Wieland B. Huttner

Publications

• Prominins Control Ciliary Length Throughout the Animal Kingdom: New Lessons from Human Prominin-1 and Zebrafish Prominin-3
  The Journal of Biological Chemistry. May, 2020  |   Pubmed ID: 32201384
• Extracellular Matrix-inducing Sox9 Promotes Both Basal Progenitor Proliferation and Gliogenesis in Developing Neocortex
  ELife. Mar, 2020  |   Pubmed ID: 32191207
• A Truncating Aspm Allele Leads to a Complex Cognitive Phenotype and Region-specific Reductions in Parvalbuminergic Neurons
  Translational Psychiatry. Feb, 2020  |   Pubmed ID: 32066665
• Signs of Reduced Basal Progenitor Levels and Cortical Neurogenesis in Human Fetuses with Open Spina Bifida at 11-15 Weeks of Gestation
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2020  |   Pubmed ID: 31953373
• Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis
  Neuron. Mar, 2020  |   Pubmed ID: 31883789
• Genetic Modification of Brain Organoids
  Frontiers in Cellular Neuroscience. 2019  |   Pubmed ID: 31920558
• Organoid Single-cell Genomic Atlas Uncovers Human-specific Features of Brain Development
  Nature. 10, 2019  |   Pubmed ID: 31619793
• Robotic Platform for Microinjection into Single Cells in Brain Tissue
  EMBO Reports. 10, 2019  |   Pubmed ID: 31469223
• The Golgi Apparatus in Polarized Neuroepithelial Stem Cells and Their Progeny: Canonical and Noncanonical Features
  Results and Problems in Cell Differentiation. 2019  |   Pubmed ID: 31435803
• Malformations of Human Neocortex in Development - Their Progenitor Cell Basis and Experimental Model Systems
  Frontiers in Cellular Neuroscience. 2019  |   Pubmed ID: 31338027
• The Mode of Stem Cell Division Is Dependent on the Differential Interaction of β-Catenin with the Kat3 Coactivators CBP or P300
  Cancers. Jul, 2019  |   Pubmed ID: 31324005
• YAP Activity Is Necessary and Sufficient for Basal Progenitor Abundance and Proliferation in the Developing Neocortex
  Cell Reports. 04, 2019  |   Pubmed ID: 31018127
• Transport, Metabolism, and Function of Thyroid Hormones in the Developing Mammalian Brain
  Frontiers in Endocrinology. 2019  |   Pubmed ID: 31001205
• How the Extracellular Matrix Shapes Neural Development
  Open Biology. 01, 2019  |   Pubmed ID: 30958121
• Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology
  Cell Stem Cell. 04, 2019  |   Pubmed ID: 30905618
• The Centrosome Protein AKNA Regulates Neurogenesis Via Microtubule Organization
  Nature. 03, 2019  |   Pubmed ID: 30787442
• Primate Neocortex Development and Evolution: Conserved Versus Evolved Folding
  The Journal of Comparative Neurology. 07, 2019  |   Pubmed ID: 30552689
• Prominin-1 Controls Stem Cell Activation by Orchestrating Ciliary Dynamics
  The EMBO Journal. Jan, 2019  |   Pubmed ID: 30523147
• Prominin-1 (CD133) Modulates the Architecture and Dynamics of Microvilli
  Traffic (Copenhagen, Denmark). 01, 2019  |   Pubmed ID: 30328220
• Human-specific Induces Hallmarks of Neocortical Expansion in Developing Ferret Neocortex
  ELife. 11, 2018  |   Pubmed ID: 30484771
• A Novel Population of Hopx-dependent Basal Radial Glial Cells in the Developing Mouse Neocortex
  Development (Cambridge, England). 10, 2018  |   Pubmed ID: 30266827
• Extracellular Matrix Components HAPLN1, Lumican, and Collagen I Cause Hyaluronic Acid-Dependent Folding of the Developing Human Neocortex
  Neuron. 08, 2018  |   Pubmed ID: 30078576
• Brain Organoids As Models to Study Human Neocortex Development and Evolution
