bacille Calmette-Guérin Mutants That Secrete Listeriolysin The Journal of Clinical Investigation. Sep, 2005 | Pubmed ID: 16110326 FTY720 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Drug Resistance Cancer Research. Aug, 2005 | Pubmed ID: 16103102 Novel Immunomodulator FTY720 is Phosphorylated in Rats and Humans to Form a Single Stereoisomer. Identification, Chemical Proof, and Biological Characterization of the Biologically Active Species and Its Enantiomer Journal of Medicinal Chemistry. Aug, 2005 | Pubmed ID: 16078855 Prohibitin is Required for Ras-induced Raf-MEK-ERK Activation and Epithelial Cell Migration Nature Cell Biology. Aug, 2005 | Pubmed ID: 16041367 Protection of Mouse Small Bowel Allografts by FTY720 and Costimulation Blockade Transplantation. Jun, 2005 | Pubmed ID: 15973172 Immunomodulator FTY720 Induces ENOS-dependent Arterial Vasodilatation Via the Lysophospholipid Receptor S1P3 Circulation Research. Apr, 2005 | Pubmed ID: 15802614 Modified Immunohistological Staining Allows Detection of Ziehl-Neelsen-negative Mycobacterium Tuberculosis Organisms and Their Precise Localization in Human Tissue The Journal of Pathology. Apr, 2005 | Pubmed ID: 15776475 The Heart Rate Decrease Caused by Acute FTY720 Administration is Mediated by the G Protein-gated Potassium Channel I American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Mar, 2005 | Pubmed ID: 15707407 FTY720: Mechanism of Action and Potential Benefit in Organ Transplantation Yonsei Medical Journal. Dec, 2004 | Pubmed ID: 15627289 Lack of Stage-specific Proteins in Coccoid Helicobacter Pylori Cells Infection and Immunity. Nov, 2004 | Pubmed ID: 15501814 Interaction of Chlamydia Trachomatis Serovar L2 with the Host Autophagic Pathway Infection and Immunity. Aug, 2004 | Pubmed ID: 15271937 FTY720: Sphingosine 1-phosphate Receptor-1 in the Control of Lymphocyte Egress and Endothelial Barrier Function American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Jul, 2004 | Pubmed ID: 15196057 Helicobacter Pylori Induces AGS Cell Motility and Elongation Via Independent Signaling Pathways Infection and Immunity. Jun, 2004 | Pubmed ID: 15155677 Calcium and a Calcium-dependent Protein Kinase Regulate Gamete Formation and Mosquito Transmission in a Malaria Parasite Cell. May, 2004 | Pubmed ID: 15137943 Efficacy and Safety of ABI793, a Novel Human Anti-human CD154 Monoclonal Antibody, in Cynomolgus Monkey Renal Allotransplantation Transplantation. Mar, 2004 | Pubmed ID: 15021835 Neutrophil Extracellular Traps Kill Bacteria Science (New York, N.Y.). Mar, 2004 | Pubmed ID: 15001782 The Sphingosine 1-phosphate Receptor Agonist FTY720 Supports CXCR4-dependent Migration and Bone Marrow Homing of Human CD34+ Progenitor Cells Blood. Jun, 2004 | Pubmed ID: 14988150 From the Inside Out--processing of the Chlamydial Autotransporter PmpD and Its Role in Bacterial Adhesion and Activation of Human Host Cells Molecular Microbiology. Jan, 2004 | Pubmed ID: 14756775 Lymphocyte Egress from Thymus and Peripheral Lymphoid Organs is Dependent on S1P Receptor 1 Nature. Jan, 2004 | Pubmed ID: 14737169 Saposin C is Required for Lipid Presentation by Human CD1b Nature Immunology. Feb, 2004 | Pubmed ID: 14716313 Inhibition of Th1- and Th2-mediated Airway Inflammation by the Sphingosine 1-phosphate Receptor Agonist FTY720 Journal of Immunology (Baltimore, Md. : 1950). Dec, 2003 | Pubmed ID: 14634137 Highly Biased Type 1 Immune Responses in Mice Deficient in LFA-1 in Listeria Monocytogenes Infection Are Caused by Elevated IL-12 Production by Granulocytes Journal of Immunology (Baltimore, Md. : 1950). Oct, 2003 | Pubmed ID: 14530315 Phosphorylation and Action of the Immunomodulator FTY720 Inhibits Vascular Endothelial Cell Growth Factor-induced Vascular Permeability The Journal of Biological