W. Jonathan Lederer Center for Biomedical Engineering and Technology and Department of Physiology University of Maryland School of Medicine Biography Publications Institution JoVE Articles W. Jonathan Lederer has not added a biography. If you are W. Jonathan Lederer and would like to personalize this page please email our Author Liaison for assistance. Publications The Physiological Sensor Channels TRP and Piezo: Nobel Prize in Physiology or Medicine 2021 Physiological Reviews. 04, 2022 | Pubmed ID: 35129367 Pyruvate-Driven Oxidative Phosphorylation is Downregulated in Sepsis-Induced Cardiomyopathy: A Study of Mitochondrial Proteome Shock (Augusta, Ga.). 04, 2022 | Pubmed ID: 34506367 Metabolic Control of Cardiac Pacemaking Function (Oxford, England). 2021 | Pubmed ID: 35330951 Attenuating Persistent Sodium Current-induced Atrial Myopathy and Fibrillation by Preventing Mitochondrial Oxidative Stress JCI Insight. 10, 2021 | Pubmed ID: 34710060 Effect of Crista Morphology on Mitochondrial ATP Output: A Computational Study Current Research in Physiology. 2021 | Pubmed ID: 34396153 Parkin-independent Mitophagy Via Drp1-mediated Outer Membrane Severing and Inner Membrane Ubiquitination The Journal of Cell Biology. 06, 2021 | Pubmed ID: 33851959 Tubulin Acetylation Increases Cytoskeletal Stiffness to Regulate Mechanotransduction in Striated Muscle The Journal of General Physiology. 07, 2021 | Pubmed ID: 33740038 Calcium Influx Through the Mitochondrial Calcium Uniporter Holocomplex, MCU Journal of Molecular and Cellular Cardiology. 02, 2021 | Pubmed ID: 33147447 How the Mitochondrial Calcium Uniporter Complex (MCU) Works Proceedings of the National Academy of Sciences of the United States of America. 09, 2020 | Pubmed ID: 32879002 ATP- and Voltage-dependent Electro-metabolic Signaling Regulates Blood Flow in Heart Proceedings of the National Academy of Sciences of the United States of America. 03, 2020 | Pubmed ID: 32170008 Regulation of Mitochondrial ATP Production: Ca Signaling and Quality Control Trends in Molecular Medicine. Jan, 2020 | Pubmed ID: 31767352 Author Correction: Voltage-energized Calcium-sensitive ATP Production by Mitochondria Nature Metabolism. Nov, 2019 | Pubmed ID: 32694862 Voltage-energized Calcium-sensitive ATP Production by Mitochondria Nature Metabolism. Oct, 2019 | Pubmed ID: 31950102 Dynamics of the Mitochondrial Permeability Transition Pore: Transient and Permanent Opening Events Archives of Biochemistry and Biophysics. 05, 2019 | Pubmed ID: 30930285 Real-time Local Oxygen Measurements for High Resolution Cellular Imaging Journal of Molecular and Cellular Cardiology. 02, 2019 | Pubmed ID: 30528909 IP Receptors Regulate Vascular Smooth Muscle Contractility and Hypertension JCI Insight. Oct, 2016 | Pubmed ID: 27777977 Axial Tubule Junctions Control Rapid Calcium Signaling in Atria The Journal of Clinical Investigation. 10, 2016 | Pubmed ID: 27643434 Mitochondrial E3 Ubiquitin Ligase MARCH5 Controls Mitochondrial Fission and Cell Sensitivity to Stress-induced Apoptosis Through Regulation of MiD49 Protein Molecular Biology of the Cell. Jan, 2016 | Pubmed ID: 26564796 Modeling Local X-ROS and Calcium Signaling in the Heart Biophysical Journal. Nov, 2015 | Pubmed ID: 26588563 Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling Via Phospholamban Phosphorylation Journal of the American College of Cardiology. Jul, 2015 | Pubmed ID: 26184620 Transient Assembly of F-actin on the Outer Mitochondrial Membrane Contributes to Mitochondrial Fission The Journal of Cell Biology. Jan, 2015 | Pubmed ID: 25547155 Mitochondrial Calcium and the Regulation of Metabolism in the Heart Journal of Molecular and Cellular Cardiology. Jan, 2015 | Pubmed ID: 25450609 Tachycardia-induced Silencing of Subcellular Ca2+ Signaling in Atrial Myocytes The Journal of Clinical Investigation. Nov, 2014 | Pubmed ID: 25329692 Calcium Movement in Cardiac Mitochondria Biophysical Journal. Sep, 2014 | Pubmed ID: 25229137 The Connection Between Inner Membrane Topology and Mitochondrial Function Journal of Molecular and Cellular Cardiology. Sep, 2013 | Pubmed ID: 23672826 X-ROS Signalling is Enhanced and Graded by Cyclic Cardiomyocyte Stretch Cardiovascular Research. May, 2013 | Pubmed ID: 23524301 Mitofusin 2 Joins the Sarcoplasmic Reticulum and Mitochondria at the Hip to Sustain Cardiac Energetics Circulation Research. Sep, 2012 | Pubmed ID: 22982869 Microtubules Underlie Dysfunction in Duchenne Muscular Dystrophy Science Signaling. Aug, 2012 | Pubmed ID: 22871609 Cell Biology. Superresolution Subspace Signaling Science (New York, N.Y.). May, 2012 | Pubmed ID: 22556238 Elementary Calcium Release Events from the Sarcoplasmic Reticulum in the Heart Advances in Experimental Medicine and Biology. 2012 | Pubmed ID: 22453956 Stochastic Simulation of Cardiac Ventricular Myocyte Calcium Dynamics and Waves Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2011 | Pubmed ID: 22255381 Golgi Export of the Kir2.1 Channel is Driven by a Trafficking Signal Located Within Its Tertiary Structure Cell. Jun, 2011 | Pubmed ID: 21703452 FKBP12 is a Critical Regulator of the Heart Rhythm and the Cardiac Voltage-gated Sodium Current in Mice Circulation Research. Apr, 2011 | Pubmed ID: 21372286 Mesenchymal Stem Cells Stimulate Protective Genetic Reprogramming of Injured Cardiac Ventricular Myocytes Journal of Molecular and Cellular Cardiology. Feb, 2011 | Pubmed ID: 20837021 Novel Function of Cardiac Protein Kinase D1 As a Dynamic Regulator of Ca2+ Sensitivity of Contraction The Journal of Biological Chemistry. Dec, 2010 | Pubmed ID: 21041300 Camera-based Measurements of Intracellular [Na+] in Murine Atrial Myocytes Libet Garber1,2, Humberto C. Joca1, Andrew K. Coleman1, Liron Boyman1, W. Jonathan Lederer1, Maura Greiser1 1Center for Biomedical Engineering and Technology and Department of Physiology, University of Maryland School of Medicine, 2Fischell Department of Bioengineering, University of Maryland JoVE 59600 Biology
Camera-based Measurements of Intracellular [Na+] in Murine Atrial Myocytes Libet Garber1,2, Humberto C. Joca1, Andrew K. Coleman1, Liron Boyman1, W. Jonathan Lederer1, Maura Greiser1 1Center for Biomedical Engineering and Technology and Department of Physiology, University of Maryland School of Medicine, 2Fischell Department of Bioengineering, University of Maryland JoVE 59600 Biology