  Current Opinion in Cell Biology. 12, 2018  |   Pubmed ID: 30006054
• Epigenetic and Transcriptional Pre-patterning-An Emerging Theme in Cortical Neurogenesis
  Frontiers in Neuroscience. 2018  |   Pubmed ID: 29896084
• Evolution and Cell-type Specificity of Human-specific Genes Preferentially Expressed in Progenitors of Fetal Neocortex
  ELife. 03, 2018  |   Pubmed ID: 29561261
• Insm1 Induces Neural Progenitor Delamination in Developing Neocortex Via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7
  Neuron. 03, 2018  |   Pubmed ID: 29503187
• Novel Gene Function and Regulation in Neocortex Expansion
  Current Opinion in Cell Biology. 12, 2017  |   Pubmed ID: 29227861
• Epigenome Profiling and Editing of Neocortical Progenitor Cells During Development
  The EMBO Journal. 09, 2017  |   Pubmed ID: 28765163
• A Tunable Refractive Index Matching Medium for Live Imaging Cells, Tissues and Model Organisms
  ELife. 07, 2017  |   Pubmed ID: 28708059
• Human-specific Genomic Signatures of Neocortical Expansion
  Current Opinion in Neurobiology. 02, 2017  |   Pubmed ID: 27912138
• Neural Progenitor Cells and Their Role in the Development and Evolutionary Expansion of the Neocortex
  Wiley Interdisciplinary Reviews. Developmental Biology. 01, 2017  |   Pubmed ID: 27865053
• A Single Splice Site Mutation in Human-specific Causes Basal Progenitor Amplification
  Science Advances. Dec, 2016  |   Pubmed ID: 27957544
• Monoclonal Antibodies 13A4 and AC133 Do Not Recognize the Canine Ortholog of Mouse and Human Stem Cell Antigen Prominin-1 (CD133)
  PloS One. 2016  |   Pubmed ID: 27701459
• Differences and Similarities Between Human and Chimpanzee Neural Progenitors During Cerebral Cortex Development
  ELife. 09, 2016  |   Pubmed ID: 27669147
• ASPM and CITK Regulate Spindle Orientation by Affecting the Dynamics of Astral Microtubules
  EMBO Reports. 10, 2016  |   Pubmed ID: 27562601
• Neocortex Expansion in Development and Evolution - from Cell Biology to Single Genes
  Current Opinion in Neurobiology. 08, 2016  |   Pubmed ID: 27258840
• GEMC1 is a Critical Regulator of Multiciliated Cell Differentiation
  The EMBO Journal. 05, 2016  |   Pubmed ID: 26933123
• Comment on "Cortical Folding Scales Universally with Surface Area and Thickness, Not Number of Neurons"
  Science (New York, N.Y.). Feb, 2016  |   Pubmed ID: 26912886
• Relief of Hypoxia by Angiogenesis Promotes Neural Stem Cell Differentiation by Targeting Glycolysis
  The EMBO Journal. May, 2016  |   Pubmed ID: 26856890
• CRISPR/Cas9-induced Disruption of Gene Expression in Mouse Embryonic Brain and Single Neural Stem Cells in Vivo
  EMBO Reports. Mar, 2016  |   Pubmed ID: 26758805
• Abnormal Spindle-like Microcephaly-associated (ASPM) Mutations Strongly Disrupt Neocortical Structure but Spare the Hippocampus and Long-term Memory
  Cortex; a Journal Devoted to the Study of the Nervous System and Behavior. Jan, 2016  |   Pubmed ID: 26691732
• S-phase Duration is the Main Target of Cell Cycle Regulation in Neural Progenitors of Developing Ferret Neocortex
  The Journal of Comparative Neurology. Feb, 2016  |   Pubmed ID: 25963823
• Human Cerebral Organoids Recapitulate Gene Expression Programs of Fetal Neocortex Development
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2015  |   Pubmed ID: 26644564
• Novel Insights into Mammalian Embryonic Neural Stem Cell Division: Focus on Microtubules
  Molecular Biology of the Cell. Dec, 2015  |   Pubmed ID: 26628750