Chemistry. Nov, 2003 | Pubmed ID: 12954648 Apoptosis Facilitates Antigen Presentation to T Lymphocytes Through MHC-I and CD1 in Tuberculosis Nature Medicine. Aug, 2003 | Pubmed ID: 12872166 Increased Resistance of LFA-1-deficient Mice to Lipopolysaccharide-induced Shock/liver Injury in the Presence of TNF-alpha and IL-12 is Mediated by IL-10: a Novel Role for LFA-1 in the Regulation of the Proinflammatory and Anti-inflammatory Cytokine Balance Journal of Immunology (Baltimore, Md. : 1950). Jul, 2003 | Pubmed ID: 12847222 The Immune Modulator FYT720 Prevents Autoimmune Diabetes in Nonobese Diabetic Mice Small Star, Filled Clinical Immunology (Orlando, Fla.). Apr, 2003 | Pubmed ID: 12738247 Neutrophilia in LFA-1-deficient Mice Confers Resistance to Listeriosis: Possible Contribution of Granulocyte-colony-stimulating Factor and IL-17 Journal of Immunology (Baltimore, Md. : 1950). May, 2003 | Pubmed ID: 12734371 Expression and Translocation of Chlamydial Protease During Acute and Persistent Infection of the Epithelial HEp-2 Cells with Chlamydophila (Chlamydia) Pneumoniae Cellular Microbiology. May, 2003 | Pubmed ID: 12713490 Oral Efficacy of the New Immunomodulator FTY720 in Cynomolgus Monkey Kidney Allotransplantation, Given Alone or in Combination with Cyclosporine or RAD Transplantation. Oct, 2002 | Pubmed ID: 12394836 FTY720 Pretreatment Reduces Warm Hepatic Ischemia Reperfusion Injury Through Inhibition of T-lymphocyte Infiltration American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Oct, 2002 | Pubmed ID: 12392290 Argyrins, Immunosuppressive Cyclic Peptides from Myxobacteria. I. Production, Isolation, Physico-chemical and Biological Properties The Journal of Antibiotics. Jun, 2002 | Pubmed ID: 12195959 FTY720: Targeting G-protein-coupled Receptors for Sphingosine 1-phosphate in Transplantation and Autoimmunity Current Opinion in Immunology. Oct, 2002 | Pubmed ID: 12183155 T-cell Depletion and Graft Survival Induced by Anti-human CD3 Immunotoxins in Human CD3epsilon Transgenic Mice Transplantation. May, 2002 | Pubmed ID: 12042656 Long-term Islet Graft Survival in Streptozotocin- and Autoimmune-induced Diabetes Models by Immunosuppressive and Potential Insulinotropic Agent FTY720 Transplantation. May, 2002 | Pubmed ID: 12023620 The Immune Modulator FTY720 Targets Sphingosine 1-phosphate Receptors The Journal of Biological Chemistry. Jun, 2002 | Pubmed ID: 11967257 The IFN-inducible Golgi- and Endoplasmic Reticulum- Associated 47-kDa GTPase IIGP is Transiently Expressed During Listeriosis Journal of Immunology (Baltimore, Md. : 1950). Apr, 2002 | Pubmed ID: 11907101 Distinct Mechanisms of Internalization of Neisseria Gonorrhoeae by Members of the CEACAM Receptor Family Involving Rac1- and Cdc42-dependent and -independent Pathways The EMBO Journal. Feb, 2002 | Pubmed ID: 11847104 Neisserial Immunoglobulin A1 Protease Induces Specific T-cell Responses in Humans Infection and Immunity. Jan, 2002 | Pubmed ID: 11748199 Immunofluorescence merking av menneskelige og murine nøytrofile ekstracellulære feller i parafin-embedded tissue Ulrike Abu Abed1,2, Volker Brinkmann1 1Microscopy Core Facility, Max Planck Institute for Infection Biology, 2Cellular Microbiology, Max Planck Institute for Infection Biology JoVE 60115 Medicine Neutrophil Extracellular Traps: How to Generate and Visualize Them JoVE 1724 Immunology and Infection
Immunofluorescence merking av menneskelige og murine nøytrofile ekstracellulære feller i parafin-embedded tissue Ulrike Abu Abed1,2, Volker Brinkmann1 1Microscopy Core Facility, Max Planck Institute for Infection Biology, 2Cellular Microbiology, Max Planck Institute for Infection Biology JoVE 60115 Medicine
Neutrophil Extracellular Traps: How to Generate and Visualize Them JoVE 1724 Immunology and Infection