• Lipidome of Midbody Released from Neural Stem and Progenitor Cells During Mammalian Cortical Neurogenesis
  Frontiers in Cellular Neuroscience. 2015  |   Pubmed ID: 26379497
• Sustained Pax6 Expression Generates Primate-like Basal Radial Glia in Developing Mouse Neocortex
  PLoS Biology. Aug, 2015  |   Pubmed ID: 26252244
• Neurodevelopmental LincRNA Microsyteny Conservation and Mammalian Brain Size Evolution
  PloS One. 2015  |   Pubmed ID: 26134977
• Stem Cells: Slow and Steady Wins the Race
  Nature Neuroscience. May, 2015  |   Pubmed ID: 25919957
• Analysis of Primary Cilia in the Developing Mouse Brain
  Methods in Cell Biology. 2015  |   Pubmed ID: 25837388
• Human-specific Gene ARHGAP11B Promotes Basal Progenitor Amplification and Neocortex Expansion
  Science (New York, N.Y.). Mar, 2015  |   Pubmed ID: 25721503
• An Adaptive Threshold in Mammalian Neocortical Evolution
  PLoS Biology. Nov, 2014  |   Pubmed ID: 25405475
• The Role of α-E-catenin in Cerebral Cortex Development: Radial Glia Specific Effect on Neuronal Migration
  Frontiers in Cellular Neuroscience. 2014  |   Pubmed ID: 25147501
• The Cell Biology of Neurogenesis: Toward an Understanding of the Development and Evolution of the Neocortex
  Annual Review of Cell and Developmental Biology. 2014  |   Pubmed ID: 25000993
• Specific Polar Subpopulations of Astral Microtubules Control Spindle Orientation and Symmetric Neural Stem Cell Division
  ELife. Jul, 2014  |   Pubmed ID: 24996848
• Human Prominin-1 (CD133) is Detected in Both Neoplastic and Non-neoplastic Salivary Gland Diseases and Released into Saliva in a Ubiquitinated Form
  PloS One. 2014  |   Pubmed ID: 24911657
• Neural Progenitors, Neurogenesis and the Evolution of the Neocortex
  Development (Cambridge, England). Jun, 2014  |   Pubmed ID: 24866113
• Microinjection of Membrane-impermeable Molecules into Single Neural Stem Cells in Brain Tissue
  Nature Protocols. May, 2014  |   Pubmed ID: 24762784
• 3' UTR-dependent, MiR-92-mediated Restriction of Tis21 Expression Maintains Asymmetric Neural Stem Cell Division to Ensure Proper Neocortex Size
  Cell Reports. Apr, 2014  |   Pubmed ID: 24726360
• Neurogenesis During Development of the Vertebrate Central Nervous System
  EMBO Reports. Apr, 2014  |   Pubmed ID: 24639559
• Integrin αvβ3 and Thyroid Hormones Promote Expansion of Progenitors in Embryonic Neocortex
  Development (Cambridge, England). Feb, 2014  |   Pubmed ID: 24496617
• Progenitor Networking in the Fetal Primate Neocortex
  Neuron. Oct, 2013  |   Pubmed ID: 24139029
• Asymmetric Inheritance of Centrosome-associated Primary Cilium Membrane Directs Ciliogenesis After Cell Division
  Cell. Oct, 2013  |   Pubmed ID: 24120134
• Conical Expansion of the Outer Subventricular Zone and the Role of Neocortical Folding in Evolution and Development
  Frontiers in Human Neuroscience. 2013  |   Pubmed ID: 23914167
• The Secondary Loss of Gyrencephaly As an Example of Evolutionary Phenotypical Reversal
  Frontiers in Neuroanatomy. 2013  |   Pubmed ID: 23805079
• Prominin-1 (CD133) and the Cell Biology of Neural Progenitors and Their Progeny
  Advances in Experimental Medicine and Biology. 2013  |   Pubmed ID: 23161077
• Transcriptomes of Germinal Zones of Human and Mouse Fetal Neocortex Suggest a Role of Extracellular Matrix in Progenitor Self-renewal
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2012  |   Pubmed ID: 22753484
• Abundant Occurrence of Basal Radial Glia in the Subventricular Zone of Embryonic Neocortex of a Lissencephalic Primate, the Common Marmoset Callithrix Jacchus
  Cerebral Cortex (New York, N.Y. : 1991). Feb, 2012  |   Pubmed ID: 22114084
• Basolateral Rather Than Apical Primary Cilia on Neuroepithelial Cells Committed to Delamination
  Development (Cambridge, England). Jan, 2012  |   Pubmed ID: 22096071
• A New Approach to Manipulate the Fate of Single Neural Stem Cells in Tissue
  Nature Neuroscience. Dec, 2011  |   Pubmed ID: 22179113
• Proliferating Versus Differentiating Stem and Cancer Cells Exhibit Distinct Midbody-release Behaviour
  Nature Communications. Oct, 2011  |   Pubmed ID: 22009035
• Neural Stem and Progenitor Cells Shorten S-phase on Commitment to Neuron Production
  Nature Communications. Jan, 2011  |   Pubmed ID: 21224845
• Cortical Progenitor Expansion, Self-renewal and Neurogenesis-a Polarized Perspective
  Current Opinion in Neurobiology. Feb, 2011  |   Pubmed ID: 21036598
• Prominin-1 (CD133) is Not Restricted to Stem Cells Located in the Basal Compartment of Murine and Human Prostate
  The Prostate. Feb, 2011  |   Pubmed ID: 20717901
• Neural Progenitor Nuclei IN Motion
  Neuron. Sep, 2010  |   Pubmed ID: 20869589
• Mutations in Mouse Aspm (abnormal Spindle-like Microcephaly Associated) Cause Not Only Microcephaly but Also Major Defects in the Germline
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010  |   Pubmed ID: 20823249
• OSVZ Progenitors of Human and Ferret Neocortex Are Epithelial-like and Expand by Integrin Signaling
  Nature Neuroscience. Jun, 2010  |   Pubmed ID: 20436478
• Tis21 Expression Marks Not Only Populations of Neurogenic Precursor Cells but Also New Postmitotic Neurons in Adult Hippocampal Neurogenesis
  Cerebral Cortex (New York, N.Y. : 1991). Feb, 2010  |   Pubmed ID: 19482889
• Autonomic Function in Hypertension; Role of Genetic Variation at the Catecholamine Storage Vesicle Protein Chromogranin B
  Circulation. Cardiovascular Genetics. Feb, 2009  |   Pubmed ID: 20011129
• Myosin II is Required for Interkinetic Nuclear Migration of Neural Progenitors
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009  |   Pubmed ID: 19805325
• Ablation of Cholesterol Biosynthesis in Neural Stem Cells Increases Their VEGF Expression and Angiogenesis but Causes Neuron Apoptosis
  Proceedings of the National Academy of Sciences of the United States of America. May, 2009  |   Pubmed ID: 19416849
• Nonselective Sister Chromatid Segregation in Mouse Embryonic Neocortical Precursor Cells
  Cerebral Cortex (New York, N.Y. : 1991). Jul, 2009  |   Pubmed ID: 19342402
• Release of Extracellular Membrane Vesicles from Microvilli of Epithelial Cells is Enhanced by Depleting Membrane Cholesterol
  FEBS Letters. Mar, 2009  |   Pubmed ID: 19302789
• MiRNAs Are Essential for Survival and Differentiation of Newborn Neurons but Not for Expansion of Neural Progenitors During Early Neurogenesis in the Mouse Embryonic Neocortex
  Development (Cambridge, England). Dec, 2008  |   Pubmed ID: 18997113
• Cytokinesis of Neuroepithelial Cells Can Divide Their Basal Process Before Anaphase
  The EMBO Journal. Dec, 2008  |   Pubmed ID: 18971946
• Insulinoma-associated 1 Has a Panneurogenic Role and Promotes the Generation and Expansion of Basal Progenitors in the Developing Mouse Neocortex
  Neuron. Oct, 2008  |   Pubmed ID: 18940587
• The Cell Biology of Neural Stem and Progenitor Cells and Its Significance for Their Proliferation Versus Differentiation During Mammalian Brain Development
  Current Opinion in Cell Biology. Dec, 2008  |   Pubmed ID: 18930817
• Making Bigger Brains-the Evolution of Neural-progenitor-cell Division
  Journal of Cell Science. Sep, 2008  |   Pubmed ID: 18716282
• Live Imaging at the Onset of Cortical Neurogenesis Reveals Differential Appearance of the Neuronal Phenotype in Apical Versus Basal Progenitor Progeny
  PloS One. 2008  |   Pubmed ID: 18545663
• Neuronal and Glial Cell Biology
  Current Opinion in Neurobiology. Oct, 2007  |   Pubmed ID: 18093823
• On the Origin of Neurons
  Genome Biology. 2007  |   Pubmed ID: 17666121
• Cell Polarity from Cell Division
  Developmental Cell. May, 2007  |   Pubmed ID: 17488617
• Midbody and Primary Cilium of Neural Progenitors Release Extracellular Membrane Particles Enriched in the Stem Cell Marker Prominin-1
  The Journal of Cell Biology. Feb, 2007  |   Pubmed ID: 17283184
• Single-cell Detection of MicroRNAs in Developing Vertebrate Embryos After Acute Administration of a Dual-fluorescence Reporter/sensor Plasmid
  BioTechniques. Dec, 2006  |   Pubmed ID: 17191618
• Aspm Specifically Maintains Symmetric Proliferative Divisions of Neuroepithelial Cells
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2006  |   Pubmed ID: 16798874
• Tyrosine O-sulfation
  Current Protocols in Protein Science. Mar, 2005  |   Pubmed ID: 18429275
• Symmetric Versus Asymmetric Cell Division During Neurogenesis in the Developing Vertebrate Central Nervous System
  Current Opinion in Cell Biology. Dec, 2005  |   Pubmed ID: 16243506
• Selective Lengthening of the Cell Cycle in the Neurogenic Subpopulation of Neural Progenitor Cells During Mouse Brain Development
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2005  |   Pubmed ID: 16014714
• Release of Extracellular Membrane Particles Carrying the Stem Cell Marker Prominin-1 (CD133) from Neural Progenitors and Other Epithelial Cells
  Journal of Cell Science. Jul, 2005  |   Pubmed ID: 15976444
• Identification of Novel Prominin-1/CD133 Splice Variants with Alternative C-termini and Their Expression in Epididymis and Testis
  Journal of Cell Science. Aug, 2004  |   Pubmed ID: 15316084
• Asymmetric Distribution of the Apical Plasma Membrane During Neurogenic Divisions of Mammalian Neuroepithelial Cells
  The EMBO Journal. Jun, 2004  |   Pubmed ID: 15141162
• Tissue-specific RNA Interference in Post-implantation Mouse Embryos Using Directional Electroporation and Whole Embryo Culture
  Differentiation; Research in Biological Diversity. Mar, 2004  |   Pubmed ID: 15066189
• Neurons Arise in the Basal Neuroepithelium of the Early Mammalian Telencephalon: a Major Site of Neurogenesis
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004  |   Pubmed ID: 14963232
• An Inhibition of Cyclin-dependent Kinases That Lengthens, but Does Not Arrest, Neuroepithelial Cell Cycle Induces Premature Neurogenesis
  Journal of Cell Science. Dec, 2003  |   Pubmed ID: 14625388
• AC133 Antigen, CD133, Prominin-1, Prominin-2, Etc.: Prominin Family Gene Products in Need of a Rational Nomenclature
  Stem Cells (Dayton, Ohio). 2003  |   Pubmed ID: 12832703
• Characterization of Prominin-2, a New Member of the Prominin Family of Pentaspan Membrane Glycoproteins
  The Journal of Biological Chemistry. Mar, 2003  |   Pubmed ID: 12514187
• Tissue-specific RNA Interference in Postimplantation Mouse Embryos with Endoribonuclease-prepared Short Interfering RNA
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002  |   Pubmed ID: 12391321